Muscarinic acetylcholine receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Atropine	Ki	1.0 [1], 2.4 [2]
	3-Quinuclidinyl benzilate	Ki	0.04 [1], 0.05 [2], 0.2 [3], 0.24 [4]
	3-(Benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	9.6 [1], 31.0 [2], 59.0 [3], 67.0 [4]
	3-(2-Thienyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	290.0 [1], 620.0 [2], 1200.0 [3], 1500.0 [4]
	1-Azabicyclo[2.2.2]oct-2-ene, 3-(2-furanyl)-	Ki	300.0 [1], 390.0 [2], 850.0 [3], 1100.0 [4]
	3-(7-Bromo-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	15.0 [1], 44.0 [2], 97.0 [3], 216.0 [4]
	1-[5-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-3-furanyl]ethanone	Ki	1300.0 [1], 2400.0 [2], 3200.0 [3], 4100.0 [4]
	2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-1-benzofuran-5-carbaldehyde	Ki	364.0 [1], 920.0 [2], 1300.0 [3], 1571.0 [4]
	3-(5-Bromo-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	6.4 [1], 15.0 [2], 28.0 [3], 29.0 [4]
	[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-1-benzofuran-5-yl]methanol	Ki	1400.0 [1], 1840.0 [2], 2900.0 [3], 10700.0 [4]
	3-(3-Bromo-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	40.0 [1], 106.0 [2], 116.0 [3], 161.0 [4]
	2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-1-benzofuran-7-carbaldehyde	Ki	648.0 [1], 1612.0 [2], 1700.0 [3], 3023.0 [4]
	2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-7-methoxy-1-benzofuran-5-carbaldehyde	Ki	1170.0 [1], 2040.0 [2], 3900.0 [3], 7600.0 [4]
	3-(3-Phenyl-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	20.0 [1], 56.0 [2], 72.0 [3], 107.0 [4]
	3-(5-Methyl-2-furyl)quinuclidin-2-ene	Ki	12.0 [1], 35.0 [2], 64.0 [3]
	1-[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-3-furanyl]ethanone	Ki	570.0 [1], 1200.0 [2], 2300.0 [3], 2500.0 [4]
	CID 10566215	Ki	135.0 [1], 260.0 [2], 330.0 [3], 410.0 [4]
	[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-7-iodo-1-benzofuran-5-yl]methanol	Ki	197.0 [1], 462.0 [2], 802.0 [3], 970.0 [4]
	3-(7-Iodo-5-nitro-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	150.0 [1], 1000.0 [2], 1600.0 [3], 1900.0 [4]
	3-(3-Methyl-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	520.0 [1], 575.0 [2], 1300.0 [3]
	3-(5-Phenyl-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	289.0 [1], 332.0 [2], 376.0 [3], 410.0 [4]
	3-(5-Methyl-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	116.0 [1], 238.0 [2], 295.0 [3], 364.0 [4]
	3-(5-Fluoro-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	6.3 [1], 30.0 [2], 34.0 [3], 37.0 [4]
	3-(4-Phenyl-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	730.0 [1], 1600.0 [2], 1765.0 [3], 1900.0 [4]
	[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-7-methoxy-1-benzofuran-5-yl]methanol	Ki	3665.0 [1], 5400.0 [2], 9400.0 [3], 20000.0 [4]
	3-(5-Ethyl-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	7.4 [1], 24.0 [2], 40.0 [3], 47.0 [4]
	5-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-N-phenylfuran-2-carboxamide	Ki	3320.0 [1], 3600.0 [2], 5100.0 [3], 20000.0 [4]
	2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-5-iodo-1-benzofuran-7-carbaldehyde	Ki	314.0 [1], 358.0 [2], 600.0 [3], 2300.0 [4]
	[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-1-benzofuran-7-yl]methanol	Ki	330.0 [1], 1024.0 [2], 1360.0 [3], 2000.0 [4]
	3-(5-Phenyl-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	330.0 [1], 547.0 [2], 970.0 [3], 1800.0 [4]
	1-[5-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-2-furanyl]ethanone	Ki	1100.0 [1], 2460.0 [2], 3900.0 [3], 4600.0 [4]
	Methyl 5-(1-azabicyclo[2.2.2]oct-2-en-3-yl)furan-2-carboxylate	Ki	810.0 [1], 2500.0 [2], 2530.0 [3], 3900.0 [4]
	[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-5-iodo-1-benzofuran-7-yl]methanol	Ki	480.0 [1], 1100.0 [2], 2460.0 [3], 2700.0 [4]
	2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)furo[3,2-b]pyridine	Ki	21.0 [1], 61.0 [2], 83.0 [3], 110.0 [4]
	3-(4-Bromo-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	130.0 [1], 320.0 [2], 460.0 [3], 540.0 [4]
	2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-7-iodo-1-benzofuran-5-carbaldehyde	Ki	221.0 [1], 517.0 [2], 1000.0 [3], 1300.0 [4]
	3-(5-Butyl-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	17.1 [1], 48.0 [2], 58.0 [3], 80.0 [4]
	3-(3-Bromo-2-furyl)quinuclidin-2-ene	Ki	140.0 [1], 210.0 [2], 390.0 [3], 420.0 [4]
	1-Azabicyclo[2.2.2]oct-2-ene, 3-(5-methyl-2-thienyl)-	Ki	73.0 [1], 230.0 [2], 264.0 [3], 500.0 [4]
	3-(4-Methyl-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	99.0 [1], 400.0 [2], 670.0 [3], 680.0 [4]
	3-(3-Phenyl-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	2.8 [1], 6.9 [2], 8.6 [3], 13.0 [4]
	3-(5-Bromo-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	39.0 [1], 86.0 [2], 109.0 [3], 156.0 [4]
	CID 57345320	IC50	14000.0 [1], 30000.0 [2], 33300.0 [3]
	Methyl 5-(1-azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-carboxylate	Ki	1100.0 [1], 2840.0 [2], 2900.0 [3]
	3-[3-[4-(Trifluoromethyl)phenyl]-2-furanyl]-1-azabicyclo[2.2.2]oct-2-ene	Ki	130.0 [1], 180.0 [2], 830.0 [3]
	3-(3-Phenyl-5-bromo-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	1.55 [1], 2.4 [2], 7.7 [3]
	4-[4-[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-yl]phenyl]morpholine	Ki	420.0 [1], 780.0 [2], 2760.0 [3]
	3-(7-Methyl-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	25.0 [1], 76.0 [2]
	2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-1-benzofuran-5-amine	Ki	212.0 [1], 683.0 [2], 837.0 [3]
	3-[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-yl]benzonitrile	Ki	7.8 [1], 11.0 [2], 58.0 [3]
	3-[3-(3-Butoxyphenyl)-2-furanyl]-1-azabicyclo[2.2.2]oct-2-ene	Ki	8.4 [1], 9.5 [2], 33.0 [3]
	Methyl 2-(1-azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-carboxylate	Ki	60.0 [1], 120.0 [2], 240.0 [3]
	3-(3-Phenyl-5-methyl-2-furanyl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	2.39 [1], 3.1 [2], 4.4 [3]
	3-[3-[3-(Trifluoromethyl)phenyl]-2-furanyl]-1-azabicyclo[2.2.2]oct-2-ene	Ki	5.7 [1], 10.7 [2], 25.0 [3]
	3-(3-Methyl-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	25.3 [1], 77.8 [2], 204.0 [3]
	2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-1-benzofuran-5-carbonitrile	Ki	60.0 [1], 160.0 [2], 236.0 [3]
	3-[3-(4-Ethylphenyl)furan-2-yl]-1-azabicyclo[2.2.2]oct-2-ene	Ki	38.0 [1], 59.0 [2], 124.0 [3]
	Trifluoromethyl 3-[2-(1-azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-yl]benzenesulfonate	Ki	16.0 [1], 25.0 [2], 38.0 [3]
	2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-3-furancarbonitrile	Ki	400.0 [1], 460.0 [2], 1200.0 [3]
	5-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-3-furancarbonitrile	Ki	710.0 [1], 2000.0 [2], 3400.0 [3]
	3-[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-yl]phenol	Ki	0.27 [1], 0.61 [2], 0.72 [3]
	3-[3-(3-Ethylphenyl)-2-furanyl]-1-azabicyclo[2.2.2]oct-2-ene	Ki	1.9 [1], 2.1 [2], 6.9 [3]
	3-[3-(4-Butoxyphenyl)-2-furanyl]-1-azabicyclo[2.2.2]oct-2-ene	Ki	280.0 [1], 370.0 [2], 940.0 [3]
	4-[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-yl]benzonitrile	Ki	190.0 [1], 230.0 [2], 320.0 [3]
	Methyl 3-[2-(1-azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-yl]benzenesulfonate	Ki	8.2 [1], 11.0 [2], 16.0 [3]
	4-[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-yl]phenol	Ki	0.79 [1], 1.12 [2], 3.9 [3]
	3-(5-Nitro-1-benzofuran-2-yl)-1-azabicyclo[2.2.2]oct-2-ene	Ki	139.0 [1], 460.0 [2], 515.0 [3]
	Methyl 4-[2-(1-azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-yl]benzoate	Ki	2.2 [1], 3.3 [2], 4.2 [3]
	5-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-2-furancarbonitrile	Ki	93.0 [1], 230.0 [2], 720.0 [3]
	2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-N-phenylfuran-3-carboxamide	Ki	800.0 [1], 1200.0 [2], 1900.0 [3]
	5-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-N-phenylfuran-3-carboxamide	Ki	220.0 [1], 580.0 [2], 2600.0 [3]
	4-[3-[2-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-yl]phenyl]morpholine	Ki	2.3 [1], 5.0 [2], 10.3 [3]
	Methyl 3-[2-(1-azabicyclo[2.2.2]oct-2-en-3-yl)furan-3-yl]benzoate	Ki	0.8 [1], 0.95 [2], 2.2 [3]
	Risperidone	Ki	5000.0 [1], 6300.0 [2]
	Olanzapine	Ki	26.0 [1], 68.0 [2]
	Aprofene	Ki	23.0 [1], 51.0 [2]
	5'-Chloro-N,N-dimethylspiro[cyclohex-2-ene-4,2'-tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaene]-1-amine	Ki	4.3 [1], 7.2 [2]
	Carbastat	Ki	5.0 [1]
	Haloperidol	Ki	4670.0 [1]
	Clozapine	Ki	34.0 [1]
	Quetiapine	Ki	1020.0 [1]
	Pirenzepine	Ki	530.0 [1]
	Ziprasidone	Ki	5000.0 [1]
	Pyridostigmine	Ki	100000.0 [1]
	Bethanechol	Ki	97.0 [1]
	Harmine	Ki	10000.0 [1]
	Zafirlukast	IC50	10000.0 [1]
	Sertindole	Ki	5000.0 [1]
	(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine	IC50	17000.0 [1]
	N-Methylcarbamylcholine	Ki	150.0 [1]
	N-Methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide	Ki	330.0 [1]
	Harmalan	Ki	10000.0 [1]
	Naluzotan	Ki	2000.0 [1]
	N-Desmethylolanzapine	Ki	333.0 [1]
	6-Methoxyharmalan	Ki	10000.0 [1]
	Azaprophen	Ki	0.27 [1]
	Abaperidone	Ki	1130.0 [1]
	7-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole	Ki	10000.0 [1]
	Acetamide, N-methyl-N-(4-(1-pyrrolidinyl)-2-butynyl)-	Ki	4960.0 [1]
	3-(Pyridin-3-yl)-1-azabicylo[2.2.2]oct-2-ene	Ki	6100.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Muscarinic acetylcholine receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/muscarinic-acetylcholine-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Muscarinic acetylcholine receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/muscarinic-acetylcholine-receptor-inhibitors-ic50-ki.
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