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Multidrug resistance-associated protein 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
VerlukastIC50400.0 [1], 3300.0 [2], 5220.0 [3]
VerlukastKi600.0 [1], 134700.0 [2], 139600.0 [3]
Cyclosporin AIC502700.0 [1], 2810.0 [2], 2970.0 [3], 3530.0 [4], 4780.0 [5]
Cyclosporin AKi5000.0 [1]
VerapamilIC503500.0 [1], 6800.0 [2], 9660.0 [3]
VerapamilKi13200.0 [1], 13400.0 [2]
4-(2-Phenylethylamino)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 4980.0 [2], 6300.0 [3], 8370.0 [4]
DaunorubicinIC508000.0 [1]
DaunorubicinKi70.0 [1], 950.0 [2]
MitoxantroneIC501.5 [1], 1.9 [2]
MyricetinIC5020000.0 [1]
MyricetinKi2400.0 [1], 13300.0 [2]
4-[[4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-6,8-dinitro-5H-pyrimido[5,4-b]indol-2-yl]methyl]morpholineIC5019.0 [1], 118.0 [2], 250.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indole-9-carboxamideIC5065.0 [1], 183.0 [2], 250.0 [3]
4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrileIC50197.0 [1], 370.0 [2], 690.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N-pyridin-4-yl-5H-pyrimido[5,4-b]indole-9-carboxamideIC50250.0 [1], 650.0 [2], 708.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5-(pyridin-4-ylmethyl)pyrimido[5,4-b]indole-9-carboxamideIC5020.0 [1], 250.0 [2], 270.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,13-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaeneIC5094.0 [1], 250.0 [2], 270.0 [3]
Ethyl 2-[4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-8-nitropyrimido[5,4-b]indol-5-yl]acetateIC5078.0 [1], 138.0 [2], 250.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-9-methyl-5H-pyrimido[5,4-b]indoleIC50250.0 [1], 632.0 [2], 1235.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8,13-dimethyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaeneIC5021.0 [1], 33.0 [2], 250.0 [3]
13-Chloro-6-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaeneIC5041.0 [1], 130.0 [2], 250.0 [3]
8-Benzyl-6-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaeneIC5048.0 [1], 250.0 [2], 545.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-N-(pyridin-2-ylmethyl)-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-13-amineIC5015.0 [1], 106.0 [2], 250.0 [3]
4-[[13-Chloro-6-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl]methyl]morpholineIC5017.0 [1], 90.0 [2], 250.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indol-9-amineIC50250.0 [1], 708.0 [2], 1900.0 [3]
Methyl 4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indole-8-carboxylateIC5059.0 [1], 113.0 [2], 250.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-9-nitro-5-(pyridin-4-ylmethyl)pyrimido[5,4-b]indoleIC5013.7 [1], 80.0 [2], 250.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-9-nitro-5-(2-phenylethyl)pyrimido[5,4-b]indoleIC5040.9 [1], 222.0 [2], 250.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N,8-dimethyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-13-amineIC5028.0 [1], 115.0 [2], 250.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-9-nitro-5H-pyrimido[5,4-b]indoleIC5059.0 [1], 183.0 [2], 250.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene-13-carboxamideIC5012.0 [1], 110.0 [2], 250.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N,N,8-trimethyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-13-amineIC5012.0 [1], 166.0 [2], 250.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5-methyl-9-nitropyrimido[5,4-b]indoleIC50147.0 [1], 231.0 [2], 250.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-4-(morpholin-4-ylmethyl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene-13-carboxamideIC5010.0 [1], 97.0 [2], 250.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaeneIC5024.0 [1], 44.0 [2], 250.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene-13-carbonitrileIC5045.0 [1], 250.0 [2], 355.0 [3]
9-Chloro-4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indoleIC50167.0 [1], 250.0 [2], 367.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indole-9-carbonitrileIC50169.0 [1], 250.0 [2], 277.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methoxy-5H-pyrimido[5,4-b]indoleIC50250.0 [1], 608.0 [2], 820.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5-methyl-2-(morpholin-4-ylmethyl)pyrimido[5,4-b]indole-9-carboxamideIC5029.0 [1], 230.0 [2], 250.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methoxy-9-nitro-5H-pyrimido[5,4-b]indoleIC5078.0 [1], 156.0 [2], 250.0 [3]
11-Chloro-6-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaeneIC5087.0 [1], 250.0 [2], 1200.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-13-methoxy-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaeneIC5063.0 [1], 172.0 [2], 250.0 [3]
13-Chloro-6-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-4-(methoxymethyl)-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaeneIC5013.0 [1], 244.0 [2], 250.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-9-nitro-5-(pyridin-3-ylmethyl)pyrimido[5,4-b]indoleIC5026.5 [1], 250.0 [2], 621.0 [3]
4-[6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-13-yl]morpholineIC5010.0 [1], 71.0 [2], 250.0 [3]
4-[[4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-nitro-5H-pyrimido[5,4-b]indol-2-yl]methyl]morpholineIC50107.0 [1], 250.0 [2], 672.0 [3]
6-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-methyl-13-propan-2-yloxy-3,5,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaeneIC5027.0 [1], 250.0 [2], 265.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-pyrrolidin-1-ylsulfonyl-5H-pyrimido[5,4-b]indoleIC50235.0 [1], 250.0 [2], 542.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-8-nitro-5H-pyrimido[5,4-b]indoleIC5051.0 [1], 133.0 [2], 250.0 [3]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5-methylpyrimido[5,4-b]indole-9-carboxamideIC5024.0 [1], 62.0 [2], 250.0 [3]
IndomethacinIC5012000.0 [1], 12600.0 [2]
QuercetinKi2400.0 [1], 8100.0 [2]
ApigeninKi2400.0 [1], 4900.0 [2]
KaempferolKi2400.0 [1]
NaringeninKi2400.0 [1], 20800.0 [2]
BenzbromaroneIC504000.0 [1]
BenzbromaroneKi190.0 [1]
MK-571 sodiumIC507570.0 [1], 30000.0 [2]
IvermectineIC503800.0 [1]
IvermectineKi500.0 [1]
(5S,6R,7E,9E,11Z,14Z)-6-[(2S)-2-[[(4S)-4-Amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acidKi300.0 [1], 530.0 [2]
6-Methyl-2-[4-[2-[2-[2-[2-[2-[4-(6-methyl-4-oxochromen-2-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]chromen-4-oneKi190.0 [1], 200.0 [2]
Unii-73CI11LH7FIC50800.0 [1]
N-(3,4-Dimethoxyphenyl)-2-phenylquinazolin-4-amineIC5011180.0 [1]
Phenyl-[4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizin-10-yl]methanoneIC50250.0 [1], 1370.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N-pyridin-3-yl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carboxamideIC5076.0 [1], 250.0 [2]
4-(4-Phenacylpiperazin-1-yl)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 1850.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50229.0 [1], 250.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-2-pyridin-3-yl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50218.0 [1], 250.0 [2]
4-[4-[2-(3-Nitrophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 410.0 [2]
4-[4-(3-Phenylpropyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 7350.0 [2]
4-[4-[2-(4-Nitrophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 523.0 [2]
4-[4-[2-(4-Methoxyphenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 50000.0 [2]
2-Phenyl-4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 715.0 [2]
4,5-Dimethyl-2-[4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizin-10-yl]-1,3-thiazoleIC50250.0 [1], 533.0 [2]
2-Iodo-4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 887.0 [2]
4-(4-Benzylsulfonylpiperazin-1-yl)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 6650.0 [2]
4-[4-[2-(3-Chlorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 920.0 [2]
Methyl 4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carboxylateIC50250.0 [1], 910.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carboxamideIC50138.0 [1], 250.0 [2]
N-[4-[10-Cyano-4-[4-(2-phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizin-2-yl]phenyl]acetamideIC50250.0 [1], 570.0 [2]
4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)ethylamino]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 6350.0 [2]
4-[4-[2-(4-Chlorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 399.0 [2]
4-(Methyl-phenethyl-amino)-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 9000.0 [2]
1-[4-[4-(2-Phenylethyl)piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizin-10-yl]propan-1-oneIC50250.0 [1], 2800.0 [2]
4-[4-[2-(3-Methoxyphenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 2300.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indole-8-carboxamideIC50250.0 [1], 3440.0 [2]
N-[4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-5H-pyrimido[5,4-b]indol-8-yl]acetamideIC50250.0 [1], 2710.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-7-methoxy-5H-pyrimido[5,4-b]indoleIC50250.0 [1], 3150.0 [2]
N-(10-Cyano-6,7,8,9-tetrahydropyrimido[4,5-b]indolizin-4-yl)-1-phenylmethanesulfonamideIC50250.0 [1], 20900.0 [2]
4-[4-(2-Phenylethyl)piperazin-1-yl]-10-pyrimidin-2-yl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizineIC50250.0 [1], 675.0 [2]
4-[4-[2-(2-Nitrophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 1415.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N-ethyl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carboxamideIC50120.0 [1], 250.0 [2]
4-[4-[2-(2-Chlorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 955.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-2-(2-methylphenyl)-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50250.0 [1], 620.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-N-[(2,3-dimethoxyphenyl)methyl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carboxamideIC5043.0 [1], 250.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-7-methoxy-6-nitro-5H-pyrimido[5,4-b]indoleIC50250.0 [1], 3450.0 [2]
4-[4-[2-(3,4-Difluorophenyl)ethyl]piperazin-1-yl]-2-pyridin-4-yl-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrileIC50105.0 [1], 250.0 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Multidrug resistance-associated protein 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/multidrug-resistance-associated-protein-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Multidrug resistance-associated protein 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/multidrug-resistance-associated-protein-1-inhibitors-ic50-ki.
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