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mTORC1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-[6-(2-Hydroxypropan-2-yl)pyridin-3-yl]-8-(oxan-4-ylmethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-oneIC50386.0 [1], 390.0 [2]
8-(4-Methoxycyclohexyl)-2-[2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-oneIC5085.0 [1], 203.0 [2]
5-(4-Hydroxycyclohexyl)-3-[2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC506.0 [1], 12.0 [2]
2-[6-(2-Hydroxypropan-2-yl)pyridin-3-yl]-8-(4-methoxycyclohexyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-oneIC50340.0 [1], 530.0 [2]
5-[(4-Methoxycyclohexyl)methyl]-3-[2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC504.0 [1], 27.0 [2]
DactolisibIC5044.0 [1]
PI-103IC5020.0 [1]
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanolIC5027.0 [1]
VistusertibIC50200.0 [1]
Ku-0063794IC50660.0 [1]
OmipalisibKi0.18 [1]
N-[4-({3-[(3,5-Dimethoxyphenyl)amino]quinoxalin-2-yl}sulfamoyl)phenyl]-3-methoxy-4-methylbenzamideIC50190.0 [1]
Cc-223IC5030.0 [1]
Cc-115IC5023.0 [1]
Mtor-IN-1IC509.1 [1]
8-[2-(Oxan-4-yl)ethyl]-2-[4-(1H-1,2,4-triazol-5-yl)phenyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-oneIC5046.0 [1]
2-[2-Methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-oneIC50108.0 [1]
3-[2-Methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC508.0 [1]
3-[2-(Oxan-4-yl)ethyl]-5-[4-(1H-1,2,4-triazol-5-yl)phenyl]-1H-imidazo[4,5-b]pyrazin-2-oneIC5040.0 [1]
1-[2-(Diethylamino)ethyl]-3-[6-[5-[(4-fluorophenyl)sulfonylamino]-6-methoxypyridin-3-yl]-1,3-benzothiazol-2-yl]ureaIC5078.0 [1]
[(1S,5R)-3-[10-(6-Phenylpyridin-3-yl)-1,3,4,8,12-pentazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-7-yl]-8-azabicyclo[3.2.1]octan-8-yl]-(1H-1,2,4-triazol-5-yl)methanoneIC501.0 [1]
[(1S,5R)-3-[10-[6-(1H-Imidazol-2-yl)pyridin-3-yl]-1,3,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-7-yl]-8-azabicyclo[3.2.1]octan-8-yl]-(1H-1,2,4-triazol-5-yl)methanoneIC501.0 [1]
[(1S,5R)-3-[5-Methyl-10-(6-phenylpyridin-3-yl)-1,3,4,8,12-pentazatricyclo[7.3.0.02,6]dodeca-2,5,7,9,11-pentaen-7-yl]-8-azabicyclo[3.2.1]octan-8-yl]-(1H-1,2,4-triazol-5-yl)methanoneIC50100.0 [1]
5-[6-(2-Hydroxypropan-2-yl)pyridin-3-yl]-3-(oxan-4-ylmethyl)-1H-imidazo[4,5-b]pyrazin-2-oneIC502410.0 [1]
8-Ethyl-2-[2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-oneIC5053.0 [1]
8-(2-Methoxyethyl)-2-[2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-oneIC5066.0 [1]
2-[6-(2-Hydroxypropan-2-yl)pyridin-3-yl]-8-[(4-methoxycyclohexyl)methyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-oneIC50230.0 [1]
3-[2-Methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-5-propan-2-yl-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC5044.0 [1]
5-(2-Methoxyethyl)-3-[2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC5010.0 [1]
3-[6-(2-Hydroxypropan-2-yl)pyridin-3-yl]-5-(2-methoxyethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC50650.0 [1]
1-Ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-pyrazin-2-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]ureaIC507.8 [1]
1-Ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]ureaIC5019.0 [1]
3-[2-Methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-5-(oxan-4-ylmethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC5015.0 [1]
2-[6-(2-Hydroxypropan-2-yl)pyridin-3-yl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-oneIC50240.0 [1]
5-(4-Methoxycyclohexyl)-3-[2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC5020.0 [1]
3-[6-(2-Hydroxypropan-2-yl)pyridin-3-yl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC50240.0 [1]
3-[2-Methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-5-(2-morpholin-4-ylethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC5054.0 [1]
3-[2-Methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl]-5-(oxan-4-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC5010.0 [1]
3-[6-(2-Hydroxypropan-2-yl)pyridin-3-yl]-5-(oxan-4-ylmethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-oneIC50200.0 [1]
1-Ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(5-methyl-1,3,4-oxadiazol-2-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]ureaIC5062.0 [1]
1-Ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-pyridazin-3-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]ureaIC5035.0 [1]
[(1R,5S)-3-[8-Amino-3-[6-(1H-imidazol-2-yl)pyridin-3-yl]imidazo[1,2-a]pyrazin-6-yl]-8-azabicyclo[3.2.1]octan-8-yl]-(1H-1,2,4-triazol-5-yl)methanoneIC5010000.0 [1]
1-[(1R,5S)-3-[8-Amino-3-(6-phenylpyridin-3-yl)imidazo[1,2-a]pyrazin-6-yl]-8-azabicyclo[3.2.1]octan-8-yl]-2-hydroxyethanoneIC50100.0 [1]
[(1R,5S)-3-[8-Amino-3-(6-phenylpyridin-3-yl)imidazo[1,2-a]pyrazin-6-yl]-8-azabicyclo[3.2.1]octan-8-yl]-(1H-1,2,4-triazol-5-yl)methanoneIC50100.0 [1]
1-Ethyl-3-[4-[(1R,9S)-12-methyl-3-[(3S)-3-methylmorpholin-4-yl]-4,6,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-5-yl]phenyl]ureaIC508.2 [1]
1-Ethyl-3-[4-[(1S,9R)-12-methyl-3-[(3S)-3-methylmorpholin-4-yl]-4,6,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-5-yl]phenyl]ureaIC5015.0 [1]
1-Ethyl-3-[4-[(1R,9S)-12-ethyl-3-[(3S)-3-methylmorpholin-4-yl]-4,6,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-5-yl]phenyl]ureaIC507.4 [1]
6-Aza-PATIC507.7 [1]
1-Ethyl-3-[4-[(1S,9R)-3-[(3S)-3-methylmorpholin-4-yl]-12-(oxetan-3-yl)-4,6,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-5-yl]phenyl]ureaIC5082.0 [1]
1-Ethyl-3-[4-[(1R,9S)-3-[(3S)-3-methylmorpholin-4-yl]-12-methylsulfonyl-4,6,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-5-yl]phenyl]ureaIC5025.0 [1]
1-[4-[(1R,9S)-12-Acetyl-3-[(3S)-3-methylmorpholin-4-yl]-4,6,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-5-yl]phenyl]-3-ethylureaIC5015.0 [1]
1-Ethyl-3-[4-[(1S,9R)-12-methyl-6-[(3S)-3-methylmorpholin-4-yl]-3,5,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-4-yl]phenyl]ureaIC508.2 [1]
1-Ethyl-3-[4-[(1R,9S)-12-methyl-6-[(3S)-3-methylmorpholin-4-yl]-3,5,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-4-yl]phenyl]ureaIC502.4 [1]
1-Ethyl-3-[4-[(1R,9S)-6-[(3S)-3-methylmorpholin-4-yl]-12-methylsulfonyl-3,5,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-4-yl]phenyl]ureaIC501.3 [1]
1-[4-[(1R,9S)-12-Acetyl-6-[(3S)-3-methylmorpholin-4-yl]-3,5,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-4-yl]phenyl]-3-ethylureaIC502.0 [1]
2-[(1R,9S)-4-[4-(Ethylcarbamoylamino)phenyl]-6-[(3S)-3-methylmorpholin-4-yl]-3,5,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-12-yl]-N,2-dimethylpropanamideIC500.7 [1]
1-Ethyl-3-[4-[(1R,9S)-6-[(3S)-3-methylmorpholin-4-yl]-12-(oxetan-3-yl)-3,5,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-4-yl]phenyl]ureaIC502.7 [1]
1-Ethyl-3-[4-[(1R,9S)-12-(2-methoxyacetyl)-6-[(3S)-3-methylmorpholin-4-yl]-3,5,12-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-trien-4-yl]phenyl]ureaIC503.3 [1]
[(1R,5S)-3-[8-Amino-3-(1-phenylpyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl]-8-azabicyclo[3.2.1]octan-8-yl]-(1H-1,2,4-triazol-5-yl)methanoneIC501863.0 [1]
1-[(1R,3S,5S)-3-[8-Amino-3-[6-(1H-imidazol-2-yl)pyridin-3-yl]imidazo[1,2-a]pyrazin-6-yl]-1-methyl-8-azabicyclo[3.2.1]octan-8-yl]-2-hydroxyethanoneIC5010000.0 [1]
[(1R,5S)-3-[8-Amino-3-[6-(1-methylpyrazol-3-yl)pyridin-3-yl]imidazo[1,2-a]pyrazin-6-yl]-8-azabicyclo[3.2.1]octan-8-yl]-(1H-1,2,4-triazol-5-yl)methanoneIC501000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ mTORC1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/mtorc1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ mTORC1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mtorc1-inhibitors-ic50-ki.
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