Motilin receptor Inhibitors (IC50, Ki)

Name: Motilin receptor Inhibitors (IC50, Ki)
Creator: AAT Bioquest
License: https://www.aatbio.com/tou.html

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(6R,9R,12S,16E)-6-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	IC50	74.0 ^[1]
	(6R,9R,12S,16E)-6-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	137.0 ^[1]
	Erythromycin	IC50	43.65 ^[1], 70.79 ^[2]
	Erythromycin	Ki	37000.0 ^[1]
	Erythromycin A enol ether	IC50	3.39 ^[1], 223.87 ^[2]
	(2S)-5-Amino-2-[[2-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-4-carboxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]acetyl]amino]-5-oxopentanoic acid	Ki	0.36 ^[1], 3.1 ^[2]
	(6R,9R,12S,16E)-12-(4-Aminobutyl)-6-[(4-hydroxyphenyl)methyl]-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	664.0 ^[1]
	2-[(6R,9R,12S,16E)-6-[(4-Hydroxyphenyl)methyl]-7,10,13-trioxo-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraen-12-yl]acetic acid	Ki	2553.0 ^[1]
	(6R,9R,12S)-6-[(4-Methoxyphenyl)methyl]-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	IC50	23.0 ^[1]
	(6R,9R,12S)-6-[(4-Methoxyphenyl)methyl]-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	8.0 ^[1]
	(6R,9R,12S)-9-Propan-2-yl-12-(pyrrolidin-1-ylmethyl)-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	IC50	2.0 ^[1]
	(6R,9R,12S)-9-Propan-2-yl-12-(pyrrolidin-1-ylmethyl)-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	4.6 ^[1]
	(6R,9R,12S)-6-[(3-Chlorophenyl)methyl]-9-propan-2-yl-12-(pyrazol-1-ylmethyl)-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	IC50	56.0 ^[1]
	(6R,9R,12S)-6-[(3-Chlorophenyl)methyl]-9-propan-2-yl-12-(pyrazol-1-ylmethyl)-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	18.0 ^[1]
	(6R,9R,12S)-12-(Aminomethyl)-9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	IC50	8.0 ^[1]
	(6R,9R,12S)-12-(Aminomethyl)-9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	15.0 ^[1]
	(6R,9R,12S)-6-[(4-Chlorophenyl)methyl]-12-(methylaminomethyl)-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	IC50	33.0 ^[1]
	(6R,9R,12S)-6-[(4-Chlorophenyl)methyl]-12-(methylaminomethyl)-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	31.0 ^[1]
	(6R,9R,12S)-12-(Methylaminomethyl)-9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	IC50	3.0 ^[1]
	(6R,9R,12S)-12-(Methylaminomethyl)-9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	6.0 ^[1]
	(6R,9R,12S)-6-[(3-Chlorophenyl)methyl]-12-[(dimethylamino)methyl]-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	IC50	95.0 ^[1]
	(6R,9R,12S)-6-[(3-Chlorophenyl)methyl]-12-[(dimethylamino)methyl]-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	27.0 ^[1]
	2-[[(6R,9R,12S)-7,10,13-Trioxo-9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-12-yl]methyl]guanidine	IC50	28.0 ^[1]
	2-[[(6R,9R,12S)-7,10,13-Trioxo-9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-12-yl]methyl]guanidine	Ki	6.0 ^[1]
	(2R,3R,4R,11R,12S)-11-[(3R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-5-ethyl-3-hydroxy-9-[(2R,4R,5S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-2,4,8,10,12,14-hexamethyl-6,15,16-trioxatricyclo[10.2.1.11,4]hexadecan-7-one	IC50	154.88 ^[1], 169.82 ^[2]
	(2R,3R,4S,11R,12S)-5-Ethyl-11-[(3R)-4-[ethyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-3-hydroxy-9-[(2R,4R,5S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-4-methoxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)-en-7-one	IC50	4.68 ^[1], 8.32 ^[2]
	(2R,3R,4S,11R,12S)-5-Ethyl-3-hydroxy-9-[(2R,4R,5S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-11-[(3R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-4-methoxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)-en-7-one	IC50	6.92 ^[1], 15.14 ^[2]
	(2R,3R,4S,11R,12S)-5-Ethyl-11-[(3R)-4-[ethyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-3,4-dihydroxy-9-[(4R,5S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-2,4,8,12,14-pentamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)-en-7-one	IC50	3.16 ^[1], 302.0 ^[2]
	(2R,3R,4S,11R,12S)-11-[(3R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-5-ethyl-3-hydroxy-9-[(2R,4R,5S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-4-methoxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)-en-7-one	IC50	7.59 ^[1], 39.81 ^[2]
	Cipargamin	IC50	10000.0 ^[1]
	(2S,4R,5R,8R,9S,10S,11R,12S)-5-Ethyl-9-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-11-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-4-methoxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)-ene-3,7-dione	IC50	3.98 ^[1]
	(2R,3S,4R,5R,8R,9S,10S,11R,12R)-5-Ethyl-11-[(2S,3R,4S,6R)-4-[ethyl(methyl)amino]-3-hydroxy-6-methyloxan-2-yl]oxy-3-hydroxy-9-[(2S,4S,6R)-4-methoxy-4,6-dimethyloxan-2-yl]oxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)-en-7-one	Ki	3.4 ^[1]
	[3-[4-[[(3S,5R)-3,5-Dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]-[4-(4-fluoroanilino)piperidin-1-yl]methanone	IC50	3.98 ^[1]
	N-[(2S)-1-[[(2S)-1-Amino-1-oxo-4-phenylbutan-2-yl]amino]-1-oxo-4-phenylbutan-2-yl]-2-(1,3-benzodioxol-5-ylmethyl)-1,3-dioxospiro[7,8-dihydro-6H-[1,2,4]triazolo[1,2-a]pyridazine-5,4'-piperidine]-8-carboxamide	Ki	0.7 ^[1]
	(6R,9R,12S)-12-(Aminomethyl)-6-[(4-chlorophenyl)methyl]-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	60.0 ^[1]
	(6R,9R,12S,16E)-6-[(4-Hydroxyphenyl)methyl]-12-(2-methylpropyl)-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	62.0 ^[1]
	N-[(2S)-1-[[(2S)-1-Amino-1-oxo-4-phenylbutan-2-yl]amino]-1-oxo-4-phenylbutan-2-yl]-2-(1,3-benzodioxol-5-ylmethyl)-1,3-dioxospiro[8H-[1,2,4]triazolo[1,2-a]pyridazine-5,4'-piperidine]-8-carboxamide	Ki	2.0 ^[1]
	(6R,9R,12S)-6-(1H-Indol-3-ylmethyl)-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	255.0 ^[1]
	(6R,9R,12S,16E)-6-Benzyl-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	78.0 ^[1]
	2-[[(6R,9R,12S)-6-[(4-Chlorophenyl)methyl]-7,10,13-trioxo-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-12-yl]methyl]guanidine	Ki	6.0 ^[1]
	N-[(2R)-1-Amino-1-oxo-4-phenylbutan-2-yl]-2-(1,3-benzodioxol-5-ylmethyl)-1,3-dioxospiro[8H-[1,2,4]triazolo[1,2-a]pyridazine-5,4'-piperidine]-8-carboxamide	Ki	10000.0 ^[1]
	(6R,9R,12S)-6-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	55.0 ^[1]
	(6R,9R,12S)-6-[(4-Hydroxyphenyl)methyl]-11-methyl-12-(2-methylpropyl)-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	222.0 ^[1]
	(6R,9R,12S)-12-(Aminomethyl)-6-[(3-chlorophenyl)methyl]-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	64.0 ^[1]
	N-[(2S)-1-Amino-1-oxo-4-phenylbutan-2-yl]-2-(1,3-benzodioxol-5-ylmethyl)-1,3-dioxospiro[8H-[1,2,4]triazolo[1,2-a]pyridazine-5,4'-piperidine]-8-carboxamide	Ki	10000.0 ^[1]
	(6R,9R,12S)-6-[(4-Chlorophenyl)methyl]-12-[(dimethylamino)methyl]-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	16.0 ^[1]
	(6R,9R,12S)-6-(Naphthalen-1-ylmethyl)-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	8.3 ^[1]
	(6R,9R,12S)-6-(1-Benzothiophen-3-ylmethyl)-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	11.0 ^[1]
	(6R,9R,12S,16E)-6-Methyl-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	10000.0 ^[1]
	(6R,9R,12S,16E)-6,9-Di(propan-2-yl)-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	3566.0 ^[1]
	(6R,9R,12S,16E)-6-(4-Aminobutyl)-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	10000.0 ^[1]
	(6R,9S,12S,16E)-6-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	10000.0 ^[1]
	(6R,9R,12S,16E)-9-(Hydroxymethyl)-6-[(4-hydroxyphenyl)methyl]-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	10000.0 ^[1]
	(6R,9R,12S,16E)-6-[(4-Hydroxyphenyl)methyl]-12-methyl-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	1389.0 ^[1]
	(6R,9R,12R,16E)-6-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	335.0 ^[1]
	(6R,9R,12S,16E)-12-Benzyl-6-[(4-hydroxyphenyl)methyl]-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	185.0 ^[1]
	(2E,7S,10R,13R)-13-[(4-Hydroxyphenyl)methyl]-10-propan-2-yl-7-propyl-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),2,18,20-tetraene-6,9,12-trione	Ki	10000.0 ^[1]
	(6S,9R,12R)-12-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-6-propyl-4,7,10,13-tetrazabicyclo[15.4.0]henicosa-1(21),17,19-triene-5,8,11-trione	Ki	10000.0 ^[1]
	(5R,8R,11S)-5-[(4-Hydroxyphenyl)methyl]-8-propan-2-yl-11-propyl-4,7,10,13-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione	Ki	6064.0 ^[1]
	(5R,8R,11S)-5-[(4-Hydroxyphenyl)methyl]-8-propan-2-yl-11-propyl-4,7,10,13-tetrazabicyclo[15.4.0]henicosa-1(21),17,19-triene-6,9,12-trione	Ki	10000.0 ^[1]
	(6S,9R,12R)-12-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-6-propyl-4,7,10,13-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-5,8,11-trione	Ki	6064.0 ^[1]
	(3S,6R,9R,12E)-9-[(4-Hydroxyphenyl)methyl]-6-propan-2-yl-3-propyl-1,4,7,10-tetrazacyclopentadec-12-ene-2,5,8-trione	Ki	701.0 ^[1]
	(6R,9R,12S)-6-Benzyl-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	57.0 ^[1]
	(6R,9R,12S)-6-Phenyl-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	10000.0 ^[1]
	(6R,9R,12S)-6-(Naphthalen-2-ylmethyl)-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	79.0 ^[1]
	(6R,9R,12S)-6-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-12-propyl-2,8-dioxa-5,11,14-triazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	192.0 ^[1]
	(6R,9R,12S)-6-[(4-Hydroxyphenyl)methyl]-8-methyl-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	10000.0 ^[1]
	(6R,9R,12S)-6-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-10,13-dione	Ki	3237.0 ^[1]
	(6R,10R,13S)-6-[(4-Hydroxyphenyl)methyl]-10-propan-2-yl-13-propyl-2-oxa-5,8,9,12,15-pentazabicyclo[17.4.0]tricosa-1(23),19,21-triene-7,11,14-trione	Ki	2373.0 ^[1]
	(6S,9R,12S,16E)-6-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	10000.0 ^[1]
	3-[(6R,9R,12S,16E)-7,10,13-Trioxo-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraen-6-yl]propanoic acid	Ki	10000.0 ^[1]
	(6R,9R,12S,16E)-6-[(4-Hydroxyphenyl)methyl]-9-methyl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	196.0 ^[1]
	3-[(6R,9R,12S,16E)-6-[(4-Hydroxyphenyl)methyl]-7,10,13-trioxo-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraen-9-yl]propanoic acid	Ki	4898.0 ^[1]
	(6R,9R,12S,16E)-9-Benzyl-6-[(4-hydroxyphenyl)methyl]-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	1524.0 ^[1]
	(6R,9R,12S,16E)-12-(Hydroxymethyl)-6-[(4-hydroxyphenyl)methyl]-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-7,10,13-trione	Ki	650.0 ^[1]
	(7S,10R,13R)-13-[(4-Hydroxyphenyl)methyl]-10-propan-2-yl-7-propyl-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione	Ki	10000.0 ^[1]
	(5R,8R,11S,15E)-5-[(4-Hydroxyphenyl)methyl]-8-propan-2-yl-11-propyl-4,7,10,13-tetrazabicyclo[15.4.0]henicosa-1(21),15,17,19-tetraene-6,9,12-trione	Ki	9726.0 ^[1]
	(4R,7R,10S)-4-[(4-Hydroxyphenyl)methyl]-7-propan-2-yl-10-propyl-3,6,9,12-tetrazabicyclo[15.4.0]henicosa-1(21),17,19-triene-5,8,11-trione	Ki	10000.0 ^[1]
	(6R,9R,12S)-6-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[15.4.0]henicosa-1(21),17,19-triene-7,10,13-trione	Ki	982.0 ^[1]
	(3S,6R,9R)-9-[(4-Hydroxyphenyl)methyl]-6-propan-2-yl-3-propyl-1,4,7,10-tetrazacyclooctadecane-2,5,8-trione	Ki	1197.0 ^[1]
	(6R,9R,12S)-6-(Cyclohexylmethyl)-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	3247.0 ^[1]
	(6R,9R,12S)-6-(2-Phenylethyl)-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	1486.0 ^[1]
	(6R,9R,12S)-6-[(4-Hydroxyphenyl)methyl]-9-propan-2-yl-12-propyl-2,11-dioxa-5,8,14-triazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	1876.0 ^[1]
	(6R,9R,12S)-6-[(4-Hydroxyphenyl)methyl]-5-methyl-9-propan-2-yl-12-propyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	2777.0 ^[1]
	N-[[(1R,3S)-3-[Benzyl(2,2-dimethylpropanoyl)amino]cyclohexyl]methyl]-4-fluoro-N-[3-(2-pyrrolidin-1-ylethoxy)phenyl]benzamide	IC50	2480.0 ^[1]
	N-[[3-[(3-Chlorophenyl)methyl-(2,2,2-trichloroacetyl)amino]cyclohexyl]methyl]-4-fluoro-N-[3-(2-piperidin-1-ylethoxy)phenyl]benzamide	IC50	228.0 ^[1]
	N-[[3-[Benzyl(2,2-dimethylpropanoyl)amino]cyclohexyl]methyl]-4-fluoro-N-[3-(2-pyrrolidin-1-ylethoxy)phenyl]benzamide	IC50	990.0 ^[1]
	2-[2-[(6R,9R,12S)-6-[(3-Chlorophenyl)methyl]-7,10,13-trioxo-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-12-yl]ethyl]guanidine	Ki	33.0 ^[1]
	(6R,9R,12S)-6-[(3-Chlorophenyl)methyl]-12-(imidazol-1-ylmethyl)-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	62.0 ^[1]
	3-[(6R,9R,12S)-6-[(3-Chlorophenyl)methyl]-7,10,13-trioxo-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-12-yl]propanimidamide	Ki	27.0 ^[1]
	(6R,9R,12S)-6-[(3-Chlorophenyl)methyl]-12-[(4,5-dihydro-1H-imidazol-2-ylamino)methyl]-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	51.0 ^[1]
	(6R,9R,12S)-6-[(3-Chlorophenyl)methyl]-9-propan-2-yl-12-[(1,4,5,6-tetrahydropyrimidin-2-ylamino)methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	87.0 ^[1]
	2-[[(6R,9R,12S)-6-[(3-Chlorophenyl)methyl]-7,10,13-trioxo-9-propan-2-yl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-trien-12-yl]methyl]-1-cyanoguanidine	Ki	100.0 ^[1]
	(6R,9R,12S)-9-Propan-2-yl-12-[(pyrimidin-2-ylamino)methyl]-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	20.0 ^[1]
	(6R,9R,12S)-12-[(5-Methyltriazol-1-yl)methyl]-9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	17.0 ^[1]
	(6R,9R,12S)-12-[(5-Methyltetrazol-1-yl)methyl]-9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	21.0 ^[1]
	(6R,9R,12S)-12-[(4,5-Dimethyltriazol-1-yl)methyl]-9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methyl]-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione	Ki	23.0 ^[1]
	Methyl (2R)-2-[[2-(1,3-benzodioxol-5-ylmethyl)-1,3-dioxospiro[8H-[1,2,4]triazolo[1,2-a]pyridazine-5,4'-piperidine]-8-carbonyl]amino]-4-phenylbutanoate	Ki	10000.0 ^[1]
	N-[(2R)-1-[[(2R)-1-Amino-1-oxo-4-phenylbutan-2-yl]amino]-1-oxo-4-phenylbutan-2-yl]-2-(1,3-benzodioxol-5-ylmethyl)-1,3-dioxospiro[7,8-dihydro-6H-[1,2,4]triazolo[1,2-a]pyridazine-5,4'-piperidine]-8-carboxamide	Ki	2.7 ^[1]
	N-[[3-[(3-Chlorophenyl)methyl-(2,2,2-trichloroacetyl)amino]cyclohexyl]methyl]-4-fluoro-N-[3-(2-pyrrolidin-1-ylethoxy)phenyl]benzamide	IC50	267.0 ^[1]

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References

This online tool may be cited as follows

MLA	"Quest Database™ Motilin receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/motilin-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Motilin receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/motilin-receptor-inhibitors-ic50-ki.
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Motilin receptor Inhibitors (IC50, Ki)

References

This online tool may be cited as follows

MLA

APA