 | 5-(3-Hydroxypropylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)pyrrolo[3,4-d]pyridazin-4-one | IC50 | 105.0 [1] |
| 5-(3-Hydroxypropylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)pyrrolo[3,4-d]pyridazin-4-one | Ki | 0.1 [1], 0.71 [2] |
 | 5-[(3R)-3-Hydroxypyrrolidine-1-carbonyl]-3-methyl-1-(2-methylpropyl)-6-(quinolin-4-ylmethyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 3.31 [1], 4.8 [2], 30.9 [3] |
 | 5-(3-Hydroxypropylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.08 [1], 0.28 [2], 0.3 [3] |
 | Pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione, 1 | Ki | 0.33 [1] |
 | 3-Methyl-1-(2-methylpropyl)-5-(pyrrolidine-1-carbonyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 5.5 [1], 5.62 [2] |
 | 5-(3-Hydroxypropylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.35 [1], 0.5 [2] |
 | 5-[(3R)-3-Hydroxypyrrolidine-1-carbonyl]-6-(1H-indol-3-ylmethyl)-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.79 [1], 3.16 [2], 6.31 [3] |
 | 3-Methyl-1-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione | Ki | 15.49 [1], 46.77 [2] |
 | 5-[(3R)-3-Hydroxypyrrolidine-1-carbonyl]-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 1.9 [1], 4.9 [2] |
 | 5-(2,5-Dihydropyrrole-1-carbonyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 3.39 [1], 10.72 [2] |
 | CID 10226546 | Ki | 1.2 [1] |
 | 6-[(4,5-Dichloro-2-methylimidazol-1-yl)methyl]-N-methoxy-N,3-dimethyl-1-(2-methylpropyl)-2,4-dioxothieno[2,3-d]pyrimidine-5-carboxamide | Ki | 3.2 [1] |
 | 5-[(4S)-4-Hydroxy-1,2-oxazolidine-2-carbonyl]-3-methyl-6-[[2-(methylamino)benzimidazol-1-yl]methyl]-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 1.7 [1] |
 | 5-[(4S)-4-Hydroxy-1,2-oxazolidine-2-carbonyl]-3-methyl-1-(2-methylpropyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.43 [1] |
 | 5-[(4S)-4-Hydroxy-1,2-oxazolidine-2-carbonyl]-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.09 [1] |
 | 6-[(Z)-5-Hydroxypent-1-enyl]-3-methyl-1-(2-methylpropyl)-7-(naphthalen-1-ylmethyl)pteridine-2,4-dione | IC50 | 116.0 [1] |
 | 1-(2-Methylpropyl)-3-methyl-5-(4-hydroxybutyl)-7-(1-naphthylmethyl)pteridine-2,4,6(1H,3H,5H)-trione | IC50 | 548.0 [1] |
 | 6-(3-Hydroxypropylsulfanyl)-3-methyl-1-(2-methylpropyl)-7-(naphthalen-1-ylmethyl)pteridine-2,4-dione | IC50 | 858.0 [1] |
 | 3-Methyl-1-(2-methylpropyl)-7-(naphthalen-1-ylmethyl)-5-propylpteridine-2,4,6-trione | IC50 | 2000.0 [1] |
 | 6-(4-Hydroxybutyl)-3-methyl-1-(2-methylpropyl)-7-(naphthalen-1-ylmethyl)pteridine-2,4-dione | IC50 | 2000.0 [1] |
 | 6-[(6-Fluoroquinolin-4-yl)methyl]-5-[(3R)-3-hydroxypyrrolidine-1-carbonyl]-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.81 [1] |
 | N,N,3-Trimethyl-2,4-dioxo-1-propan-2-yl-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-5-carboxamide | Ki | 117.0 [1] |
 | 5-(1,1-Dioxo-1,3-thiazolidine-3-carbonyl)-3-methyl-1-propan-2-yl-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 190.0 [1] |
 | 5-[(3S,4R)-3,4-Dihydroxypyrrolidine-1-carbonyl]-3-methyl-1-(2-methylpropyl)-6-(quinolin-4-ylmethyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 29.0 [1] |
 | 5-(Azetidine-1-carbonyl)-3-methyl-6-[[2-(methylamino)benzimidazol-1-yl]methyl]-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 59.0 [1] |
 | 5-[(3R)-3-Hydroxypyrrolidine-1-carbonyl]-3-methyl-1-(2-methylpropyl)-6-naphthalen-1-yloxythieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.31 [1] |
 | 5-Ethylsulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 6.0 [1] |
 | 3-Methyl-1-(2-methylpropyl)-5-propan-2-ylsulfanyl-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 2.2 [1] |
 | 5-Cyclobutylsulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 13.0 [1] |
 | 5-Cyclopentylsulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 3.2 [1] |
 | 5-Cyclohexylsulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 6.0 [1] |
 | 5-[(1R,2R)-2-Hydroxycyclopentyl]sulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 2.7 [1] |
 | 5-[(1R,3R)-3-Hydroxycyclopentyl]sulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.29 [1] |
 | 5-[(1R,3S)-3-Hydroxycyclopentyl]sulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.42 [1] |
 | 5-[(3R,4S)-3,4-Dihydroxycyclopentyl]sulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.68 [1] |
 | 5-(2,3-Dihydroxypropylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 6.5 [1] |
 | 5-[(1R,3S)-3-Hydroxycyclopentyl]sulfonyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 12.0 [1] |
 | 5-[(3R)-3-Hydroxypyrrolidin-1-yl]sulfonyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 1.1 [1] |
 | 5-(Azetidine-1-carbonyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 9.2 [1] |
 | 3-Methyl-1-(2-methylpropyl)-5-(piperidine-1-carbonyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 8.7 [1] |
 | N,N,3-Trimethyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-5-carboxamide | Ki | 37.0 [1] |
 | 5-(3-Hydroxy-3-methylazetidine-1-carbonyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 3.5 [1] |
 | 5-[(3R)-3-Hydroxypyrrolidine-1-carbonyl]-3-methyl-1-(2-methylpropyl)-6-(quinolin-5-ylmethyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 5.3 [1] |
 | 5-[(3R)-3-Hydroxypyrrolidine-1-carbonyl]-6-(isoquinolin-4-ylmethyl)-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 3.9 [1] |
 | 5-[(3R)-3-Hydroxypyrrolidine-1-carbonyl]-3-methyl-1-(2-methylpropyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 4.7 [1] |
 | 5-[(3R)-3-Hydroxypyrrolidine-1-carbonyl]-3-methyl-6-[[2-(methylamino)benzimidazol-1-yl]methyl]-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 6.6 [1] |
 | 5-[(3R)-3-Hydroxypyrrolidine-1-carbonyl]-3-methyl-6-[(2-methylbenzimidazol-1-yl)methyl]-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 16.0 [1] |
 | 6-[(4,5-Dichloro-2-methylimidazol-1-yl)methyl]-5-[(3R)-3-hydroxypyrrolidine-1-carbonyl]-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 26.0 [1] |
 | 6-[(4-Azido-3-(125I)iodanylphenyl)methyl]-3-methyl-1-(2-methylpropyl)pyrrolo[3,4-d]pyridazin-4-one | Ki | 23.0 [1] |
 | 5-(Azetidine-1-carbonyl)-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione | Ki | 199.53 [1] |
 | 1-(2-Methylpropyl)-3-methyl-6-(5-hydroxypentyl)-7-(1-naphthylmethyl)pteridine-2,4(1H,3H)-dione | IC50 | 192.0 [1] |
 | 1-(2-Methylpropyl)-3-methyl-6-(4-hydroxybutylthio)-7-(1-naphthylmethyl)pteridine-2,4(1H,3H)-dione | IC50 | 669.0 [1] |
 | 5-[(4S)-4-Hydroxy-1,2-oxazolidine-2-carbonyl]-3-methyl-1-(2-methylpropyl)-6-(quinolin-4-ylmethyl)thieno[2,3-d]pyrimidine-2,4-dione | Ki | 0.52 [1] |
Calculator
