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Monoacylglycerol lipase ABHD6 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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▼
Standard Values (in nM)
▲
▼
OrlistatIC5013.18 [1], 14.13 [2], 19.95 [3], 37.15 [4], 48.0 [5]
(4-Morpholin-4-yl-1,2,5-thiadiazol-3-yl) N-cyclooctyl-N-methylcarbamateIC5044.0 [1], 87.1 [2], 91.2 [3], 93.33 [4]
3-(3-Aminobenzyl)-5-methoxy-1,3,4-oxadiazole-2(3H)-oneIC50216.0 [1], 3311.31 [2], 3630.78 [3], 3801.89 [4], 4073.8 [5]
[4-(13-Chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]-(1,2,4-triazol-1-yl)methanoneIC501780.0 [1]
[(2S)-2-Benzylpiperidin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC50630.96 [1]
[(2R)-2-Benzylpiperidin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC502.51 [1]
(4-([1,1'-Biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-benzylpiperidin-1-yl)methanoneIC5039.81 [1]
2-[(2,2-Dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[(4-phenoxyphenyl)methyl]amino]acetic acidKi800.0 [1]
[(2R,5R)-2-Benzyl-5-prop-2-ynoxypiperidin-1-yl]-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanoneIC502.51 [1]
1,2,4-Triazol-1-yl-[4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidin-1-yl]methanoneIC50750.0 [1]
3-[(3-Nitrophenyl)methyl]-5-phenoxy-1,3,4-oxadiazol-2-oneIC50130.0 [1]
3-[(3-Aminophenyl)methyl]-5-phenoxy-1,3,4-oxadiazol-2-oneIC5073.0 [1]
Methyl 3-[(5-methoxy-2-oxo-1,3,4-oxadiazol-3-yl)methyl]benzoateIC50450.0 [1]
5-Methoxy-3-[[3-(trifluoromethyl)phenyl]methyl]-1,3,4-oxadiazol-2-oneIC50870.0 [1]
(2-Benzylpiperidin-1-yl)-[4-(1-hydroxy-1-phenylethyl)triazol-2-yl]methanoneIC503162.28 [1]
[4-[Hydroxy(diphenyl)methyl]triazol-2-yl]-[2-(phenoxymethyl)piperidin-1-yl]methanoneIC50158.49 [1]
[(2R,5R)-2-Benzyl-5-(cyclopropylmethoxy)piperidin-1-yl]-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanoneIC5039.81 [1]
[(3S,6S)-6-Benzyl-3-hydroxy-3,6-dihydro-2H-pyridin-1-yl]-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanoneIC50251.19 [1]
[4-[Bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]-[2-[(4-methoxyphenyl)methyl]piperidin-1-yl]methanoneIC50251.19 [1]
(2-Benzylpiperidin-1-yl)-[4-[dicyclohexyl(hydroxy)methyl]triazol-2-yl]methanoneIC507943.28 [1]
[(3R,6S)-6-Benzyl-3-hydroxy-3,6-dihydro-2H-pyridin-1-yl]-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanoneIC5039.81 [1]
[4-[Bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]-[2-[(4-fluorophenoxy)methyl]piperidin-1-yl]methanoneIC50199.53 [1]
[(2R,5S)-2-Benzyl-5-methoxypiperidin-1-yl]-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanoneIC50125.89 [1]
(2-Benzylpiperidin-1-yl)-[4-[bis(4-fluorophenyl)-methoxymethyl]triazol-2-yl]methanoneIC5010000.0 [1]
[(2R,5R)-2-Benzyl-5-methoxypiperidin-1-yl]-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanoneIC5050.12 [1]
[4-[Bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]-[2-(phenoxymethyl)piperidin-1-yl]methanoneIC50199.53 [1]
[(2R,5R)-2-Benzyl-5-hydroxypiperidin-1-yl]-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanoneIC50158.49 [1]
[4-[Bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]-[2-[(3-methoxyphenyl)methyl]piperidin-1-yl]methanoneIC50158.49 [1]
(2-Benzylpiperidin-1-yl)-[4-[hydroxy(dipyridin-2-yl)methyl]triazol-2-yl]methanoneIC503162.28 [1]
[(2R,5S)-2-Benzyl-5-(cyclopropylmethoxy)piperidin-1-yl]-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanoneIC502511.89 [1]
(2-Benzylpiperidin-1-yl)-[4-(2-hydroxypropan-2-yl)triazol-2-yl]methanoneIC5010000.0 [1]
(2-Benzylpiperidin-1-yl)-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanoneIC5025.12 [1]
(2-Benzylpiperidin-1-yl)-[4-(1-hydroxycyclohexyl)triazol-2-yl]methanoneIC503162.28 [1]
[2-[(4-Fluorophenoxy)methyl]piperidin-1-yl]-[4-[hydroxy(diphenyl)methyl]triazol-2-yl]methanoneIC50251.19 [1]
[(2R,5S)-2-Benzyl-5-hydroxypiperidin-1-yl]-[4-[bis(4-fluorophenyl)-hydroxymethyl]triazol-2-yl]methanoneIC50199.53 [1]
(4-Benzylpiperidin-1-yl)-[5-(4-hydroxyphenyl)-1-[(3-methylphenyl)methyl]pyrazol-3-yl]methanoneIC507100.0 [1]
N-Cycloheptyl-1-[(4-fluorophenyl)methyl]-4-(4-methoxyphenyl)-2-oxopyridine-3-carboxamideIC5010000.0 [1]
5-Bromo-N-cycloheptyl-1-[(4-fluorophenyl)methyl]-4-(4-methoxyphenyl)-2-oxopyridine-3-carboxamideIC5010000.0 [1]
N-Cycloheptyl-1-[(4-fluorophenyl)methyl]-5-(4-methoxyphenyl)-4-methyl-2-oxopyridine-3-carboxamideIC5010000.0 [1]
5-Bromo-N-cycloheptyl-2-[(4-fluorophenyl)methoxy]-4-methylpyridine-3-carboxamideIC50530.0 [1]
5-Bromo-N-cycloheptyl-1-[(4-fluorophenyl)methyl]-2-oxo-4-phenylpyridine-3-carboxamideIC503000.0 [1]
N-Cycloheptyl-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxo-5-phenylpyridine-3-carboxamideIC5010000.0 [1]
N-Cycloheptyl-1-[(4-fluorophenyl)methyl]-2-oxo-4,5-diphenylpyridine-3-carboxamideIC5010000.0 [1]
N-Cycloheptyl-1-[(4-fluorophenyl)methyl]-2-oxo-4-phenylpyridine-3-carboxamideIC5010000.0 [1]
N-Cycloheptyl-2-[(4-fluorophenyl)methoxy]-4-methylpyridine-3-carboxamideIC5010000.0 [1]
N-Cycloheptyl-1-[(4-fluorophenyl)methyl]-5-(4-methoxyphenyl)-2-oxo-4-phenylpyridine-3-carboxamideIC5010000.0 [1]
5-Bromo-N-cycloheptyl-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridine-3-carboxamideIC5010000.0 [1]
N-Cycloheptyl-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridine-3-carboxamideIC5010000.0 [1]
4-(3-Fluoro-4-hydroxyphenyl)-2-[(E)-N-hydroxy-C-tridecylcarbonimidoyl]phenolIC5010000.0 [1]
4-(3-Fluoro-4-hydroxyphenyl)-2-[(E)-N-hydroxy-C-undecylcarbonimidoyl]phenolIC5010000.0 [1]
(2-Benzylpiperidin-1-yl)-[4-[hydroxy(diphenyl)methyl]triazol-1-yl]methanoneIC5039.81 [1]
(2-Benzylpiperidin-1-yl)-[4-[hydroxy(diphenyl)methyl]triazol-2-yl]methanoneIC5019.95 [1]
[(3S,6R)-3-Hydroxy-6-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC5010.0 [1]
[(6R)-6-(Phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC5012.59 [1]
[(2R,3R)-3-Hydroxy-2-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC50251.19 [1]
[(6S)-6-Benzyl-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC502.51 [1]
[(2R)-2-(Phenylmethoxymethyl)piperidin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC503.16 [1]
[(2S,3R)-3-Hydroxy-2-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC50794.33 [1]
[4-(4-Bromophenyl)imidazol-1-yl]-[(6R)-6-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]methanoneIC5010000.0 [1]
[4-(4-Nitrophenyl)triazol-1-yl]-[(6R)-6-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]methanoneIC5031.62 [1]
[3-(4-Bromophenyl)pyrazol-1-yl]-[(6R)-6-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]methanoneIC5010000.0 [1]
[(3R,6R)-3-Hydroxy-6-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC505.01 [1]
[(6R)-6-Benzyl-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC5025.12 [1]
[(3R,6S)-3-Hydroxy-6-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC50316.23 [1]
[(6S)-6-(Phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC50100.0 [1]
(4-Nitrophenyl) (6R)-6-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridine-1-carboxylateIC5010000.0 [1]
[4-(4-Phenoxyphenyl)triazol-1-yl]-[(6R)-6-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]methanoneIC506.31 [1]
[(3R,6S)-6-Benzyl-3-hydroxy-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)triazol-1-yl]methanoneIC503.16 [1]
[(6R)-6-(Phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[3-(4-phenylphenyl)-1,2,4-triazol-1-yl]methanoneIC5010000.0 [1]
[(6R)-6-(Phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[3-(4-phenylphenyl)pyrazol-1-yl]methanoneIC5010000.0 [1]
[(6R)-6-(Phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-(4-phenyltriazol-1-yl)methanoneIC50158.49 [1]
[(6R)-6-(Phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]-[4-(4-phenylphenyl)imidazol-1-yl]methanoneIC5010000.0 [1]
[4-(4-Bromophenyl)triazol-1-yl]-[(6R)-6-(phenylmethoxymethyl)-3,6-dihydro-2H-pyridin-1-yl]methanoneIC5015.85 [1]
Items per page: 1 - 10 of 73
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References

This online tool may be cited as follows

MLA

"Quest Database™ Monoacylglycerol lipase ABHD6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/monoacylglycerol-lipase-abhd6-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Monoacylglycerol lipase ABHD6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/monoacylglycerol-lipase-abhd6-inhibitors-ic50-ki.
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