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MLL1-ASH2L/RbBP5/WDR5/DPY30 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-Benzhydryl-1-[[(2S)-5-(diaminomethylideneamino)-2-[[2-ethyl-2-(2-methylpropanoylamino)butanoyl]amino]pentanoyl]amino]cyclopentane-1-carboxamideIC50578.0 [1]
MM-589 (Tfa)IC5012.7 [1]
N-[(3R,6S,9S,12R)-9-[3-[(N,N'-Dimethylcarbamimidoyl)amino]propyl]-6-ethyl-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclohexadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC501259.0 [1]
N-[(3R,6S,9S,12R)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-1,12-dimethyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclohexadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC50190.0 [1]
N-[(3R,6S,9S,12R)-6-Ethyl-12-methyl-9-[3-[(N'-methylcarbamimidoyl)amino]propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclooctadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC50216.0 [1]
N-[(3R,6S,9S,12R)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclotetradec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC5012.6 [1]
N-[(3S,6S,9S,12R)-6-Ethyl-12-methyl-9-[3-[(N'-methylcarbamimidoyl)amino]propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclotetradec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC50477.0 [1]
N-[(3R,6S,9S,12R)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclopentadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC5010000.0 [1]
N-[(3R,6S,9S,12R)-6-Ethyl-12-methyl-9-[3-[(N'-methylcarbamimidoyl)amino]propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclohexadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC50452.0 [1]
N-[(3R,6S,9S,12R)-6-Ethyl-12-methyl-9-[3-[(N'-methylcarbamimidoyl)amino]propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacycloicos-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC50744.0 [1]
N-[(3R,6S,9S,12R)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclopentadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC5084.8 [1]
N-[(3R,6S,9S,12R)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-3-(4-fluorophenyl)-1,12-dimethyl-2,5,8,11-tetraoxo-1,4,7,10-tetrazacyclohexadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC50138.0 [1]
N-[(3R,6S,9S,12R)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclotridec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC5010000.0 [1]
N-[(3R,6S,9S,12R)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclohexadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC5010000.0 [1]
N-[(3R,6S,9S,12R)-3-(4-Chlorophenyl)-9-[3-(diaminomethylideneamino)propyl]-6-ethyl-1,12-dimethyl-2,5,8,11-tetraoxo-1,4,7,10-tetrazacyclohexadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC50124.0 [1]
N-[(3R,6S,9S,12R)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacycloheptadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC501527.0 [1]
N-[(3R,6S,9S,12R)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclohexadec-12-yl]-2-methylpropanamide;2,2,2-trifluoroacetic acidIC50373.0 [1]
N-[(3S,6R,9R,12S)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclohexadec-12-yl]-2-methylpropanamideIC5010000.0 [1]
N-[(3R,6S,9S,12R)-9-[3-(Diaminomethylideneamino)propyl]-6-ethyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetrazacyclotetradec-12-yl]-2-methylpropanamideIC501800.0 [1]
Items per page: 1 - 10 of 19
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References

This online tool may be cited as follows

MLA

"Quest Database™ MLL1-ASH2L/RbBP5/WDR5/DPY30 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/mll1-ash2l-rbbp5-wdr5-dpy30-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ MLL1-ASH2L/RbBP5/WDR5/DPY30 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mll1-ash2l-rbbp5-wdr5-dpy30-inhibitors-ic50-ki.
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