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Mitogen-activated protein kinase kinase kinase kinase 4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-[4-(4-Chlorophenyl)pyrazol-1-yl]benzamideIC50248.0 [1], 10000.0 [2], 30000.0 [3]
4-[5-(4-Cyclopropyloxyphenyl)pyridin-3-yl]benzamideIC5048.0 [1], 6200.0 [2], 9800.0 [3]
4-[5-(4-Chlorophenyl)-1,3-Oxazol-2-Yl]benzamideIC5094.0 [1], 6300.0 [2], 10000.0 [3]
5-(6-Aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amineIC503.7 [1], 160.0 [2]
6-(3-Fluorophenyl)quinazolin-4-amineIC5058.0 [1]
4-{6-Amino-5-[4-(Methylsulfonyl)phenyl]pyridin-3-Yl}phenolIC5021.0 [1], 2900.0 [2]
4-[5-(4-Methoxyphenyl)pyridin-3-yl]benzamideIC5045.0 [1], 600.0 [2]
4-[6-Amino-5-(4-methylsulfonylphenyl)pyridin-3-yl]benzamideIC5064.0 [1], 4200.0 [2]
5-[6-Amino-5-(4-chlorophenyl)pyridin-3-yl]-1H-pyridin-2-oneIC5096.0 [1], 2900.0 [2]
4-[5-(4-Chlorophenyl)pyridin-3-yl]benzamideIC5046.0 [1], 7500.0 [2]
4-[1-(4-Chlorophenyl)imidazol-4-yl]benzamideIC50270.0 [1], 30000.0 [2]
4-[6-Amino-5-(4-chlorophenyl)pyridin-3-yl]-1H-pyridin-2-oneIC5020.0 [1], 590.0 [2]
4-[4-(4-Chlorophenyl)pyridin-2-yl]benzamideIC501722.0 [1], 30000.0 [2]
Map4K4-IN-3IC5014.9 [1], 470.0 [2]
4-[6-Amino-5-(4-chlorophenyl)pyridin-3-yl]benzamideIC5013.0 [1], 360.0 [2]
4-[4-(4-Chlorophenyl)pyrimidin-2-yl]benzamideIC50861.0 [1], 30000.0 [2]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
8-Amino-N-[1-(Cyclopropylcarbonyl)azetidin-3-Yl]-2-(3-Fluorophenyl)-1,7-Naphthyridine-5-CarboxamideIC503.7 [1]
6,9-Dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-oneKi812.4 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC50892.0 [1]
CID 27666048IC50100000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
CID 71553154IC5018.0 [1]
8-(4-Ethylphenyl)-5-Methyl-2,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-DioxideIC501600.0 [1]
1-Ethyl-8-(4-Ethylphenyl)-5-Methyl-1,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-DioxideIC5010000.0 [1]
(13R)-11-(4-Bromophenyl)-13-methyl-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-oneIC50100000.0 [1]
6-(3-Fluorophenyl)pyrido[3,2-d]pyrimidin-4-amineIC5017.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi1000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi1000.0 [1]
N-Pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC501600.0 [1]
6-Bromo-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC50150.0 [1]
Ethyl 4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylateIC5070.0 [1]
4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazine-6-carbonitrileIC50710.0 [1]
[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanolIC50160.0 [1]
2-[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]propan-2-olIC50840.0 [1]
4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamideIC50300.0 [1]
N-Ethyl-4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamideIC50640.0 [1]
Azetidin-1-yl-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanoneIC50130.0 [1]
Morpholin-4-yl-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanoneIC50180.0 [1]
Furan-3-yl-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanoneIC5010.0 [1]
[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]-(2H-tetrazol-5-yl)methanoneIC5070.0 [1]
1H-Pyrazol-4-yl-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]methanoneIC5010.0 [1]
6-(2-Fluorophenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC5011000.0 [1]
6-(2-Methylphenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC5019000.0 [1]
6-(2-Chlorophenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC5037000.0 [1]
6-(3-Methylphenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC507000.0 [1]
6-(3-Chlorophenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC5023000.0 [1]
[3-[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]methanolIC503000.0 [1]
6-(4-Fluorophenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC5010000.0 [1]
[4-[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]methanolIC506000.0 [1]
6-[4-[(Dimethylamino)methyl]phenyl]-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC501000.0 [1]
6-(4-Ethylsulfonylphenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC502000.0 [1]
N-Methyl-4-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]benzenesulfonamideIC502000.0 [1]
6-[4-(4-Methylpiperazin-1-yl)phenyl]-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC501000.0 [1]
6-(4-Morpholin-4-ylphenyl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC502000.0 [1]
6-[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC502000.0 [1]
6-(6-Morpholin-4-ylpyridin-3-yl)-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC502000.0 [1]
6-[4-[1-(2-Morpholin-4-ylethyl)pyrazol-4-yl]phenyl]-N-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC506000.0 [1]
2-[4-[4-[4-(Pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]pyrazol-1-yl]ethanolIC503000.0 [1]
2-Methyl-1-[4-[4-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]pyrazol-1-yl]propan-2-olIC505000.0 [1]
N-Methyl-2-[4-[4-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]pyrazol-1-yl]acetamideIC5010000.0 [1]
N,2-Dimethyl-2-[4-[4-[4-(pyridin-4-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl]phenyl]pyrazol-1-yl]propanamideIC508000.0 [1]
3-(4-Chlorophenyl)-5-phenylpyridin-2-amineIC5084.0 [1]
N-[4-[(4-Phenylpiperazin-1-yl)methyl]phenyl]-1H-indazole-3-carboxamideIC50410.0 [1]
4-[5-(4-Chlorophenyl)-1-methylimidazol-2-yl]benzamideIC501509.0 [1]
(13S)-13-Methyl-11-(4-phenylphenyl)-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-oneIC50100000.0 [1]
N-[4-[(13S)-13-Methyl-14-oxo-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-11-yl]phenyl]acetamideIC50100000.0 [1]
(13S)-11-(4-Bromophenyl)-13-propan-2-yl-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-oneIC5044000.0 [1]
(13S)-11-(4-Bromophenyl)-13-[(2-methylpropan-2-yl)oxymethyl]-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-oneIC505600.0 [1]
(13S)-11-(2,4-Dichlorophenyl)-13-methyl-2,8,10,12-tetrazatricyclo[7.5.0.02,7]tetradeca-1(9),3,5,7,11-pentaen-14-oneIC50100000.0 [1]
8-(4-Hydroxyphenyl)-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-3H-[1]benzothiolo[3,2-d]pyrimidin-4-oneKi1000.0 [1]
5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-oneIC5010000.0 [1]
N-[(Pyridin-2-Yl)methyl]-4-[4-(Pyridin-4-Yl)-1h-Pyrazol-1-Yl]benzamideIC505000.0 [1]
4-[1-Ethynyl-4-(4-fluorophenyl)-5-pyridin-4-ylimidazol-2-yl]but-3-yn-1-olIC504200.0 [1]
4-Amino-6-(4-fluorophenyl)-quinazolineIC50381.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC501000.0 [1]
2-N-(1H-Indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamineIC5010000.0 [1]
N~4~-Cyclopropyl-N~2~-(3-Methyl-1h-Indazol-6-Yl)furo[3,2-D]pyrimidine-2,4-DiamineIC509430.0 [1]
2-N-(3-Chloro-4-morpholin-4-ylphenyl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamineIC5010000.0 [1]
6-(3-Aminophenyl)quinazolin-4-amineIC50189.0 [1]
2-(3,5-Dichloroanilino)-4-[[4-(dimethylamino)cyclohexyl]amino]-N-(1-methylpiperidin-4-yl)pyrimidine-5-carboxamideIC50120.0 [1]
2-(3,5-Dichloroanilino)-4-[[(3R,4S)-4-hydroxyoxolan-3-yl]amino]-N-(1-methylpiperidin-4-yl)pyrimidine-5-carboxamideIC502480.0 [1]
CID 71657853IC501.4 [1]
1-Amino-7-(3-fluorophenyl)isoquinoline-4-carboxamideIC5018.0 [1]
1-Amino-N-(cyanomethyl)-7-(3-fluorophenyl)isoquinoline-4-carboxamideIC5046.0 [1]
1-Amino-N-cyclopropyl-7-(3-fluorophenyl)isoquinoline-4-carboxamideIC5016.0 [1]
N-(1-Acetylazetidin-3-yl)-1-amino-7-(3-fluorophenyl)isoquinoline-4-carboxamideIC5032.0 [1]
1-Amino-7-(3-fluorophenyl)-N-[1-(methylcarbamoyl)azetidin-3-yl]isoquinoline-4-carboxamideIC5015.0 [1]
1-Amino-7-(3-fluorophenyl)-N-(3-hydroxycyclobutyl)isoquinoline-4-carboxamideIC5041.0 [1]
(2S)-N-[5-(6-Aminopyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]-4,4,4-trifluoro-2-methylbutanamideIC508000.0 [1]
6-(3-Chlorophenyl)quinazolin-4-AmineIC5077.0 [1]
6-(3,5-Difluorophenyl)quinazolin-4-amineIC50132.0 [1]
6-Phenyl-N-(Pyridin-4-Yl)pyrrolo[2,1-F][1,2,4]triazin-4-AmineIC508.0 [1]
6-(3-Amino-5-fluoro-phenyl)quinazolin-4-amineIC5060.0 [1]
1-Amino-N-(azetidin-3-yl)-7-(3-fluorophenyl)isoquinoline-4-carboxamideIC50401.0 [1]
8-Amino-2-(3-fluorophenyl)-N-(1-propanoylazetidin-3-yl)-1,7-naphthyridine-5-carboxamideIC503.5 [1]
8-Amino-2-(3-fluorophenyl)-N-[1-(methylcarbamoyl)azetidin-3-yl]-1,7-naphthyridine-5-carboxamideIC501.6 [1]
8-Amino-2-(3-fluorophenyl)-N-(3-hydroxycyclobutyl)-1,7-naphthyridine-5-carboxamideIC503.7 [1]
6-(2-Methoxyphenyl)quinazolin-4-amineIC50546.0 [1]
6-(4-Methoxyphenyl)quinazolin-4-amineIC50689.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Mitogen-activated protein kinase kinase kinase kinase 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-kinase-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Mitogen-activated protein kinase kinase kinase kinase 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-kinase-4-inhibitors-ic50-ki.
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