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Mitogen-activated protein kinase kinase kinase 8 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-(2-Morpholin-4-ylethyl)-6-(8-phenylimidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amineIC5016.0 [1], 270.0 [2], 280.0 [3], 2500.0 [4]
N-[(2R)-1-Morpholin-4-ylpropan-2-yl]-6-(8-pyridin-4-ylimidazo[4,5-c][1,7]naphthyridin-1-yl)quinolin-2-amineIC504.0 [1], 30.0 [2], 80.0 [3]
1-Quinolin-6-yl-8-thiophen-3-ylimidazo[4,5-c][1,7]naphthyridineIC5020.0 [1], 440.0 [2], 540.0 [3], 1780.0 [4]
N-(1-Morpholin-4-ylpropan-2-yl)-6-(8-pyridin-4-ylimidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amineIC509.0 [1], 70.0 [2], 80.0 [3], 600.0 [4]
N-(1-Morpholin-4-ylpropan-2-yl)-6-(8-thiophen-2-ylimidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amineIC5022.0 [1], 280.0 [2], 290.0 [3], 10000.0 [4]
N-(1-Morpholin-4-ylpropan-2-yl)-6-(8-phenylimidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amineIC509.0 [1], 120.0 [2], 130.0 [3], 1010.0 [4]
N-(1-Morpholin-4-ylpropan-2-yl)-6-(8-pyridin-4-ylimidazo[4,5-c][1,7]naphthyridin-1-yl)quinolin-2-amineIC506.0 [1], 60.0 [2], 200.0 [3]
4-[(3-Chloro-4-fluorophenyl)amino]-6-[(1H-imidazol-4-ylmethyl)amino]quinoline-3-carbonitrileIC5019.0 [1], 20.0 [2]
4-(3-Chloro-4-fluoro-phenylamino)-6-(2-morpholin-4-yl-ethylamino)-1,7-naphthyridine-3-carbonitrileIC501200.0 [1]
5-[4-(4-Phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1H-1,2,3,4-tetrazoleIC50130.0 [1], 150.0 [2], 4300.0 [3]
N-[(2S)-1-Morpholin-4-ylpropan-2-yl]-6-(8-pyridin-4-ylimidazo[4,5-c][1,7]naphthyridin-1-yl)quinolin-2-amineIC5038.0 [1], 620.0 [2], 1250.0 [3]
8-Bromo-4-(3-chloro-4-fluoroanilino)-6-[(1-methylimidazol-4-yl)methylamino]quinoline-3-carbonitrileIC5030.0 [1]
(R)-4-(3-Chloro-4-fluorophenylamino)-6-(1-phenylethylamino)-1,7-naphthyridine-3-carbonitrileIC5012.0 [1], 16.0 [2]
8-Bromo-4-(3-chloro-4-fluoroanilino)-6-(2H-triazol-4-ylmethylamino)quinoline-3-carbonitrileIC5018.0 [1]
8-Chloro-4-(3-chloro-4-fluoroanilino)-6-(1H-imidazol-5-ylmethylamino)-3-quinolinecarbonitrileIC5012.0 [1], 20.0 [2]
4-[4-[2-(2H-Tetrazol-5-yl)thieno[2,3-c]pyridin-4-yl]oxyphenyl]benzamideIC5010.0 [1], 130.0 [2]
6-(Benzylamino)-4-(3-chloro-4-fluorophenylamino)-1,7-naphthyridine-3-carbonitrileIC5073.0 [1], 140.0 [2]
(S)-4-(3-Chloro-4-fluorophenylamino)-6-(1-phenylethylamino)-1,7-naphthyridine-3-carbonitrileIC5027000.0 [1], 36000.0 [2]
2-(2H-Tetrazol-5-yl)-4-[4-[4-(trifluoromethyl)phenyl]phenoxy]thieno[2,3-c]pyridineIC50280.0 [1], 560.0 [2]
4-[4-(4-Fluorophenyl)phenoxy]-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridineIC50170.0 [1], 6500.0 [2]
4-[4-(4-Chlorophenyl)phenoxy]-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridineIC5090.0 [1], 2100.0 [2]
Ellagic acidIC502370.0 [1]
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamideIC5025000.0 [1]
Nvp-aew541IC5010000.0 [1]
A-770041IC5025000.0 [1]
Tpl2 Kinase InhibitorIC5050.0 [1]
CID 11634725Ki4000.0 [1]
(12E,25E,28E)-5,16,21,32-Tetrabromo-4,20-dihydroxy-12,25-bis(hydroxyimino)-2,18-dioxa-10,27-diazapentacyclo[28.2.2.214,17.13,7.119,23]octatriaconta-1(32),3,5,7(38),14,16,19,21,23(35),28,30,33,36-tridecaene-11,26-dioneIC503300.0 [1]
MEK Inhibitor IIIC5050.0 [1]
Cot inhibitor-2IC501.6 [1]
2-({2-[(3-Hydroxyphenyl)amino]pyrimidin-4-YL}amino)benzamideIC5050000.0 [1]
(12E,25E)-5,16,21,32,33,36-Hexabromo-4,20-dihydroxy-12,25-bis(hydroxyimino)-2,18-dioxa-10,27-diazapentacyclo[28.2.2.214,17.13,7.119,23]octatriaconta-1(32),3,5,7(38),14,16,19,21,23(35),30,33,36-dodecaene-11,26-dioneIC504800.0 [1]
Cot inhibitor-1IC5028.0 [1]
(2Z)-3-[3-Bromo-5-[3-bromo-5-[(2Z)-3-[2-(3-bromo-4-hydroxyphenyl)ethylamino]-2-hydroxyimino-3-oxopropyl]-2-hydroxyphenyl]-4-hydroxyphenyl]-N-[2-(3-bromo-4-hydroxyphenyl)ethyl]-2-hydroxyiminopropanamideIC501600.0 [1]
5-Propan-2-yl-7,8-dihydro-6H-indeno[1,2-b]indole-9,10-dioneIC5035000.0 [1]
5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrileIC5010000.0 [1]
Pyrazolo[1,5-a]pyrimidine-3-carboxylateIC5010000.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC5010000.0 [1]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5010000.0 [1]
1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanoneIC50100000.0 [1]
3-(4-(4-Iodophenoxy)thieno[2,3-c]pyridin-2-yl)-1,2,4-oxadiazol-5(2H)-oneIC501120.0 [1]
4-(4-Chlorophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridineIC50710.0 [1]
N-(3-(2-(Pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamideIC5050000.0 [1]
6-(2-Morpholinoethylamino)-4-(4-phenoxyphenylamino)-1,7-naphthyridine-3-carbonitrileIC50380.0 [1]
4-(3-Chloro-4-fluorophenylamino)-6-cyclopentylamino-[1,7]naphthyridine-3-carbonitrileIC5040000.0 [1]
4-(3-Chloro-4-fluorophenylamino)-6-(2-morpholinoethylamino)quinoline-3-carbonitrileIC501000.0 [1]
4-(4-Iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridineIC50410.0 [1]
4-Phenoxy-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridineIC502200.0 [1]
2-(2H-Tetrazol-5-yl)-4-(p-tolyloxy)thieno[2,3-c]pyridineIC507500.0 [1]
5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amineIC5010000.0 [1]
7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrileIC5010000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC501262.0 [1]
CID 11058385IC50940.0 [1]
Ethyl-{4-methyl-5-[3-(1H-tetrazol-5-yl)-1H-indazol-5-yl]-pyridin-3-ylmethyl}-amineIC50100000.0 [1]
2-[4-(7-Chloro-8-thiophen-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]acetonitrileIC50800.0 [1]
N-Benzyl-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamideIC5020000.0 [1]
4-(4-Benzylphenylamino)-6-(2-morpholinoethylamino)-1,7-naphthyridine-3-carbonitrileIC502.0 [1]
[(1S,3Ar,6E,9S,9aR,10R,11aS)-6-[[3-(dimethylamino)propyl-methylamino]methylidene]-1,5-dihydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-10-yl] acetateIC5040000.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi4000.0 [1]
N-Butyl-N-methyl-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamideIC5020000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi4000.0 [1]
2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi4000.0 [1]
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-oneIC50100000.0 [1]
4-(3-Chloro-4-fluorophenylamino)-6-(furan-2-ylmethylamino)quinoline-3-carbonitrileIC50240.0 [1]
1-(3H-Benzimidazol-5-yl)-8-(3-methylphenyl)imidazo[4,5-c][1,7]naphthyridineIC50200.0 [1]
1-(3H-Benzimidazol-5-yl)-8-(cyclohexen-1-yl)imidazo[4,5-c][1,7]naphthyridineIC501300.0 [1]
8-Phenyl-1-quinolin-6-ylimidazo[4,5-c][1,7]naphthyridineIC5096.0 [1]
1-(3H-Benzimidazol-5-yl)-8-chloroimidazo[4,5-c][1,7]naphthyridineIC5010000.0 [1]
1-(3H-Benzimidazol-5-yl)-8-phenylimidazo[4,5-c][1,7]naphthyridineIC5090.0 [1]
2-[4-(8-Thiophen-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]acetonitrileIC502600.0 [1]
1-(3H-Benzimidazol-5-yl)-8-(1H-pyrazol-4-yl)imidazo[4,5-c][1,7]naphthyridineIC50150.0 [1]
4-[1-(3H-Benzimidazol-5-yl)imidazo[4,5-c][1,7]naphthyridin-8-yl]-1,2-thiazoleIC50160.0 [1]
2-[4-(8-Thiophen-3-ylimidazo[4,5-c][1,7]naphthyridin-1-yl)phenyl]acetonitrileIC5050.0 [1]
2-Methyl-6-(8-phenylimidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazoleIC5080.0 [1]
1-(3H-Benzimidazol-5-yl)-8-pyridin-3-ylimidazo[4,5-c][1,7]naphthyridineIC50670.0 [1]
1-(3H-Benzimidazol-5-yl)-8-pyridin-4-ylimidazo[4,5-c][1,7]naphthyridineIC50100.0 [1]
1-(3H-Benzimidazol-5-yl)-8-(4-methylphenyl)imidazo[4,5-c][1,7]naphthyridineIC501300.0 [1]
1-(3H-Benzimidazol-5-yl)-8-thiophen-3-ylimidazo[4,5-c][1,7]naphthyridineIC5040.0 [1]
1-(3H-Benzimidazol-5-yl)-8-piperidin-1-ylimidazo[4,5-c][1,7]naphthyridineIC503500.0 [1]
2-[[5-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridin-3-yl]methylamino]ethanolIC5047.0 [1]
4-[[5-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridin-3-yl]methyl]morpholineIC50100000.0 [1]
5-(5-Ethylaminomethyl-4-methylpyridin-3-yl)-3-(1H-imidazol-2-yl)-1H-indazoleIC5025000.0 [1]
5-(3-(1H-Benzo[D]imidazol-2-YL)-1H-indazol-5-YL)-4-methylpyridin-3-OLIC50100000.0 [1]
3-(1H-Benzimidazol-2-yl)-5-(4,5-dimethylpyridin-3-yl)-1H-indazoleIC50100000.0 [1]
N-[[4-Methyl-5-[3-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)-1H-indazol-5-yl]pyridin-3-yl]methyl]ethanamineIC5038000.0 [1]
N-[[5-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamineIC50109.0 [1]
5-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridine-3-carboxamideIC50100000.0 [1]
N-[[5-[3-[5-(3-Fluorophenyl)-1H-imidazol-2-yl]-1H-indazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamineIC504500.0 [1]
N-[[5-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridin-3-yl]methyl]-2-methylpropan-1-amineIC5016000.0 [1]
4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]-6-iodo-4H-isoquinoline-1,3-dioneIC504000.0 [1]
N-[[4-Methyl-5-[3-[5-methyl-4-(2-methylpropyl)-1H-imidazol-2-yl]-1H-indazol-5-yl]pyridin-3-yl]methyl]ethanamineIC5018700.0 [1]
N-[[4-Methyl-5-[3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-1H-indazol-5-yl]pyridin-3-yl]methyl]ethanamineIC503000.0 [1]
N-[[4-Methyl-5-[3-[6-(piperidin-1-ylmethyl)-1H-benzimidazol-2-yl]-1H-indazol-5-yl]pyridin-3-yl]methyl]ethanamineIC503200.0 [1]
N-[[5-[3-(6-Bromo-1H-benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamineIC501126.0 [1]
N-[[5-[3-(5,6-Dimethyl-1H-benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamineIC50240.0 [1]
N-[[5-[3-(4,5-Dichloro-1H-benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamineIC5010280.0 [1]
N-[[4-Methyl-5-[3-(6-methyl-1H-benzimidazol-2-yl)-1H-indazol-5-yl]pyridin-3-yl]methyl]ethanamineIC50418.0 [1]
N-[[5-[3-(5-Chloro-6-methyl-1H-benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamineIC501734.0 [1]
N-[[5-[3-(6-Tert-butyl-1H-benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamineIC501995.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Mitogen-activated protein kinase kinase kinase 8 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-8-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Mitogen-activated protein kinase kinase kinase 8 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-8-inhibitors-ic50-ki.
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