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Mitogen-activated protein kinase kinase kinase 5 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
StaurosporineIC500.69 [1], 37.0 [2], 1000.0 [3]
SelonsertibIC505.0 [1], 5.01 [2], 6.0 [3]
HymenialdisineIC50150.0 [1], 7000.0 [2]
Ethyl 8,15-dioxo-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9(17),10,12-heptaene-16-carboxylateIC503000.0 [1]
Ethyl 8,15-dioxo-14-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2,4,6,9(17),10,12-heptaene-16-carboxylateKi500.0 [1]
4-Tert-Butyl-N-[6-(1h-Imidazol-1-Yl)imidazo[1,2-A]pyridin-2-Yl]benzamideIC5014.0 [1]
2-Fluoro-4-methyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamideIC5050.12 [1], 55.0 [2]
5-(4-Cyclopropylimidazol-1-yl)-2-fluoro-4-methyl-N-pyridin-2-ylbenzamideIC506000.0 [1], 6309.57 [2]
3-((1-Methyl-1H-indol-3-yl)methylene)indolin-2-oneIC5082700.0 [1], 100000.0 [2]
2-Methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-5-sulfamoylbenzamideIC501.5 [1], 736.0 [2]
4-Methoxy-1-N-methyl-3-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzene-1,3-dicarboxamideIC502.4 [1], 272.0 [2]
4-Methoxy-3-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzene-1,3-dicarboxamideIC501.0 [1], 94.0 [2]
2-Methoxy-4-methyl-5-methylsulfonyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamideIC504.0 [1], 73.0 [2]
5-(Ethylsulfonylamino)-2-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamideIC500.32 [1], 41.0 [2]
2-Methoxy-4-methyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-5-sulfamoylbenzamideIC500.1 [1], 84.0 [2]
2-Methoxy-5-methylsulfonyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamideIC505.0 [1], 140.0 [2]
4-Methoxy-6-methyl-3-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzene-1,3-dicarboxamideIC500.42 [1], 28.0 [2]
2-[(5Z)-5-[[5-(3,4-Dichlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acidIC50650.0 [1]
2-[(5Z)-5-[[5-(3,4-Dichlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acidKi340.0 [1]
4-[4-(1-Benzothiophen-4-yloxy)-3-chloroanilino]-N-(2-hydroxyethyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxamideIC5010000.0 [1]
N-(3-Chloro-1-cyclopropylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamideIC504.0 [1], 6.0 [2]
N-(3-Bromo-1-cyclopropylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamideIC502.0 [1], 7.0 [2]
N-(3-Chloro-1-methylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamideIC5011.0 [1], 18.0 [2]
N-(2,3-Dichloro-1-methylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamideIC5060.0 [1], 146.0 [2]
N-(3-Chloro-1-ethylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2S)-1,2-dihydroxypropan-2-yl]benzamideIC509.0 [1], 12.0 [2]
N-[1-(Cyclopropylmethyl)pyrrolo[3,2-c]pyridin-6-yl]-4-(2-hydroxypropan-2-yl)benzamideIC5081.0 [1], 237.0 [2]
N-[3-Bromo-1-(cyclopropylmethyl)pyrrolo[3,2-c]pyridin-6-yl]-4-(2-hydroxypropan-2-yl)benzamideIC503.0 [1], 62.0 [2]
N-(3-Bromo-1-ethylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamideIC503.0 [1], 8.0 [2]
N-(1-Ethyl-3-methylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamideIC507.0 [1], 20.0 [2]
4-[(2R)-1,2-Dihydroxypropan-2-yl]-N-(1-ethylpyrrolo[3,2-c]pyridin-6-yl)benzamideIC5055.0 [1], 64.0 [2]
N-(3-Chloro-1-ethylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamideIC506.0 [1], 16.0 [2]
N-(3-Bromo-1-methylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamideIC505.0 [1], 10.0 [2]
N-(3-Bromo-1-methylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamideIC507.0 [1], 20.0 [2]
N-(1-Cyclopropylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamideIC5069.0 [1], 214.0 [2]
4-[(2R)-1,2-Dihydroxypropan-2-yl]-N-(1-ethyl-3-methylpyrrolo[3,2-c]pyridin-6-yl)benzamideIC5014.0 [1], 17.0 [2]
N-(1,3-Dimethylpyrrolo[3,2-c]pyridin-6-yl)-4-(2-hydroxypropan-2-yl)benzamideIC5019.0 [1], 29.0 [2]
N-(3-Bromo-1-ethylpyrrolo[3,2-c]pyridin-6-yl)-4-[(2R)-1,2-dihydroxypropan-2-yl]benzamideIC502.0 [1], 10.0 [2]
DoramapimodIC5030000.0 [1]
AnilinoquinazolineIC5010000.0 [1]
6-O-Cyclohexylmethyl guanineIC5025100.0 [1]
Tak-285IC5010000.0 [1]
CID 46215815IC5027542.0 [1]
6-MethylthioguanineIC5013300.0 [1]
6-(Piperidin-1-yl)-9H-purineIC5017000.0 [1]
CID 59604787IC5010000.0 [1]
(5Z)-5-(Furan-2-ylmethylidene)-3-pyridin-3-yl-2-sulfanylidene-1,3-thiazolidin-4-oneIC5033000.0 [1]
6-AnilinopurineIC5010000.0 [1]
N,N-Dipropyl-9H-purin-6-amineIC5025800.0 [1]
1-Acetyl-3H-naphtho[1,2,3-de]quinoline-2,7-dioneIC5015000.0 [1]
N-(5-(Cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamideIC5093.0 [1]
1-(2-Hydroxy-ethylamino)-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dioneIC5025000.0 [1]
5-(3-Pyridylmethylene)rhodanineIC5033000.0 [1]
N-(3-Chlorophenyl)-7H-purin-6-amineIC5010000.0 [1]
2,2-Dimethyl-7-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-1-[(1R)-1-phenylethyl]-3H-quinazolin-4-oneIC501000.0 [1]
(Z)-2-(5-(Furan-2-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acidIC5033000.0 [1]
3-[(5Z)-5-[[5-(3-Chlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acidIC501000.0 [1]
(5Z)-5-(3-Bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-oneIC5033000.0 [1]
4-[(5Z)-5-[[5-(3-Chlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acidIC50350.0 [1]
(Z)-3-(5-((5-(4-Nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acidIC50650.0 [1]
N6-(2,5-Dimethoxyphenyl)-9H-purine-2,6-diamineIC5018900.0 [1]
5-[5-(2-Nitro-phenyl)-furan-2-ylmethylene]-2-thioxo-thiazolidin-4-oneIC5033000.0 [1]
4-Tert-Butyl-N-[6-(1h-Pyrazol-4-Yl)imidazo[1,2-A]pyridin-2-Yl]benzamideIC506.3 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
6-(2-Aminopyrimidin-4-Yl)-1h-Indazol-3-AmineIC505690.0 [1]
7H-ADENINE, N-(p-FLUOROPHENYL)-IC5010000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
1-(Ethylamino)-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dioneIC5010000.0 [1]
(Z)-2-(5-((5-(2-Fluorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acidIC503000.0 [1]
(Z)-4-(5-((5-(2-Fluorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acidIC503000.0 [1]
(4Z)-5-(4-Chlorophenyl)-1-(6-ethoxy-1,3-benzothiazol-2-yl)-4-[hydroxy(phenyl)methylidene]pyrrolidine-2,3-dioneIC504200.0 [1]
(4Z)-5-(4-Tert-butylphenyl)-1-(6-ethoxy-1,3-benzothiazol-2-yl)-4-[hydroxy(phenyl)methylidene]pyrrolidine-2,3-dioneIC505000.0 [1]
(4Z)-5-(4-Tert-butylphenyl)-1-(6-ethoxy-1,3-benzothiazol-2-yl)-4-[hydroxy-(4-methylphenyl)methylidene]pyrrolidine-2,3-dioneIC502000.0 [1]
(4Z)-5-(4-Tert-butylphenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(6-methyl-1,3-benzothiazol-2-yl)pyrrolidine-2,3-dioneIC504400.0 [1]
(4Z)-5-(4-Tert-butylphenyl)-1-(6-fluoro-1,3-benzothiazol-2-yl)-4-[hydroxy-(4-methylphenyl)methylidene]pyrrolidine-2,3-dioneIC507600.0 [1]
(4Z)-5-(4-Chlorophenyl)-4-[(4-fluorophenyl)-hydroxymethylidene]-1-(6-methyl-1,3-benzothiazol-2-yl)pyrrolidine-2,3-dioneIC502900.0 [1]
(4Z)-4-[(4-Ethoxyphenyl)-hydroxymethylidene]-5-(4-fluorophenyl)-1-(6-methyl-1,3-benzothiazol-2-yl)pyrrolidine-2,3-dioneIC505500.0 [1]
(4Z)-4-[(4-Chlorophenyl)-hydroxymethylidene]-1-(4,6-dimethyl-1,3-benzothiazol-2-yl)-5-(4-propan-2-ylphenyl)pyrrolidine-2,3-dioneIC506300.0 [1]
(4Z)-1-(6-Fluoro-1,3-benzothiazol-2-yl)-5-(3-fluorophenyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]pyrrolidine-2,3-dioneIC5017000.0 [1]
4-[(5Z)-4-Oxo-5-(pyridin-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]benzoic acidIC5033000.0 [1]
2-[(5Z)-5-[[5-(2-Chlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acidIC501250.0 [1]
3-[(5Z)-5-[[5-(2-Chlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acidIC50750.0 [1]
2-[4-(Propan-2-Yl)-4h-1,2,4-Triazol-3-Yl]-N-(Pyridin-2-Yl)-1,3-Thiazole-4-CarboxamideIC50400.0 [1]
6-[[(2S)-4-Methylmorpholin-2-yl]methoxy]-2-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-3H-isoindol-1-oneIC506.31 [1]
2-[6-[4-[(2R)-1-Hydroxypropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-6-propan-2-yloxy-3H-isoindol-1-oneIC505.01 [1]
2-[6-(4-Propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-3H-isoindol-1-oneIC5012.59 [1]
2-[6-[4-[(2R)-Butan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-oneIC5050.12 [1]
2-[6-[4-[(2S)-1-Hydroxypropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-oneIC5031.62 [1]
3-[3-[6-(3-Oxo-1H-isoindol-2-yl)pyridin-2-yl]-1,2,4-triazol-4-yl]butanenitrileIC5019.95 [1]
2-[6-[4-(1-Fluoropropan-2-yl)-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-oneIC5012.59 [1]
2-[6-[4-(Oxetan-2-ylmethyl)-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-oneIC50794.33 [1]
2-[6-[4-(4-Hydroxybutan-2-yl)-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-oneIC5039.81 [1]
2-[6-[4-[(2S)-Butan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-oneIC5019.95 [1]
6-Propan-2-yloxy-2-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-3H-isoindol-1-oneIC5015.85 [1]
6-(2-Methoxyethoxy)-2-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-3H-isoindol-1-oneIC507.94 [1]
2-[6-[4-[(2R)-1-Hydroxypropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-6-(2-methoxyethoxy)-3H-isoindol-1-oneIC507.94 [1]
N-[6-(4-Propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamideIC50398.11 [1]
2-[6-[4-[(2R)-1-Hydroxypropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-3H-isoindol-1-oneIC5010.0 [1]
4-[(5Z)-5-[[5-(4-Bromophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acidIC50200.0 [1]
4-[(5Z)-5-[[5-(2,5-Dichlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acidIC50350.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Mitogen-activated protein kinase kinase kinase 5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-5-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Mitogen-activated protein kinase kinase kinase 5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-5-inhibitors-ic50-ki.
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