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Mitogen-activated protein kinase kinase kinase 14 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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NIK Inhibitor C33IC5040.0 [1], 67.0 [2]
NIK Inhibitor C33Ki0.3 [1], 0.47 [2]
NIK Inhibitor C32IC50102.0 [1], 199.0 [2]
NIK Inhibitor C32Ki0.4 [1], 3.0 [2]
Nik smi1IC5034.0 [1], 70.0 [2]
Nik smi1Ki0.23 [1]
4-{3-[2-Amino-5-(2-Methoxyethoxy)pyrimidin-4-Yl]-1h-Indol-5-Yl}-2-Methylbut-3-Yn-2-OlIC5020.0 [1], 40.0 [2], 70.0 [3]
9-Fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2-oxazol-3-yl)but-1-ynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideIC50156.0 [1]
9-Fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2-oxazol-3-yl)but-1-ynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi0.3 [1]
6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazine-2-carboxamideIC50170.0 [1]
6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazine-2-carboxamideKi1.3 [1]
6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamideIC5080.0 [1]
6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamideKi0.42 [1]
4-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrimidine-2-carboxamideIC50355.0 [1]
4-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrimidine-2-carboxamideKi2.0 [1]
2-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxypyrimidine-4-carboxamideIC5069.0 [1]
2-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxypyrimidine-4-carboxamideKi0.59 [1]
3-Amino-6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamideIC5016.0 [1]
3-Amino-6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamideKi0.07 [1]
3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]isoquinoline-1-carboxamideIC5010.0 [1]
3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]isoquinoline-1-carboxamideKi0.07 [1]
3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamideIC50500.0 [1]
3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamideKi4.7 [1]
1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]-4,5,6,7-tetrahydroindazole-3-carboxamideIC5084.0 [1]
1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]-4,5,6,7-tetrahydroindazole-3-carboxamideKi0.86 [1]
5-Cyclopropyl-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamideIC502100.0 [1]
5-Cyclopropyl-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamideKi16.0 [1]
5-Amino-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamideIC504300.0 [1]
5-Amino-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamideKi9.4 [1]
1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazolo[3,4-b]pyridine-3-carboxamideIC5038.0 [1]
1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazolo[3,4-b]pyridine-3-carboxamideKi0.23 [1]
1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-3-carboxamideIC5015.0 [1]
1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-3-carboxamideKi0.18 [1]
1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamideIC5020000.0 [1]
1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamideKi28.0 [1]
1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamideIC5033.0 [1]
1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamideKi0.08 [1]
5-Fluoro-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamideIC50220.0 [1]
5-Fluoro-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamideKi0.17 [1]
5-Fluoro-1-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamideIC5039.0 [1]
5-Fluoro-1-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamideKi0.27 [1]
1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-5-methoxypyrazolo[3,4-b]pyridine-3-carboxamideIC5021.0 [1]
1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-5-methoxypyrazolo[3,4-b]pyridine-3-carboxamideKi0.13 [1]
1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamideIC5029.0 [1]
1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamideKi0.23 [1]
1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxyimidazo[1,5-a]pyridine-3-carboxamideIC504.7 [1]
1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxyimidazo[1,5-a]pyridine-3-carboxamideKi0.05 [1]
3-[[4-[(3R)-7-Cyano-3-(hydroxymethyl)-3-methyl-1,2-dihydroindol-5-yl]pyrimidin-2-yl]amino]-N,4-dimethylbenzamideIC501.8 [1], 2.2 [2]
(3R)-5-[2-[5-Cyano-2-(4-fluoro-1-methylpyrrolidin-3-yl)oxyanilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrileIC504.6 [1], 21.4 [2]
3-[[4-[(3R)-7-Cyano-3-(hydroxymethyl)-3-methyl-1,2-dihydroindol-5-yl]pyrimidin-2-yl]amino]-N-methyl-4-propan-2-yloxybenzamideIC505.5 [1], 19.5 [2]
(3R)-5-[2-(5-Cyano-4-fluoro-2-methylanilino)pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrileIC501.8 [1], 6.0 [2]
(3R)-5-[2-[5-Cyano-2-(2-hydroxy-2-methylpropoxy)anilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrileIC504.1 [1], 25.7 [2]
(3R)-5-[2-[4-Fluoro-5-(hydroxymethyl)-2-methylanilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrileIC502.3 [1], 7.8 [2]
(3R)-5-[2-[5-Cyano-2-(hydroxymethyl)anilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrileIC501.3 [1], 6.3 [2]
(3R)-3-(Hydroxymethyl)-5-[2-[5-(hydroxymethyl)-2-propan-2-yloxyanilino]pyrimidin-4-yl]-3-methyl-1,2-dihydroindole-7-carbonitrileIC501.4 [1], 6.6 [2]
(3R)-5-[2-(5-Cyano-2-cyclopropyloxyanilino)pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrileIC507.4 [1], 11.5 [2]
(3R)-5-[2-(5-Cyano-2-methylanilino)-5-fluoropyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrileIC501.2 [1], 3.9 [2]
(3R)-5-[2-[5-Cyano-2-methyl-4-(2-morpholin-4-ylethyl)anilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrileIC501.3 [1], 1.8 [2]
7-Ethoxy-3-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamideIC50380.0 [1]
7-Ethoxy-3-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamideKi5.9 [1]
(3R)-5-[2-[5-[Dideuterio(hydroxy)methyl]-2-methylanilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrileIC500.8 [1], 2.2 [2]
11-Bromo-5,6,7,8-Tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-B]indol-2-AmineIC50100.0 [1], 4600.0 [2]
4-(4-Amino-3,5,12-triazatetracyclo[9.7.0.02,7.013,18]octadeca-1(11),2,4,6,13(18),14,16-heptaen-16-yl)-2-methylbut-3-yn-2-olIC5041.0 [1], 170.0 [2]
3-Cyclopropyl-9-fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi37.0 [1], 41.0 [2]
9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi25.0 [1], 35.5 [2]
3-Cyano-9-fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi172.0 [1], 201.0 [2]
10-(3-Methyl-3-Oxidanyl-But-1-Ynyl)-5,6-Dihydroimidazo[1,2-D][1,4]benzoxazepine-2-CarboxamideKi310.0 [1], 319.0 [2]
9-(3-Hydroxy-3-methyl-but-1-ynyl)-4,5-dihydro-[1]benzoxepino[5,4-d]thiazole-2-carboxamideKi28.0 [1], 33.0 [2]
9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi34.0 [1], 36.0 [2]
4-Hydroxy-9-(3-hydroxy-3-methylbut-1-ynyl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole-2-carboxamideKi93.0 [1], 101.0 [2]
9-Fluoro-10-[2-(1-hydroxycyclobutyl)ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi10.0 [1], 20.2 [2]
9-Fluoro-3-[(2-fluorophenyl)methyl]-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi7.5 [1], 12.0 [2]
4,4-Difluoro-9-(3-hydroxy-3-methylbut-1-ynyl)-5H-[1]benzoxepino[5,4-d][1,3]thiazole-2-carboxamideKi40.0 [1], 57.0 [2]
9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-(1H-pyrazol-4-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi5.4 [1], 7.0 [2]
9-Fluoro-10-(3-hydroxy-3-pyridazin-3-ylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi3.2 [1], 4.0 [2]
9-Fluoro-10-[3-hydroxy-3-(1,3-thiazol-2-yl)but-1-ynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi1.5 [1], 2.0 [2]
10-[4-(Dimethylamino)-3-hydroxy-3-methyl-4-oxobut-1-ynyl]-9-fluoro-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi721.0 [1], 986.0 [2]
9-Fluoro-10-[2-(3-hydroxy-1-methyl-2-oxopiperidin-3-yl)ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi3.0 [1], 5.0 [2]
9-Fluoro-10-(4-fluoro-3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi8.0 [1], 8.7 [2]
9-Fluoro-10-[2-(3-hydroxyoxetan-3-yl)ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi3600.0 [1], 4282.0 [2]
9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-[(2-methylpyrazol-3-yl)methyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi7.8 [1], 9.9 [2]
9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-N,3-N-dimethyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamideKi2000.0 [1], 2503.0 [2]
(6R)-10-(3-Hydroxy-3-methylbut-1-ynyl)-6-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi620.0 [1], 1164.0 [2]
9-Fluoro-10-[2-[(3S)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi210.0 [1], 405.0 [2]
9-Fluoro-10-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi0.8 [1], 210.0 [2]
(6S)-10-(3-Hydroxy-3-methylbut-1-ynyl)-6-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamideKi547.0 [1], 620.0 [2]
9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-N-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamideKi2.0 [1], 3.0 [2]
10-(3-Hydroxy-3-methylbut-1-ynyl)-5,6,7,12-tetrahydro-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamideKi20.0 [1], 22.0 [2]
StaurosporineIC502300.0 [1]
PlumbaginIC50100000.0 [1]
N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamideIC50100000.0 [1]
N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamideIC50100000.0 [1]
4-(1H-Indol-3-yl)pyrimidin-2-amineIC5041000.0 [1]
Isoquinoline-1,3(2H,4H)-dioneIC5051000.0 [1]
CID 11634725Ki5000.0 [1]
3-Methyl-4-phenyl-1H-pyrazol-5-amineIC50100000.0 [1]
4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-amineIC5061100.0 [1]
4-(Ethoxymethylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dioneIC5050000.0 [1]
1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanoneIC508400.0 [1]
4-(2-Methylimidazo[1,2-a]pyridin-3-yl)-2-pyrimidinamineIC5080000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Mitogen-activated protein kinase kinase kinase 14 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-14-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Mitogen-activated protein kinase kinase kinase 14 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-kinase-kinase-14-inhibitors-ic50-ki.
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