![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_d6d7c0c63057eeb5e0f21773befb51ea.svg) | NIK Inhibitor C33 | IC50 | 40.0 [1], 67.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_d6d7c0c63057eeb5e0f21773befb51ea.svg) | NIK Inhibitor C33 | Ki | 0.3 [1], 0.47 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_de73aab65e38978c4862bda6518fbc39.svg) | NIK Inhibitor C32 | IC50 | 102.0 [1], 199.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_de73aab65e38978c4862bda6518fbc39.svg) | NIK Inhibitor C32 | Ki | 0.4 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_220a29bd69080b9633c6bdc1ef0f6330.svg) | Nik smi1 | IC50 | 34.0 [1], 70.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_220a29bd69080b9633c6bdc1ef0f6330.svg) | Nik smi1 | Ki | 0.23 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_39d409ecd6b0d536ed49540962c315d2.svg) | 4-{3-[2-Amino-5-(2-Methoxyethoxy)pyrimidin-4-Yl]-1h-Indol-5-Yl}-2-Methylbut-3-Yn-2-Ol | IC50 | 20.0 [1], 40.0 [2], 70.0 [3] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_341ca536517b1142b3d24572f9393ace.svg) | 9-Fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2-oxazol-3-yl)but-1-ynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | IC50 | 156.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_341ca536517b1142b3d24572f9393ace.svg) | 9-Fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2-oxazol-3-yl)but-1-ynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 0.3 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_3f1e2d2934cedc4d75a332b9ee41d9d7.svg) | 6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazine-2-carboxamide | IC50 | 170.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_3f1e2d2934cedc4d75a332b9ee41d9d7.svg) | 6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazine-2-carboxamide | Ki | 1.3 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_23681d0c310a4bbec2bf49ec03ce65da.svg) | 6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamide | IC50 | 80.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_23681d0c310a4bbec2bf49ec03ce65da.svg) | 6-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamide | Ki | 0.42 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_537a0ab5011dd65870a87f383aa3d258.svg) | 4-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrimidine-2-carboxamide | IC50 | 355.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_537a0ab5011dd65870a87f383aa3d258.svg) | 4-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrimidine-2-carboxamide | Ki | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_0411e5e82cb73cc9bce5c06ffc171047.svg) | 2-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxypyrimidine-4-carboxamide | IC50 | 69.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_0411e5e82cb73cc9bce5c06ffc171047.svg) | 2-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxypyrimidine-4-carboxamide | Ki | 0.59 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_20157d92f5cdbe8e904436583373b7e5.svg) | 3-Amino-6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamide | IC50 | 16.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_20157d92f5cdbe8e904436583373b7e5.svg) | 3-Amino-6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyridine-2-carboxamide | Ki | 0.07 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_7fb4833a97f0b94401b316e7e55ef239.svg) | 3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]isoquinoline-1-carboxamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_7fb4833a97f0b94401b316e7e55ef239.svg) | 3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]isoquinoline-1-carboxamide | Ki | 0.07 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_b979657cf1485a62c7dbfc86d8669742.svg) | 3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamide | IC50 | 500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_b979657cf1485a62c7dbfc86d8669742.svg) | 3-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamide | Ki | 4.7 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_446a22dd59fe5f4d3d94c2d687515f9b.svg) | 1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]-4,5,6,7-tetrahydroindazole-3-carboxamide | IC50 | 84.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_446a22dd59fe5f4d3d94c2d687515f9b.svg) | 1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]-4,5,6,7-tetrahydroindazole-3-carboxamide | Ki | 0.86 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_eeb46ab74b4f2ba5dc098fbeb9057f81.svg) | 5-Cyclopropyl-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide | IC50 | 2100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_eeb46ab74b4f2ba5dc098fbeb9057f81.svg) | 5-Cyclopropyl-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide | Ki | 16.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_e22347eb502715f8b1def63d0c611ba7.svg) | 5-Amino-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide | IC50 | 4300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_e22347eb502715f8b1def63d0c611ba7.svg) | 5-Amino-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide | Ki | 9.4 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_136e12082421d084845d50563c6f00ee.svg) | 1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazolo[3,4-b]pyridine-3-carboxamide | IC50 | 38.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_136e12082421d084845d50563c6f00ee.svg) | 1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]pyrazolo[3,4-b]pyridine-3-carboxamide | Ki | 0.23 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_ad28ec244542ca5d752596e5b5058ba7.svg) | 1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-3-carboxamide | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_ad28ec244542ca5d752596e5b5058ba7.svg) | 1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-3-carboxamide | Ki | 0.18 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_bcafa0c3f4f8b3420759ea7ef02627f0.svg) | 1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_bcafa0c3f4f8b3420759ea7ef02627f0.svg) | 1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]pyrazole-3-carboxamide | Ki | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_82dc0482a7af8d12e9f6d4cd44ea7c9e.svg) | 1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide | IC50 | 33.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_82dc0482a7af8d12e9f6d4cd44ea7c9e.svg) | 1-[4-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide | Ki | 0.08 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_9f2b2e724a3c921d94cdd0fd55a518a7.svg) | 5-Fluoro-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide | IC50 | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_9f2b2e724a3c921d94cdd0fd55a518a7.svg) | 5-Fluoro-1-[4-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide | Ki | 0.17 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_c9c3896035881bbc8d23252b658cd9a5.svg) | 5-Fluoro-1-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamide | IC50 | 39.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_c9c3896035881bbc8d23252b658cd9a5.svg) | 5-Fluoro-1-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamide | Ki | 0.27 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_1413f259563cf1066668974397548657.svg) | 1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-5-methoxypyrazolo[3,4-b]pyridine-3-carboxamide | IC50 | 21.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_1413f259563cf1066668974397548657.svg) | 1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-5-methoxypyrazolo[3,4-b]pyridine-3-carboxamide | Ki | 0.13 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_7c6a4a52c9e4979e6c6aeca21fcc0096.svg) | 1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamide | IC50 | 29.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_7c6a4a52c9e4979e6c6aeca21fcc0096.svg) | 1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]indazole-3-carboxamide | Ki | 0.23 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_7e563f0dbfbe27cb8ad02c52da085be1.svg) | 1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxyimidazo[1,5-a]pyridine-3-carboxamide | IC50 | 4.7 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_7e563f0dbfbe27cb8ad02c52da085be1.svg) | 1-[3-[2-[(3R)-3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]-6-methoxyimidazo[1,5-a]pyridine-3-carboxamide | Ki | 0.05 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_824798a426d6195cc0e1806b1e0eb1c2.svg) | 3-[[4-[(3R)-7-Cyano-3-(hydroxymethyl)-3-methyl-1,2-dihydroindol-5-yl]pyrimidin-2-yl]amino]-N,4-dimethylbenzamide | IC50 | 1.8 [1], 2.2 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_45cf768fb3eb1bb02be0b1b77aa3fcf4.svg) | (3R)-5-[2-[5-Cyano-2-(4-fluoro-1-methylpyrrolidin-3-yl)oxyanilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile | IC50 | 4.6 [1], 21.4 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_d0518e87589f41ff9869477a3f18deff.svg) | 3-[[4-[(3R)-7-Cyano-3-(hydroxymethyl)-3-methyl-1,2-dihydroindol-5-yl]pyrimidin-2-yl]amino]-N-methyl-4-propan-2-yloxybenzamide | IC50 | 5.5 [1], 19.5 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_ad90719dcc3797d05e68e8ab52566f16.svg) | (3R)-5-[2-(5-Cyano-4-fluoro-2-methylanilino)pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile | IC50 | 1.8 [1], 6.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_f9feb646ca395c83879dd538db96cc7d.svg) | (3R)-5-[2-[5-Cyano-2-(2-hydroxy-2-methylpropoxy)anilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile | IC50 | 4.1 [1], 25.7 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_c9325713276bab8f9c9aea1bdf02cf7f.svg) | (3R)-5-[2-[4-Fluoro-5-(hydroxymethyl)-2-methylanilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile | IC50 | 2.3 [1], 7.8 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_b8525b6674006c04333441543fd31e33.svg) | (3R)-5-[2-[5-Cyano-2-(hydroxymethyl)anilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile | IC50 | 1.3 [1], 6.3 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_d3b45c744af0337e4ea54f7d113eaeed.svg) | (3R)-3-(Hydroxymethyl)-5-[2-[5-(hydroxymethyl)-2-propan-2-yloxyanilino]pyrimidin-4-yl]-3-methyl-1,2-dihydroindole-7-carbonitrile | IC50 | 1.4 [1], 6.6 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_33eb9cb7ec6e015b2f7dd33ca6bb51b2.svg) | (3R)-5-[2-(5-Cyano-2-cyclopropyloxyanilino)pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile | IC50 | 7.4 [1], 11.5 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_926464a104f2f9ad82f1eb99a5abed5a.svg) | (3R)-5-[2-(5-Cyano-2-methylanilino)-5-fluoropyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile | IC50 | 1.2 [1], 3.9 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_2f012756dfd403d7985b4455ba74e0ed.svg) | (3R)-5-[2-[5-Cyano-2-methyl-4-(2-morpholin-4-ylethyl)anilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile | IC50 | 1.3 [1], 1.8 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_b157204f5ff30c9acd10f9eb9a01f2e6.svg) | 7-Ethoxy-3-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamide | IC50 | 380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_b157204f5ff30c9acd10f9eb9a01f2e6.svg) | 7-Ethoxy-3-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl]imidazo[1,5-a]pyridine-1-carboxamide | Ki | 5.9 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_5407fe819c3d70afa08071651ad1fe24.svg) | (3R)-5-[2-[5-[Dideuterio(hydroxy)methyl]-2-methylanilino]pyrimidin-4-yl]-3-(hydroxymethyl)-3-methyl-1,2-dihydroindole-7-carbonitrile | IC50 | 0.8 [1], 2.2 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_78d8d4a48dcd6e44c7e5c53691e9c191.svg) | 11-Bromo-5,6,7,8-Tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-B]indol-2-Amine | IC50 | 100.0 [1], 4600.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_60d078d068fbb05be9e3bf1e6619bf76.svg) | 4-(4-Amino-3,5,12-triazatetracyclo[9.7.0.02,7.013,18]octadeca-1(11),2,4,6,13(18),14,16-heptaen-16-yl)-2-methylbut-3-yn-2-ol | IC50 | 41.0 [1], 170.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_47df89784f9dbfca0afaaed382b7c0d1.svg) | 3-Cyclopropyl-9-fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 37.0 [1], 41.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_0bf76d78bc985d9dcca80593247a53d9.svg) | 9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 25.0 [1], 35.5 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_f44a70f66a9c15fa140f2a174e408c12.svg) | 3-Cyano-9-fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 172.0 [1], 201.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_6f8d01ce444ac0debab27b6595fedfb3.svg) | 10-(3-Methyl-3-Oxidanyl-But-1-Ynyl)-5,6-Dihydroimidazo[1,2-D][1,4]benzoxazepine-2-Carboxamide | Ki | 310.0 [1], 319.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_5e61958f5b33aee4807b36a918cc592e.svg) | 9-(3-Hydroxy-3-methyl-but-1-ynyl)-4,5-dihydro-[1]benzoxepino[5,4-d]thiazole-2-carboxamide | Ki | 28.0 [1], 33.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_9623a55a10f3c5195b6f1b0b6ab0c10c.svg) | 9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 34.0 [1], 36.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_4f56dffd5d4a2fee741dea4a5a6861f1.svg) | 4-Hydroxy-9-(3-hydroxy-3-methylbut-1-ynyl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole-2-carboxamide | Ki | 93.0 [1], 101.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_d79f210dd568f98d65c93a5abd1e14dc.svg) | 9-Fluoro-10-[2-(1-hydroxycyclobutyl)ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 10.0 [1], 20.2 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_985a8399b37864238f732cfed779eb24.svg) | 9-Fluoro-3-[(2-fluorophenyl)methyl]-10-(3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 7.5 [1], 12.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_db7e015274b162ea715dfc458950110e.svg) | 4,4-Difluoro-9-(3-hydroxy-3-methylbut-1-ynyl)-5H-[1]benzoxepino[5,4-d][1,3]thiazole-2-carboxamide | Ki | 40.0 [1], 57.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_33ae3acbc3e11599a8c7d9a35819cf22.svg) | 9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-(1H-pyrazol-4-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 5.4 [1], 7.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_5b56ef0ca3c4b215074595d4de392142.svg) | 9-Fluoro-10-(3-hydroxy-3-pyridazin-3-ylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 3.2 [1], 4.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_874a94327a2df8e00f38384c324eb868.svg) | 9-Fluoro-10-[3-hydroxy-3-(1,3-thiazol-2-yl)but-1-ynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 1.5 [1], 2.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_6a1a3e885e260e47fbae7d50024521d1.svg) | 10-[4-(Dimethylamino)-3-hydroxy-3-methyl-4-oxobut-1-ynyl]-9-fluoro-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 721.0 [1], 986.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_3a8c6970b3d8bed310e7b56d872b4508.svg) | 9-Fluoro-10-[2-(3-hydroxy-1-methyl-2-oxopiperidin-3-yl)ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 3.0 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_c926105d4960b39f2d69e5091f150d0d.svg) | 9-Fluoro-10-(4-fluoro-3-hydroxy-3-methylbut-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 8.0 [1], 8.7 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_c51b6bd5bb2834240c9485711eb01cdf.svg) | 9-Fluoro-10-[2-(3-hydroxyoxetan-3-yl)ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 3600.0 [1], 4282.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_e87e4a2b55264dc36ed134a888f8da0e.svg) | 9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-[(2-methylpyrazol-3-yl)methyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 7.8 [1], 9.9 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_e857fd792e04cc3810b791600165935b.svg) | 9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-N,3-N-dimethyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide | Ki | 2000.0 [1], 2503.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_5da6eb8eb7e37b75034fc8b1aa0cf542.svg) | (6R)-10-(3-Hydroxy-3-methylbut-1-ynyl)-6-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 620.0 [1], 1164.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_4f67b230f11024c77b5a312a2a084ade.svg) | 9-Fluoro-10-[2-[(3S)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 210.0 [1], 405.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_007922a92a66761ced75fe276108bdd6.svg) | 9-Fluoro-10-[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 0.8 [1], 210.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_435d055557c96a24626c5f642c310f5e.svg) | (6S)-10-(3-Hydroxy-3-methylbut-1-ynyl)-6-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | Ki | 547.0 [1], 620.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_ac2b4a697383572e36f94f3a8a5451c9.svg) | 9-Fluoro-10-(3-hydroxy-3-methylbut-1-ynyl)-3-N-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide | Ki | 2.0 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_5c493ed4efbe59b909a2378a756e2b36.svg) | 10-(3-Hydroxy-3-methylbut-1-ynyl)-5,6,7,12-tetrahydro-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide | Ki | 20.0 [1], 22.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_1d5eba4b4bb57896dda18b1604bab021.svg) | Staurosporine | IC50 | 2300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_ee5e134a0f9db83ed684beb97013f149.svg) | Plumbagin | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_e02f47dfecdec520aa0e453d4d995fe9.svg) | N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_1ed2abe58887dc0b39d0a378921ec617.svg) | N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_900bf376077255cac8b3e349da2d1f67.svg) | 4-(1H-Indol-3-yl)pyrimidin-2-amine | IC50 | 41000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_02cd25f3427845ca55db5b7e887380c8.svg) | Isoquinoline-1,3(2H,4H)-dione | IC50 | 51000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_d44bb541aaceb7d87194194110f1e1e1.svg) | CID 11634725 | Ki | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_d08c8df6e94005871234961fea54ad8e.svg) | 3-Methyl-4-phenyl-1H-pyrazol-5-amine | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_ae731e7b3444ffc61b7ea08d4dd4951a.svg) | 4-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-amine | IC50 | 61100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_6e2c162750e8a2957726836cf2ad8ca7.svg) | 4-(Ethoxymethylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione | IC50 | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_f64ae507fb96828f441cbfe1c221da9b.svg) | 1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanone | IC50 | 8400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-14_ac0bd98a8bad0d0c926542a69fc92926.svg) | 4-(2-Methylimidazo[1,2-a]pyridin-3-yl)-2-pyrimidinamine | IC50 | 80000.0 [1] |