![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_e23fa1bfdcc40f6f273a1efeafdbdbed.svg) | Dlk-IN-1 | IC50 | 129.0 [1], 195.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_e23fa1bfdcc40f6f273a1efeafdbdbed.svg) | Dlk-IN-1 | Ki | 1.9 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_f5abe3234d4b41fad1784bb6b6683e98.svg) | 5-[1-(Cyclopropylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 144.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_f5abe3234d4b41fad1784bb6b6683e98.svg) | 5-[1-(Cyclopropylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 0.17 [1], 4.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_61297e14f4d39d71da54de5cbfe43b52.svg) | 5-[5-[(1S,5R)-3-(Oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 180.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_61297e14f4d39d71da54de5cbfe43b52.svg) | 5-[5-[(1S,5R)-3-(Oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 1.6 [1], 16.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_15e13c6ccb0c1cd566fa648cee1de112.svg) | 5-[5-[1-(Oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine | IC50 | 485.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_15e13c6ccb0c1cd566fa648cee1de112.svg) | 5-[5-[1-(Oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine | Ki | 2.3 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_d4e12ba936e2e633f44e88857348e147.svg) | 3-Methyl-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine | IC50 | 303.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_d4e12ba936e2e633f44e88857348e147.svg) | 3-Methyl-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine | Ki | 3.7 [1], 4.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_11ccd905e080f2a9765f159e0e3b5e51.svg) | 3-Fluoro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine | IC50 | 2800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_11ccd905e080f2a9765f159e0e3b5e51.svg) | 3-Fluoro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine | Ki | 96.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_e76bf60d8c32899b33fb0d18c8b225dd.svg) | 5-[5-[1-(Oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 1900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_e76bf60d8c32899b33fb0d18c8b225dd.svg) | 5-[5-[1-(Oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 150.0 [1], 154.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_90632831cd4cf2406fedcbf072eae6a6.svg) | 3-Chloro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine | IC50 | 1700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_90632831cd4cf2406fedcbf072eae6a6.svg) | 3-Chloro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine | Ki | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_60fe01f8199588c08ac58b5504d33214.svg) | 3-Chloro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine | IC50 | 574.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_60fe01f8199588c08ac58b5504d33214.svg) | 3-Chloro-5-[5-[1-(oxetan-3-yl)piperidin-4-yl]-1-propan-2-ylpyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine | Ki | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_9bd8fe44cfe77c4d726a0cc9cbc9c169.svg) | 5-[5-[(1S,5R)-3-(2,2-Difluoroethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 611.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_9bd8fe44cfe77c4d726a0cc9cbc9c169.svg) | 5-[5-[(1S,5R)-3-(2,2-Difluoroethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_aafd61796b6d0f531277ecb3b5a669a3.svg) | 1-[(1R,5S)-6-[5-[6-Amino-5-(trifluoromethyl)pyridin-3-yl]-2-propan-2-ylpyrazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]ethanone | IC50 | 302.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_aafd61796b6d0f531277ecb3b5a669a3.svg) | 1-[(1R,5S)-6-[5-[6-Amino-5-(trifluoromethyl)pyridin-3-yl]-2-propan-2-ylpyrazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]ethanone | Ki | 5.6 [1], 6.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_5f673f3cc8e746eb0a1af686e9c1415e.svg) | 5-[5-[(1S,5R)-3-(2-Methoxyethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 265.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_5f673f3cc8e746eb0a1af686e9c1415e.svg) | 5-[5-[(1S,5R)-3-(2-Methoxyethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 9.0 [1], 9.4 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_927daed958c3d7ecddd8dc75575eaeac.svg) | 5-[5-[(1S,5R)-3-(Oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 250.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_927daed958c3d7ecddd8dc75575eaeac.svg) | 5-[5-[(1S,5R)-3-(Oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 2.7 [1], 7.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_a891876356b1d33d533658f67431b67a.svg) | 3-Methoxy-5-[5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine | IC50 | 873.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_a891876356b1d33d533658f67431b67a.svg) | 3-Methoxy-5-[5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine | Ki | 7.0 [1], 7.4 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_7e92ca0d3a8a2165c668c2469c054f1b.svg) | 3-(Difluoromethyl)-5-[5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine | IC50 | 1200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_7e92ca0d3a8a2165c668c2469c054f1b.svg) | 3-(Difluoromethyl)-5-[5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine | Ki | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_df59706b32f88e8f396bb825de6d5b5d.svg) | 5-[1-(Cyclobutylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 210.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_df59706b32f88e8f396bb825de6d5b5d.svg) | 5-[1-(Cyclobutylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 8.1 [1], 11.0 [2] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_efe7865ae113e61173d7577baa39dca0.svg) | 3-(Difluoromethoxy)-5-[5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine | IC50 | 328.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_efe7865ae113e61173d7577baa39dca0.svg) | 3-(Difluoromethoxy)-5-[5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]pyridin-2-amine | Ki | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_8d08a07d2297c26adb17a3359934bc8c.svg) | CID 72547959 | IC50 | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_8d08a07d2297c26adb17a3359934bc8c.svg) | CID 72547959 | Ki | 0.5 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_9b77e0d646f6d1ac3a7ddedb939fdf94.svg) | 2-[[1-Cyclopentyl-5-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyrazol-3-Yl]amino]pyridine-4-Carbonitrile | IC50 | 536.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_9b77e0d646f6d1ac3a7ddedb939fdf94.svg) | 2-[[1-Cyclopentyl-5-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyrazol-3-Yl]amino]pyridine-4-Carbonitrile | Ki | 42.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_f0cfbb4a22586c5004c1275b3622cd88.svg) | 2-(3,3-Difluoropyrrolidin-1-yl)-6-piperidin-4-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine | IC50 | 410.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_f0cfbb4a22586c5004c1275b3622cd88.svg) | 2-(3,3-Difluoropyrrolidin-1-yl)-6-piperidin-4-yl-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine | Ki | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_f54e436d59d340ee7737bb3ac6b80fb0.svg) | [3-[2-Methyl-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone | IC50 | 229.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_f54e436d59d340ee7737bb3ac6b80fb0.svg) | [3-[2-Methyl-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone | Ki | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_9d0ee47657576558eba0ac2122fcc14c.svg) | 1-[4-[2-(3,3-Difluoropyrrolidin-1-yl)-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyrimidin-4-yl]piperidin-1-yl]ethanone | IC50 | 300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_9d0ee47657576558eba0ac2122fcc14c.svg) | 1-[4-[2-(3,3-Difluoropyrrolidin-1-yl)-6-[[4-(trifluoromethyl)pyridin-2-yl]amino]pyrimidin-4-yl]piperidin-1-yl]ethanone | Ki | 33.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_dc4896966f50bdc1ea6a721dca3be67e.svg) | 2-(3,3-Difluoropyrrolidin-1-yl)-6-(oxan-4-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine | IC50 | 440.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_dc4896966f50bdc1ea6a721dca3be67e.svg) | 2-(3,3-Difluoropyrrolidin-1-yl)-6-(oxan-4-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]pyrimidin-4-amine | Ki | 41.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_a8e100bcd3f3876de6a67768cbba915e.svg) | 2-[[6-Ethyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | IC50 | 213.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_a8e100bcd3f3876de6a67768cbba915e.svg) | 2-[[6-Ethyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | Ki | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_33d21fc011e27c0627739220dc11467f.svg) | 2-[[6-(3,3-Difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)azetidin-3-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | IC50 | 57.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_33d21fc011e27c0627739220dc11467f.svg) | 2-[[6-(3,3-Difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)azetidin-3-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | Ki | 0.7 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_e398d53741db2ced9602b4ad9bfad463.svg) | 2-[[6-Cyclopropyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | IC50 | 62.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_e398d53741db2ced9602b4ad9bfad463.svg) | 2-[[6-Cyclopropyl-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | Ki | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_a7ccb3b0709b3627d41fad3a168051fa.svg) | [3-[2-Methyl-6-[(5-methyl-1,3-thiazol-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone | IC50 | 641.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_a7ccb3b0709b3627d41fad3a168051fa.svg) | [3-[2-Methyl-6-[(5-methyl-1,3-thiazol-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone | Ki | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_72b6f96ffc4a16b4cca6c4adc0aeaf9a.svg) | [3-[2-Methyl-6-[(4-propan-2-ylpyridin-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone | IC50 | 1300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_72b6f96ffc4a16b4cca6c4adc0aeaf9a.svg) | [3-[2-Methyl-6-[(4-propan-2-ylpyridin-2-yl)amino]pyrimidin-4-yl]piperidin-1-yl]-phenylmethanone | Ki | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_2c890ea5816d2f8d8912373741b94bf5.svg) | [3-[6-[(4-Cyclopropylpyridin-2-yl)amino]-2-methylpyrimidin-4-yl]piperidin-1-yl]-phenylmethanone | IC50 | 486.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_2c890ea5816d2f8d8912373741b94bf5.svg) | [3-[6-[(4-Cyclopropylpyridin-2-yl)amino]-2-methylpyrimidin-4-yl]piperidin-1-yl]-phenylmethanone | Ki | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_a41a782d824965291bd3c73c200434d9.svg) | 2-[[6-(1-Benzoylpiperidin-3-yl)-2-methylpyrimidin-4-yl]amino]pyridine-4-carbonitrile | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_a41a782d824965291bd3c73c200434d9.svg) | 2-[[6-(1-Benzoylpiperidin-3-yl)-2-methylpyrimidin-4-yl]amino]pyridine-4-carbonitrile | Ki | 90.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_98b1af11e8f5e78560b225cabefbb33d.svg) | [3-[6-[(4-Methoxypyridin-2-yl)amino]-2-methylpyrimidin-4-yl]piperidin-1-yl]-phenylmethanone | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_98b1af11e8f5e78560b225cabefbb33d.svg) | [3-[6-[(4-Methoxypyridin-2-yl)amino]-2-methylpyrimidin-4-yl]piperidin-1-yl]-phenylmethanone | Ki | 57.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_c8540cd3bb445a41f4bdd16fc6cee8db.svg) | 2-[[4-(2-Cyanopropan-2-yl)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile | IC50 | 193.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_c8540cd3bb445a41f4bdd16fc6cee8db.svg) | 2-[[4-(2-Cyanopropan-2-yl)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile | Ki | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_6eb533c046c500904285d6782731d39f.svg) | 2-[[6-(3,3-Difluoropyrrolidin-1-yl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile | IC50 | 125.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_6eb533c046c500904285d6782731d39f.svg) | 2-[[6-(3,3-Difluoropyrrolidin-1-yl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]amino]pyridine-4-carbonitrile | Ki | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_bc5142f195aafe340f5c3970524b6215.svg) | 2-[[6-Cyclobutyloxy-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | IC50 | 64.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_bc5142f195aafe340f5c3970524b6215.svg) | 2-[[6-Cyclobutyloxy-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | Ki | 0.2 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_54fcaaf8f126479b175e459dbcf85211.svg) | 2-[[1-(3,3-Difluorocyclopentyl)-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile | IC50 | 721.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_54fcaaf8f126479b175e459dbcf85211.svg) | 2-[[1-(3,3-Difluorocyclopentyl)-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile | Ki | 48.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_ec707fb0e1dc79d4efde10affd764c32.svg) | 2-[[1-(Cyclobutylmethyl)-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile | IC50 | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_ec707fb0e1dc79d4efde10affd764c32.svg) | 2-[[1-(Cyclobutylmethyl)-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile | Ki | 133.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_b4699f2eeb5ca6218055d265b37afc33.svg) | 2-[[1-Cyclopentyl-5-[1-(oxetan-3-yl)azetidin-3-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile | IC50 | 459.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_b4699f2eeb5ca6218055d265b37afc33.svg) | 2-[[1-Cyclopentyl-5-[1-(oxetan-3-yl)azetidin-3-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile | Ki | 48.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_579509945a599f90ccef214dd1071f79.svg) | 2-[[1-Cyclopentyl-5-[1-(oxetan-3-yl)pyrrolidin-3-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile | IC50 | 632.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_579509945a599f90ccef214dd1071f79.svg) | 2-[[1-Cyclopentyl-5-[1-(oxetan-3-yl)pyrrolidin-3-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile | Ki | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_561f7684d2c6ed4c251f5024e412d408.svg) | 2-[[1-Cyclopentyl-5-(oxolan-3-yl)pyrazol-3-yl]amino]pyridine-4-carbonitrile | IC50 | 698.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_561f7684d2c6ed4c251f5024e412d408.svg) | 2-[[1-Cyclopentyl-5-(oxolan-3-yl)pyrazol-3-yl]amino]pyridine-4-carbonitrile | Ki | 54.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_cbda541ab9c60eb184b8b600ad618aa7.svg) | 2-[[4-Cyclopropyl-5-[1-(oxetan-3-yl)piperidin-4-yl]-1,3-thiazol-2-yl]amino]pyridine-4-carbonitrile | IC50 | 8600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_cbda541ab9c60eb184b8b600ad618aa7.svg) | 2-[[4-Cyclopropyl-5-[1-(oxetan-3-yl)piperidin-4-yl]-1,3-thiazol-2-yl]amino]pyridine-4-carbonitrile | Ki | 569.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_265170578ba81068a5063aee8829e430.svg) | 5-[1-(Cyclopropylmethyl)-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethoxy)pyridin-2-amine | IC50 | 304.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_265170578ba81068a5063aee8829e430.svg) | 5-[1-(Cyclopropylmethyl)-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethoxy)pyridin-2-amine | Ki | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_dc9c17cf7de5c5ded292d0a7e91efbc9.svg) | 5-[1-(Cyclopentylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 202.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_dc9c17cf7de5c5ded292d0a7e91efbc9.svg) | 5-[1-(Cyclopentylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_69a60297683f4e8e6d5275198af5a357.svg) | 5-[1-Methyl-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethoxy)pyridin-2-amine | IC50 | 1300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_69a60297683f4e8e6d5275198af5a357.svg) | 5-[1-Methyl-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethoxy)pyridin-2-amine | Ki | 67.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_bfe74342aea5703cea9fac96e1762351.svg) | 5-[1-Ethyl-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 406.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_bfe74342aea5703cea9fac96e1762351.svg) | 5-[1-Ethyl-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_77cf38e1bba934f952695b0e86f6324d.svg) | 5-[5-[(1S,5R)-3-(Oxetan-3-ylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 274.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_77cf38e1bba934f952695b0e86f6324d.svg) | 5-[5-[(1S,5R)-3-(Oxetan-3-ylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_7f9719607209adb683fd876080913605.svg) | 1-[(1R,5S)-6-[5-[6-Amino-5-(trifluoromethyl)pyridin-3-yl]-2-propan-2-ylpyrazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]propan-2-ol | IC50 | 208.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_7f9719607209adb683fd876080913605.svg) | 1-[(1R,5S)-6-[5-[6-Amino-5-(trifluoromethyl)pyridin-3-yl]-2-propan-2-ylpyrazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]propan-2-ol | Ki | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_4640014513b5ec9ca1f116ae9497e342.svg) | 5-[1-(2-Methylpropyl)-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 99.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_4640014513b5ec9ca1f116ae9497e342.svg) | 5-[1-(2-Methylpropyl)-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_3f078d192e66329228b7b379ff582b1c.svg) | 5-[1-Methyl-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | IC50 | 1800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_3f078d192e66329228b7b379ff582b1c.svg) | 5-[1-Methyl-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amine | Ki | 82.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_6b5730fa3d46605871cd3b12a767f18a.svg) | 1-[3-[6-Amino-5-(trifluoromethyl)pyridin-3-yl]-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-1-yl]-2-methylpropan-2-ol | IC50 | 829.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_6b5730fa3d46605871cd3b12a767f18a.svg) | 1-[3-[6-Amino-5-(trifluoromethyl)pyridin-3-yl]-5-[(1S,5R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-1-yl]-2-methylpropan-2-ol | Ki | 23.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_52ec7b160c7240a1e0c69d0ada1e792d.svg) | 2-[[6-(Azetidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | IC50 | 141.0 [1] |
![](https://images.aatbio.com/dataset/ic50/mitogen-activated-protein-kinase-kinase-kinase-12_52ec7b160c7240a1e0c69d0ada1e792d.svg) | 2-[[6-(Azetidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | Ki | 8.0 [1] |