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Mitogen-activated protein kinase; ERK1/ERK2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
ERK1/2 inhibitor 1IC502.3 [1], 3.5 [2]
Pyridone 6IC501780.0 [1]
CID 24866313IC5020.0 [1]
4-({5-Amino-1-[(2,6-Difluorophenyl)carbonyl]-1h-1,2,4-Triazol-3-Yl}amino)benzenesulfonamideIC5019400.0 [1]
Unii-NA856793UTIC5050000.0 [1]
(E)-5-(1-(2-Hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oximeIC5063.0 [1]
UlixertinibIC50140.0 [1]
Cdk1/2 Inhibitor IIIIC501000.0 [1]
2-{[(1r,2s)-2-Aminocyclohexyl]amino}-4-[(3-Methylphenyl)amino]pyrimidine-5-CarboxamideIC5015.85 [1]
2-{[(3r,4r)-3-Aminotetrahydro-2h-Pyran-4-Yl]amino}-4-[(4-Methylphenyl)amino]pyrimidine-5-CarboxamideIC5079.43 [1]
1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC507100.0 [1]
4-(4-Phenoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)-3-quinolinecarbonitrileIC50380.0 [1]
N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamideIC5030000.0 [1]
N-(1,3-Benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamideIC5030000.0 [1]
4-[3-Chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinoline-3-carbonitrileIC500.01 [1]
(NE)-N-[5-[1-(oxan-4-yl)-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC5048.0 [1]
(NE)-N-[5-[1-(1-methylpiperidin-4-yl)-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC5010.0 [1]
(1E)-5-(1-Piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oximeIC509.0 [1]
4-{1-Methyl-4-[4-(4-methyl-1H-pyrazol-3-yl)phenyl]-1H-pyrazol-3-yl}pyridineIC5018000.0 [1]
1-[2-Amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC5050000.0 [1]
N-[(1S)-1-(3-Chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(oxan-4-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamideIC5045.0 [1]
N-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-2-(oxan-4-ylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxamideIC5020.0 [1]
(4S,6E,9R,10S,12E)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dioneIC505700.0 [1]
(NE)-N-[5-(1-cyclopentyl-3-pyridin-4-ylpyrazol-4-yl)-2,3-dihydroinden-1-ylidene]hydroxylamineIC5057.0 [1]
(1S,2S)-2-[4-[(1E)-1-Hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]cyclopentan-1-olIC5037.0 [1]
3-[4-[(1E)-1-Hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]propane-1,2-diolIC5022.0 [1]
(NE)-N-[5-[1-(piperidin-4-ylmethyl)-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC50332.0 [1]
(NE)-N-[5-(1-methyl-3-pyridin-4-ylpyrazol-4-yl)-2,3-dihydroinden-1-ylidene]hydroxylamineIC5033.0 [1]
(NE)-N-[5-[1-(3-aminopropyl)-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC5020.0 [1]
(NE)-N-[5-[1-(2-aminoethyl)-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC50119.0 [1]
7-Ethenylsulfonyl-N-(oxan-4-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-amineIC501100.0 [1]
N-(3-Pyridin-4-yl-1H-indazol-5-yl)ethenesulfonamideIC50470.0 [1]
5-Ethenylsulfonyl-3-(2-methylpyridin-4-yl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridineIC501000.0 [1]
7-Ethylsulfonyl-N-(Oxan-4-Yl)-6,8-Dihydro-5h-Pyrido[3,4-D]pyrimidin-2-AmineIC5030000.0 [1]
N-(3-Pyridin-4-yl-1H-indazol-5-yl)ethanesulfonamideIC5030000.0 [1]
4-Fluoro-N-methyl-2-[[2-(oxan-4-ylamino)-5-(trifluoromethyl)pyridin-4-yl]amino]benzamideIC502400.0 [1]
N-[2-[[5-Chloro-2-(oxan-4-ylamino)pyridin-4-yl]amino]phenyl]prop-2-enamideIC50400.0 [1]
N-[2-[[5-Chloranyl-2-(Oxan-4-Ylamino)pyrimidin-4-Yl]amino]phenyl]propanamideIC5030000.0 [1]
N-[4-[[5-Chloro-2-(oxan-4-ylamino)pyrimidin-4-yl]amino]pyridin-3-yl]prop-2-enamideIC5028.0 [1]
N-[2-[[5-Methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]amino]phenyl]prop-2-enamideIC50740.0 [1]
N-[2-[[5-Chloro-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]amino]phenyl]prop-2-enamideIC50120.0 [1]
N-[2-[[5-Chloro-2-[[4-(dimethylamino)cyclohexyl]amino]pyrimidin-4-yl]amino]phenyl]prop-2-enamideIC50200.0 [1]
N-[2-[[5-Methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]amino]phenyl]prop-2-enamideIC50280.0 [1]
N-Tert-butyl-2-[5-[5-chloro-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxo-1H-isoindol-2-yl]-N-methylacetamideIC50630.0 [1]
N-[5-(1-Methyl-3-pyridin-4-ylpyrazol-4-yl)-3H-isoindol-1-yl]hydroxylamineIC5056.0 [1]
(NE)-N-[5-(5-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydroinden-1-ylidene]hydroxylamineIC5053.0 [1]
N-[6-(1-Methyl-3-pyridin-4-ylpyrazol-4-yl)-3,4-dihydroisoquinolin-1-yl]hydroxylamineIC5010000.0 [1]
(NE)-N-[5-(1-methyl-5-pyridin-4-ylpyrazol-4-yl)-2,3-dihydroinden-1-ylidene]hydroxylamineIC50165.0 [1]
N'-Hydroxy-4-(1-methyl-3-pyridin-4-ylpyrazol-4-yl)benzenecarboximidamideIC5020000.0 [1]
4-(4-{2H,4H-Indeno[1,2-c]pyrazol-6-yl}-1-methyl-1H-pyrazol-3-yl)pyridineIC501900.0 [1]
4-[[1-(2,6-Difluoro-3-methylbenzoyl)-5-methyl-1,2,4-triazol-3-yl]amino]benzenesulfonamideIC509500.0 [1]
(NE)-N-[5-(1-ethyl-3-pyridin-4-ylpyrazol-4-yl)-2,3-dihydroinden-1-ylidene]hydroxylamineIC5018.0 [1]
(1R,2S)-2-[4-[(1E)-1-Hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]cyclopentan-1-olIC50245.0 [1]
(1S,3R)-3-[4-[(1E)-1-Hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]cyclohexan-1-olIC507.0 [1]
(1R,3R)-3-[4-[(1E)-1-Hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]cyclohexan-1-olIC5017.0 [1]
(NE)-N-[5-[1-(2-methoxyethyl)-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC50569.0 [1]
3-[4-[(1E)-1-Hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]propan-1-olIC5026.0 [1]
2-[4-[(1E)-1-Hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]propane-1,3-diolIC50171.0 [1]
(NE)-N-[5-[1-[2-(dimethylamino)ethyl]-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC50607.0 [1]
(NE)-N-[5-[1-[3-(dimethylamino)propyl]-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC50122.0 [1]
(NE)-N-[5-[1-(piperidin-3-ylmethyl)-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC50154.0 [1]
(NE)-N-[5-[1-[3-(methylamino)cyclohexyl]-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC5018.0 [1]
(NE)-N-[5-[1-methyl-3-(1,3-oxazol-5-yl)pyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC502400.0 [1]
(NE)-N-[5-[3-(2-aminopyridin-4-yl)-1-methylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamineIC501000.0 [1]
4-[4-[(1E)-1-Hydroxyimino-2,3-dihydroinden-5-yl]-1-methylpyrazol-3-yl]-1H-pyridin-2-oneIC50800.0 [1]
(NE)-N-[5-(1-methyl-3-pyrimidin-4-ylpyrazol-4-yl)-2,3-dihydroinden-1-ylidene]hydroxylamineIC501500.0 [1]
1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3fIC505900.0 [1]
4-(3-Methylanilino)-2-[[(2S)-pyrrolidin-2-yl]methylamino]pyrimidine-5-carboxamideIC50199.53 [1]
4-(3-Methylanilino)-2-[[(3S)-pyrrolidin-3-yl]amino]pyrimidine-5-carboxamideIC501584.89 [1]
2-[[(3R,4R)-3-Aminooxan-4-yl]amino]-4-(4-methoxyanilino)pyrimidine-5-carboxamideIC50125.89 [1]
2-[[(3R,4R)-3-Aminooxan-4-yl]amino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC5019.95 [1]
4-(3-Methylanilino)-2-[[(3S)-piperidin-3-yl]amino]pyrimidine-5-carboxamideIC50125.89 [1]
2-[(3S)-3-Aminopiperidin-1-yl]-4-[3-(trifluoromethyl)anilino]pyrimidine-5-carboxamideIC501995.26 [1]
2-[[(3S,4R)-4-Aminooxolan-3-yl]amino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC5012589.25 [1]
2-[[(1R,2S)-2-Amino-4,4-difluorocyclohexyl]amino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC50316.23 [1]
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-(4-methylanilino)pyrimidine-5-carboxamideIC5079.43 [1]
4-(3-Methylanilino)-2-[[(3R)-piperidin-3-yl]amino]pyrimidine-5-carboxamideIC50158.49 [1]
2-[[(1S,2R)-2-Aminocyclohexyl]amino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC50316.23 [1]
2-[[(1R,2S)-2-Amino-5,5-difluorocyclohexyl]amino]-4-(3-methylanilino)pyrimidine-5-carboxamideIC5063.1 [1]
2-[[2-[(2,5-Dimethylpyrazol-3-yl)amino]-5-(trifluoromethyl)pyridin-4-yl]amino]-4-fluoro-N-methylbenzamideIC505100.0 [1]
1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC5017.0 [1]
1-[(1S)-1-(3-Fluorophenyl)-2-hydroxyethyl]-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC5042.0 [1]
1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[[(2R)-1-hydroxy-3-methoxypropan-2-yl]amino]pyrimidin-4-yl]pyridin-2-oneIC501368.0 [1]
1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(1,3-difluoropropan-2-ylamino)pyrimidin-4-yl]pyridin-2-oneIC50887.0 [1]
1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1,1-dioxothiolan-3-yl)amino]pyrimidin-4-yl]pyridin-2-oneIC502953.0 [1]
1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(oxetan-3-ylamino)pyrimidin-4-yl]pyridin-2-oneIC5032.0 [1]
1-[2-Hydroxy-1-[3-(trifluoromethyl)phenyl]ethyl]-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC5082.0 [1]
3-[2-Hydroxy-1-[4-[2-(oxan-4-ylamino)pyrimidin-4-yl]-2-oxopyridin-1-yl]ethyl]benzonitrileIC50484.0 [1]
1-[2-Hydroxy-1-(3-methoxyphenyl)ethyl]-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC50227.0 [1]
1-[1-(3-Chlorophenyl)-2-hydroxyethyl]-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC5039.0 [1]
1-[2-Hydroxy-1-(3-methylphenyl)ethyl]-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC50100.0 [1]
1-[1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC5049.0 [1]
1-[1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[5-fluoro-2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC5030.0 [1]
1-[1-(3-Fluorophenyl)-2-hydroxyethyl]-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC5079.0 [1]
1-[1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-5-fluoro-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC505000.0 [1]
1-[1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-3-fluoro-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC5082.0 [1]
1-[1-(3,5-Dichlorophenyl)-2-hydroxyethyl]-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC5027.0 [1]
1-[1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-5-methyl-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC50687.0 [1]
1-[1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-6-methyl-4-[2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC501619.0 [1]
1-[1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[5-chloro-2-(oxan-4-ylamino)pyrimidin-4-yl]pyridin-2-oneIC50116.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Mitogen-activated protein kinase; ERK1/ERK2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-erk1-erk2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Mitogen-activated protein kinase; ERK1/ERK2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/mitogen-activated-protein-kinase-erk1-erk2-inhibitors-ic50-ki.
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