Microtubule-associated protein tau Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Curcumin	IC50	3000.0 [1], 3500.0 [2], 13000.0 [3]
	Methylene blue	IC50	1400.0 [1], 1900.0 [2], 3400.0 [3]
	3-Amino-7-(dimethylamino)phenothiazin-5-ium	IC50	69.0 [1], 2600.0 [2], 3000.0 [3]
	Myricetin	IC50	1200.0 [1], 3000.0 [2]
	Fddnp	IC50	1635.0 [1]
	Fddnp	Ki	256.0 [1]
	Methoxy-X04	IC50	246.0 [1]
	Tolonium	IC50	69.0 [1]
	Tolonium	Ki	69.0 [1]
	(-)-Epicatechin	IC50	200000.0 [1]
	(-)-Epigallocatechin gallate	IC50	1800.0 [1]
	Lansoprazole	Ki	2.5 [1]
	2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol	IC50	3255.0 [1]
	3-Imino-3H-phenothiazin-7-amine	IC50	69.0 [1]
	Gossypetin	IC50	3000.0 [1]
	3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one	Ki	261.5 [1]
	Methylene Blue cation	IC50	2200.0 [1]
	1-Fluoro-3-(2-(4-(methylamino)phenyl)quinolin-6-yloxy)propan-2-ol	Ki	10.5 [1]
	3-(4-Nitrobenzylidene)indolin-2-one	Ki	362.5 [1]
	1,3-Bis(3,4-dihydroxyphenyl)prop-2-en-1-one	IC50	21440.0 [1]
	4-[(6-Iodo-1,3-benzothiazol-2-yl)diazenyl]-N,N-dimethylaniline	Ki	0.48 [1]
	Benzenamine, N-methyl-4-(2-quinolinyl)-	IC50	10000.0 [1]
	5-[7-Tert-butyl-10-[4-(N-phenylanilino)phenyl]-3,11-dithia-7-azatricyclo[6.3.0.02,6]undeca-1(8),2(6),4,9-tetraen-4-yl]thiophene-2-carbaldehyde	IC50	10000.0 [1]
	(E)-3-[5-[7-Tert-butyl-10-[4-(N-phenylanilino)phenyl]-3,11-dithia-7-azatricyclo[6.3.0.02,6]undeca-1(8),2(6),4,9-tetraen-4-yl]thiophen-2-yl]-2-cyanoprop-2-enamide	IC50	10000.0 [1]
	5-[7-Tert-butyl-10-(4-methoxyphenyl)-3,11-dithia-7-azatricyclo[6.3.0.02,6]undeca-1(8),2(6),4,9-tetraen-4-yl]thiophene-2-carbaldehyde	IC50	290.0 [1]
	(E)-3-[5-[7-Tert-butyl-10-(4-methoxyphenyl)-3,11-dithia-7-azatricyclo[6.3.0.02,6]undeca-1(8),2(6),4,9-tetraen-4-yl]thiophen-2-yl]-2-cyanoprop-2-enamide	IC50	300.0 [1]
	(Z)-1-Methyl-3-(4-dimethylaminobenzylidene)indoline-2-one	Ki	617.6 [1]
	4-[[6-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]-1,3-benzothiazol-2-yl]diazenyl]-N,N-dimethylaniline	Ki	13.0 [1]
	(E)-2-Cyano-3-[5-[5-[4-(N-phenylanilino)phenyl]thiophen-2-yl]thiophen-2-yl]prop-2-enoic acid	IC50	1700.0 [1]
	2-[[5-[5-[4-(N-Phenylanilino)phenyl]thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile	IC50	10000.0 [1]
	5-[7-[4-(N-Phenylanilino)phenyl]-2,1,3-benzothiadiazol-4-yl]thiophene-2-carbaldehyde	IC50	10000.0 [1]
	1-Benzyl-3-[(E)-4-nitrobenzylidene]-2,3-dihydro-1H-indole-2-one	Ki	1410.0 [1]
	(E)-2-Cyano-3-[5-[5-[4-(N-phenylanilino)phenyl]thiophen-2-yl]thiophen-2-yl]prop-2-enamide	IC50	10000.0 [1]
	5-[[5-[5-[4-(N-Phenylanilino)phenyl]thiophen-2-yl]thiophen-2-yl]methylidene]-1,3-diazinane-2,4,6-trione	IC50	10000.0 [1]
	1,3-Dimethyl-5-[[5-[5-[4-(N-phenylanilino)phenyl]thiophen-2-yl]thiophen-2-yl]methylidene]-1,3-diazinane-2,4,6-trione	IC50	10000.0 [1]
	2-[[5-[7-[4-(N-Phenylanilino)phenyl]-2,1,3-benzothiadiazol-4-yl]thiophen-2-yl]methylidene]propanedinitrile	IC50	10000.0 [1]
	(E)-2-Cyano-3-[5-[7-[4-(N-phenylanilino)phenyl]-2,1,3-benzothiadiazol-4-yl]thiophen-2-yl]prop-2-enamide	IC50	10000.0 [1]
	2-[[5-[7-Tert-butyl-10-[4-(N-phenylanilino)phenyl]-3,11-dithia-7-azatricyclo[6.3.0.02,6]undeca-1(8),2(6),4,9-tetraen-4-yl]thiophen-2-yl]methylidene]propanedinitrile	IC50	10000.0 [1]
	2-[[5-[7-Tert-butyl-10-(4-methoxyphenyl)-3,11-dithia-7-azatricyclo[6.3.0.02,6]undeca-1(8),2(6),4,9-tetraen-4-yl]thiophen-2-yl]methylidene]propanedinitrile	IC50	10000.0 [1]
	5-[5-(1H-Indol-5-yl)thiophen-2-yl]thiophene-2-carbaldehyde	IC50	1600.0 [1]
	(Z)-3-(4-Dimethylaminobenzylidene)-5-hydroxyindoline-2-one	Ki	212.4 [1]
	(3Z)-3-[[4-(Dimethylamino)phenyl]methylidene]-1-[(4-methoxyphenyl)methyl]indol-2-one	Ki	431.7 [1]
	(3Z)-3-[[4-(Dimethylamino)phenyl]methylidene]-1-pyridin-4-ylindol-2-one	Ki	364.0 [1]
	Ethyl (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-2-oxoindole-1-carboxylate	Ki	1116.2 [1]
	(3Z)-1-Benzyl-3-[[4-(dimethylamino)phenyl]methylidene]pyrrolo[2,3-b]pyridin-2-one	Ki	858.8 [1]
	(3Z)-3-[[4-(Dimethylamino)phenyl]methylidene]-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridin-2-one	Ki	853.5 [1]
	(3Z)-3-[(E)-3-(4-Methoxyphenyl)prop-2-enylidene]-1H-indol-2-one	Ki	169.0 [1]
	(3Z)-3-[(E)-3-[4-(Dimethylamino)phenyl]prop-2-enylidene]-1H-indol-2-one	Ki	53.7 [1]
	(3Z)-3-[(E)-3-[4-(Dimethylamino)phenyl]prop-2-enylidene]-1H-pyrrolo[2,3-b]pyridin-2-one	Ki	35.1 [1]
	(3Z)-3-[(E)-3-[4-(Dimethylamino)phenyl]prop-2-enylidene]-5-hydroxy-1H-indol-2-one	Ki	48.0 [1]
	(3Z)-1-Benzyl-3-[(E)-3-phenylprop-2-enylidene]indol-2-one	Ki	682.4 [1]
	(3Z)-1-Benzyl-3-[(E)-3-(4-methoxyphenyl)prop-2-enylidene]indol-2-one	Ki	717.6 [1]
	(3Z)-3-[(E)-3-[4-(Dimethylamino)phenyl]prop-2-enylidene]-1-methylindol-2-one	Ki	229.1 [1]
	(3Z)-1-Benzyl-3-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enylidene]indol-2-one	Ki	374.0 [1]
	(3Z)-3-[(E)-3-[4-(Dimethylamino)phenyl]prop-2-enylidene]-1-[(4-methoxyphenyl)methyl]indol-2-one	Ki	239.7 [1]
	(3Z)-3-[(E)-3-[4-(Dimethylamino)phenyl]prop-2-enylidene]-1-[(4-nitrophenyl)methyl]indol-2-one	Ki	90.0 [1]
	(3Z)-3-[(E)-3-[4-(Dimethylamino)phenyl]prop-2-enylidene]-1-pyridin-4-ylindol-2-one	Ki	188.0 [1]
	Ethyl (3Z)-3-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enylidene]-2-oxoindole-1-carboxylate	Ki	263.2 [1]
	(3Z)-1-Benzyl-3-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enylidene]pyrrolo[2,3-b]pyridin-2-one	Ki	257.0 [1]
	(3Z)-3-[(E)-3-[4-(Dimethylamino)phenyl]prop-2-enylidene]-1-[(4-methoxyphenyl)methyl]pyrrolo[2,3-b]pyridin-2-one	Ki	204.3 [1]
	(3Z)-1-[(4-Aminophenyl)methyl]-3-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enylidene]indol-2-one	Ki	131.1 [1]
	(3Z)-3-[(E)-3-[4-(Dimethylamino)phenyl]prop-2-enylidene]-1-phenylindol-2-one	Ki	465.1 [1]
	(3Z)-3-[(E)-3-(4-Aminophenyl)prop-2-enylidene]-1H-indol-2-one	Ki	38.3 [1]
	(3Z)-1-Benzyl-3-[(4-nitrophenyl)methylidene]indol-2-one	Ki	1756.7 [1]
	(3Z)-3-[(E)-3-(4-Nitrophenyl)prop-2-enylidene]-1H-indol-2-one	Ki	27.1 [1]
	(3E)-3-[(E)-3-(4-Nitrophenyl)prop-2-enylidene]-1H-indol-2-one	Ki	208.7 [1]
	(3Z)-1-Benzyl-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	Ki	121.5 [1]
	(3E)-1-Benzyl-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	Ki	590.5 [1]
	(3Z)-1-[(4-Methoxyphenyl)methyl]-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	Ki	72.4 [1]
	(3E)-1-[(4-Methoxyphenyl)methyl]-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	Ki	318.1 [1]
	(3Z)-1-[(3-Methoxyphenyl)methyl]-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	Ki	228.6 [1]
	(3E)-1-[(3-Methoxyphenyl)methyl]-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	Ki	354.6 [1]
	(3Z)-1-[(3,4-Dimethoxyphenyl)methyl]-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	Ki	151.7 [1]
	(3E)-1-[(3,4-Dimethoxyphenyl)methyl]-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	Ki	630.3 [1]
	(3Z)-1-[[4-(2-Fluoroethoxy)phenyl]methyl]-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	Ki	80.1 [1]
	(3E)-1-[[4-(2-Fluoroethoxy)phenyl]methyl]-3-[(E)-3-(4-nitrophenyl)prop-2-enylidene]indol-2-one	Ki	455.7 [1]
	(1E,6E)-1-(4-Hydroxy-2-methoxyphenyl)-7-(1H-indol-6-yl)hepta-1,6-diene-3,5-dione	IC50	230.0 [1]
	4-Methyl-N-[(E)-(2,3,4-trihydroxyphenyl)methylideneamino]benzamide	IC50	970.0 [1]
	1-(3-Methoxy-4-hydroxyphenyl)-7-phenyl-1,6-heptadiene-3,5-dione	IC50	1400.0 [1]
	[(2R,3R)-3,5-Dihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-4-oxo-2,3-dihydrochromen-7-yl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	IC50	12900.0 [1]
	[(2R,3R)-3,5-Dihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-4-oxo-2,3-dihydrochromen-7-yl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate	IC50	27200.0 [1]
	(1E,6E)-1-(3-Hydroxy-2-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione	IC50	710.0 [1]
	2,5-Bis[2-(4-methoxyphenyl)ethenyl]pyrazine	IC50	13.0 [1]
	2-[(2Z)-2-[(2E)-2-[[3-(2-Hydroxyethyl)-5-methoxy-1,3-benzothiazol-3-ium-2-yl]methylidene]butylidene]-5-methoxy-1,3-benzothiazol-3-yl]ethanol	IC50	380.0 [1]
	(1E,6E)-1,7-Bis(4-hydroxy-2-methoxyphenyl)hepta-1,6-diene-3,5-dione	IC50	10000.0 [1]
	3-((1Z,2E)-3-Phenyl-2-propene-1-ylidene)indoline-2-one	Ki	522.1 [1]
	(1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(1H-indol-6-yl)hepta-1,6-diene-3,5-dione	IC50	440.0 [1]
	(1E,6E)-1-(1,3-Benzodioxol-5-yl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione	IC50	1200.0 [1]
	4-[(E)-2-[6-[(E)-2-[4-(Dimethylamino)phenyl]ethenyl]pyrimidin-4-yl]ethenyl]-N,N-dimethylaniline	IC50	4.0 [1]
	(1Z,3E,28E,30Z)-6,26,32,52-Tetrathia-39,45-diaza-13,19-diazonianonacyclo[43.7.0.05,13.07,12.019,27.020,25.031,39.033,38.046,51]dopentaconta-1,3,5(13),7,9,11,19(27),20,22,24,28,30,33,35,37,46,48,50-octadecaene	IC50	80.0 [1]
	3-[(E)-4-Nitrobenzylidene]-1H-indol-2(3H)-one	Ki	528.5 [1]
	3-[[4-(Dimethylamino)phenyl]methylidene]-5-iodo-1H-indol-2-one	Ki	599.0 [1]
	5'-(4-(Diphenylamino)phenyl)-2,2'-bithiophene-5-carbaldehyde	IC50	10000.0 [1]
	(Z)-1-Benzyl-3-(4-dimethylaminobenzylidene)indoline-2-one	Ki	797.8 [1]
	(3Z)-3-[[4-(Dimethylamino)phenyl]methylidene]-1H-pyrrolo[2,3-b]pyridin-2-one	Ki	191.3 [1]
	CID 66571561	IC50	660.0 [1]
	(1E,6E)-1-(2-Hydroxy-6-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione	IC50	910.0 [1]
	(1E,6E)-1-(4-Hydroxy-2-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione	IC50	580.0 [1]
	(1E,6E)-1-(2-Hydroxy-3-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione	IC50	690.0 [1]
	(1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(5-hydroxy-2-methoxyphenyl)hepta-1,6-diene-3,5-dione	IC50	600.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Microtubule-associated protein tau Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/microtubule-associated-protein-tau-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Microtubule-associated protein tau Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/microtubule-associated-protein-tau-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan