Microtubule-associated protein 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Ebselen	IC50	2430.0 [1]
	Ebselen diselenide	IC50	230.0 [1]
	5-Bromo-1H-indazole	IC50	37000.0 [1]
	5-Chloro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine	IC50	9000.0 [1]
	N'-(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine	IC50	100000.0 [1]
	2-{4-[5-Chloro-6-Methyl-2-(Pyridin-2-Yl)pyrimidin-4-Yl]piperazin-1-Yl}ethanol	IC50	100000.0 [1]
	5-Chloro-N-[1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]-6-methyl-2-pyridin-2-ylpyrimidin-4-amine	IC50	100000.0 [1]
	2-Methyl-1,2-benzoselenazol-3-one	IC50	10400.0 [1]
	6-Bromo-1H-indazole	IC50	1100.0 [1]
	1,2-Benzoselenazol-3-one	IC50	4970.0 [1]
	N'-(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-N-[6-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine	IC50	100000.0 [1]
	N-Benzyl-5-chloro-6-methyl-2-pyridin-3-ylpyrimidin-4-amine	IC50	100000.0 [1]
	4-Benzylsulfanyl-5-chloro-6-methyl-2-pyridin-2-ylpyrimidine	IC50	100000.0 [1]
	N-Benzyl-5-chloro-N,6-dimethyl-2-pyridin-2-ylpyrimidin-4-amine	IC50	13000.0 [1]
	6-Methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine	IC50	100000.0 [1]
	2-(2-Phenylethyl)-1,2-benzoselenazol-3-one	IC50	7570.0 [1]
	6-(1-Methylpyrazol-4-yl)-1H-indazole	IC50	100000.0 [1]
	7-[5-(4-Methylpiperazin-1-yl)pyridin-3-yl]-5-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c][1,5]naphthyridin-4-one	IC50	24000.0 [1]
	7-(4-Fluorophenyl)-5-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c][1,5]naphthyridin-4-one	IC50	234000.0 [1]
	7-(2-Methylphenyl)-5-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c][1,5]naphthyridin-4-one	IC50	3000.0 [1]
	5-(2,2,2-Trifluoroethyl)-7-[2-(trifluoromethyl)phenyl]-1H-pyrazolo[4,3-c][1,5]naphthyridin-4-one	IC50	20000.0 [1]
	2-[4-Oxo-5-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c][1,5]naphthyridin-7-yl]benzamide	IC50	1020000.0 [1]
	N-Methyl-2-[4-oxo-5-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c][1,5]naphthyridin-7-yl]benzenesulfonamide	IC50	4000.0 [1]
	N-[2-[4-Oxo-5-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c][1,5]naphthyridin-7-yl]phenyl]methanesulfonamide	IC50	8000.0 [1]
	7-[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]-5-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c][1,5]naphthyridin-4-one	IC50	5000.0 [1]
	7-(2-Morpholin-4-ylphenyl)-5-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c][1,5]naphthyridin-4-one	IC50	187000.0 [1]
	7-[2-[(Cyclopropylamino)methyl]phenyl]-5-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c][1,6]naphthyridin-4-one	IC50	21000.0 [1]
	7-(3-Chloropyridin-2-yl)-5-(2,2,2-trifluoroethyl)-1H-pyrazolo[4,3-c][1,6]naphthyridin-4-one	IC50	13000.0 [1]
	6-Fluoro-4-phenyl-1H-indazole	IC50	960.0 [1]
	6-Methyl-4-phenyl-1H-indazole	IC50	220.0 [1]
	6-Methoxy-4-phenyl-1H-indazole	IC50	730.0 [1]
	4-Phenyl-1H-indazole-6-carbonitrile	IC50	62.0 [1]
	4-Phenyl-6-(trifluoromethoxy)-1H-indazole	IC50	91.0 [1]
	6-Methylsulfonyl-4-phenyl-1H-indazole	IC50	360.0 [1]
	(3S)-1-[4-Methyl-5-[6-(trifluoromethyl)-1H-indazol-4-yl]pyrimidin-2-yl]pyrrolidin-3-ol	IC50	6.0 [1]
	6-(1-Methylpyrazol-4-yl)-4-phenyl-1H-indazole	IC50	24000.0 [1]
	4-Phenyl-6-propan-2-yl-1H-indazole	IC50	550.0 [1]
	(3S)-1-[6-Methyl-5-[6-(trifluoromethyl)-1H-indazol-4-yl]pyridin-2-yl]pyrrolidin-3-ol	IC50	5.0 [1]
	6-Chloro-4-phenyl-1H-indazole	IC50	79.0 [1]
	(3R)-1-[6-Methyl-5-[6-(trifluoromethyl)-1H-indazol-4-yl]pyridin-2-yl]pyrrolidin-3-ol	IC50	5.0 [1]
	6-Chloro-4-pyridin-3-yl-1H-pyrazolo[4,3-b]indole	IC50	5.01 [1]
	3-Chloro-5-(7-fluoro-1H-pyrazolo[4,3-b]indol-4-yl)pyridin-2-amine	IC50	7.94 [1]
	2-Benzyl-1,2-benzoselenazol-3-one	IC50	320.0 [1]
	N-(5-Chloro-2-methoxyphenyl)-2-[[2-[(5-chloro-2-methoxyphenyl)carbamoyl]phenyl]diselanyl]benzamide	IC50	4470.0 [1]
	2-(5-Chloro-2-methoxyphenyl)-1,2-benzoselenazol-3-one	IC50	2350.0 [1]
	2-(2-Methoxy-5-methylphenyl)-1,2-benzoselenazol-3-one	IC50	920.0 [1]
	N-(2-Chloro-4-methylphenyl)-2-[[2-[(2-chloro-4-methylphenyl)carbamoyl]phenyl]diselanyl]benzamide	IC50	119200.0 [1]
	2-(4-Methoxy-2-methylphenyl)-1,2-benzoselenazol-3-one	IC50	1350.0 [1]
	2-(5-Tert-butyl-2-methoxyphenyl)-1,2-benzoselenazol-3-one	IC50	2670.0 [1]
	2-(4-Butoxyphenyl)-1,2-benzoselenazol-3-one	IC50	6270.0 [1]
	2-[(4-Tert-butylphenyl)methyl]-1,2-benzoselenazol-3-one	IC50	8850.0 [1]
	1,4-Dihydropyrazolo[4,3-b]indole	IC50	1000.0 [1]
	2-(3-Fluorophenyl)-1,2-benzoselenazol-3-one	IC50	935.0 [1]
	N-(2-Hydroxyphenyl)-2-[[2-[(2-hydroxyphenyl)carbamoyl]phenyl]diselanyl]benzamide	IC50	5440.0 [1]
	N-(4-Methoxyphenyl)-2-[[2-[(4-methoxyphenyl)carbamoyl]phenyl]diselanyl]benzamide	IC50	13900.0 [1]
	N-(2-Methoxyphenyl)-2-[[2-[(2-methoxyphenyl)carbamoyl]phenyl]diselanyl]benzamide	IC50	6790.0 [1]
	Benzamide, 2,2'-diselenobis[N-(phenylmethyl)-	IC50	3430.0 [1]
	7-Fluoro-1,4-dihydropyrazolo[4,3-b]indole	IC50	79.43 [1]
	4-[[(2R)-1-([1,2,4]Triazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-2-yl]methoxy]isoquinoline	IC50	38.0 [1]
	4-[(2R)-2-[(3-Fluorophenoxy)methyl]pyrrolidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidine	IC50	50000.0 [1]
	2-[(2-Carbamoylphenyl)diselanyl]benzamide	IC50	9130.0 [1]
	6-[(2R)-2-[(3-Fluorophenoxy)methyl]pyrrolidin-1-yl]-7H-purine	IC50	2000.0 [1]
	6-[(2R)-2-[(2,3-Difluorophenoxy)methyl]pyrrolidin-1-yl]-7H-purine	IC50	1600.0 [1]
	4-[[(2R)-1-(7H-Purin-6-yl)pyrrolidin-2-yl]methoxy]benzonitrile	IC50	1300.0 [1]
	6-[(2R)-2-[(4-Fluorophenoxy)methyl]pyrrolidin-1-yl]-7H-purine	IC50	3800.0 [1]
	6-[(2R)-2-[(2-Methylphenoxy)methyl]pyrrolidin-1-yl]-7H-purine	IC50	700.0 [1]
	6-[(2R)-2-[(2-Chlorophenoxy)methyl]pyrrolidin-1-yl]-7H-purine	IC50	1000.0 [1]
	6-(Trifluoromethyl)-1H-Indazole	IC50	50.12 [1]
	6-Bromo-1H-indazol-3-ol	IC50	2800.0 [1]
	5-Chloro-N,6-dimethyl-2-pyridin-2-ylpyrimidin-4-amine	IC50	14000.0 [1]
	1,2-Benzisoselenazol-3(2H)-one, 2-(4-methylphenyl)-	IC50	24300.0 [1]
	1,2-Benzisoselenazol-3(2H)-one, 2-(4-fluorophenyl)-	IC50	10900.0 [1]
	1,2-Benzisoselenazol-3(2H)-one, 2-(4-methoxyphenyl)-	IC50	2070.0 [1]
	1,2-Benzisoselenazol-3(2H)-one, 2-(2-hydroxyphenyl)-	IC50	10200.0 [1]
	7-[(2R)-2-[(2-Chlorophenoxy)methyl]pyrrolidin-1-yl]-1H-imidazo[4,5-b]pyridine	IC50	2200.0 [1]
	4-[(2R)-2-[(2-Chlorophenoxy)methyl]pyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine	IC50	8600.0 [1]
	6-[(2R)-2-(Naphthalen-1-yloxymethyl)pyrrolidin-1-yl]-7H-purine	IC50	450.0 [1]
	7-[(2R)-2-[(2-Chlorophenoxy)methyl]pyrrolidin-1-yl]-[1,2,5]thiadiazolo[3,4-b]pyridine	IC50	2800.0 [1]
	4-[(2R)-2-[(2-Chlorophenoxy)methyl]pyrrolidin-1-yl]pyrido[2,3-d]pyrimidine	IC50	50000.0 [1]
	5-[[(2R)-1-(7H-Purin-6-yl)pyrrolidin-2-yl]methoxy]isoquinoline	IC50	230.0 [1]
	7-[(2R)-2-(Naphthalen-1-yloxymethyl)pyrrolidin-1-yl]-[1,2,4]triazolo[1,5-a]pyrimidine	IC50	110.0 [1]
	5-[(2R)-2-(Naphthalen-1-yloxymethyl)pyrrolidin-1-yl]imidazo[1,2-a]pyrimidine	IC50	560.0 [1]
	5,6-Dimethyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine	IC50	100000.0 [1]
	5-Chloro-4-methyl-6-(2-phenylethylsulfanyl)-2-pyridin-2-ylpyrimidine	IC50	100000.0 [1]
	7-[(2R)-2-(Naphthalen-1-yloxymethyl)pyrrolidin-1-yl]-[1,2,4]triazolo[1,5-a][1,3,5]triazine	IC50	1800.0 [1]
	6-[(2S)-2-[(2-Chlorophenoxy)methyl]pyrrolidin-1-yl]-7H-purine	IC50	50000.0 [1]
	N-[(1R)-2-[(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]-3-piperazin-1-ylpropanamide	IC50	22000.0 [1]
	N-[(1R)-2-[(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]-3-[4-(2-hydroxyethyl)piperazin-1-yl]propanamide	IC50	114000.0 [1]
	N-[(1R)-2-[(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]-4-piperazin-1-ylbutanamide	IC50	300000.0 [1]
	(1R)-N'-(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-1-phenyl-N-(4-piperazin-1-ylbutyl)ethane-1,2-diamine	IC50	188000.0 [1]
	N-[(1R)-2-[(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]-2-piperazin-1-ylethanesulfonamide	IC50	9400.0 [1]
	5-Fluoro-6-methyl-N-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine	IC50	62000.0 [1]
	(1R)-N'-(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)-1-phenyl-N-(3-piperazin-1-ylpropyl)ethane-1,2-diamine	IC50	108000.0 [1]
	2-[4-[4-[[(1R)-2-[(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]amino]butyl]piperazin-1-yl]ethanol	IC50	197000.0 [1]
	N-[(1R)-2-[(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonamide	IC50	95000.0 [1]
	2-[4-[3-[[(1R)-2-[(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]amino]propyl]piperazin-1-yl]ethanol	IC50	101000.0 [1]
	N-[(1R)-2-[(5-Chloro-6-methyl-2-pyridin-2-ylpyrimidin-4-yl)amino]-1-phenylethyl]-4-[4-(2-hydroxyethyl)piperazin-1-yl]butanamide	IC50	300000.0 [1]
	7-[[2-[(Z)-3-(Diethylamino)prop-1-enyl]-4-fluorophenyl]sulfonylamino]-4H-pyrrolo[2,1-c][1,4]benzoxazine-6-carboxylic acid	IC50	50.0 [1]
	CID 71735205	IC50	20.0 [1]
	4-(3-Methylpyridin-4-yl)-6-(trifluoromethyl)-1H-indazole	IC50	11.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Microtubule-associated protein 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/microtubule-associated-protein-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Microtubule-associated protein 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/microtubule-associated-protein-2-inhibitors-ic50-ki.
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