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Microsomal triglyceride transfer protein large subunit Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
LomitapideIC500.8 [1], 8.0 [2]
DirlotapideIC500.01 [1], 2.7 [2], 2.9 [3]
Unii-0Z473OO6GBIC500.03 [1], 1.0 [2]
3-Methyl-N-[(2S)-2-(pyridin-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC50100.0 [1], 2350.0 [2]
Methyl N-[(2S)-5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamateIC504.3 [1], 70.0 [2]
N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-(4-propan-2-yloxyphenyl)benzoyl]amino]quinoline-6-carboxamideIC500.0 [1], 0.77 [2]
3-Methyl-N-[(2R)-2-(pyridin-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC503.5 [1], 410.0 [2]
Methyl N-[(2R)-5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamateIC500.9 [1], 70.0 [2]
9-[4-[2-Methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamideIC500.15 [1], 1.0 [2]
9-[4-[2-Propan-2-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamideIC500.06 [1], 4.0 [2]
N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]fluorene-9-carboxamideIC500.24 [1], 5.0 [2]
9-[4-[5-Methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamideIC500.02 [1], 1.0 [2]
2-[[2-(4-Tert-butylphenyl)benzoyl]amino]-N-[(1S)-2-[(4-fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]quinoline-6-carboxamideIC500.0 [1], 1.2 [2]
2-[[2-(4-Tert-butylphenyl)benzoyl]amino]-N-[(1S)-2-[(4-fluorophenyl)methylamino]-2-oxo-1-phenylethyl]quinoline-6-carboxamideIC500.0 [1], 1.2 [2]
N-[(1S)-2-Amino-2-oxo-1-phenylethyl]-1-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamideIC500.34 [1], 1.5 [2]
N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-(4-methylphenyl)benzoyl]amino]quinoline-6-carboxamideIC500.01 [1], 2.2 [2]
N-[(1S)-2-[(4-Fluorophenyl)methylamino]-2-oxo-1-phenylethyl]-2-[[2-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]benzoyl]amino]quinoline-6-carboxamideIC500.06 [1], 4.3 [2]
2-[[2-(4-Tert-butylphenyl)benzoyl]amino]-N-[(1S)-2-(methylamino)-2-oxo-1-phenylethyl]quinoline-6-carboxamideIC500.02 [1], 0.56 [2]
2-[4-[2-[[6-[[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]carbamoyl]quinolin-2-yl]carbamoyl]phenyl]phenoxy]propanoic acidIC500.48 [1], 22.0 [2]
N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-(4-propan-2-ylphenyl)benzoyl]amino]quinoline-6-carboxamideIC500.0 [1], 0.6 [2]
N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-[4-(1-hydroxy-2-methylpropan-2-yl)phenyl]benzoyl]amino]quinoline-6-carboxamideIC500.03 [1], 1.1 [2]
N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-[4-(1-hydroxypropan-2-yloxy)phenyl]benzoyl]amino]quinoline-6-carboxamideIC500.12 [1], 9.4 [2]
1-Methyl-N-[(1S)-2-(methylamino)-2-oxo-1-phenylethyl]-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamideIC500.38 [1], 1.8 [2]
2-[4-[2-[[6-[[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]carbamoyl]quinolin-2-yl]carbamoyl]phenyl]phenyl]-2-methylpropanoic acidIC500.07 [1], 7.5 [2]
2-[4-[2-[[6-[[(1S)-2-[(4-Fluorophenyl)methylamino]-2-oxo-1-phenylethyl]carbamoyl]quinolin-2-yl]carbamoyl]phenyl]phenyl]-2-methylpropanoic acidIC500.25 [1], 12.0 [2]
N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]quinoline-6-carboxamideIC500.0 [1], 0.74 [2]
N-[(1S)-2-(Methylamino)-2-oxo-1-phenylethyl]-2-[[2-(4-propan-2-yloxyphenyl)benzoyl]amino]quinoline-6-carboxamideIC500.1 [1], 0.63 [2]
N-[(1S)-2-[(4-Fluorophenyl)methyl-methylamino]-2-oxo-1-phenylethyl]-2-[[2-(4-hydroxyphenyl)benzoyl]amino]quinoline-6-carboxamideIC500.1 [1], 11.0 [2]
N-[(1S)-2-[(4-Fluorophenyl)methylamino]-2-oxo-1-phenylethyl]-2-[[2-(4-propan-2-yloxyphenyl)benzoyl]amino]quinoline-6-carboxamideIC500.01 [1], 1.21 [2]
Benzyl N-[2-oxo-2-[4-[9-(2,2,2-trifluoroethylcarbamoyl)fluoren-9-yl]butyl]-1,3,2lambda5-dioxaphosphinan-5-yl]carbamateIC5014.0 [1], 210.0 [2]
Jnj-31020028IC50710.0 [1]
N-[4-[4-[2-(Diethylamino)-2-oxo-1-phenylethyl]piperidin-1-yl]-3-fluorophenyl]-3,5-dimethyl-1,2-oxazole-4-carboxamideIC5010000.0 [1]
9-(4-Dibutoxyphosphorylbutyl)-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamideIC5022.0 [1]
N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]propyl]fluorene-9-carboxamideIC5010.0 [1]
9-[4-[2-Propyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamideIC502.0 [1]
2-(4-Chlorophenyl)-N-[7-(methanesulfonamido)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-3-methylbenzamideIC5090.0 [1]
2-(4-Chlorophenyl)-3-methyl-N-[2-(thiophen-2-ylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]benzamideIC50120.0 [1]
2-(4-Fluorophenyl)-N-[2-(methanesulfonamido)-2,3-dihydro-1H-inden-5-yl]-3-methylbenzamideIC50170.0 [1]
N-[(2R)-2-(Methanesulfonamido)-2,3-dihydro-1H-inden-5-yl]-3-methyl-2-[4-(trifluoromethyl)phenyl]benzamideIC5034.0 [1]
Methyl N-[3-[[3,5-dimethyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl]carbamateIC5020.0 [1]
N-(2-Acetamido-2,3-dihydro-1H-inden-5-yl)-2-[4-(trifluoromethyl)phenyl]benzamideIC5080.0 [1]
N-[(2S)-2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC50650.0 [1]
2-(4-Chlorophenyl)-N-[2-(methanesulfonamidomethyl)-2,3-dihydro-1H-inden-5-yl]-3-methylbenzamideIC50500.0 [1]
Methyl N-[[5-[[2-(4-chlorophenyl)-3-methylbenzoyl]amino]-2,3-dihydro-1H-inden-2-yl]methyl]carbamateIC50100.0 [1]
N-[2-(Benzylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC504800.0 [1]
N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-(4-cyanophenyl)-3-methylbenzamideIC50120.0 [1]
[(R)-5-[2-[4-(Trifluoromethyl)phenyl]benzoylamino]-2-indanyl]carbamic acid methyl esterIC50110.0 [1]
N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-(4-chlorophenyl)-3-methylbenzamideIC50100.0 [1]
N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-(4-chlorophenyl)-3-methoxybenzamideIC50110.0 [1]
Methyl N-[[5-[[3,5-dimethyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]methyl]carbamateIC5040.0 [1]
N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-(4-fluorophenyl)-3-methylbenzamideIC50240.0 [1]
N-[2-(Dimethylcarbamoylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC5080.0 [1]
Methyl N-[(2R)-5-[[3,5-dimethyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamateIC5090.0 [1]
Methyl N-[3-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl]carbamateIC5020.0 [1]
2-(4-Fluorophenyl)-3-methyl-N-[2-(thiophen-2-ylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]benzamideIC5050.0 [1]
Methyl 4-[(2S)-5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]piperazine-1-carboxylateIC5040.0 [1]
3,5-Dimethyl-N-[(2R)-2-(thiophen-2-ylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC5020.0 [1]
2-(4-Chlorophenyl)-N-[2-(methanesulfonamido)-2,3-dihydro-1H-inden-5-yl]-3-methylbenzamideIC50100.0 [1]
N-[2-(Methanesulfonamidomethyl)-2,3-dihydro-1H-inden-5-yl]-3-methyl-2-[4-(trifluoromethyl)phenyl]benzamideIC50150.0 [1]
N-[7-(Methanesulfonamido)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-3-methyl-2-[4-(trifluoromethyl)phenyl]benzamideIC5080.0 [1]
Methyl N-[(2S)-5-[[3,5-dimethyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamateIC5070.0 [1]
[(S)-5-[2-[4-(Trifluoromethyl)phenyl]benzoylamino]-2-indanyl]carbamic acid methyl esterIC5068.0 [1]
3-Methyl-N-[7-(thiophen-2-ylsulfonylamino)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC50140.0 [1]
2-(4-Chlorophenyl)-N-[2-(methanesulfonamido)-2,3-dihydro-1H-inden-5-yl]-3-methoxybenzamideIC5070.0 [1]
Methyl N-[2-[5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]ethyl]carbamateIC5070.0 [1]
N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-2-phenylbenzamideIC50710.0 [1]
Methyl N-[[5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]methyl]carbamateIC5024.0 [1]
3-Methyl-N-[2-[(thiophen-2-ylsulfonylamino)methyl]-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC5014.0 [1]
Methyl N-[3-[[2-(4-chlorophenyl)-3-methylbenzoyl]amino]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl]carbamateIC5080.0 [1]
N-[2-(Benzenesulfonamido)-2,3-dihydro-1H-inden-5-yl]-3-methyl-2-(4-methylphenyl)benzamideIC5093.0 [1]
2-[1-[4-[(3,5-Dimethyl-1,2-oxazol-4-yl)carbamoylamino]-2-fluorophenyl]piperidin-4-yl]-N-ethyl-2-phenylacetamideIC5010000.0 [1]
2-[1-[4-[(3,5-Dimethyl-1,2-oxazol-4-yl)carbamoylamino]-2-fluorophenyl]piperidin-4-yl]-N,N-diethyl-2-phenylacetamideIC5010000.0 [1]
N-[(2S)-2-(Furan-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-3-methyl-2-[4-(trifluoromethyl)phenyl]benzamideIC50150.0 [1]
3-Methyl-N-[(2S)-2-(thiophen-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC50140.0 [1]
3-Methyl-N-[(2R)-2-(1,3-thiazol-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC500.6 [1]
Methyl N-[(2S)-5-[[5-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamateIC50170.0 [1]
Methyl N-[5-[[2-(4-chlorophenyl)-3,5-dimethylbenzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamateIC50120.0 [1]
3-Methyl-N-[(2R)-2-(thiophen-2-ylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamideIC5050.0 [1]
Methyl N-[(2S)-5-[[5-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamateIC50410.0 [1]
Methyl N-[(2S)-5-[[3-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamateIC5050.0 [1]
N-[2-Oxo-2-[4-[9-(2,2,2-trifluoroethylcarbamoyl)fluoren-9-yl]butyl]-1,3,2lambda5-dioxaphosphinan-5-yl]-1-phenylpiperidine-2-carboxamideIC509.0 [1]
Unii-71G1A1S0OGIC505.0 [1]
N-[(1S)-2-Oxo-1-phenyl-2-(propylamino)ethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamideIC505.53 [1]
N-[(1S)-2-(Benzylamino)-2-oxo-1-phenylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamideIC5026.8 [1]
N-[(1S)-2-Oxo-1-phenyl-2-piperidin-1-ylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamideIC5029.0 [1]
N-[(1S)-2-Oxo-1-phenyl-2-pyrrolidin-1-ylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamideIC5014.9 [1]
N-[(1S)-2-[Ethyl(propyl)amino]-2-oxo-1-phenylethyl]-6-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]pyridine-3-carboxamideIC5013.29 [1]
N-[(1S)-2-(Benzylamino)-2-oxo-1-phenylethyl]-3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamideIC503.85 [1]
3-Methoxy-N-[(1S)-2-oxo-1-phenyl-2-piperidin-1-ylethyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamideIC506.38 [1]
3-Methyl-N-[(1S)-2-oxo-1-phenyl-2-(propylamino)ethyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamideIC501.64 [1]
N-[(1S)-2-Morpholin-4-yl-2-oxo-1-phenylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamideIC5072.7 [1]
N-[(1S)-2-[Butyl(methyl)amino]-2-oxo-1-phenylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]-2,3-dihydroindole-5-carboxamideIC5085.5 [1]
N-[4-[2-[[(1S)-2-[Butyl(methyl)amino]-2-oxo-1-phenylethyl]amino]-2-oxoethyl]sulfanylphenyl]-2-[4-(trifluoromethyl)phenyl]benzamideIC5017.27 [1]
N-[4-[2-Oxo-2-[[(1S)-2-oxo-1-phenyl-2-(propylamino)ethyl]amino]ethyl]sulfanylphenyl]-2-[4-(trifluoromethyl)phenyl]benzamideIC5035.92 [1]
N-[4-[[2-[[(1S)-2-[Butyl(methyl)amino]-2-oxo-1-phenylethyl]amino]-2-oxoethyl]carbamoyl]phenyl]-2-[4-(trifluoromethyl)phenyl]benzamideIC50100.0 [1]
N-[4-[[2-Oxo-2-[[(1S)-2-oxo-1-phenyl-2-(propylamino)ethyl]amino]ethyl]carbamoyl]phenyl]-2-[4-(trifluoromethyl)phenyl]benzamideIC50100.0 [1]
N-[(1S)-2-(Benzylamino)-2-oxo-1-phenylethyl]-1-[2-[4-(trifluoromethyl)phenyl]benzoyl]piperidine-4-carboxamideIC5069.52 [1]
N-[[4-[[(1S)-2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl]carbamoyl]phenyl]methyl]-2-[4-(trifluoromethyl)phenyl]benzamideIC504.11 [1]
3-Methoxy-N-[(1S)-2-oxo-1-phenyl-2-pyrrolidin-1-ylethyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamideIC501.75 [1]
N-[(1S)-2-(Benzylamino)-2-oxo-1-phenylethyl]-3-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzamideIC503.5 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Microsomal triglyceride transfer protein large subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Dec. 2024, https://www.aatbio.com/data-sets/microsomal-triglyceride-transfer-protein-large-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 22). Quest Database™ Microsomal triglyceride transfer protein large subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/microsomal-triglyceride-transfer-protein-large-subunit-inhibitors-ic50-ki.
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