Metabotropic glutamate receptor 5 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-Methyl-6-(phenylethynyl)pyridine	IC50	22.0 [1]
	2-Methyl-4-(pyridin-3-ylethynyl)thiazole	IC50	5.0 [1], 47.3 [2], 462.0 [3]
	2-Methyl-4-(pyridin-3-ylethynyl)thiazole	Ki	32.7 [1]
	Fenobam	IC50	36.3 [1], 43.0 [2], 330.0 [3]
	Fenobam	Ki	6.76 [1], 31.62 [2], 162.2 [3]
	Unii-5900NS9zhi	IC50	13.0 [1], 133.0 [2]
	Unii-5900NS9zhi	Ki	4.9 [1], 10.8 [2], 12.1 [3]
	Glutamic acid	Ki	390.0 [1], 1160.0 [2], 4677.35 [3], 11400.0 [4]
	(E)-3-(2-(6-Methylpyridin-2-yl)ethynyl)cyclohex-2-enone O-methyl oxime	IC50	2.3 [1], 2.4 [2]
	(E)-3-(2-(6-Methylpyridin-2-yl)ethynyl)cyclohex-2-enone O-methyl oxime	Ki	1.7 [1], 3.5 [2]
	2-Methyl-6-(2-phenylethenyl)pyridine	IC50	290.0 [1], 1100.0 [2], 3000.0 [3]
	2-Methyl-6-(2-phenylethenyl)pyridine	Ki	290.0 [1]
	Mavoglurant	IC50	10.0 [1], 71.6 [2]
	Mavoglurant	Ki	5.6 [1], 10.0 [2]
	3-Fluoro-N-(4-methyl-1,3-thiazol-2-yl)-5-pyrimidin-5-yloxybenzamide	IC50	23.0 [1], 26.0 [2], 49.0 [3]
	3-Fluoro-N-(4-methyl-1,3-thiazol-2-yl)-5-pyrimidin-5-yloxybenzamide	Ki	6.8 [1]
	2-Methyl-4-[2-(6-pyridin-3-ylpyridin-3-yl)ethynyl]-1,3-thiazole	IC50	2.0 [1], 6.1 [2]
	2-Methyl-4-[2-(6-pyridin-3-ylpyridin-3-yl)ethynyl]-1,3-thiazole	Ki	4.7 [1], 5.65 [2]
	9-(Dimethylamino)-3-(4-methoxyphenyl)-4-pyrido[1,2]thieno[3,4-d]pyrimidinone	IC50	3000.0 [1], 10000.0 [2]
	CID 6324634	IC50	300000.0 [1]
	CID 6324634	Ki	300000.0 [1]
	3-(3,4-Dimethyl-benzenesulfonyl)-4-(morpholin-4-yl)-quinoline	Ki	52.0 [1]
	(5-Chloro-6-((6-methylpyridin-3-yl)amino)pyridin-3-yl)-((2R)-2-ethylpiperidin-1-yl)methanone	IC50	32.0 [1], 36.0 [2]
	(5-Chloro-6-((6-methylpyridin-3-yl)amino)pyridin-3-yl)-((2R)-2-ethylpiperidin-1-yl)methanone	Ki	38.0 [1]
	N-(1-Methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-N'-phenylurea	IC50	1360.0 [1], 3300.0 [2], 4900.0 [3]
	(1E)-1-(1-Methyl-4-oxoimidazolidin-2-ylidene)-3-(3-methylpyridin-2-yl)urea	IC50	320.0 [1], 681.0 [2], 1900.0 [3]
	2-Methyl-6-[2-[3-(tritritiomethoxymethyl)phenyl]ethynyl]pyridine	IC50	3.6 [1], 7.0 [2], 10.0 [3]
	N-[5-[8-[4-[[2-Methoxy-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]phenoxy]methyl]triazol-1-yl]octyl-methylamino]pentyl]-2-[5-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridin-3-yl]oxyacetamide	IC50	110.0 [1]
	N-[5-[8-[4-[[2-Methoxy-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]phenoxy]methyl]triazol-1-yl]octyl-methylamino]pentyl]-2-[5-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridin-3-yl]oxyacetamide	Ki	1000.0 [1], 1300.0 [2]
	N-[4-[2-[(5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-propylamino]ethyl]phenyl]-3-[1-[8-[methyl-[5-[[2-[5-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridin-3-yl]oxyacetyl]amino]pentyl]amino]octyl]triazol-4-yl]propanamide	IC50	170.0 [1]
	N-[4-[2-[(5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-propylamino]ethyl]phenyl]-3-[1-[8-[methyl-[5-[[2-[5-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridin-3-yl]oxyacetyl]amino]pentyl]amino]octyl]triazol-4-yl]propanamide	Ki	1100.0 [1], 2300.0 [2]
	N-[5-[8-Azidooctyl(methyl)amino]pentyl]-2-[5-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridin-3-yl]oxyacetamide	IC50	2600.0 [1]
	N-[5-[8-Azidooctyl(methyl)amino]pentyl]-2-[5-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridin-3-yl]oxyacetamide	Ki	5700.0 [1], 5800.0 [2]
	4-[(S)-Amino(carboxy)methyl]-3-methylbenzoic acid	IC50	100000.0 [1], 300000.0 [2]
	2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine	IC50	8200.0 [1]
	2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine	Ki	8200.0 [1]
	(2S)-2-Amino-4-phosphonobutanoic acid	Ki	1000000.0 [1]
	6-Methyl-2-(phenylazo)-3-pyridinol	IC50	370.0 [1]
	6-Methyl-2-(phenylazo)-3-pyridinol	Ki	370.0 [1]
	Ctep	IC50	10.0 [1]
	Ctep	Ki	20.0 [1]
	Basimglurant	IC50	7.0 [1]
	Basimglurant	Ki	36.0 [1]
	3-[(S)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid	IC50	300000.0 [1]
	3-[(S)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid	Ki	103000.0 [1]
	Ftidc	IC50	6200.0 [1], 10000.0 [2]
	(S)-4-Carboxyphenylglycine	IC50	155000.0 [1]
	(S)-4-Carboxyphenylglycine	Ki	2000000.0 [1]
	3-Fluoro-5-[5-(pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile	IC50	3.9 [1], 4.0 [2]
	13-(Dimethylamino)-5-(4-ethylphenyl)-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one	IC50	442.0 [1]
	3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile	IC50	70.0 [1], 73.0 [2]
	2-(2-Methyl-thiazol-4-ylethynyl)-pyridine	IC50	53.0 [1]
	6,6-Dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one	IC50	20.0 [1], 23.2 [2]
	3-Chloro-5-[6-(5-Fluoropyridin-2-Yl)pyrimidin-4-Yl]benzonitrile	IC50	0.63 [1]
	3-Chloro-5-[6-(5-Fluoropyridin-2-Yl)pyrimidin-4-Yl]benzonitrile	Ki	0.5 [1]
	3-(3-(Pyridin-2-yl)-1,2,4-oxadiazol-5-yl)benzonitrile	IC50	43.0 [1], 100.0 [2]
	2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid	IC50	300000.0 [1]
	2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid	Ki	300000.0 [1]
	3-[(2-Methyl-4-thiazolyl)ethynyl]benzonitrile	IC50	0.94 [1]
	3-[(2-Methyl-4-thiazolyl)ethynyl]benzonitrile	Ki	0.37 [1]
	[(1R)-1-(6-Methyl-[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)ethyl] N-phenylcarbamate	IC50	39.81 [1], 31622.78 [2]
	3-Cyano-N-(6-methylpyridin-2-yl)benzamide	IC50	5330.0 [1]
	1-Adamantyl-[4-(1,3-thiazol-2-yl)piperazin-1-yl]methanone	IC50	540.0 [1]
	1-Adamantyl-[4-(1,3-thiazol-2-yl)piperazin-1-yl]methanone	Ki	440.0 [1]
	(1R,2R)-N-(3-(4-Methoxyphenyl)-4-methyl-5-isothiazolyl)-2-methylcyclopropanecarboxamide	IC50	158.0 [1]
	6-(5-(3-Cyano-5-fluorophenyl)-1,2,4-oxadiazol-3-yl)nicotinonitrile	Ki	17.9 [1], 28.0 [2]
	4-[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine	IC50	28.0 [1]
	4-[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine	Ki	22.0 [1]
	2-Methyl-4-phenylethynyl-thiazole	IC50	4.0 [1], 6.0 [2]
	4-(2-Methyl-thiazol-4-ylethynyl)-pyridine	IC50	122.0 [1], 127.0 [2]
	3-Hydroxy-6-methyl-N-(6-methylpyridin-2-yl)pyridine-2-carboxamide	IC50	7.0 [1]
	2-Methyl-4-(m-tolylethynyl)thiazole	IC50	2.0 [1], 82.6 [2]
	1-Benzyl-APDC	IC50	300000.0 [1]
	1-Benzyl-APDC	Ki	600000.0 [1]
	4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)benzamide	IC50	7900.0 [1]
	4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)benzamide	Ki	7900.0 [1]
	4-(4-Chloro-phenyl)-3-(4-methyl-benzenesulfonyl)-quinoline	Ki	17.0 [1]
	N-Cyclopentyl-6-(2-phenylethynyl)nicotinamide	Ki	1800.0 [1], 3300.0 [2]
	3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene	IC50	41.0 [1]
	3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene	Ki	10.76 [1]
	2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine	IC50	0.5 [1]
	2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine	Ki	5.49 [1]
	1-(3-Chlorophenyl)-3-(1-methyl-5-oxo-4H-imidazol-2-yl)urea	IC50	58.0 [1], 10000.0 [2]
	[(2R)-2-[6-(3-Chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone	IC50	17.0 [1]
	[(2R)-2-[6-(3-Chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone	Ki	12.0 [1]
	(4R,5R)-5-(3-Fluorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one	Ki	1.5 [1], 1.6 [2]
	3-Chloro-4-Fluoro-5-[6-(1h-Pyrazol-1-Yl)pyrimidin-4-Yl]benzonitrile	IC50	2.51 [1]
	3-Chloro-4-Fluoro-5-[6-(1h-Pyrazol-1-Yl)pyrimidin-4-Yl]benzonitrile	Ki	0.5 [1]
	4-[2-Methyl-4-[2-(2-methylpyridin-4-yl)ethynyl]imidazol-1-yl]benzonitrile	IC50	70.0 [1]
	4-[2-Methyl-4-[2-(2-methylpyridin-4-yl)ethynyl]imidazol-1-yl]benzonitrile	Ki	83.0 [1]
	3-[2-Methyl-4-[2-(2-methylpyridin-4-yl)ethynyl]imidazol-1-yl]benzonitrile	IC50	28.0 [1]
	3-[2-Methyl-4-[2-(2-methylpyridin-4-yl)ethynyl]imidazol-1-yl]benzonitrile	Ki	90.0 [1]
	2-Methyl-6-(2-(pyridin-3-yl)ethynyl)pyridine	IC50	10.0 [1], 66.0 [2]
	4-[2-[1-(3-Fluorophenyl)-2-methylimidazol-4-yl]ethynyl]-2-methylpyridine	IC50	12.0 [1]
	4-[2-[1-(3-Fluorophenyl)-2-methylimidazol-4-yl]ethynyl]-2-methylpyridine	Ki	17.0 [1]
	1-[4-(3-Nitro-2-pyridinyl)piperazino]-3-phenyl-2-propyne-1-one	IC50	0.9 [1]
	1-[4-(3-Nitro-2-pyridinyl)piperazino]-3-phenyl-2-propyne-1-one	Ki	0.5 [1]
	4-[2-[1-(2,4-Difluorophenyl)-2-methylimidazol-4-yl]ethynyl]-2-methylpyridine	IC50	97.0 [1]
	4-[2-[1-(2,4-Difluorophenyl)-2-methylimidazol-4-yl]ethynyl]-2-methylpyridine	Ki	32.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 99 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Metabotropic glutamate receptor 5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-5-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Metabotropic glutamate receptor 5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-5-inhibitors-ic50-ki.
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