Metabotropic glutamate receptor 4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Glutamic acid	Ki	1400.0 [1], 1600.0 [2], 2400.0 [3], 3235.94 [4], 17000.0 [5]
	(2S)-2-Amino-4-phosphonobutanoic acid	Ki	160.0 [1], 470.0 [2], 910.0 [3]
	CID 6324634	IC50	300000.0 [1]
	CID 6324634	Ki	300000.0 [1]
	Quisqualic acid	Ki	112000.0 [1], 1000000.0 [2]
	alpha-Methyl-4-carboxyphenylglycine	IC50	1000000.0 [1]
	alpha-Methyl-4-carboxyphenylglycine	Ki	1000000.0 [1]
	2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine	IC50	22000.0 [1]
	2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine	Ki	22000.0 [1]
	(RS)-4-Carboxy-3-hydroxyphenylglycine	IC50	1000000.0 [1]
	(RS)-4-Carboxy-3-hydroxyphenylglycine	Ki	1000000.0 [1]
	(2R,1S,2R,3S)-2-(2-Carboxy-3-phenylcyclopropyl)glycine	IC50	300000.0 [1]
	(2R,1S,2R,3S)-2-(2-Carboxy-3-phenylcyclopropyl)glycine	Ki	280000.0 [1]
	3-[(S)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid	IC50	300000.0 [1]
	3-[(S)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid	Ki	300000.0 [1]
	(S)-4-Carboxyphenylglycine	Ki	838000.0 [1], 1000000.0 [2]
	2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid	IC50	300000.0 [1]
	2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid	Ki	300000.0 [1]
	1-Amino-3-phosphono-3-cyclopentene-1-carboxylic acid	IC50	100000.0 [1]
	(1S,2R,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1S,2R,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	1-Amino-3-phosphono-2-cyclopentene-1-carboxylic acid	IC50	100000.0 [1]
	(1R,2R,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1R,2R,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1S,2R,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1S,2R,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1R,2S,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1R,2S,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1S,2S,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1S,2S,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1S,2S,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1S,2S,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1R,2R,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1R,2R,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1S,2R,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1S,2R,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1S,2S,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1S,2S,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1S,2R,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1S,2R,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1R,2R,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1R,2R,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1R,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1R,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	(1R,2R,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	IC50	300000.0 [1]
	(1R,2R,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid	Ki	280000.0 [1]
	Ibotenic acid	Ki	1000000.0 [1]
	2-Methyl-6-(phenylethynyl)pyridine	Ki	100000.0 [1]
	(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid	Ki	98000.0 [1]
	(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid	Ki	21000.0 [1]
	Eglumetad	Ki	100000.0 [1]
	Aida	Ki	1000000.0 [1]
	L-Homocysteic acid	Ki	53000.0 [1]
	(S)-4-((1-Carboxyethyl)amino)benzoic acid	IC50	1000000.0 [1]
	(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine	Ki	50000.0 [1]
	(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid	Ki	300000.0 [1]
	CPCCOEt	Ki	100000.0 [1]
	4-Carboxyphenylglycine	IC50	1000000.0 [1]
	2-Methyl-6-(2-phenylethenyl)pyridine	Ki	26000.0 [1]
	6-Methyl-2-(phenylazo)-3-pyridinol	Ki	100000.0 [1]
	L-2-Aminoadipic acid	Ki	3000000.0 [1]
	Benzonitrile, 3-fluoro-5-(2-(2-(fluoromethyl)-4-thiazolyl)ethynyl)-	Ki	10000.0 [1]
	(S)-3,5-Dihydroxyphenylglycine	Ki	1000000.0 [1]
	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-hydroxy-3-methoxy-5-nitrophenyl)methyl]phosphoryl]butanoic acid	IC50	8600.0 [1]
	N-(4-Chloro-3-methoxyphenyl)pyridine-2-carboxamide	IC50	5.13 [1]
	(RS)-Ppg	Ki	5200.0 [1]
	13-(Dimethylamino)-5-(4-ethylphenyl)-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one	IC50	10000.0 [1]
	(S)-2-Amino-5-phosphonopentanoic acid	Ki	1000000.0 [1]
	6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-5H-1,3-benzoxazol-4-one	IC50	10000.0 [1]
	CID 10058694	Ki	100000.0 [1]
	4-Methylene-L-glutamic acid	Ki	1000000.0 [1]
	(S)-2-Amino-4-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-butyric acid	Ki	1000000.0 [1]
	(2S,4S)-4-Methylglutamic acid	Ki	470000.0 [1]
	(S)-Hibo	Ki	1000000.0 [1]
	4-[(S)-Amino(carboxy)methyl]cubane-1-carboxylic acid	Ki	1000000.0 [1]
	(2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycine	Ki	1000000.0 [1]
	(1r,2s,4r,5r,6r)-2-Amino-4-(1h-1,2,4-Triazol-3-Ylsulfanyl)bicyclo[3.1.0]hexane-2,6-Dicarboxylic Acid	IC50	12500.0 [1]
	(S)-2-Amino-3-(4-butyl-3-hydroxy-isoxazol-5-yl)-propionic acid	Ki	1000000.0 [1]
	1-[(Z)-2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1,2,4-triazole	Ki	100000.0 [1]
	(1S,2S)-4-Aminocyclopentane-1,2,4-tricarboxylic acid	Ki	8800.0 [1]
	1-Adamantyl-[4-(1,3-thiazol-2-yl)piperazin-1-yl]methanone	IC50	30000.0 [1]
	N-(3-(Difluoromethoxy)phenyl)picolinamide	IC50	4.57 [1]
	N-Methyl-5-(phenylethynyl)pyrimidin-2-amine	IC50	10000.0 [1]
	3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile	Ki	10000.0 [1]
	CID 5311344	Ki	50000.0 [1]
	2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid	Ki	1000000.0 [1]
	(1S,3R)-1-Amino-3-(carboxymethyl)cyclopentane-1-carboxylic Acid	Ki	1000000.0 [1]
	(2R,4R)-1,4-Diamino-pyrrolidine-2,4-dicarboxylic acid	Ki	1000000.0 [1]
	3,4-Dimethoxy-N-[2-(1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl]benzamide	IC50	10000.0 [1]
	1-Benzyl-APDC	IC50	300000.0 [1]
	N-[3-(Methylsulfanyl)phenyl]pyridine-2-carboxamide	IC50	4.9 [1]
	N-(4-Fluoro-3-methoxyphenyl)picolinamide	IC50	31.62 [1]
	2-Amino-bicyclo[3.2.0]heptane-2,7-dicarboxylic acid	Ki	1000000.0 [1]
	N-[3-Chloro-4-(4-methyl-1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide	IC50	11.0 [1]
	3-[(R)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid	IC50	300000.0 [1]
	(2R,4R)-4-Amino-1-naphthalen-1-ylmethyl-pyrrolidine-2,4-dicarboxylic acid	IC50	300000.0 [1]
	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-(2-phenylethyl)cyclopropane-1-carboxylic acid	IC50	11410.0 [1]
	N-(4-Chloro-3-methoxyphenyl)-6-fluoropyridine-2-carboxamide	IC50	7.41 [1]
	N-[3-(Difluoromethoxy)phenyl]-6-fluoropyridine-2-carboxamide	IC50	6.61 [1]
	Amino(3-hydroxyphenyl)acetic acid	Ki	1000000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Metabotropic glutamate receptor 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Metabotropic glutamate receptor 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-4-inhibitors-ic50-ki.
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