Metabotropic glutamate receptor 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Eglumetad	IC50	5.6 [1]
	Eglumetad	Ki	84.7 [1]
	Glutamic acid	Ki	1200.0 [1], 1819.7 [2], 6400.0 [3], 11000.0 [4], 12000.0 [5]
	2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine	IC50	2.9 [1], 21.0 [2], 23.0 [3], 200.0 [4]
	2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine	Ki	21.0 [1]
	CID 6324634	IC50	400.0 [1], 50000.0 [2]
	CID 6324634	Ki	50000.0 [1]
	(1R,2S,4R,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid	IC50	7000.0 [1], 7020.0 [2], 12500.0 [3]
	(1R,2S,4R,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid	Ki	420.0 [1]
	alpha-Methyl-4-carboxyphenylglycine	IC50	50000.0 [1], 340000.0 [2]
	alpha-Methyl-4-carboxyphenylglycine	Ki	340000.0 [1]
	(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid	Ki	2.7 [1], 14.1 [2], 2000.0 [3]
	(2S)-2-Amino-4-phosphonobutanoic acid	Ki	129000.0 [1], 1000000.0 [2]
	CID 11158623	IC50	14.0 [1], 296.0 [2]
	2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid	IC50	3000.0 [1], 18000.0 [2]
	2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid	Ki	18000.0 [1]
	(1R,2S,4S,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid	IC50	12500.0 [1], 15300.0 [2]
	(1R,2S,4S,5R,6R)-2-Amino-4-phenylsulfanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid	Ki	1230.0 [1]
	Quisqualic acid	Ki	113000.0 [1], 1000000.0 [2]
	(RS)-4-Carboxy-3-hydroxyphenylglycine	IC50	48000.0 [1]
	(RS)-4-Carboxy-3-hydroxyphenylglycine	Ki	20000.0 [1]
	CID 9886034	IC50	20.0 [1]
	CID 9886034	Ki	2.2 [1]
	(S)-3,5-Dihydroxyphenylglycine	Ki	1000000.0 [1]
	2(1H)-Pyridinone, 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-	IC50	68.0 [1]
	2(1H)-Pyridinone, 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-	Ki	180.0 [1]
	3-[(S)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid	IC50	300000.0 [1]
	3-[(S)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid	Ki	300000.0 [1]
	(1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid	Ki	40.6 [1]
	3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine	IC50	15.0 [1]
	3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine	Ki	15.0 [1]
	(S)-(2,4-Dichlorobenzyl)-[1-(5-bromopyrimidin-2-yl)-pyrrolidin-3-yl]-amine	IC50	12500.0 [1], 17000.0 [2]
	1-[(Z)-2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1,2,4-triazole	IC50	533.0 [1]
	1-[(Z)-2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1,2,4-triazole	Ki	110.0 [1]
	(1S,2S)-2-(1-Amino-1-carboxy-3-phenylpropyl)cyclopropane-1-carboxylic acid	IC50	850.0 [1]
	1-Benzyl-APDC	IC50	300000.0 [1]
	1-Benzyl-APDC	Ki	200000.0 [1]
	(7E)-7-Hydroxyimino-N-(4-methylphenyl)-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide	IC50	1500.0 [1]
	(7E)-7-Hydroxyimino-N-(4-methylphenyl)-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide	Ki	600.0 [1]
	(1S,2S,3R)-2-[Amino(carboxy)methyl]-3-(9H-xanthen-9-ylmethyl)cyclopropane-1-carboxylic acid	IC50	6400.0 [1]
	(1S,2S,3R)-2-[Amino(carboxy)methyl]-3-(9H-xanthen-9-ylmethyl)cyclopropane-1-carboxylic acid	Ki	2700.0 [1]
	(1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid	IC50	1750.0 [1]
	(1S,2S,3R,5R,6S)-2-Amino-3-methyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid	Ki	983.0 [1]
	(1S,2S,4S,5R,6S)-2-Amino-4-(3-phenylpropanoylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid	IC50	5540.0 [1]
	(1S,2S,4S,5R,6S)-2-Amino-4-(3-phenylpropanoylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid	Ki	595.0 [1]
	(1S,2S,4S,5R,6S)-2-Amino-4-(cyclohexanecarbonylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid	IC50	12000.0 [1]
	(1S,2S,4S,5R,6S)-2-Amino-4-(cyclohexanecarbonylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid	Ki	1520.0 [1]
	(1S,2S,4S,5R,6S)-2-Amino-4-[(2-cyclohexylacetyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid	IC50	7660.0 [1]
	(1S,2S,4S,5R,6S)-2-Amino-4-[(2-cyclohexylacetyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid	Ki	627.0 [1]
	(7E)-N-(4-Chlorophenyl)-7-hydroxyimino-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide	IC50	800.0 [1]
	(7E)-N-(4-Chlorophenyl)-7-hydroxyimino-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide	Ki	1000.0 [1]
	(7E)-7-Hydroxyimino-N-(4-methoxyphenyl)-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide	IC50	1000.0 [1]
	(7E)-7-Hydroxyimino-N-(4-methoxyphenyl)-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide	Ki	800.0 [1]
	4-[2-Chloro-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]anilino]cyclohexan-1-ol	Ki	2.19 [1], 9.33 [2]
	4-[2-Chloro-4-[8-chloro-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]phenoxy]cyclohexan-1-ol	Ki	11.48 [1], 32.36 [2]
	(1S,2S,3R)-2-[Amino(carboxy)methyl]-3-[2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid	IC50	200.0 [1]
	(1S,2S,3R)-2-[Amino(carboxy)methyl]-3-[2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid	Ki	85.0 [1]
	Ibotenic acid	Ki	110000.0 [1]
	2-Methyl-6-(phenylethynyl)pyridine	Ki	100000.0 [1]
	(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid	Ki	5000.0 [1]
	(S)-Mcpg	IC50	4300.0 [1]
	2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cyclopropanecarboxylic acid	IC50	200.0 [1]
	Dcg-IV	Ki	110.0 [1]
	Aida	Ki	1000000.0 [1]
	L-Homocysteic acid	Ki	300000.0 [1]
	(S)-4-((1-Carboxyethyl)amino)benzoic acid	IC50	339000.0 [1]
	(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine	Ki	490.0 [1]
	(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid	Ki	450.0 [1]
	CPCCOEt	Ki	100000.0 [1]
	4-Carboxyphenylglycine	IC50	577000.0 [1]
	2-Methyl-6-(2-phenylethenyl)pyridine	Ki	100000.0 [1]
	6-Methyl-2-(phenylazo)-3-pyridinol	Ki	100000.0 [1]
	2,2,2-Trifluoro-N-(4-(2-methoxyphenoxy)phenyl)-N-(pyridin-3-ylmethyl)ethanesulfonamide	IC50	100000.0 [1]
	(1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide	Ki	149.0 [1]
	(+)-(1R,2R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2-oxide	Ki	508.0 [1]
	L-2-Aminoadipic acid	Ki	35000.0 [1]
	Biphenylindanone A	Ki	60.26 [1]
	(2R,1S,2R,3S)-2-(2-Carboxy-3-phenylcyclopropyl)glycine	IC50	300000.0 [1]
	Benzonitrile, 3-fluoro-5-(2-(2-(fluoromethyl)-4-thiazolyl)ethynyl)-	Ki	10000.0 [1]
	CID 25125217	Ki	371.54 [1]
	(RS)-Ppg	Ki	300000.0 [1]
	(S)-4-Carboxyphenylglycine	Ki	577000.0 [1]
	13-(Dimethylamino)-5-(4-ethylphenyl)-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one	IC50	10000.0 [1]
	4-Fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide	IC50	10000.0 [1]
	Talaglumetad	Ki	10000.0 [1]
	2-Amino-2-(4-phosphonophenyl)propanoic acid	Ki	11000.0 [1]
	(S)-2-Amino-5-phosphonopentanoic acid	Ki	205000.0 [1]
	CID 10058694	Ki	3.9 [1]
	4-Methylene-L-glutamic acid	Ki	230.0 [1]
	[(3R)-3-(Hydroxymethyl)piperidin-1-yl]-[4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanone	IC50	10000.0 [1]
	(S)-2-Amino-4-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-butyric acid	Ki	23000.0 [1]
	Dfmti	IC50	10000.0 [1]
	(2S,4S)-4-Methylglutamic acid	Ki	2000.0 [1]
	1-(Cyclopropylmethyl)-2-oxo-4-(4-phenylpiperidin-1-yl)pyridine-3-carbonitrile	Ki	26.3 [1]
	(S)-Hibo	Ki	1000000.0 [1]
	4-[(S)-Amino(carboxy)methyl]cubane-1-carboxylic acid	Ki	55000.0 [1]
	N-Pyridin-2-yl-5-thia-3,11,12-triazatricyclo[8.3.0.02,6]trideca-1(10),2(6),3,12-tetraen-4-amine	IC50	10000.0 [1]
	(RS)-Apica	Ki	30000.0 [1]
	(2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycine	Ki	84000.0 [1]
	(1r,2s,4r,5r,6r)-2-Amino-4-(1h-1,2,4-Triazol-3-Ylsulfanyl)bicyclo[3.1.0]hexane-2,6-Dicarboxylic Acid	Ki	144.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Metabotropic glutamate receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Metabotropic glutamate receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-2-inhibitors-ic50-ki.
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