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Metabotropic glutamate receptor 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
alpha-Methyl-4-carboxyphenylglycineIC50155000.0 [1], 700000.0 [2]
alpha-Methyl-4-carboxyphenylglycineKi50000.0 [1], 540000.0 [2]
3-[(S)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acidIC5025000.0 [1], 32000.0 [2]
3-[(S)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acidKi25000.0 [1]
Glutamic acidKi250.0 [1], 570.0 [2], 1584.89 [3], 10000.0 [4]
AidaIC507000.0 [1], 214000.0 [2]
AidaKi214000.0 [1]
CPCCOEtIC503400.0 [1], 6600.0 [2], 23000.0 [3]
CPCCOEtKi9900.0 [1]
(S)-4-CarboxyphenylglycineIC5010000.0 [1], 58000.0 [2], 65000.0 [3]
(S)-4-CarboxyphenylglycineKi84000.0 [1]
4-[(S)-Amino(carboxy)methyl]cubane-1-carboxylic acidIC5076000.0 [1], 230000.0 [2], 232000.0 [3]
4-[(S)-Amino(carboxy)methyl]cubane-1-carboxylic acidKi232000.0 [1]
2-Methyl-6-(phenylethynyl)pyridineIC50100000.0 [1]
2-Methyl-6-(phenylethynyl)pyridineKi36.0 [1], 30000.0 [2]
4-[(S)-Amino(carboxy)methyl]-3-methylbenzoic acidIC508000.0 [1], 8800.0 [2], 300000.0 [3]
(3,4-Dihydro-2h-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanoneIC501.21 [1], 106.0 [2]
(3,4-Dihydro-2h-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanoneKi0.34 [1]
(RS)-4-Carboxy-3-hydroxyphenylglycineIC5040000.0 [1], 200000.0 [2]
(RS)-4-Carboxy-3-hydroxyphenylglycineKi30000.0 [1]
13-(Dimethylamino)-5-(4-ethylphenyl)-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-oneIC503.0 [1]
9-(Dimethylamino)-3-(4-methoxyphenyl)-4-pyrido[1,2]thieno[3,4-d]pyrimidinoneIC509.5 [1]
CID 6324634IC50300000.0 [1]
CID 6324634Ki300000.0 [1]
2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-AlanineIC507800.0 [1]
2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-AlanineKi6800.0 [1]
(2S)-2-Amino-4-phosphonobutanoic acidKi1000000.0 [1]
2-Methyl-6-(2-phenylethenyl)pyridineIC50100000.0 [1]
2-Methyl-6-(2-phenylethenyl)pyridineKi100000.0 [1]
6-Methyl-2-(phenylazo)-3-pyridinolIC50100000.0 [1]
6-Methyl-2-(phenylazo)-3-pyridinolKi100000.0 [1]
(2R,1S,2R,3S)-2-(2-Carboxy-3-phenylcyclopropyl)glycineIC50300000.0 [1]
(2R,1S,2R,3S)-2-(2-Carboxy-3-phenylcyclopropyl)glycineKi270000.0 [1]
FtidcIC505.6 [1], 5.8 [2]
(S)-4-Carboxy-3-hydroxyphenylglycineIC5040000.0 [1]
4-Fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamideIC505.1 [1], 10000.0 [2]
5-[1-(2-(18F)Fluoranylpyridin-3-yl)-5-methyltriazol-4-yl]-2-propyl-3H-isoindol-1-oneKi0.4 [1]
(3-Ethyl-2-(111C)methylquinolin-6-yl)-(4-methoxycyclohexyl)methanoneKi0.87 [1]
2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acidIC50300000.0 [1]
2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acidKi300000.0 [1]
Pyrido(3',2':4,5)thieno(3,2-d)pyrimidin-4(3H)-one, 3-(4-methoxyphenyl)-9-(2-propynylamino)-IC502.1 [1], 6.7 [2]
CID 5311344IC50300000.0 [1]
CID 5311344Ki270000.0 [1]
(S)-3-Carboxy-4-hydroxyphenylglycineIC5040000.0 [1], 290000.0 [2]
(1R,2R)-N-(3-(4-Methoxyphenyl)-4-methyl-5-isothiazolyl)-2-methylcyclopropanecarboxamideIC509.0 [1]
cis-10 [PMID: 15771457]IC5020.0 [1], 94.0 [2]
1-Benzyl-APDCIC50300000.0 [1]
1-Benzyl-APDCKi1000000.0 [1]
4-[1-(2-(18F)Fluoranylpyridin-3-yl)-5-methyltriazol-4-yl]-N-methyl-N-propan-2-yl-3,6-dihydro-2H-pyridine-1-carboxamideKi2.0 [1], 3.9 [2]
3-[(3R)-4-(Adamantane-1-carbonyl)-3-methylpiperazin-1-yl]pyridine-2-carbonitrileIC5099.0 [1]
(1S,2R,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1S,2R,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi270000.0 [1]
(1R,2R,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1R,2R,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi60000.0 [1]
(1S,2R,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1S,2R,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi270000.0 [1]
(1R,2S,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50140000.0 [1]
(1R,2S,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi44000.0 [1]
(1S,2S,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1S,2S,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi270000.0 [1]
(1S,2S,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1S,2S,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi270000.0 [1]
(1R,2R,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1R,2R,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi270000.0 [1]
(1S,2R,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1S,2R,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi270000.0 [1]
(1S,2S,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1S,2S,3R)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi270000.0 [1]
(1S,2R,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1S,2R,3S)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi260000.0 [1]
(1R,2R,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1R,2R,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi205000.0 [1]
(1R,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1R,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi270000.0 [1]
7-Phenyl-3-p-tolylthieno[3,2-d]pyrimidin-4(3H)-oneIC50112.0 [1]
7-Phenyl-3-(3-vinylphenyl)thieno[3,2-D]pyrimidin-4(3H)-oneIC5074.0 [1]
3-(2-Fluorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-oneIC50407.0 [1], 677.0 [2]
3-(3-Chlorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4-oneIC5058.0 [1], 374.0 [2]
3-(4-Chlorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-oneIC5066.0 [1], 162.0 [2]
4-(Amino-carboxy-methyl)-2-hydroxy-3-methyl-benzoic AcidIC506000.0 [1]
4-(Amino-carboxy-methyl)-2-hydroxy-3-methyl-benzoic AcidKi6000.0 [1]
(1R,2R,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidIC50300000.0 [1]
(1R,2R,3S)-2-[(R)-Amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acidKi135000.0 [1]
Ibotenic acidKi43000.0 [1]
Quisqualic acidKi1100.0 [1]
(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acidKi42000.0 [1]
(S)-McpgIC504300.0 [1]
2-Methyl-4-(pyridin-3-ylethynyl)thiazoleIC50100000.0 [1]
(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acidKi100000.0 [1]
EglumetadKi100000.0 [1]
L-Homocysteic acidKi87000.0 [1]
(S)-4-((1-Carboxyethyl)amino)benzoic acidIC5057000.0 [1]
(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycineKi50000.0 [1]
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acidKi100000.0 [1]
FenobamKi6.7 [1]
4-CarboxyphenylglycineIC5065000.0 [1]
Philanthotoxin 343IC5023.0 [1]
1H-Cyclopenta(C)furan-1-one, hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-, (3aS,6aS)-IC50160.0 [1]
L-2-Aminoadipic acidKi1000000.0 [1]
2-(4-Carboxy-2-methylphenyl)glycineKi8800.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Metabotropic glutamate receptor 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Metabotropic glutamate receptor 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/metabotropic-glutamate-receptor-1-inhibitors-ic50-ki.
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