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Melatonin receptor 1B Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
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▼
Standard Values (in nM)
▲
▼
MelatoninIC500.3 [1], 0.53 [2]
MelatoninKi0.12 [1], 0.28 [2], 0.29 [3], 0.31 [4], 0.7 [5]
N-[2-[7-[4-[8-(2-Acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]acetamideKi72.7 [1], 73.2 [2], 167.0 [3]
N-[2-[7-[3-[8-(2-Acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamideKi112.0 [1], 149.0 [2], 354.81 [3]
N-[2-(11-Methoxy-6,7-dihydro-5H-indolo[2,1-a][2]benzazepin-13-yl)ethyl]butanamideKi0.5 [1]
N-(2-(5-Methoxybenzofuran-3-yl)ethyl)acetamideIC500.7 [1]
N-(2-(5-Methoxybenzofuran-3-yl)ethyl)acetamideKi0.34 [1]
CID 10428383Ki8.7 [1], 8.71 [2], 9.0 [3]
CID 9998187Ki0.25 [1], 0.32 [2], 0.33 [3]
N-[2-(7,17-Dimethoxy-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4(9),5,7,10,14(19),15,17-heptaen-10-yl)ethyl]acetamideKi407.38 [1], 410.0 [2]
2-IodomelatoninKi0.15 [1], 0.16 [2], 0.22 [3]
LuzindoleKi10.2 [1], 44.7 [2], 46.77 [3]
4-P-PdotKi0.02 [1], 0.46 [2], 1.5 [3]
N-[(6-Methoxy-9-tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaenyl)methyl]acetamideKi0.66 [1], 1.3 [2]
4-AzamelatoninKi0.3 [1], 0.36 [2]
N-[2-(2-Benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-acetamideKi0.05 [1]
N-[2-(7-Methoxy-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4(9),5,7,10,14,16,18-heptaen-10-yl)ethyl]acetamideKi64.57 [1], 65.0 [2], 65.2 [3]
1-[1-(2,2-Diphenyl-ethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-ethanoneIC509.7 [1]
1-[1-(2,2-Diphenyl-ethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-ethanoneKi9.77 [1]
N-[3-[5-Methoxy-2-[(3-methoxyphenyl)methoxy]phenyl]propyl]propanamideKi0.29 [1], 1.7 [2]
5-Methoxycarbonylamino-N-acetyltryptamineIC504000.0 [1]
N-[2-(2-Methoxy-6H-isoindolo[2,1-a]indol-11-yl)ethyl]butanamideKi0.05 [1]
N-[2-(5-Methoxy-1-methyl-1H-indol-3-yl)-ethyl]-acetamideKi1.74 [1], 3.1 [2]
7-AzamelatoninKi117.0 [1]
N-[2-(2,7-Dimethoxy-naphthalen-1-yl)-ethyl]-propionamideKi0.38 [1]
N-[(6-Methoxy-9-tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaenyl)methyl]propanamideKi0.16 [1]
N-[2-(5-Methoxy-2-phenyl-benzofuran-3-yl)-ethyl]-acetamideKi0.02 [1]
N-[2-[5-Methoxy-2-[(3-methoxyphenyl)methyl]-1-benzofuran-3-yl]ethyl]but-3-enamideKi0.11 [1]
N-[2-(1-Benzyl-5-methoxyindol-3-yl)ethyl]acetamideKi6.46 [1]
Acetylaminoethyl-methyl-phenylbutoxyphenyl-amineKi91.0 [1], 91.2 [2]
N-(3-(3-Methoxyphenyl)-3-phenylallyl)acetamideKi0.22 [1], 2.5 [2]
N-[2-(3,13-Diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-4,6,8,10,14,16,18-heptaen-10-yl)ethyl]acetamideKi1700.0 [1]
N-[2-(7-Phenyl-2,6-dihydro-1H-cyclopenta[e][1]benzofuran-8-yl)ethyl]acetamideKi0.01 [1]
N-[3-[2-(4-Phenylbutyl)-1,3-benzoxazol-7-yl]propyl]cyclopropanecarboxamideKi22.0 [1]
1-[6,7-Dimethoxy-1-(2-phenylethyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanoneIC5076.0 [1]
CID 44436051Ki12.59 [1], 67.61 [2]
N-(2-(6-Methoxy-1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl)acetamideKi0.6 [1]
N-[2-[7-[8-(2-Acetamidoethyl)naphthalen-2-yl]naphthalen-1-yl]ethyl]acetamideKi246.0 [1]
N-[2-[5-(3-Phenoxypropoxy)-1H-indol-3-yl]ethyl]acetamideKi87.0 [1]
N-[2-(6-Hexoxy-3,4-dihydro-2H-chromen-4-yl)ethyl]acetamideKi21.4 [1], 29.0 [2]
DopamineKi9100.0 [1]
SerotoninKi100000.0 [1]
RamelteonKi0.04 [1]
N,N-Dimethyl-5-methoxytryptamineKi16.0 [1]
6-ChloromelatoninKi0.2 [1]
n-[(2r)-2-(6-Chloro-5-methoxy-1h-indol-3-yl)propyl]acetamideKi0.04 [1]
N-[2-(N-(4-Methoxyphenyl)anilino)ethyl]acetamideKi27.54 [1]
CID 44208891Ki0.8 [1]
5-MethoxyluzindoleKi0.25 [1]
n-[2-(5,6-Dimethoxy-1h-indol-3-yl)ethyl]acetamideKi3.5 [1]
Acetamide,n-[2-(2-iodo-5-methoxy-1-methyl-4-nitro-1h-indol-3-yl)ethyl]-Ki39.0 [1]
N-[(4-Methoxy-1H-indol-2-yl)methyl]propanamideKi288.4 [1]
N-[2-(N-(3-Methoxyphenyl)anilino)ethyl]acetamideKi0.07 [1]
N-(3-(3-Methoxyphenyl)propyl)propionamideKi7.07 [1]
N-[2-(5-Methoxy-1H-indol-2-yl)ethyl]acetamideKi9332.54 [1]
N-[(4-Methoxy-1H-indol-2-yl)methyl]cyclobutanecarboxamideKi645.65 [1]
N-[(1-Benzyl-4-methoxyindol-2-yl)methyl]propanamideKi7.59 [1]
N-[3-(3-Methoxyphenyl)propyl]acetamideKi0.75 [1]
N-[2-(5-Methoxy-1-methyl-4-nitro-1H-indol-3-yl)-ethyl]-acetamideKi194.0 [1]
N-(2-Phenoxyethyl)AcetamideKi5495.41 [1]
N-[2-[3-(3-Aminophenyl)-7-methoxynaphthalen-1-yl]ethyl]acetamideKi0.27 [1]
N-[2-(3-Methoxy-N-methylanilino)ethyl]acetamideKi0.65 [1]
EfppeaKi0.42 [1]
N-[2-(4-Methoxyphenoxy)ethyl]acetamideKi45708.82 [1]
Acetamide, N-[(E)-2-(1-naphthalenyl)ethenyl]-Ki1.4 [1]
N-[(6-Methoxy-9-tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaenyl)methyl]butanamideKi0.25 [1]
Acetamide,n-[2-(2-iodo-5-methoxy-4-nitro-1h-indol-3-yl)ethyl]-Ki23.7 [1]
1-(Ethylcarbamoyl)-4-[(1R)-6-methoxyindan-1-yl]piperazineIC501.7 [1]
N-[2-(5-Methoxy-1-phenylindol-3-yl)ethyl]acetamideKi134.9 [1]
Acetamide, N-[2-(1H-indol-2-yl)ethyl]-Ki1621.81 [1]
N-[2-(4-Methoxy-1H-indol-2-yl)ethyl]acetamideKi933.25 [1]
N-[2-(6H-Isoindolo[2,1-a]indol-11-yl)-ethyl]-acetamideKi17.0 [1]
N-[2-(6H-Isoindolo[2,1-a]indol-11-yl)-ethyl]-propionamideKi17.4 [1]
N-[2-(4-Methoxy-1-phenylindol-2-yl)ethyl]acetamideKi7.76 [1]
N-[2-(2-Ethoxy-6H-isoindolo[2,1-a]indol-11-yl)-ethyl]-butyramideKi0.16 [1]
N-[2-(10-Methoxy-5,6-dihydro-indolo[2,1-a]isoquinolin-12-yl)-ethyl]-butyramideKi0.2 [1]
N-[2-(6H-Isoindolo[2,1-a]indol-11-yl)ethyl]cyclobutanecarboxamideKi1120.0 [1]
N-[2-(6H-Isoindolo[2,1-a]indol-11-yl)ethyl]cyclopropanecarboxamideKi224.0 [1]
N-[2-(4-Methoxy-1-phenylindol-2-yl)ethyl]propanamideKi1.66 [1]
N-[2-(6H-Isoindolo[2,1-a]indol-11-yl)-ethyl]-butyramideKi12.0 [1]
N-[2-(10-Methoxy-5,6-dihydroindolo[2,1-a]isoquinolin-12-yl)ethyl]cyclobutanecarboxamideKi324.0 [1]
N-[2-(6-Methoxy-1H-indol-2-yl)ethyl]acetamideKi1445.44 [1]
N-[2-(4-Methoxy-1H-indol-2-yl)ethyl]propanamideKi223.87 [1]
N-[2-(10-Methoxy-5,6-dihydro-indolo[2,1-a]isoquinolin-12-yl)-ethyl]-acetamideKi0.51 [1]
N-[2-(2-Ethoxy-6H-isoindolo[2,1-a]indol-11-yl)-ethyl]-propionamideKi0.26 [1]
N-[2-(11-Ethoxy-6,7-dihydro-5H-indolo[2,1-a][2]benzazepin-13-yl)ethyl]cyclopropanecarboxamideKi85.1 [1]
N-[2-(3-Bromo-6-methoxy-1H-indol-2-yl)ethyl]acetamideKi354.81 [1]
N-[2-(1-Benzyl-4-methoxyindol-2-yl)ethyl]propanamideKi17.78 [1]
Acetamide, N-[(4-methoxy-1H-indol-2-yl)methyl]-Ki812.83 [1]
N-[3-(5-Methoxy-1H-indol-2-yl)propyl]acetamideKi102329.3 [1]
N-[2-(6,7-Dihydro-5H-indolo[2,1-a][2]benzazepin-13-yl)ethyl]propanamideKi45.7 [1]
N-[2-(11-Ethoxy-6,7-dihydro-5H-indolo[2,1-a][2]benzazepin-13-yl)ethyl]acetamideKi117.0 [1]
N-[2-(7-Methoxy-1H-indol-2-yl)ethyl]acetamideKi4265.8 [1]
N-[2-(6-Methoxy-1-methylindol-2-yl)ethyl]acetamideKi1230.27 [1]
N-[2-(5,6-Dihydro-indolo[2,1-a]isoquinolin-12-yl)-ethyl]-acetamideKi36.3 [1]
N-[2-(2-Methoxy-6H-isoindolo[2,1-a]indol-11-yl)ethyl]cyclopropanecarboxamideKi0.95 [1]
N-[2-(10-Methoxy-5,6-dihydro-indolo[2,1-a]isoquinolin-12-yl)-ethyl]-propionamideKi0.12 [1]
N-[2-(11-Ethoxy-6,7-dihydro-5H-indolo[2,1-a][2]benzazepin-13-yl)ethyl]propanamideKi21.9 [1]
N-[2-(5,6-Dihydroindolo[2,1-a]isoquinolin-12-yl)ethyl]cyclobutanecarboxamideKi355.0 [1]
Items per page: 1 - 10 of 99
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References

This online tool may be cited as follows

MLA

"Quest Database™ Melatonin receptor 1B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/melatonin-receptor-1b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Melatonin receptor 1B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/melatonin-receptor-1b-inhibitors-ic50-ki.
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