![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_62aee3ef1fc3e473cda1780733f00927.svg) | Melanotan-1 | IC50 | 0.4 [1], 1.16 [2], 3.6 [3] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_125e9ccf1d0c6298e431c20db084fd62.svg) | Thiq | IC50 | 1.2 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_125e9ccf1d0c6298e431c20db084fd62.svg) | Thiq | Ki | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_553f211bad3c5350fc925b7dad4a3cbe.svg) | Msh, 2-tyr-alpha- | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_ab3a6ed7fae6692e5b0014d4e91815cf.svg) | Melanotan II | IC50 | 0.72 [1], 1.1 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_ab3a6ed7fae6692e5b0014d4e91815cf.svg) | Melanotan II | Ki | 1.26 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_4c4ac6957f2a2b7020f5f0fa5fbb30ae.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 10.8 [1], 11.0 [2], 12.0 [3] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_37a10a740ab8407febf2112ced9dfe41.svg) | 1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-4-(trifluoromethyl)phenyl]piperazin-1-yl]-3-(2,4-dichlorophenyl)propan-1-one | Ki | 74.0 [1], 75.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_e7c6516f01c9ed7837fe17d06846c68d.svg) | N-[2-[(2-Amino-2-oxoethyl)-[(1R)-1-phenylethyl]amino]-2-oxoethyl]-N-benzhydryl-2-[3-(diaminomethylideneamino)propylamino]acetamide | IC50 | 1900.0 [1], 2100.0 [2], 3100.0 [3] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_40f8654c54214f641f785c708d75fa84.svg) | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-[[(2S)-1-[[(2S)-1-(carboxymethylamino)-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 760.0 [1], 770.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_40f8654c54214f641f785c708d75fa84.svg) | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-[[(2S)-1-[[(2S)-1-(carboxymethylamino)-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | Ki | 730.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_f9c30893478e7cd68c36fddd90e36b8c.svg) | 3-Amino-N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]propanamide | Ki | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_f689bb4441a02ac0d70376170e448d24.svg) | 2-Amino-N-[(1S)-1-[2-[4-[3-(2,4-dichlorophenyl)propanoyl]piperazin-1-yl]-5-(trifluoromethyl)phenyl]-3-methylbutyl]acetamide | IC50 | 1300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_f689bb4441a02ac0d70376170e448d24.svg) | 2-Amino-N-[(1S)-1-[2-[4-[3-(2,4-dichlorophenyl)propanoyl]piperazin-1-yl]-5-(trifluoromethyl)phenyl]-3-methylbutyl]acetamide | Ki | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_62694b679532a93af6984473413f1b81.svg) | (2R)-1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-4-methylphenyl]piperazin-1-yl]-3-(4-chlorophenyl)-2-methylpropan-1-one | IC50 | 560.0 [1], 570.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_62694b679532a93af6984473413f1b81.svg) | (2R)-1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-4-methylphenyl]piperazin-1-yl]-3-(4-chlorophenyl)-2-methylpropan-1-one | Ki | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_af41ddbb8cabc40ab2d204db625b28d5.svg) | (2R)-1-[4-[2-[(1S)-1-Amino-2-methylpropyl]-4-methylphenyl]piperazin-1-yl]-3-(4-chlorophenyl)-2-methylpropan-1-one | IC50 | 2400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_af41ddbb8cabc40ab2d204db625b28d5.svg) | (2R)-1-[4-[2-[(1S)-1-Amino-2-methylpropyl]-4-methylphenyl]piperazin-1-yl]-3-(4-chlorophenyl)-2-methylpropan-1-one | Ki | 69.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_31b38795cad2a0a86f1c77ee8a9e28da.svg) | (2R)-3-(4-Chloro-2-fluorophenyl)-2-methyl-1-[4-[4-methyl-2-[(1S)-2-methyl-1-[2-(methylamino)ethylamino]propyl]phenyl]piperazin-1-yl]propan-1-one | IC50 | 660.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_31b38795cad2a0a86f1c77ee8a9e28da.svg) | (2R)-3-(4-Chloro-2-fluorophenyl)-2-methyl-1-[4-[4-methyl-2-[(1S)-2-methyl-1-[2-(methylamino)ethylamino]propyl]phenyl]piperazin-1-yl]propan-1-one | Ki | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_d14c99d54fc7210eedcc089f8049d720.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(4-Chloro-2-fluorophenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-2-(methylamino)acetamide | IC50 | 410.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_d14c99d54fc7210eedcc089f8049d720.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(4-Chloro-2-fluorophenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-2-(methylamino)acetamide | Ki | 2.8 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_359957fc65df4466fdd9ae29044ee9a5.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(4-Chloro-2-fluorophenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide | IC50 | 190.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_359957fc65df4466fdd9ae29044ee9a5.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(4-Chloro-2-fluorophenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide | Ki | 2.2 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_394dd0418ae97c9452e1ceb07e0f3203.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(4-Chloro-2-methylphenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide | IC50 | 92.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_394dd0418ae97c9452e1ceb07e0f3203.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(4-Chloro-2-methylphenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide | Ki | 0.6 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_f9f2ebc7c7098dc44289cd9b4eb31bcd.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(4-Chlorophenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide | IC50 | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_f9f2ebc7c7098dc44289cd9b4eb31bcd.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(4-Chlorophenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide | Ki | 2.8 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_9bf3d067a4170f972a75f9754acfdfc4.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(4-Chlorophenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(methylamino)propanamide | IC50 | 87.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_9bf3d067a4170f972a75f9754acfdfc4.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(4-Chlorophenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(methylamino)propanamide | Ki | 5.7 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_4f36e26a1c660442ae4be58628b059d9.svg) | 3-Amino-N-[(1S)-1-[2-[4-[(2R)-3-(4-chlorophenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]propanamide | IC50 | 280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_4f36e26a1c660442ae4be58628b059d9.svg) | 3-Amino-N-[(1S)-1-[2-[4-[(2R)-3-(4-chlorophenyl)-2-methylpropanoyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]propanamide | Ki | 5.9 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_7f391a1e3ff7a85eb621af92336f152d.svg) | 1-[(2R)-1-[4-[2-[(1S)-1-(2-Aminoethylamino)-3-methylbutyl]-6-fluorophenyl]piperazin-1-yl]-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl]pyrrolidin-2-one | IC50 | 21.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_7f391a1e3ff7a85eb621af92336f152d.svg) | 1-[(2R)-1-[4-[2-[(1S)-1-(2-Aminoethylamino)-3-methylbutyl]-6-fluorophenyl]piperazin-1-yl]-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl]pyrrolidin-2-one | Ki | 0.9 [1], 0.94 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_3cade8ea4b6d59f584abffc733de073f.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(2,4-Dichlorophenyl)-2-(2-oxopyrrolidin-1-yl)propanoyl]piperazin-1-yl]-5-methylphenyl]-3-methylbutyl]-3-(dimethylamino)propanamide | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_3cade8ea4b6d59f584abffc733de073f.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(2,4-Dichlorophenyl)-2-(2-oxopyrrolidin-1-yl)propanoyl]piperazin-1-yl]-5-methylphenyl]-3-methylbutyl]-3-(dimethylamino)propanamide | Ki | 0.59 [1], 0.6 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_059c638c56870d6b52d20963fcf65b83.svg) | 1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-4-(trifluoromethyl)phenyl]piperazin-1-yl]-3-(4-chloro-2-methoxyphenyl)-2-methylpropan-1-one | IC50 | 1700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_059c638c56870d6b52d20963fcf65b83.svg) | 1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-4-(trifluoromethyl)phenyl]piperazin-1-yl]-3-(4-chloro-2-methoxyphenyl)-2-methylpropan-1-one | Ki | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_591c07f4f67e00e1ee4c74d154d83e0e.svg) | (3S,6S,9R,12S,15R,23S)-15-[[(2R)-2-Acetamidohexanoyl]amino]-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | IC50 | 0.06 [1], 0.6 [2], 1.8 [3] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_ca2e32d822e5dffd4c916c4f346ca9aa.svg) | Ac-His-DPhe-Arg-Trp-NH2 | IC50 | 359.0 [1], 1153.0 [2], 4600.0 [3] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_c98c154e663dba1c9eda009a01679c77.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-oxo-1-[4-[2-[1-(piperidin-3-ylamino)ethyl]phenyl]piperazin-1-yl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 6.4 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_027cc066378ed822feae0aef8e8b010d.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-oxo-1-[4-[2-(1,2,4-triazol-1-ylmethyl)phenyl]piperazin-1-yl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 270.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_76fefdc958295fbe0c15709c3badd274.svg) | N-[(1S)-1-[2-[1-[(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide | IC50 | 70.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_73938fd4cafd4a9ab51660dd6f176201.svg) | (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid | IC50 | 15.0 [1], 16.0 [2], 19.0 [3] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_8d503e9352bfbd1e7e4b6cb8a2a92563.svg) | (3R)-N-[(2R)-1-[4-[2-(Aminomethyl)phenyl]piperazin-1-yl]-3-(4-chlorophenyl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_ba77de80a7850ff6ba597ad2595e2661.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-[4-[2-(diethylaminomethyl)phenyl]piperazin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 14.0 [1], 34.0 [2], 52.0 [3] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_24aaa2c20d124184bc773c11b67333de.svg) | 1-[(2R)-1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-6-fluorophenyl]piperazin-1-yl]-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl]pyrrolidin-2-one | Ki | 9.7 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_c7269a89bf773de9ef633fb91fcbe50b.svg) | Ac-Tyr-D-Phe-Arg-2-Nal-NHCH3 | Ki | 104.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_1d9f18be0001a98a37f1aa0028a526b5.svg) | (2R)-1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-4-(trifluoromethyl)phenyl]piperazin-1-yl]-3-(4-chlorophenyl)-2-methylpropan-1-one | Ki | 31.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_84d1817cd611d8cbbbdc47478e680d6e.svg) | (2R)-1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-4-(trifluoromethyl)phenyl]piperazin-1-yl]-3-(2,4-dichlorophenyl)-2-methylpropan-1-one | Ki | 26.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_8593bb0bfca09a5d3484e6e49c015ed4.svg) | 3-Amino-N-[(2R)-3-(4-chlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]propanamide | Ki | 20.5 [1], 21.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_934d8d0058ab058961e08c5826685b29.svg) | 1-[(2R)-1-[4-[2-[(1S)-1-Amino-3-methylbutyl]phenyl]piperazin-1-yl]-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl]pyrrolidin-2-one | IC50 | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_934d8d0058ab058961e08c5826685b29.svg) | 1-[(2R)-1-[4-[2-[(1S)-1-Amino-3-methylbutyl]phenyl]piperazin-1-yl]-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl]pyrrolidin-2-one | Ki | 6.4 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_7e0340c39f978976f1cb8d1c9762977e.svg) | 1-[(2R)-1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-4-(trifluoromethyl)phenyl]piperazin-1-yl]-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl]pyrrolidin-2-one | IC50 | 360.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_7e0340c39f978976f1cb8d1c9762977e.svg) | 1-[(2R)-1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-4-(trifluoromethyl)phenyl]piperazin-1-yl]-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl]pyrrolidin-2-one | Ki | 4.5 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_799f5962afce8c0e15ead3d1d2ebe907.svg) | N-[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-6-(4-butyltriazol-1-yl)hexanamide | Ki | 350.0 [1], 990.0 [2], 1900.0 [3] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_74587bc665f8d77ba2c62e2b0367a88b.svg) | 3-Amino-N-[(2R)-3-(2,4-dichlorophenyl)-1-[4-[1-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]cyclohexyl]piperazin-1-yl]-1-oxopropan-2-yl]propanamide | Ki | 2.8 [1], 4.2 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_eaf136d7d0562927ceed95ac2310ad27.svg) | 5-[[2-[4-[3-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-oxopropyl]triazol-1-yl]acetyl]amino]-2-[[2-[[2-[4-[3-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-oxopropyl]triazol-1-yl]acetyl]amino]acetyl]amino]-2-[3-[[2-[4-[3-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-oxopropyl]triazol-1-yl]acetyl]amino]propyl]-N-(3-amino-3-oxopropyl)pentanamide | IC50 | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_eaf136d7d0562927ceed95ac2310ad27.svg) | 5-[[2-[4-[3-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-oxopropyl]triazol-1-yl]acetyl]amino]-2-[[2-[[2-[4-[3-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-oxopropyl]triazol-1-yl]acetyl]amino]acetyl]amino]-2-[3-[[2-[4-[3-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-oxopropyl]triazol-1-yl]acetyl]amino]propyl]-N-(3-amino-3-oxopropyl)pentanamide | Ki | 4.3 [1], 11.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_1e0f4b5a6a29bfc3a9b463de5da5d7f2.svg) | [(3R,4S)-4-(4-Chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[[(3-fluoro-4-methoxyphenyl)methylamino]methyl]cyclohexyl]piperazin-1-yl]methanone | IC50 | 48.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_1e0f4b5a6a29bfc3a9b463de5da5d7f2.svg) | [(3R,4S)-4-(4-Chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[1-[[(3-fluoro-4-methoxyphenyl)methylamino]methyl]cyclohexyl]piperazin-1-yl]methanone | Ki | 0.5 [1], 540.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_a9e69c98b7b2cbf0f46343f44815ac5a.svg) | N-[(2R)-3-(2,4-Dichlorophenyl)-1-[4-[2-(1-hydroxy-3-methylbutyl)phenyl]piperazin-1-yl]-1-oxopropan-2-yl]-2-(methylamino)acetamide | IC50 | 420.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_a9e69c98b7b2cbf0f46343f44815ac5a.svg) | N-[(2R)-3-(2,4-Dichlorophenyl)-1-[4-[2-(1-hydroxy-3-methylbutyl)phenyl]piperazin-1-yl]-1-oxopropan-2-yl]-2-(methylamino)acetamide | Ki | 8.3 [1], 500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_929df89068bba8b7ac2bf52ef8338a85.svg) | (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | Ki | 22.0 [1], 87.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_ee08b8426afc4144617472414e1c4428.svg) | (2S,5R,8S,11S,18S)-N-[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-benzyl-8-[3-(diaminomethylideneamino)propyl]-2-(1H-imidazol-5-ylmethyl)-3,6,9,15,19-pentaoxo-18-(pentanoylamino)-1,4,7,10,14-pentazacyclononadecane-11-carboxamide | Ki | 365.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_84af465f617a7ad770a4c02f151e268c.svg) | (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-12-(2-aminoethyl)-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,19-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | Ki | 4.0 [1], 35.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_1ba69baf5ecd4fa9645263bfc1553e22.svg) | Bremelanotide | Ki | 0.25 [1], 24.55 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_969fbe3fd395bcf3d6a0021b2faeb769.svg) | Ac-His-Phe-Arg-Trp-NH2 | Ki | 246.0 [1], 280.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_8ac5d95ac1e49aec96df16a782cbd4ae.svg) | N-[2-[(1R)-1'-[(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]propan-2-yl]acetamide | IC50 | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_f0949ee8aef541411b08cb5b05fa5e2a.svg) | (3S)-4-[4-[2-[1-[Acetyl(ethyl)amino]ethyl]phenyl]piperazin-1-yl]-3-[(4-chlorophenyl)methyl]-N-cyclobutyl-4-oxobutanamide | IC50 | 5.8 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_f0949ee8aef541411b08cb5b05fa5e2a.svg) | (3S)-4-[4-[2-[1-[Acetyl(ethyl)amino]ethyl]phenyl]piperazin-1-yl]-3-[(4-chlorophenyl)methyl]-N-cyclobutyl-4-oxobutanamide | Ki | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_492074ff561fef08f8903bf532af833f.svg) | (2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2R)-2-[[(2S)-2-(butanoylamino)-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanamide | IC50 | 150.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_5d92e85f4b57ca159facb980ffb465f1.svg) | (3S)-3-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-[[(2S)-1-[[(2S)-1-(carboxymethylamino)-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_3f5671bd3fd05579f8b46df9c30691a1.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-[4-[2-(methanesulfonamido)phenyl]piperazin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_f86e8c89e82cfb01c5748071fc8d1105.svg) | 3-[4-[2-(4-Fluorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]piperazin-1-yl]-2-methyl-1-phenylpropan-1-one | IC50 | 52.0 [1], 217.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_f2a7757b76a9b20954c848515647492b.svg) | N-(3-Amino-propyl)-3-[(1H-indol-3-ylmethyl)-amino]-2-[(naphthalen-2-ylmethyl)-amino]-propionamide | Ki | 25118.86 [1], 27000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_158477bb076d3d0774ff5c27375d4ca8.svg) | 1-[4-[4-[4-Fluoro-beta-(4-isopropylpiperazino)phenethyl]piperazino]butyl]-2-methoxynaphthalene | IC50 | 12.7 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_158477bb076d3d0774ff5c27375d4ca8.svg) | 1-[4-[4-[4-Fluoro-beta-(4-isopropylpiperazino)phenethyl]piperazino]butyl]-2-methoxynaphthalene | Ki | 7.9 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_e26eaab13c828c579bded59046689b7b.svg) | N-[(2R)-1-[[(2S)-1-[[(2S)-1-[(2-Amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-5-bromo-2-(pentanoylamino)-3,4-dihydro-1H-naphthalene-2-carboxamide | IC50 | 105.0 [1], 200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_e99b9e52ca1b68f90fc9afbb9cf9bee6.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-[4-cyclohexyl-4-[(2-methyltetrazol-5-yl)methyl]piperidin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | IC50 | 1.2 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_e99b9e52ca1b68f90fc9afbb9cf9bee6.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-[4-cyclohexyl-4-[(2-methyltetrazol-5-yl)methyl]piperidin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 1.2 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_da2890cb6b9512c0f31d76831bf9b551.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-[4-cyclohexyl-4-(2H-tetrazol-5-ylmethyl)piperidin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | IC50 | 238.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_3eaa060da8e97e91d3bec1feb769b0b2.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-[4-cyclohexyl-4-[(1-methyltetrazol-5-yl)methyl]piperidin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | IC50 | 0.3 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_6231609b0e806a369ff4defd5d3bfbd9.svg) | N-[(2R)-3-(4-Chlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]piperidine-3-carboxamide | Ki | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_28b5e0089b656d9be925b875a71e8ac4.svg) | N-[2-[(1S)-1'-[(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]propan-2-yl]acetamide | IC50 | 4.3 [1], 4.5 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_39666c99c16a5e4ac1831d66bc2d323a.svg) | 2-Amino-N-[(2R)-3-(4-chlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]acetamide | Ki | 44.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_9ecaf57b1e0303cfd00f6514d4384e26.svg) | N-[(2R)-3-(4-Chlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]-2-methoxyacetamide | Ki | 69.5 [1], 70.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_44702657e7c079f998d31eec130921c6.svg) | (2R)-1-[4-[2-[(1S)-1-Amino-2-methylpropyl]-4-methylphenyl]piperazin-1-yl]-3-(4-chloro-2-fluorophenyl)-2-methylpropan-1-one | Ki | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_b20192764dbf2567cb374f887f4bb239.svg) | (2R)-1-[4-[2-[(1S)-1-Amino-2-methylpropyl]-4-methylphenyl]piperazin-1-yl]-3-(4-chloro-2-methylphenyl)-2-methylpropan-1-one | Ki | 9.7 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_3b12625e6dadbecc251074adde34dc61.svg) | [4-[2-[(1S)-1-Amino-2-methylpropyl]-4-methylphenyl]piperazin-1-yl]-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidin-3-yl]methanone | Ki | 11.0 [1], 12.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_8cc0cf4fa9d12a6b3d9c85a3de0583bf.svg) | (2S)-2-Amino-5-(diaminomethylideneamino)-N-(naphthalen-1-ylmethyl)-N-(naphthalen-2-ylmethyl)pentanamide | Ki | 2100.0 [1], 5011.87 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-4_502596636d1b5b0f3aaa6ea2c1cf0827.svg) | (2S)-5-(Diaminomethylideneamino)-N-[3-(diaminomethylideneamino)propyl]-2-(naphthalen-2-ylmethylamino)pentanamide | Ki | 30000.0 [1], 31622.78 [2] |