![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_ab3a6ed7fae6692e5b0014d4e91815cf.svg) | Melanotan II | IC50 | 0.2 [1], 0.25 [2], 0.4 [3], 6.7 [4] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_ab3a6ed7fae6692e5b0014d4e91815cf.svg) | Melanotan II | Ki | 0.11 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_125e9ccf1d0c6298e431c20db084fd62.svg) | Thiq | IC50 | 2063.0 [1], 2067.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_125e9ccf1d0c6298e431c20db084fd62.svg) | Thiq | Ki | 300.0 [1], 760.0 [2], 1500.0 [3], 5000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_62aee3ef1fc3e473cda1780733f00927.svg) | Melanotan-1 | IC50 | 0.51 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_62aee3ef1fc3e473cda1780733f00927.svg) | Melanotan-1 | Ki | 0.05 [1], 0.5 [2], 1.8 [3] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_553f211bad3c5350fc925b7dad4a3cbe.svg) | Msh, 2-tyr-alpha- | IC50 | 0.4 [1], 5.97 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_553f211bad3c5350fc925b7dad4a3cbe.svg) | Msh, 2-tyr-alpha- | Ki | 1.5 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_c7269a89bf773de9ef633fb91fcbe50b.svg) | Ac-Tyr-D-Phe-Arg-2-Nal-NHCH3 | Ki | 4520.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_1ba69baf5ecd4fa9645263bfc1553e22.svg) | Bremelanotide | Ki | 1.91 [1], 6.4 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_ca2e32d822e5dffd4c916c4f346ca9aa.svg) | Ac-His-DPhe-Arg-Trp-NH2 | IC50 | 105.0 [1], 615.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_969fbe3fd395bcf3d6a0021b2faeb769.svg) | Ac-His-Phe-Arg-Trp-NH2 | Ki | 35.0 [1], 37.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_40f8654c54214f641f785c708d75fa84.svg) | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-[[(2S)-1-[[(2S)-1-(carboxymethylamino)-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_492074ff561fef08f8903bf532af833f.svg) | (2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2R)-2-[[(2S)-2-(butanoylamino)-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanamide | IC50 | 580.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_8593bb0bfca09a5d3484e6e49c015ed4.svg) | 3-Amino-N-[(2R)-3-(4-chlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]propanamide | Ki | 1300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_f2a7757b76a9b20954c848515647492b.svg) | N-(3-Amino-propyl)-3-[(1H-indol-3-ylmethyl)-amino]-2-[(naphthalen-2-ylmethyl)-amino]-propionamide | Ki | 630.96 [1], 700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_62694b679532a93af6984473413f1b81.svg) | (2R)-1-[4-[2-[(1S)-1-Amino-3-methylbutyl]-4-methylphenyl]piperazin-1-yl]-3-(4-chlorophenyl)-2-methylpropan-1-one | Ki | 3100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_8cc0cf4fa9d12a6b3d9c85a3de0583bf.svg) | (2S)-2-Amino-5-(diaminomethylideneamino)-N-(naphthalen-1-ylmethyl)-N-(naphthalen-2-ylmethyl)pentanamide | Ki | 630.96 [1], 1200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_502596636d1b5b0f3aaa6ea2c1cf0827.svg) | (2S)-5-(Diaminomethylideneamino)-N-[3-(diaminomethylideneamino)propyl]-2-(naphthalen-2-ylmethylamino)pentanamide | Ki | 3981.07 [1], 4500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_aa4742aa5168f5244c1ca345b3902e87.svg) | Ac-His-D-Phe-Arg-2-Nal-NHCH3 | Ki | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_cde1b618ac069b62d505312caa28fc34.svg) | (2S)-2-[[(2R)-2-Amino-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)-N-[(2S)-1-(methylamino)-3-naphthalen-2-yl-1-oxopropan-2-yl]pentanamide | Ki | 4384.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_986cf63e928f54c857813662b0972e56.svg) | (2S)-2-[(3S)-3-(2-Aminoethyl)-4-[(2R)-2-amino-3-(4-fluorophenyl)propanoyl]-2-oxopiperazin-1-yl]-N-methyl-3-naphthalen-2-ylpropanamide | Ki | 5820.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_5236d6db74c9d3e951870db60a08673c.svg) | (2S)-2-[(3S)-4-[(2R)-2-Amino-3-(4-fluorophenyl)propanoyl]-3-[2-(diaminomethylideneamino)ethyl]-2-oxopiperazin-1-yl]-N-methyl-3-naphthalen-2-ylpropanamide | Ki | 1120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_ba9e5ed5f94c482dc8ac5a2e82785eff.svg) | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 0.5 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_e7c6516f01c9ed7837fe17d06846c68d.svg) | N-[2-[(2-Amino-2-oxoethyl)-[(1R)-1-phenylethyl]amino]-2-oxoethyl]-N-benzhydryl-2-[3-(diaminomethylideneamino)propylamino]acetamide | IC50 | 9100.0 [1], 25000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_87315f1b5449d4a03c0789b71fcdbe3a.svg) | (3S,6S,9R,12S,15S,23S)-15-[[(2R)-2-Acetamidohexanoyl]amino]-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | IC50 | 8.7 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_eba46ead8cff5ec0fe7f64b2abf64d7d.svg) | (3S,6S,9R,12S,15S,23S)-15-[[(2R)-2-Acetamidohexanoyl]amino]-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-7,13-dimethyl-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | IC50 | 4.0 [1], 14.8 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_4181c77754dcef8d56ef702fee73dfe3.svg) | (3S,6S,9R,12S,15S,23S)-15-[[(2R)-2-Acetamidohexanoyl]amino]-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-1,4,7,13-tetramethyl-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | IC50 | 8.7 [1], 9.9 [2] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_fe0cca5b57b3677fe0f10fce2e189752.svg) | CID 137659949 | IC50 | 26000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_fe0cca5b57b3677fe0f10fce2e189752.svg) | CID 137659949 | Ki | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_57b2ff41014e8bbf0c48f002958fa034.svg) | (2S,5R,8S,11S,14S,22S)-22-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-2-(2-amino-2-oxoethyl)-5-benzyl-8-[3-(diaminomethylideneamino)propyl]-11-(1H-indol-3-ylmethyl)-3,6,9,12,19,23-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-14-carboxamide | Ki | 155.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_c438806097af417214dd2a35a103ab5f.svg) | (2S,5R,8S,11S,14S,22S)-22-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-2-(2-amino-2-oxoethyl)-5-benzyl-8-[3-(diaminomethylideneamino)propyl]-11-(1H-indol-3-ylmethyl)-3,6,9,12,17,23-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-14-carboxamide | Ki | 688.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_89fa084fb52ccbfcfbc94a4c241a233d.svg) | (2S,5R,8S,11S,14S,22S)-22-[[(2R)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-2-(3-amino-3-oxopropyl)-5-benzyl-8-[3-(diaminomethylideneamino)propyl]-11-(1H-indol-3-ylmethyl)-3,6,9,12,17,23-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-14-carboxamide | Ki | 120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_aeaee47d89ef05c4d35ac279562c9c9a.svg) | (2S,5R,8S,11S,14S,22S)-22-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-2-(3-amino-3-oxopropyl)-5-benzyl-8-[3-(diaminomethylideneamino)propyl]-11-(1H-indol-3-ylmethyl)-3,6,9,12,17,23-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-14-carboxamide | Ki | 130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_5fb5aa3b347386d9448d13153d1ed3ae.svg) | (3S,6S,9R,12S,15S,23S)-15-[[(2R)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-12-(3-amino-3-oxopropyl)-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | Ki | 3350.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_f63cfa1ff06e6963a7a9981284603927.svg) | (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-12-(3-amino-3-oxopropyl)-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,19-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | Ki | 133.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_3c74a96e01e649e6c8d9eb7cac731ea0.svg) | (2S,5R,8S,11S,14S,22S)-22-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-2-(2-amino-2-oxoethyl)-5-benzyl-8-[3-(diaminomethylideneamino)propyl]-11-(1H-indol-3-ylmethyl)-3,6,9,12,16,23-hexaoxo-1,4,7,10,13,17-hexazacyclotricosane-14-carboxamide | Ki | 240.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_e1a51331cbbcb6f150c5a18e133b5c8d.svg) | (2S,5R,8S,11S,14S,22S)-22-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-2-(2-amino-2-oxoethyl)-5-benzyl-8-[3-(diaminomethylideneamino)propyl]-11-(naphthalen-2-ylmethyl)-3,6,9,12,16,23-hexaoxo-1,4,7,10,13,17-hexazacyclotricosane-14-carboxamide | Ki | 255.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_134a969281bfd313cbfb15d1d60e6a60.svg) | (2S,5R,8S,11S,14S,22S)-22-[[(2R)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-2-(2-amino-2-oxoethyl)-5-benzyl-8-[3-(diaminomethylideneamino)propyl]-11-(1H-indol-3-ylmethyl)-3,6,9,12,17,23-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-14-carboxamide | Ki | 840.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_c3190556ba483b8a1dbb794123ec2b15.svg) | (2S,5R,8S,11S,14S,22S)-22-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-2-(2-amino-2-oxoethyl)-5-benzyl-8-[3-(diaminomethylideneamino)propyl]-11-(1H-indol-3-ylmethyl)-3,6,9,12,18,23-hexaoxo-1,4,7,10,13,17-hexazacyclotricosane-14-carboxamide | Ki | 295.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_591c07f4f67e00e1ee4c74d154d83e0e.svg) | (3S,6S,9R,12S,15R,23S)-15-[[(2R)-2-Acetamidohexanoyl]amino]-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_32013b081cee3ea68c1cd09385a7b6ae.svg) | N-(1-Naphthylmethyl)-N-(2-naphthylmethyl)amine | Ki | 1000000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_4c4ac6957f2a2b7020f5f0fa5fbb30ae.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 6000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_c98c154e663dba1c9eda009a01679c77.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-oxo-1-[4-[2-[1-(piperidin-3-ylamino)ethyl]phenyl]piperazin-1-yl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 1500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_cf7c3983f29f3036f2afc9e473285353.svg) | (2S)-2-[[(2R)-2-Acetamido-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_8ac5d95ac1e49aec96df16a782cbd4ae.svg) | N-[2-[(1R)-1'-[(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]propan-2-yl]acetamide | IC50 | 1938.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_f9c30893478e7cd68c36fddd90e36b8c.svg) | 3-Amino-N-[(2R)-3-(2,4-dichlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]propanamide | Ki | 4200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_8d503e9352bfbd1e7e4b6cb8a2a92563.svg) | (3R)-N-[(2R)-1-[4-[2-(Aminomethyl)phenyl]piperazin-1-yl]-3-(4-chlorophenyl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 27.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_07b518ebd0aecb1816ca7e1377dfc753.svg) | Ac-His-Phe-Arg-DTrp-NH2 | IC50 | 6347.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_74feea8bf55fb43a8ae503fb75e425c4.svg) | (2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide | Ki | 51.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_1651dd7cb5a28f64b47ef449bb1c12b8.svg) | (2S)-N-[(2R)-1-[4-(Tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-4-methylpiperazine-2-carboxamide | IC50 | 1700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_fdd7832abd3550504747205700e945cc.svg) | (2S)-2-Amino-N-[(2R)-1-(4-butanoyl-4-phenylpiperidin-1-yl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-3-(3-methylimidazol-4-yl)propanamide | IC50 | 120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_3f5671bd3fd05579f8b46df9c30691a1.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-[4-[2-(methanesulfonamido)phenyl]piperazin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 12000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_e26eaab13c828c579bded59046689b7b.svg) | N-[(2R)-1-[[(2S)-1-[[(2S)-1-[(2-Amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-5-bromo-2-(pentanoylamino)-3,4-dihydro-1H-naphthalene-2-carboxamide | IC50 | 4900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_7edfe41e125b8ced8dce58842dbd01c7.svg) | 1-[(2R)-2-[[(1S,2S)-1-Amino-1,2,3,4-tetrahydronaphthalene-2-carbonyl]amino]-3-(4-chlorophenyl)propanoyl]-N-tert-butyl-4-cyclohexylpiperidine-4-carboxamide | IC50 | 530.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_9b49fc0e3a4ca663a18c15b5bb416d95.svg) | (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-Acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-[(1R)-1-(1H-indol-3-yl)ethyl]-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_6231609b0e806a369ff4defd5d3bfbd9.svg) | N-[(2R)-3-(4-Chlorophenyl)-1-oxo-1-[4-[2-[(2-thiophen-2-ylethylamino)methyl]phenyl]piperazin-1-yl]propan-2-yl]piperidine-3-carboxamide | Ki | 2300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_ff408d4ff63f78dae298fc953b40f3a1.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-[4-[2-[(dimethylamino)methyl]phenyl]piperazin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_92e9389156d5cb7333154d61504c1108.svg) | 2-(1H-Indol-3-yl)-N-(1H-indol-3-ylmethyl)ethanamine | Ki | 32000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_3cade8ea4b6d59f584abffc733de073f.svg) | N-[(1S)-1-[2-[4-[(2R)-3-(2,4-Dichlorophenyl)-2-(2-oxopyrrolidin-1-yl)propanoyl]piperazin-1-yl]-5-methylphenyl]-3-methylbutyl]-3-(dimethylamino)propanamide | Ki | 8400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_3b12625e6dadbecc251074adde34dc61.svg) | [4-[2-[(1S)-1-Amino-2-methylpropyl]-4-methylphenyl]piperazin-1-yl]-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidin-3-yl]methanone | Ki | 3350.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_8a5242169df28468148780ffc2975cae.svg) | (2S)-2-[[(2S)-6-Amino-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]butanedioic acid | Ki | 0.89 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_74587bc665f8d77ba2c62e2b0367a88b.svg) | 3-Amino-N-[(2R)-3-(2,4-dichlorophenyl)-1-[4-[1-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]cyclohexyl]piperazin-1-yl]-1-oxopropan-2-yl]propanamide | Ki | 5700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_5c7a91dfa8a3986012ba5b7f59108cbf.svg) | (1R,4S,6R)-N-[(2R)-1-[4-(Tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide | IC50 | 750000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_ddd18604df991fafc2e78e80231652a6.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-[4-[2-(diethylamino)-1-(2-fluorophenyl)ethyl]piperazin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 5800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_eba51d83cdf9c7d50f9d099872895fef.svg) | (2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-2-[[(2R)-2-[[(2S)-2-(butanoylamino)-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanamide | IC50 | 600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_b5829df3ba5ed53e0108c2646ae7f153.svg) | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]acetyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 0.3 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_c5e0d4f1439e1e9cc10e75c9d26b1fce.svg) | (2S)-2-[[(2R)-2-Acetamido-3-phenylpropanoyl]amino]-N-[(2R)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_5f8bfdfb0c060435c65d8f639a8cb6b0.svg) | N-[(2R)-1-[[(2S)-1-[[(2S)-1-[(2-Amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-1-(pentanoylamino)-4-phenylcyclohexane-1-carboxamide | IC50 | 7100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_cd06e11421b092a85c465cd92c77a3c4.svg) | (2S)-N-[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)-2-[[(2R)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-(4-phenylbutanoylamino)propanoyl]amino]-3-phenylpropanoyl]amino]pentanamide | Ki | 0.17 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_d49cbeb4e4f2cf0599eac55373c7e5a3.svg) | N-[2-[4-[(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N-propan-2-ylmethanesulfonamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_247457c53f66edf57691632ed390e4e3.svg) | 2-(4-Acetylanilino)-N,N-bis(3-methylbutyl)-3-(3-piperidin-1-ylpropyl)benzimidazole-5-carboxamide | Ki | 5200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_9729d0298939ffa1ba1c0a8ebac67699.svg) | (3S,9S,17S,20S,23S,26R,29S)-9-[[(2S)-2-Acetamidohexanoyl]amino]-26-benzyl-23-[3-(diaminomethylideneamino)propyl]-20-(1H-indol-3-ylmethyl)-2,8,11,19,22,25,28-heptaoxo-1,7,12,18,21,24,27-heptazatricyclo[27.3.0.03,7]dotriacontane-17-carboxamide | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_840a94ab6e497becf182424d0e8d76ec.svg) | (3S,9S,17S,20S,23S,26R,29S)-9-[[(2S)-2-Acetamidohexanoyl]amino]-23-[3-(diaminomethylideneamino)propyl]-20-(1H-indol-3-ylmethyl)-26-(naphthalen-2-ylmethyl)-2,8,11,19,22,25,28-heptaoxo-1,7,12,18,21,24,27-heptazatricyclo[27.3.0.03,7]dotriacontane-17-carboxamide | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_0f3cdf0b7b53aa0f10d3e06b4d9066e8.svg) | 1-[(2R)-2-[(1-Amino-2,3-dihydro-1H-indene-2-carbonyl)amino]-3-(4-chlorophenyl)propanoyl]-N-tert-butyl-4-cyclohexylpiperidine-4-carboxamide | IC50 | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_c9284546c23474ae44e1247465359bfe.svg) | N-[(2R)-3-(4-Chlorophenyl)-1-[4-[2-(diethylamino)-1-(2-fluorophenyl)ethyl]piperazin-1-yl]-1-oxopropan-2-yl]-2-(1-methyl-2,3-dihydroisoindol-1-yl)acetamide | Ki | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_0720ab69c2b05d48890302f78c9490ba.svg) | N-[(2R)-1-[[(2S)-1-[[(2S)-1-[(2-Amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-4-(4-ethoxyphenyl)-1-(pentanoylamino)cyclohexane-1-carboxamide | IC50 | 4700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_f2b98bdec9bcc4bb102fe5f56d7ddfaa.svg) | N-[(2R)-3-(4-Chlorophenyl)-1-[4-[2-(diethylamino)-1-(2-fluorophenyl)ethyl]piperazin-1-yl]-1-oxopropan-2-yl]-2-(2,3-dihydro-1H-isoindol-1-yl)acetamide | Ki | 6000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_70592de80823bc7f6ca546e3888683b3.svg) | N-[2-[4-[(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N-propan-2-ylacetamide | IC50 | 1800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_b8c665c949250608df3102f52c37ecbb.svg) | N-[(2R)-3-(4-Chlorophenyl)-1-oxo-1-[4-[(1R,2R)-2-(1,2,4-triazol-1-yl)cyclohexyl]piperazin-1-yl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 2000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_86086859919388b3dcf6c34c3262bc14.svg) | 1-[(2R)-2-[[(1S,2S)-1-Amino-1-methyl-3,4-dihydro-2H-naphthalene-2-carbonyl]amino]-3-(4-chlorophenyl)propanoyl]-N-tert-butyl-4-cyclohexylpiperidine-4-carboxamide | IC50 | 620.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_e19270f7781774a908dc610ead7f23cc.svg) | N-[(2R)-3-(4-Chlorophenyl)-1-[4-[2-(diethylamino)-1-(2-fluorophenyl)ethyl]piperazin-1-yl]-1-oxopropan-2-yl]-1,1-dimethyl-3,4-dihydro-2H-isoquinoline-3-carboxamide | Ki | 7000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_97a1cff155a4de0b6e9a3b9899e68d41.svg) | N-[(2R)-3-(4-Chlorophenyl)-1-[4-[2-(diethylamino)-1-(2-fluorophenyl)ethyl]piperazin-1-yl]-1-oxopropan-2-yl]isoquinoline-3-carboxamide | Ki | 7000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_0d15a009ad47cc5b36026b2d79a754c4.svg) | 1-[(2R)-2-[(5-Amino-6,7,8,9-tetrahydro-5H-benzo[7]annulene-6-carbonyl)amino]-3-(4-chlorophenyl)propanoyl]-N-tert-butyl-4-cyclohexylpiperidine-4-carboxamide | IC50 | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_9f2a0927701a42b0fabdbdbca236e607.svg) | (3R)-N-[(2R)-3-(4-Chlorophenyl)-1-[4-[2-(imidazol-1-ylmethyl)phenyl]piperazin-1-yl]-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | Ki | 4000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_d6bae66e8aca188c6489dfc1771b81f7.svg) | N-[(2R)-1-[[(2S)-1-[[(2S)-1-[(2-Amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-5-(dimethylamino)-2-(pentanoylamino)-3,4-dihydro-1H-naphthalene-2-carboxamide | IC50 | 25500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_ba5e93b460f5d37f2b1024c295401106.svg) | (3S,6S,9S,12S,15S,18S,26S)-18-[[(2S)-2-Acetamidohexanoyl]amino]-12-benzyl-9-[3-(diaminomethylideneamino)propyl]-15-(1H-imidazol-5-ylmethyl)-6-(1H-indol-3-ylmethyl)-3-methyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,21-heptazacyclohexacosane-26-carboxamide | IC50 | 22.4 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_ba043b56c48c9637e9a92e4159fdaa31.svg) | (3R,5R)-N-[(2R)-1-[4-(Tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide | IC50 | 2100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_9c22508d245a277793636dd7d17b6a35.svg) | (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-Acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-[(1S)-1-(1H-indol-3-yl)ethyl]-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | IC50 | 0.5 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_22675f062c7b8c52f56269975d1c90d6.svg) | (3R,6S,9R,12S,15S,23S)-15-[[(2S)-2-Acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-[(1S)-1-(1H-indol-3-yl)ethyl]-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide | IC50 | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_2696ad46aec30453a23c257555e91cac.svg) | (2R)-2-Amino-N-[(2R)-1-(4-butanoyl-4-phenylpiperidin-1-yl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-3-(1H-imidazol-5-yl)propanamide | IC50 | 32.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_d60798f71974083078232cfcc14e5c7a.svg) | 4-[[N-Cyclohexyl-C-[(2R,5S)-2,5-dimethylpiperazin-1-yl]carbonimidoyl]amino]-N-[2-(2,4-dichlorophenyl)ethyl]benzamide | Ki | 360.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_7b71eef8922610da48b30de490623883.svg) | (2S,4R)-N,4-Dibenzyl-1-[(2S)-5-(diaminomethylideneamino)-2-[(2-naphthalen-1-ylacetyl)amino]pentanoyl]pyrrolidine-2-carboxamide | Ki | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_39efa827757b7f18f3b6488dd4132e70.svg) | 4-[(N-Cyclohexyl-C-piperazin-1-ylcarbonimidoyl)amino]-N-[2-(2,4-dichlorophenyl)ethyl]benzamide | Ki | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_b4f6e3f016d2af8c32c8ad3d7e71ef08.svg) | 4-[(N'-Cyclohexyl-N-pyrrolidin-3-ylcarbamimidoyl)amino]-N-[2-(2,4-dichlorophenyl)ethyl]benzamide | Ki | 1900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_7ebd5542042c3b04efc387a2a4e55918.svg) | (2S,5S,8R,11S,14S,17S)-5-(3-Amino-3-oxopropyl)-2-butyl-11-[3-(diaminomethylideneamino)propyl]-14-(1H-indol-3-ylmethyl)-8-(naphthalen-2-ylmethyl)-3,6,9,12,15,20-hexaoxo-1,4,7,10,13,16-hexazacycloicosane-17-carboxamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_587ccfc34183ed6adf74e84e831af8de.svg) | 3-[(2S,5S,8R,11S,14S,17S)-2-Butyl-17-carbamoyl-11-[3-(diaminomethylideneamino)propyl]-14-(1H-indol-3-ylmethyl)-8-(naphthalen-2-ylmethyl)-3,6,9,12,15,20-hexaoxo-1,4,7,10,13,16-hexazacycloicos-5-yl]propanoic acid | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_234e7067d3a7444db14610bbd28d3bcf.svg) | c[Nle-His-D-Phe-Arg-Trp-Glu]-NH2 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_c536873f6fa0db46480e44c259b16bc0.svg) | c[Nle-Val-D-Phe-Arg-Trp-Glu]-NH2 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/melanocortin-receptor-1_3e496474f771ed49eed1f46130832e59.svg) | c[Nle-Asp-D-Phe-Arg-Trp-Glu]-NH2 | IC50 | 10000.0 [1] |