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Melanin-concentrating hormone receptor 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[6-[(Dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)benzamideIC505.5 [1], 43.0 [2], 85.0 [3], 872.0 [4]
N-[6-[(Dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)benzamideKi5.5 [1], 38.0 [2]
N-(4-Methyl-2-(4-methylpiperazin-1-yl)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamideIC5025.0 [1], 29.0 [2]
8-(Cyclohexylmethoxy)quinolin-2-amineIC5090.0 [1]
6-(4-Chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)thieno[3,2-d]pyrimidin-4(3H)-oneIC500.5 [1], 16.0 [2], 89.13 [3]
6-(4-Chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)thieno[3,2-d]pyrimidin-4(3H)-oneKi2.8 [1]
7-Fluorochromone-2-carboxamideIC503.0 [1], 29.0 [2]
N-[6-[3-(Methylamino)pyrrolidin-1-yl]pyridin-3-yl]-4-phenylbenzamideIC5012.0 [1]
N-[6-[3-(Methylamino)pyrrolidin-1-yl]pyridin-3-yl]-4-phenylbenzamideKi2.3 [1], 5.2 [2], 61.0 [3], 122.0 [4]
(E)-N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamideIC5016.0 [1], 19.0 [2], 144.0 [3]
TC-MCH 7cIC505.6 [1], 23.0 [2]
2-(4-(Benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-6-yl)acetamideIC501.4 [1], 11.0 [2]
2-(3-Chlorophenoxy)-N-[1-[[1-[4-(trifluoromethyl)phenyl]pyrrol-3-yl]methyl]piperidin-4-yl]acetamideIC5029.0 [1], 32.0 [2]
MCH-1 antagonist 1IC5014.0 [1]
MCH-1 antagonist 1Ki2.6 [1]
4-(4-Fluorophenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamideIC500.54 [1], 2.8 [2]
8-(1,3,3-Trimethyl-butoxy)-quinolin-2-ylamineIC5041.0 [1], 50.0 [2], 210.0 [3], 211.0 [4]
2-(2,4-Dichlorophenoxy)-N-[4-methyl-2-(4-methylpiperazino)-6-quinolyl]acetamideIC506.4 [1], 10.0 [2], 24.0 [3], 89.0 [4]
N-[3-(2-Amino-quinolin-8-yloxy)-propyl]-3-chloro-benzamideIC500.4 [1], 3.0 [2], 7.0 [3]
N-(4-Methyl-2-morpholin-4-ylquinolin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamideIC501.6 [1], 12.0 [2], 50.0 [3], 82.0 [4]
N-(1-(3-Fluoro-4-methoxybenzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamideIC5024.0 [1], 168.0 [2]
8-[3-(4-Chloro-3-trifluoromethyl-benzylamino)-propoxy]-quinolin-2-ylamineIC505.0 [1], 220.0 [2]
4-(4-Fluorophenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamideIC501.9 [1], 7.9 [2], 17.0 [3]
4-Bromo-N-[[4-[[[4-(dimethylamino)quinazolin-2-yl]amino]methyl]cyclohexyl]methyl]-2-(trifluoromethoxy)benzenesulfonamideIC50140.0 [1], 160.0 [2], 200.0 [3]
1-[4-(3-Cyanophenyl)phenyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]ureaKi1.8 [1], 8.9 [2]
1-[(1S,2R,5S)-5-(4-Cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[3-(4-methylpiperazin-1-yl)propyl]ureaKi2.7 [1]
2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-acetamideIC5050.0 [1], 58.0 [2], 71.0 [3]
1-[4-[2-(Aminomethyl)-1,3-thiazol-5-yl]cyclohex-3-en-1-yl]-3-(3-chloro-4-fluorophenyl)-1-(2-pyrrolidin-1-ylethyl)ureaKi13.0 [1]
3-(3-Chloro-4-fluorophenyl)-1-[(3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]ureaKi7.9 [1], 9.0 [2]
4-[(4-Chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-oneIC5023.0 [1], 26.0 [2]
N-(4-Methyl-2-(pyrrolidin-1-yl)quinolin-6-yl)-2-(4-(trifluoromethyl)phenoxy)acetamideIC5010.0 [1], 15.0 [2]
2-(4-(Benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)acetamideIC50558.0 [1], 10000.0 [2]
N-[1-(1,3-Benzodioxol-5-ylmethyl)piperidin-4-yl]-7-methoxy-4-oxo-4H-chromene-2-carboxamideIC506.0 [1], 11.0 [2], 73.0 [3]
2-(4-(Benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-4-yl)acetamideIC5024.5 [1], 25.0 [2], 71.0 [3]
MCHr1 antagonist 2IC504.0 [1], 65.0 [2], 196.0 [3]
(4Ar,11R,11aS)-11-methyl-2-[3-(oxan-4-yl)propyl]-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazoleIC500.5 [1], 6.0 [2]
N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-5-chloro-2-[(thiazol-2-ylmethyl)amino]benzamideIC502.0 [1], 16.0 [2]
N-[1-(1,3-Benzodioxol-5-ylmethyl)piperidin-4-yl]-6,7-dichloro-4-oxochromene-2-carboxamideIC503.0 [1], 83.0 [2]
(3S)-N-[(3R)-1-(4,4-Dimethylcyclohexyl)pyrrolidin-3-yl]-N-methyl-3-[methyl-[5-[4-(trifluoromethyl)phenyl]thiophene-2-carbonyl]amino]pyrrolidine-1-carboxamideIC5012.0 [1]
(3S)-N-[(3R)-1-(4,4-Dimethylcyclohexyl)pyrrolidin-3-yl]-N-methyl-3-[methyl-[5-[4-(trifluoromethyl)phenyl]thiophene-2-carbonyl]amino]pyrrolidine-1-carboxamideKi2.0 [1], 1125.0 [2]
N-(1-(Benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-yl)-5-chloro-1H-indazol-3-amineIC5016.0 [1], 20.0 [2], 260.0 [3]
N-(1-(4-Acetamidobenzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamideIC501690.0 [1], 1700.0 [2], 10000.0 [3]
1-[(2S)-6-(Diethylaminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-[2-(4-fluorophenyl)ethyl]piperazin-2-oneIC5010.0 [1]
1-[(2S)-6-(Diethylaminomethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-[2-(4-fluorophenyl)ethyl]piperazin-2-oneKi3.0 [1], 15.0 [2]
AMG-076 free baseIC500.6 [1], 1.2 [2]
AMG-076 free baseKi0.6 [1]
N-[2-(2,5-Diazabicyclo[2.2.1]heptan-2-yl)-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamideIC501.9 [1], 9.7 [2], 16.0 [3]
N-[2-(4-Amino-piperidin-1-yl)-4-methyl-quinolin-6-yl]-2-(4-trifluoromethoxy-phenoxy)-acetamideIC501.5 [1], 3.5 [2], 14.0 [3]
(R)-N-(4-Methyl-2-(3-methylpiperazin-1-yl)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamideIC504.1 [1], 18.0 [2], 100.0 [3]
2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1-yl-quinolin-6-yl)-acetamideIC505.0 [1], 16.0 [2], 74.0 [3]
(E)-N-(2-[1,4]Diazepan-1-yl-4-methyl-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamideIC506.1 [1], 23.0 [2], 65.0 [3]
N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-trifluoromethoxy-phenyl)-ureido]-benzamideIC5050.0 [1], 150.0 [2], 260.0 [3]
(E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamideIC504.0 [1], 65.0 [2], 88.0 [3]
(E)-N-[2-[2-Hydroxyethyl(methyl)amino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamideIC500.9 [1], 5.2 [2], 41.0 [3]
2-(2,4-Dichlorophenoxy)-N-[2-[2-hydroxyethyl(methyl)amino]-4-methylquinolin-6-yl]acetamideIC502.1 [1], 11.0 [2], 43.0 [3]
2-(2,4-Dichlorophenoxy)-N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]acetamideIC505.9 [1], 9.4 [2], 66.0 [3]
2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-ethoxy)-4-methyl-quinolin-6-yl]-acetamideIC5085.0 [1], 180.0 [2], 1480.0 [3]
N-[4-Methyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamideIC501.5 [1], 7.1 [2], 7.5 [3]
(E)-N-[2-[(3R,5S)-3,5-Dimethylpiperazin-1-yl]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamideIC50100.0 [1], 409.0 [2], 1160.0 [3]
N-[2-[(1-Ethylpyrrolidin-2-yl)methylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamideIC508.7 [1], 21.0 [2], 109.0 [3]
N-[2-(3-Dimethylamino-propylamino)-4-methyl-quinolin-6-yl]-2-(4-trifluoromethoxy-phenoxy)-acetamideIC502.7 [1], 3.8 [2], 16.0 [3]
N-[2-[4-(2-Hydroxyethyl)piperazin-1-yl]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamideIC501.7 [1], 5.0 [2], 23.0 [3]
N-(4-Methyl-2-(2-morpholinoethylamino)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamideIC501.3 [1], 9.6 [2], 16.0 [3]
(E)-N-[2-[1-(Dimethylamino)propan-2-ylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamideIC504.3 [1], 22.0 [2], 98.0 [3]
(E)-N-[2-[2-(Dimethylamino)ethylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamideIC503.0 [1], 13.0 [2], 42.0 [3]
2-[[6-[[2-(2,4-Dichlorophenoxy)acetyl]amino]-4-methylquinolin-2-yl]-methylamino]ethyl acetateIC502.3 [1], 14.0 [2], 29.0 [3]
N-(4-Methyl-2-piperidin-1-ylquinolin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamideIC500.92 [1], 19.0 [2], 97.0 [3]
2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-morpholin-4-yl-quinolin-6-yl)-acetamideIC505.5 [1], 15.4 [2], 59.0 [3]
2-(3,4-Difluorophenyl)-N-ethyl-N-[3-(5-fluorospiro[1H-2-benzofuran-3,4'-piperidine]-1'-yl)propyl]-2-(4-methyl(35S)sulfonyl-2-oxopiperazin-1-yl)acetamideIC500.36 [1], 3.0 [2]
2-(3,4-Difluorophenyl)-N-ethyl-N-[3-(5-fluorospiro[1H-2-benzofuran-3,4'-piperidine]-1'-yl)propyl]-2-(4-methyl(35S)sulfonyl-2-oxopiperazin-1-yl)acetamideKi0.42 [1]
N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-trifluoromethyl-phenyl)-ureido]-benzamideIC5020.0 [1], 50.0 [2], 170.0 [3]
N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-phenoxy-phenyl)-ureido]-benzamideIC50140.0 [1], 720.0 [2], 880.0 [3]
2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-methylamino-ethyl)-amino]-quinolin-6-yl}-acetamideIC506.1 [1], 6.9 [2], 28.0 [3]
N-(2-(1,4-Diazepan-1-yl)-4-methylquinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamideIC502.0 [1], 12.0 [2], 71.0 [3]
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methylquinolin-6-yl)-3-p-tolylacrylamideIC5017.0 [1], 48.0 [2], 478.0 [3]
N-(4-Methyl-2-(4-methyl-1,4-diazepan-1-yl)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamideIC503.7 [1], 20.0 [2], 244.0 [3]
2-(4-Chlorophenoxy)-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methylquinolin-6-yl)acetamideIC5033.0 [1], 83.0 [2], 807.0 [3]
N-[2-[[3-(Dimethylamino)-2,2-dimethylpropyl]amino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamideIC504.7 [1], 16.0 [2], 192.0 [3]
N-(2-(1-Benzylpiperidin-4-ylamino)-4-methylquinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamideIC5013.0 [1], 40.0 [2], 91.0 [3]
N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]propanamideIC5014.0 [1], 40.0 [2], 724.0 [3]
N-(4-Methyl-2-(2-(piperidin-1-yl)ethylamino)quinolin-6-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamideIC500.91 [1], 5.3 [2], 33.0 [3]
N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-4-[4-(trifluoromethyl)phenyl]benzamideIC5010.0 [1], 63.0 [2], 474.0 [3]
N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-4-phenylbenzamideIC505.7 [1], 25.0 [2], 42.0 [3]
4-(4-Chlorophenyl)-N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]cyclohexane-1-carboxamideIC5023.0 [1], 393.0 [2], 423.0 [3]
N-[2-[3-(Dimethylamino)pyrrolidin-1-yl]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamideIC502.4 [1], 6.2 [2], 82.0 [3]
N-[2-[2-(Dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamideIC502.3 [1], 18.0 [2], 31.0 [3]
2-[2-[4-[(Dimethylamino)methyl]-2-methylphenyl]-2-oxoethyl]-5-[(5-methoxypyridin-2-yl)methoxy]pyridazin-3-oneIC5022.0 [1], 28.0 [2]
2-[2-[4-[(Dimethylamino)methyl]-2-methylphenyl]-2-oxoethyl]-5-[(5-methoxypyridin-2-yl)methoxy]pyridazin-3-oneKi14.0 [1]
Methyl (4S)-3-[3-[4-(3-acetamidophenyl)piperidin-1-yl]propylcarbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylateIC503.0 [1], 15.0 [2]
ATC-0175 free baseIC503.4 [1], 7.2 [2]
N-(1-(Naphthalen-2-ylmethyl)piperidin-4-yl)benzamideIC50948.0 [1]
N-(1-(Naphthalen-2-ylmethyl)piperidin-4-yl)benzamideKi347.0 [1]
CID 57521365IC501.1 [1], 2.9 [2]
6-(4-Chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-oneIC5013.0 [1], 16.0 [2]
1-[[4-(3-Cyanophenyl)phenyl]methyl]-3-(1-hydroxy-2-methylpropan-2-yl)-1-[2-[1-[(4-methylphenyl)methyl]piperidin-4-yl]ethyl]ureaKi43.65 [1]
N-{1-[(6-Fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamideIC50109.0 [1]
N-{1-[(6-Fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamideKi125.0 [1]
4-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-ylamino)-6-chloro-chromen-2-oneIC502.0 [1], 28.0 [2]
4-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-ylamino)-6-methoxy-chromen-2-oneIC502.0 [1], 11.0 [2]
1-[4-(3-Cyanophenyl)phenyl]-1-(1-cyclopentylpiperidin-4-yl)-3-(3,5-dichlorophenyl)ureaKi2.5 [1], 2.6 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Melanin-concentrating hormone receptor 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/melanin-concentrating-hormone-receptor-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Melanin-concentrating hormone receptor 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/melanin-concentrating-hormone-receptor-1-inhibitors-ic50-ki.
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