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Matrix metalloproteinase 12 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
IlomastatIC501.0 [1], 5.1 [2], 5.2 [3], 13.0 [4]
IlomastatKi0.52 [1], 3.8 [2]
2-[2-[4-(4-Methoxyphenyl)phenyl]sulfonylphenyl]ethanoic acidIC50140.0 [1], 150.0 [2], 170.0 [3]
Ageladine AIC503660.0 [1]
(4S)-5-Amino-4-[[(2S)-2-[[(2S)-2-[[(4-bromophenyl)-hydroxyphosphoryl]methyl]-3-[3-[4-(3-chlorophenyl)phenyl]-1,2-oxazol-5-yl]propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoic acidKi0.19 [1], 0.24 [2], 0.26 [3]
Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-CarboxylateIC5030000.0 [1], 100000.0 [2]
N-Hydroxy-2-{2-[4-(4-methoxy-phenoxy)benzenesulfonyl]-phenyl}acetamideIC500.2 [1], 0.85 [2], 0.89 [3]
cis-2-Aminocyclohexylcarbamoylphosphonic acidIC50100000.0 [1]
Mmp inhibitor IIKi0.61 [1], 1.9 [2]
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic AcidIC5030000.0 [1], 100000.0 [2]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)benzimidazol-1-yl]methyl]benzoyl]amino]oxane-3-carboxamideIC508000.0 [1]
N-({4'-[(1-Benzofuran-2-ylcarbonyl)amino]-1,1'-biphenyl-4-YL}sulfonyl)-L-valineIC5014.0 [1]
(2S)-2-[[8-(Methoxycarbonylamino)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acidIC502.0 [1]
(Biphenyl-4-sulfonylamino)-acetic acidIC50290.0 [1]
(Biphenyl-4-sulfonylamino)-acetic acidKi18000.0 [1]
(4-Benzylphenyl)methyl-[2-[[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]carbamoyl]-4-phenylbutyl]phosphinic acidIC508.13 [1], 8.2 [2]
2-Benzenesulfonylamino-N-[5-(4-fluoro-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi346.74 [1], 350.0 [2]
2-Benzenesulfonylamino-N-[5-(4-bromo-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi338.84 [1], 340.0 [2]
2-Benzenesulfonylamino-N-[5-(4-chloro-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi520.0 [1], 524.81 [2]
(8S,11R,12S)-12-N-Hydroxy-8-N-(2-morpholin-4-yl-2-oxoethyl)-2,10-dioxo-11-[[4-[2-(trifluoromethyl)phenyl]phenyl]methyl]-1-oxa-3,9-diazacyclopentadecane-8,12-dicarboxamideKi2000.0 [1]
2-Benzenesulfonylamino-N-[5-(4-trifluoromethyl-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi300.0 [1], 302.0 [2]
2-Benzenesulfonylamino-N-(5-p-tolyl-6H-[1,3,4]thiadiazin-2-yl)-propionamideKi89.13 [1], 90.0 [2]
(2S)-2-(Benzenesulfonamido)-N-[5-(4-fluorophenyl)-6H-1,3,4-thiadiazin-2-yl]propanamideKi280.0 [1], 281.84 [2]
(2S)-2-(Benzenesulfonamido)-N-[5-(4-nitrophenyl)-6H-1,3,4-thiadiazin-2-yl]propanamideKi280.0 [1], 281.84 [2]
4-[(2-Methylquinolin-4-yl)methoxy]-N-[[5-(4-methylsulfonylpiperazin-1-yl)-2,4,6-trioxo-1,3-diazinan-5-yl]methyl]benzamideKi1020.0 [1]
N-(5-Adamantan-1-yl-6H-[1,3,4]thiadiazin-2-yl)-2-benzenesulfonylamino-propionamideKi410.0 [1]
(2S)-2-(Benzenesulfonamido)-N-[5-(4-bromophenyl)-6H-1,3,4-thiadiazin-2-yl]propanamideKi436.52 [1], 440.0 [2]
(2S)-2-(Benzenesulfonamido)-N-[5-(4-cyanophenyl)-6H-1,3,4-thiadiazin-2-yl]propanamideKi370.0 [1], 371.54 [2]
2-Benzenesulfonylamino-N-[5-(4-methoxy-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi338.84 [1], 340.0 [2]
(2R)-2-(Benzenesulfonamido)-N-[5-(4-chlorophenyl)-6H-1,3,4-thiadiazin-2-yl]propanamideKi320.0 [1], 323.59 [2]
2-Benzenesulfonylamino-N-[5-(4-chloro-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-3-methyl-butyramideKi380.0 [1], 380.19 [2]
(2R)-2-(Benzenesulfonamido)-N-[5-(4-chlorophenyl)-6H-1,3,4-thiadiazin-2-yl]-3-methylbutanamideKi346.74 [1], 350.0 [2]
(2S)-2-(Benzenesulfonamido)-N-[5-(4-methylphenyl)-6H-1,3,4-thiadiazin-2-yl]propanamideKi109.65 [1], 110.0 [2]
4-((2-Methylquinolin-4-yl)methoxy)-N-(2-(2-oxo-2,3-dihydro-1H-imidazole-5-carbonyl)phenyl)benzamideKi6023.0 [1]
5-[3-Fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]-N-[(2S)-3-methyl-1-(methylamino)-1-oxobutan-2-yl]furan-2-carboxamideIC501800.0 [1]
1'-Benzyl-5-(4-methoxyphenyl)-5'-methylspiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-oneIC5022000.0 [1]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]benzoyl]amino]oxane-3-carboxamideKi6023.0 [1]
(2S)-2-[[8-[(4-Fluorophenoxy)carbonylamino]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acidIC506.2 [1], 8.1 [2]
5-(2-Amino-2-oxoethyl)-4-oxo-N-[(3-oxo-4H-1,4-benzoxazin-6-yl)methyl]-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidine-2-carboxamideIC502500.0 [1], 10000.0 [2]
(2S)-2-[[8-(Ethoxycarbonylamino)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acidIC505.0 [1]
(2S)-2-[[7-(Methoxycarbonylamino)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acidIC5012.0 [1], 14.0 [2]
(2R)-2-(Dibenzofuran-2-ylsulfonylamino)-3-methylbutanoic acidIC5038.0 [1]
(2S)-2-(Dibenzofuran-2-ylsulfonylamino)-3-methylbutanoic acidIC50600.0 [1]
L-Valine, N-((8-(2-oxo-3-oxazolidinyl)-3-dibenzofuranyl)sulfonyl)-IC501.4 [1], 2.0 [2]
Benzyl-[2-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-phenyl-butyl]-phosphinic acidIC5093.0 [1], 93.33 [2]
(4-Benzylphenyl)methyl-[4-(4-chlorophenyl)-2-[[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]carbamoyl]butyl]phosphinic acidIC501.7 [1]
[2-[[(2S)-3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl]carbamoyl]-4-phenylbutyl]-[[4-[(2-methoxyphenyl)methyl]phenyl]methyl]phosphinic acidIC503.98 [1], 4.0 [2]
4-(4-Bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amineIC50100000.0 [1]
4-(5-Bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amineIC50100000.0 [1]
N-Hydroxy-2-[2-[4-(4-methoxyphenyl)phenyl]sulfonylphenyl]acetamideIC504.8 [1]
(6S,7S)-N-Hydroxy-5-methyl-6-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC50564.0 [1]
(6S,7S)-N-Hydroxy-5-methyl-6-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideKi29.5 [1]
N-Hydroxy-2-[(4-methoxyphenyl)sulfonyl-[2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethyl]amino]acetamideKi14.3 [1]
[4-(4-Chlorophenyl)-2-[[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]carbamoyl]butyl]-[[4-[(2-methoxyphenyl)methyl]phenyl]methyl]phosphinic acidIC505.0 [1], 5.01 [2]
2-Benzenesulfonylamino-N-[5-(4-cyano-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi360.0 [1], 363.08 [2]
4-(4-Methoxyphenyl)-N-(2-morpholin-4-ylethyl)thiophene-2-carboxamideIC50230.0 [1], 13000.0 [2]
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamideIC5026.0 [1]
N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamideIC5071.0 [1]
(2S)-2-Cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamideIC50268.0 [1], 270.0 [2]
(2S)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-3-methyl-2-[[4-(trifluoromethyl)phenyl]methyl]butanamideIC503365.0 [1], 3400.0 [2]
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-methyl-3-[4-(trifluoromethyl)phenyl]propanamideIC509.0 [1]
5-[Benzyl-(4-methoxyphenyl)sulfonylamino]-2-(diethylaminomethyl)-N-hydroxy-4-methylbenzamideKi3.53 [1], 30.0 [2]
QuercetinIC5010230.0 [1]
LuteolinIC50980.0 [1]
Clodronic AcidIC50121000.0 [1]
MarimastatIC5010000.0 [1]
DihydroquercetinIC505750.0 [1]
IsoacteosideIC508220.0 [1]
5-PhenylhydantoinIC50290.0 [1]
N-Isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acidKi4.3 [1]
Unii-Q56UE7E40YIC5017.0 [1]
N-Hydroxy-N~2~-[(4-Methoxyphenyl)sulfonyl]glycinamideKi20.0 [1]
(R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamideIC500.2 [1]
Methyl rosmarinateIC502750.0 [1]
4-(4-Methylphenoxy)-N-(4-pyridinylmethyl)benzenecarboxamideIC50100000.0 [1]
Grassystatin AIC505000.0 [1]
2-(Biphenyl-4-ylsulfonamido)-N-hydroxyacetamideKi2.0 [1]
2-(Benzenesulfonamido)-N-hydroxyacetamideKi62.0 [1]
6-(2-Methylthiazol-4-yl)-3,4-dihydroquinolin-2(1H)-oneIC505000000.0 [1]
2H-Pyran-4-carboxamide, 4-(((4-(4-fluorophenoxy)phenyl)sulfonyl)amino)tetrahydro-N-hydroxy-IC500.24 [1]
(2R,3R)-1-[4-[(2-Chloro-4-fluorophenyl)methoxy]phenyl]sulfonyl-N,3-dihydroxy-3-methylpiperidine-2-carboxamideIC501.0 [1]
Dimethyl LithospermateIC50670.0 [1]
5-MethoxybenzimidazoleIC502000000.0 [1]
(2R)-2-(4-Fluoro-3,5-dimethylanilino)-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamideKi50000.0 [1]
8-Chloro-2-methyl-2,4-dihydrothiochromeno[4,3-c]pyrazoleIC501000000.0 [1]
N,6-Dihydroxy-2-(4-nitrophenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamideIC5059.0 [1]
3-Phenyl-3-({[4-(4-pyridin-4-ylphenyl)thien-2-YL]carbonyl}amino)propanoic acidIC5014.0 [1]
(10R)-19-Cyclohexyl-10-[2-(dimethylamino)ethyl-methylamino]-8-oxa-12-azatetracyclo[10.7.0.02,7.013,18]nonadeca-1(19),2,4,6,13(18),14,16-heptaene-15-carboxylic acidIC508300.0 [1]
(2R)-N-Hydroxy-2-methyl-2-methylsulfonyl-4-(4-phenylphenyl)butanamideKi1350.0 [1]
2-Benzenesulfonylamino-N-[5-(5-chloro-thiophen-2-yl)-6H-[1,3,4]thiadiazin-2-yl]-propionamideKi240.0 [1]
N-((4-Methyl-2,5-dioxoimidazolidin-4-yl)methyl)-4-((2-methylquinolin-4-yl)methoxy)benzamideKi5025.0 [1]
(3R,4R)-N-Hydroxy-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]oxane-3-carboxamideKi100.0 [1]
6-(Benzyloxy)-N-hydroxy-2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamideIC5057.0 [1]
2-[[(2S)-2,3-Dihydroxypropyl]-(4-methoxyphenyl)sulfonylamino]-N-hydroxyacetamideKi8.0 [1]
(3S,4S)-N-Hydroxy-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]-1-prop-2-ynylpyrrolidine-3-carboxamideKi12.0 [1]
(1S)-4-Methyl-1-[[5-[(3-oxo-4H-1,4-benzoxazin-6-yl)methylcarbamoyl]pyrazolo[1,5-a]pyrimidine-7-carbonyl]amino]-2,3-dihydro-1H-indene-5-carboxylic acidIC50655.0 [1]
4-Oxo-N-[[3-[4-[(5-oxo-1,4-dihydro-1,2,4-triazol-3-yl)methylsulfonylmethyl]phenyl]phenyl]methyl]-3H-quinazoline-2-carboxamideIC509500.0 [1]
(2S)-2-[(4-Fluoro-3,5-dimethylphenyl)methyl]-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamideKi50000.0 [1]
(2R)-N,3-Dihydroxy-2-[(4-methoxyphenyl)sulfonylamino]propanamideKi6.0 [1]
2-[(4-Fluorophenyl)sulfonyl-(2-hydroxyethyl)amino]-N-hydroxyacetamideKi40.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Matrix metalloproteinase 12 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/matrix-metalloproteinase-12-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Matrix metalloproteinase 12 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/matrix-metalloproteinase-12-inhibitors-ic50-ki.
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