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Matrix metalloproteinase 10 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-[4-(4-Chloro-phenoxy)-benzenesulfonylmethyl]-tetrahydro-pyran-4-carboxylic acid hydroxyamideIC500.54 [1]
N-(3-Methoxybenzyl)-4-Oxo-3,4-Dihydroquinazoline-2-CarboxamideIC503400.0 [1]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)benzimidazol-1-yl]methyl]benzoyl]amino]oxane-3-carboxamideIC5010000.0 [1]
(8S,11R,12S)-12-N-Hydroxy-8-N-(2-morpholin-4-yl-2-oxoethyl)-2,10-dioxo-11-[[4-[2-(trifluoromethyl)phenyl]phenyl]methyl]-1-oxa-3,9-diazacyclopentadecane-8,12-dicarboxamideKi2000.0 [1]
4-[[2-[(3-Methoxyphenyl)methylcarbamoyl]-4-oxo-3H-thieno[2,3-d]pyrimidin-5-yl]methoxymethyl]benzoic acidIC50160.0 [1], 407.38 [2]
N-Hydroxy-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC504.0 [1]
4-[2-[[6-Fluoro-2-[(3-methoxyphenyl)methylcarbamoyl]-4-oxo-3H-quinazolin-5-yl]oxy]ethyl]benzoic acidIC50160.0 [1]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]methyl]benzoyl]amino]oxane-3-carboxamideKi5346.0 [1]
MarimastatIC5010000.0 [1]
(3R)-N-Hydroxy-3-[4-[4-(methylcarbamoyl)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5012.0 [1]
Grassystatin AIC505000.0 [1]
(4S)-5-Amino-4-[[(2S)-2-[[(2S)-2-[[(4-bromophenyl)-hydroxyphosphoryl]methyl]-3-[3-[4-(3-chlorophenyl)phenyl]-1,2-oxazol-5-yl]propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoic acidKi149.0 [1]
N-Phenyl-4-[(4h-1,2,4-Triazol-3-Ylsulfanyl)methyl]-1,3-Thiazol-2-AmineIC5083000.0 [1]
(2R)-N-Hydroxy-2-methyl-2-methylsulfonyl-4-(4-phenylphenyl)butanamideKi10000.0 [1]
(3R,4R)-N-Hydroxy-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]oxane-3-carboxamideKi100.0 [1]
(3S,4S)-N-Hydroxy-4-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]-1-prop-2-ynylpyrrolidine-3-carboxamideKi240.0 [1]
4-[[5-[3-[[3-(3-Carboxypropoxy)phenyl]methylamino]-3-oxoprop-1-ynyl]-2,4-dioxopyrimidin-1-yl]methyl]benzoic acidIC508400.0 [1]
4-Oxo-N-[[3-[4-[(5-oxo-1,4-dihydro-1,2,4-triazol-3-yl)methylsulfonylmethyl]phenyl]phenyl]methyl]-3H-quinazoline-2-carboxamideIC50150.0 [1]
4-[[[5-(2-Ethoxycarbonyl-1H-indol-5-yl)-1-methylpyrazole-3-carbonyl]amino]methyl]benzoic acidIC5016000.0 [1]
(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]prop-2-enamideIC50100000.0 [1]
5-(3-Chlorophenyl)-4-oxo-N-[[3-[3-(1H-1,2,4-triazol-5-yloxy)propoxy]phenyl]methyl]-3H-thieno[2,3-d]pyrimidine-2-carboxamideIC50820.0 [1]
(2S,3R)-N-Hydroxy-3-(2-methylpropyl)-N'-[(3S)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]-2-propylbutanediamideKi190.0 [1]
(8S,11R,12S)-12-N-Hydroxy-2,10-dioxo-8-N-(2-oxo-2-piperazin-1-ylethyl)-11-[[4-[2-(trifluoromethyl)phenyl]phenyl]methyl]-1-oxa-3,9-diazacyclopentadecane-8,12-dicarboxamideKi2000.0 [1]
2-(2,4-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin-3-oneIC5062000.0 [1]
Tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[[4-[(2-methylbenzimidazol-1-yl)methyl]benzoyl]amino]pyrrolidine-1-carboxylateIC501600.0 [1]
Tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[[4-[(2-methylsulfanylbenzimidazol-1-yl)methyl]benzoyl]amino]pyrrolidine-1-carboxylateIC5010000.0 [1]
Tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[[4-[(2-propan-2-ylbenzimidazol-1-yl)methyl]benzoyl]amino]pyrrolidine-1-carboxylateIC504600.0 [1]
N-[(2R,6S)-4-[2-(Hydroxyamino)-2-oxoethyl]-2,6-dimethylpiperidin-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamideKi1650.0 [1]
(8S,11R,12S)-8-N-(2-Amino-2-oxoethyl)-12-N-hydroxy-2,10-dioxo-11-[[4-[2-(trifluoromethyl)phenyl]phenyl]methyl]-1-oxa-3,9-diazacyclopentadecane-8,12-dicarboxamideKi2000.0 [1]
2-(2,5-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin-3-oneIC5053000.0 [1]
3-[4-(4-Tert-butylphenoxy)phenyl]sulfonyl-N-hydroxy-8-azaspiro[4.5]decane-3-carboxamideIC5042.0 [1]
N-Hydroxy-3-[4-(6-methoxypyridin-3-yl)oxyphenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5062.0 [1]
N-Hydroxy-3-[4-[2-(2-oxopyrrolidin-1-yl)ethoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC50435.0 [1]
N-Hydroxy-3-[4-(4-methylphenoxy)phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC507.0 [1]
N-Hydroxy-3-(4-phenylmethoxyphenyl)sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5054.0 [1]
N-Hydroxy-3-[3-(4-methoxyphenoxy)phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC50189.0 [1]
8-Acetyl-N-hydroxy-3-[4-(4-methoxyphenoxy)phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC509.0 [1]
N-Hydroxy-3-[4-(2-methoxyphenoxy)phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC50739.0 [1]
N-Hydroxy-3-[4-[4-(pyrrolidine-1-carbonyl)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5013.0 [1]
N-Hydroxy-3-[4-[[4-(methylcarbamoyl)phenyl]methoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5068.0 [1]
[4-[[3-(Hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenyl] 4-(methylcarbamoyl)benzoateIC50103.0 [1]
N-Hydroxy-3-[4-[[4-(trifluoromethoxy)phenyl]methylamino]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC50184.0 [1]
N-Hydroxy-3-[4-[3-methoxy-4-(methylcarbamoyl)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC50713.0 [1]
N-Hydroxy-3-[2-(4-methoxyphenoxy)phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5025400.0 [1]
N-Hydroxy-3-[4-(3-methoxyphenoxy)phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5014.0 [1]
N-Hydroxy-3-[4-[2-(methylcarbamoyl)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5020700.0 [1]
3-[3-Chloro-4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-N-hydroxy-8-azaspiro[4.5]decane-3-carboxamideIC508700.0 [1]
N-Hydroxy-3-(4-methoxyphenyl)sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5084.0 [1]
3-[4-[4-(Difluoromethoxy)phenoxy]phenyl]sulfonyl-N-hydroxy-8-azaspiro[4.5]decane-3-carboxamideIC503.0 [1]
Phenyl 3-[4-(cyclohexylamino)phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxylateIC5010000.0 [1]
3-(3-Chloro-4-methoxyphenyl)sulfonyl-N-(methylcarbamoyl)-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
3-[3-Chloro-4-(4-methoxyphenoxy)phenyl]sulfonyl-N-(methylcarbamoyl)-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
Phenyl 3-(3-chloro-4-methoxyphenyl)sulfonyl-8-azaspiro[4.5]decane-3-carboxylateIC5010000.0 [1]
Phenyl 3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxylateIC5010000.0 [1]
3-[4-[4-(Trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-(2-Aminophenyl)-3-(3-chloro-4-methoxyphenyl)sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
[3-[4-[4-(Trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decan-3-yl]methanolIC5010000.0 [1]
N-(Methylcarbamoyl)-8-propyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-(2-Aminophenyl)-3-[3-chloro-4-(4-methoxyphenoxy)phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-(2-Aminophenyl)-3-[3-chloro-4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-Pyridin-2-yl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-(2-Aminophenyl)-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-(1,3-Thiazol-2-yl)-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-(2-Hydroxyphenyl)-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
3-[4-[4-(Trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decaneIC5010000.0 [1]
N-(2-Amino-5-phenylphenyl)-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-(2-Amino-5-methoxyphenyl)-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-(Methylcarbamoyl)-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-(2-Amino-5-thiophen-2-ylphenyl)-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-(2-Amino-5-fluorophenyl)-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-[2-Amino-5-(5-methylfuran-2-yl)phenyl]-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
N-Hydroxy-3-[4-[[4-(trifluoromethoxy)phenyl]methoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5032.0 [1]
N-Hydroxy-3-[4-[3-(methylcarbamoyl)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5089.0 [1]
(3S)-N-Hydroxy-3-[4-[4-(methylcarbamoyl)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5017.0 [1]
(8S,11R,12S)-11-[[4-[3,5-Bis(trifluoromethyl)phenyl]phenyl]methyl]-12-N-hydroxy-2,10-dioxo-8-N-(2-oxo-2-piperazin-1-ylethyl)-1-oxa-3,9-diazacyclopentadecane-8,12-dicarboxamideKi2000.0 [1]
(4S)-5-Amino-4-[[(2S)-4-carboxy-2-[[(2R)-2-[[3-[4-(3-chlorophenyl)phenyl]-1,2-oxazol-5-yl]methyl]-4-(hydroxyamino)-4-oxobutanoyl]amino]butanoyl]amino]-5-oxopentanoic acidKi1.4 [1]
N-Methoxy-N-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamideIC5010000.0 [1]
5-(3-Chlorophenyl)-N-[(3-methoxyphenyl)methyl]-4-oxo-3H-thieno[2,3-d]pyrimidine-2-carboxamideIC506300.0 [1]
4-Oxo-N-{3-[2-(1h-1,2,4-Triazol-3-Ylsulfanyl)ethoxy]benzyl}-3,4-Dihydroquinazoline-2-CarboxamideIC50140.0 [1]
4-Oxo-N-[[3-[3-(1H-1,2,4-triazol-5-yloxy)propoxy]phenyl]methyl]-3H-quinazoline-2-carboxamideIC50220.0 [1]
5-(3-Chlorophenyl)-4-oxo-N-[[3-[4-[(5-oxo-1,4-dihydro-1,2,4-triazol-3-yl)methylsulfonylmethyl]phenyl]phenyl]methyl]-3H-thieno[2,3-d]pyrimidine-2-carboxamideIC5034.0 [1]
N-[[3-[4-[2-(1H-Imidazol-5-yl)acetyl]piperazin-1-yl]phenyl]methyl]-4-oxo-3H-quinazoline-2-carboxamideIC50460.0 [1]
N-[[3-[4-[2-[Acetyl(hydroxy)amino]-3-methylbutyl]sulfonylphenyl]phenyl]methyl]-4-oxo-3H-quinazoline-2-carboxamideIC5064.0 [1]
1-[3-[3-[[(4-Oxo-3H-quinazoline-2-carbonyl)amino]methyl]phenoxy]propylsulfonyl]piperidine-2-carboxylic acidIC50240.0 [1]
4-Oxo-N-[[3-[4-[2-(5-oxo-1,2-dihydropyrazol-3-yl)acetyl]piperazin-1-yl]phenyl]methyl]-3H-quinazoline-2-carboxamideIC5010.0 [1]
4-Oxo-N-[[3-[4-[2-(5-oxo-1,4-dihydro-1,2,4-triazol-3-yl)acetyl]piperazin-1-yl]phenyl]methyl]-3H-quinazoline-2-carboxamideIC506.2 [1]
N-[[3-[4-[2-[Carbamoyl(hydroxy)amino]-3-methylbutyl]sulfonylphenyl]phenyl]methyl]-4-oxo-3H-quinazoline-2-carboxamideIC5010.0 [1]
N-[[3-[4-[[5-(2-Ethoxyethyl)-2,4,6-trioxo-1,3-diazinan-5-yl]oxy]phenyl]phenyl]methyl]-4-oxo-3H-quinazoline-2-carboxamideIC50930.0 [1]
N-[[3-[4-[2-(2,5-Dioxoimidazolidin-4-yl)acetyl]piperazin-1-yl]phenyl]methyl]-4-oxo-3H-quinazoline-2-carboxamideIC5010.0 [1]
4-Oxo-N-[[3-[4-[2-(2H-tetrazol-5-yl)acetyl]piperazin-1-yl]phenyl]methyl]-3H-quinazoline-2-carboxamideIC50640.0 [1]
N-[[3-[4-[2-[Formyl(hydroxy)amino]-3-methylbutyl]sulfonylphenyl]phenyl]methyl]-4-oxo-3H-quinazoline-2-carboxamideIC500.35 [1]
N-[[3-[3-[2-(Hydroxycarbamoyl)piperidin-1-yl]sulfonylpropoxy]phenyl]methyl]-4-oxo-3H-quinazoline-2-carboxamideIC502.6 [1]
(2S)-3-Methyl-2-[[4-[3-[[(4-oxo-3H-quinazoline-2-carbonyl)amino]methyl]phenyl]phenyl]sulfonylamino]butanoic acidIC502.4 [1]
N-[[3-[4-[[(2S)-1-(Hydroxyamino)-3-methyl-1-oxobutan-2-yl]sulfamoyl]phenyl]phenyl]methyl]-4-oxo-3H-quinazoline-2-carboxamideIC500.3 [1]
N-[(4-Fluoro-3-methoxyphenyl)methyl]-3-[1-[[4-(methylsulfamoyl)phenyl]methyl]-2,4-dioxopyrimidin-5-yl]prop-2-ynamideIC50676.08 [1]
Methyl 2-[[4-[[5-[3-[(4-fluoro-3-methoxyphenyl)methylamino]-3-oxoprop-1-ynyl]-2,4-dioxopyrimidin-1-yl]methyl]phenyl]sulfonylamino]acetateIC50436.52 [1]
4-[[5-[3-[(4-Fluoro-3-methoxyphenyl)methylamino]-3-oxoprop-1-ynyl]-2,4-dioxopyrimidin-1-yl]methyl]-N-methylbenzamideIC50831.76 [1]
Methyl (2R)-1-[4-[[5-[3-[(4-fluoro-3-methoxyphenyl)methylamino]-3-oxoprop-1-ynyl]-2,4-dioxopyrimidin-1-yl]methyl]benzoyl]pyrrolidine-2-carboxylateIC504897.79 [1]
N-[(4-Fluoro-3-methoxyphenyl)methyl]-3-[1-[[4-(1,3-oxazol-5-yl)phenyl]methyl]-2,4-dioxopyrimidin-5-yl]prop-2-ynamideIC5029.51 [1]
4-[[5-[3-[(4-Fluoro-3-methoxyphenyl)methylamino]-3-oxoprop-1-ynyl]-2,4-dioxopyrimidin-1-yl]methyl]benzamideIC5018197.01 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Matrix metalloproteinase 10 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/matrix-metalloproteinase-10-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Matrix metalloproteinase 10 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/matrix-metalloproteinase-10-inhibitors-ic50-ki.
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