 | Leupeptin | Ki | 696.0 [1], 1900.0 [2] |
 | Nafamostat | Ki | 0.02 [1] |
 | 3-Amino-N-[3-[[(2S)-3-(3-carbamimidoylphenyl)-1-[4-[2-(diaminomethylideneamino)ethyl]piperidin-1-yl]-1-oxopropan-2-yl]sulfamoyl]phenyl]propanamide | Ki | 1.8 [1] |
 | 3-Amino-N-[3-[[(2S)-1-[4-(2-aminoethyl)piperidin-1-yl]-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl]sulfamoyl]phenyl]propanamide | Ki | 3.8 [1], 6.6 [2] |
 | 3-[(2S)-3-Oxo-3-[4-(piperidine-4-carbonyl)piperazin-1-yl]-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide | Ki | 100.0 [1], 120.0 [2] |
 | (2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methylbutanamide | Ki | 31.54 [1], 32.0 [2] |
 | 4-(4-{4-[Amino(imino)methyl]phenoxy}phenoxy)benzenecarboximidamide | Ki | 200.0 [1], 208.0 [2] |
 | 2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43R,49S)-25-(4-Aminobutyl)-49-benzyl-4,19-bis[(2S)-butan-2-yl]-34-[3-(diaminomethylideneamino)propyl]-28-[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-40-yl]acetic acid | Ki | 0.92 [1], 100.0 [2] |
 | 4-[4-[(2S)-3-(3-Carbamimidoylphenyl)-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propanoyl]piperazine-1-carbonyl]piperidine-1-carboximidamide | Ki | 4.3 [1], 14.0 [2] |
 | Benzyl 4-[(2S)-2-[[3-(3-aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperazine-1-carboxylate | Ki | 6.1 [1], 7.5 [2] |
 | N-[3-[[(2S)-1-[4-(2-Aminoethyl)piperidin-1-yl]-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl]sulfamoyl]phenyl]azetidine-3-carboxamide | Ki | 1.7 [1], 3.0 [2] |
 | 3-Amino-N-[3-[[(2S)-3-(3-carbamimidoylphenyl)-1-oxo-1-piperazin-1-ylpropan-2-yl]sulfamoyl]phenyl]propanamide | Ki | 36.0 [1], 37.0 [2] |
 | 4-[1-[(2S)-2-[[3-(3-Aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidin-4-yl]butanoic acid | Ki | 255.0 [1] |
 | 4-[1-[(2S)-2-[[3-(3-Aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidin-4-yl]butanamide | Ki | 11.8 [1], 12.0 [2] |
 | Methyl 4-[1-[(2S)-2-[[3-(3-aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidin-4-yl]butanoate | Ki | 6.1 [1] |
 | 3-Amino-N-[3-[[(2S)-3-(3-carbamimidoylphenyl)-1-oxo-1-piperidin-1-ylpropan-2-yl]sulfamoyl]phenyl]propanamide | Ki | 32.0 [1], 33.0 [2] |
 | 1-[(2S)-2-[[3-(3-Aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidine-4-carboxamide | Ki | 12.1 [1], 13.0 [2] |
 | 1-[(2S)-2-[[3-(3-Aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidine-3-carboxamide | Ki | 30.5 [1], 31.0 [2] |
 | Ethyl 4-[(2S)-2-[[3-(3-aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperazine-1-carboxylate | Ki | 65.0 [1] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-2-[[3-(4-methoxyphenyl)phenyl]sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 6.0 [1], 7.0 [2] |
 | 4-[(2S)-3-(3-Carbamimidoylphenyl)-2-[(4-cyclohexylphenyl)sulfonylamino]propanoyl]piperazine-1-carboximidamide | IC50 | 3000.0 [1] |
| 4-[(2S)-3-(3-Carbamimidoylphenyl)-2-[(4-cyclohexylphenyl)sulfonylamino]propanoyl]piperazine-1-carboximidamide | Ki | 26.0 [1] |
 | 3-[(2S)-3-[4-(2-Aminoethyl)piperidin-1-yl]-2-[[3-(2-methylpyrimidin-4-yl)phenyl]sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 28.0 [1] |
 | 3-Amino-N-[3-[[(2S)-1-[4-(2-aminoethyl)piperidin-1-yl]-3-[3-(aminomethyl)phenyl]-1-oxopropan-2-yl]sulfamoyl]phenyl]propanamide | Ki | 56.0 [1] |
 | N-[1-[4-(2-Aminoethyl)piperidin-1-yl]-3-[3-(aminomethyl)phenyl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)benzenesulfonamide | Ki | 145.0 [1] |
 | 3-[(2S)-2-[[3-(4-Aminobutyl)phenyl]sulfonylamino]-3-[4-(2-aminoethyl)piperidin-1-yl]-3-oxopropyl]benzenecarboximidamide | Ki | 0.74 [1], 1.0 [2] |
 | N-[3-[[(2S)-1-[4-(2-Aminoethyl)piperidin-1-yl]-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl]sulfamoyl]phenyl]-3-hydroxypropanamide | Ki | 117.0 [1], 120.0 [2] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-3-oxo-2-[(3-phenylphenyl)sulfonylamino]propyl]benzenecarboximidamide | Ki | 100.0 [1], 110.0 [2] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-2-[[3-(2-chlorophenyl)phenyl]sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 29.0 [1] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-2-[[3-(3-chlorophenyl)phenyl]sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 91.0 [1] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-2-[[3-(4-chlorophenyl)phenyl]sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 26.0 [1] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-2-[[3-(4-ethoxyphenyl)phenyl]sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 5.4 [1], 6.0 [2] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-3-oxo-2-[[3-(4-propan-2-yloxyphenyl)phenyl]sulfonylamino]propyl]benzenecarboximidamide | Ki | 12.0 [1] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-2-[[3-(3,4-dimethoxyphenyl)phenyl]sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 5.4 [1] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-2-[[3-(4-ethylphenyl)phenyl]sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 2.5 [1] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-3-oxo-2-[(3-pyridin-4-ylphenyl)sulfonylamino]propyl]benzenecarboximidamide | Ki | 60.0 [1] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-3-oxo-2-[(3-pyridin-3-ylphenyl)sulfonylamino]propyl]benzenecarboximidamide | Ki | 47.0 [1] |
 | 3-[3-[4-(2-Aminoethyl)piperidin-1-yl]-2-[[3-(1H-indol-5-yl)phenyl]sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 13.0 [1] |
 | 4-[1-[(2S)-2-[[3-(3-Aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidin-4-yl]-N-methylbutanamide | Ki | 6.3 [1] |
 | 3-[(2S)-3-[4-[2-(Diaminomethylideneamino)ethyl]piperidin-1-yl]-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide | IC50 | 1000.0 [1] |
| 3-[(2S)-3-[4-[2-(Diaminomethylideneamino)ethyl]piperidin-1-yl]-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide | Ki | 46.0 [1] |
 | (2S)-2-Amino-N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]pentanediamide | Ki | 0.09 [1] |
 | (2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-hydroxypentan-2-yl]amino]-1-oxopropan-2-yl]pentanediamide | Ki | 6124.0 [1] |
 | Rivaroxaban | Ki | 3350.0 [1] |
 | Pentamidine | Ki | 1160.0 [1] |
 | Benzamidine | Ki | 400000.0 [1] |
 | Hexamidine | Ki | 924.0 [1] |
 | Dibrompropamidine | Ki | 535.0 [1] |
 | 4-[4-(4-Amidinophenyl)piperazinyl]benzenecarboxamidine | Ki | 719.0 [1] |
 | 1-(3-(3-(Aminoiminomethyl)phenyl)-2-(((4-methylphenyl)sulfonyl)amino)-1-oxopropyl)piperidine | Ki | 14000.0 [1] |
 | 4-[4-(4-Carbamimidoylphenyl)-1,4-diazepan-1-yl]benzamidine | Ki | 397.0 [1] |
 | (3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-11-(carboxymethyl)-20-[3-(diaminomethylideneamino)propyl]-23-(hydroxymethyl)-17,26-bis[(4-hydroxyphenyl)methyl]-29-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid | Ki | 1000000.0 [1] |
 | Wx-uk1 free base | Ki | 320.0 [1] |
 | alpha,alpha'-Di(amidinophenoxy)-p-xylene | Ki | 816.0 [1] |
 | (5-Amino-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(4-methylphenyl)methanone | IC50 | 570.0 [1] |
 | (3-Amino-[1,2,4]triazol-4-yl)-(4-methoxy-phenyl)-methanone | IC50 | 30000.0 [1] |
 | 4-[[2-[(4-Carbamimidoylphenoxy)methyl]phenyl]methoxy]benzamidine | Ki | 2280.0 [1] |
 | 1-(4-Chlorobenzoyl)-3-pyridin-3-yl-1H-1,2,4-triazol-5-amine | IC50 | 30000.0 [1] |
 | 2-(2-Hydroxyphenyl)-1H-indole-5-carboxamidine | Ki | 60000.0 [1] |
 | 1-Benzoyl-3-(4-chlorophenyl)-5-(methylthio)-1H-1,2,4-triazole | IC50 | 420.0 [1] |
 | 1-(3,4-Dimethoxybenzoyl)-3-phenyl-1H-1,2,4-triazol-5-amine | IC50 | 30000.0 [1] |
 | 4-[6-(4-Carbamimidoylphenoxy)pyridin-2-yl]oxybenzenecarboximidamide | Ki | 9600.0 [1] |
 | (2S)-2-[[(2S)-2-Acetamido-6-aminohexanoyl]amino]-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pentanediamide | Ki | 0.92 [1] |
 | 4-[7-(4-Carbamimidoylanilino)heptylamino]benzenecarboximidamide | Ki | 558.0 [1] |
 | 4-[8-(4-Carbamimidoylanilino)octylamino]benzenecarboximidamide | Ki | 526.0 [1] |
 | 3-[3-(1-Benzyl-piperidin-4-yl)-ureido]-benzamidine | Ki | 40500.0 [1] |
 | 3-[(2S)-2-(Naphthalen-2-ylsulfonylamino)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]benzenecarboximidamide | Ki | 1800.0 [1] |
 | CID 46899577 | Ki | 55.0 [1] |
 | N-(Benzylsulfonyl)-3-Cyclohexyl-D-Alanyl-N-(4-Carbamimidoylbenzyl)-L-Prolinamide | Ki | 770.0 [1] |
 | 1-[(4S)-4-Amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine | Ki | 457.0 [1] |
 | [2,4,6-Triisopropyl-phenylsulfonyl-L-[3-amidino-phenylalanine]]-piperazine-N'-beta-alanine | Ki | 170.0 [1] |
 | Inhibitor 1 [Colombo et al., 2012] | Ki | 0.01 [1] |
 | 2-(4-Carbamimidoylanilino)-2-(7-ethyl-3-methyl-1-benzofuran-5-yl)-N-(1-methylimidazol-4-yl)sulfonylacetamide | Ki | 7180.0 [1] |
 | 3-[(2S)-3-[4-[3-(Diaminomethylideneamino)propanoyl]piperazin-1-yl]-2-(naphthalen-1-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide | Ki | 340.0 [1] |
 | 1-[(2S)-3-(3-Carbamimidoylphenyl)-2-[(9,10-dioxoanthracen-2-yl)sulfonylamino]propanoyl]-N-[2-(diaminomethylideneamino)ethyl]piperidine-4-carboxamide | Ki | 13.0 [1] |
 | 4-[4-[(2S)-3-(3-Carbamimidoylphenyl)-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propanoyl]-1,4-diazepane-1-carbonyl]piperidine-1-carboximidamide | Ki | 50.0 [1] |
 | 3-[(2S)-3-[4-[4-(Diaminomethylideneamino)butanoyl]piperazin-1-yl]-3-oxo-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide | Ki | 61.0 [1] |
 | 3-[(2S)-3-[4-[3-(Diaminomethylideneamino)propanoyl]-1,4-diazepan-1-yl]-3-oxo-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide | Ki | 65.0 [1] |
 | 3-[(2S)-2-[(4-Cyclohexylphenyl)sulfonylamino]-3-[4-[3-(diaminomethylideneamino)propanoyl]piperazin-1-yl]-3-oxopropyl]benzenecarboximidamide | Ki | 89.0 [1] |
 | 3-[(2S)-3-[4-[3-(Diaminomethylideneamino)propanoyl]piperazin-1-yl]-3-oxo-2-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]propyl]benzenecarboximidamide | Ki | 730.0 [1] |
 | 3-[(2S)-3-[4-(3-Aminopropyl)piperidin-1-yl]-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide | Ki | 160.0 [1] |
 | 3-[(2S)-2-[(4-Cyclohexylphenyl)sulfonylamino]-3-[4-[2-(diaminomethylideneamino)ethyl]piperidin-1-yl]-3-oxopropyl]benzenecarboximidamide | Ki | 88.0 [1] |
 | 3-Amino-N-[3-[[(2S)-3-(3-carbamimidoylphenyl)-1-[4-[3-(diaminomethylideneamino)propyl]piperidin-1-yl]-1-oxopropan-2-yl]sulfamoyl]phenyl]propanamide | Ki | 1.5 [1] |
 | 3-[(2S)-3-[4-[3-(Diaminomethylideneamino)propanoyl]piperazin-1-yl]-2-(2-naphthalen-1-ylethylsulfonylamino)-3-oxopropyl]benzenecarboximidamide | Ki | 690.0 [1] |
 | 3-[(2S)-3-[4-(2-Aminoethyl)piperidin-1-yl]-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide | Ki | 110.0 [1] |
 | 3-[(2S)-3-[4-[3-(Diaminomethylideneamino)propanoyl]piperazin-1-yl]-2-[[4-(2-methylbutan-2-yl)phenyl]sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 200.0 [1] |
 | 3-[3-[4-(2-Aminoacetyl)piperazin-1-yl]-3-oxo-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide | Ki | 690.0 [1] |
 | 3-[(2S)-3-[4-[2-(Diaminomethylideneamino)ethyl]piperidin-1-yl]-3-oxo-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide | Ki | 89.0 [1] |
 | 4-Amino-N-[3-[[(2S)-1-[4-(2-aminoethyl)piperidin-1-yl]-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl]sulfamoyl]phenyl]butanamide | Ki | 3.9 [1] |
 | 3-[(2S)-3-[4-(4-Aminobutanoyl)piperazin-1-yl]-3-oxo-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide | Ki | 140.0 [1] |
 | 3-[(2S)-2-(Anthracen-2-ylsulfonylamino)-3-[4-[3-(diaminomethylideneamino)propanoyl]piperazin-1-yl]-3-oxopropyl]benzenecarboximidamide | Ki | 44.0 [1] |
 | N-[3-[[(2S)-3-(3-Carbamimidoylphenyl)-1-[4-[2-(diaminomethylideneamino)ethyl]piperidin-1-yl]-1-oxopropan-2-yl]sulfamoyl]phenyl]-3-(diaminomethylideneamino)propanamide | Ki | 4.2 [1] |
 | 1-[(2S)-3-(3-Carbamimidoylphenyl)-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propanoyl]-N-[2-(diaminomethylideneamino)ethyl]piperidine-4-carboxamide | Ki | 140.0 [1] |
 | 4-[4-[(2S)-3-(3-Carbamimidoylphenyl)-2-[(4-phenylphenyl)sulfonylamino]propanoyl]piperazine-1-carbonyl]piperidine-1-carboximidamide | Ki | 61.0 [1] |
 | 2-Amino-N-[3-[[(2S)-1-[4-(2-aminoethyl)piperidin-1-yl]-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl]sulfamoyl]phenyl]acetamide | Ki | 75.0 [1] |
 | N-[4-[[(2S)-3-(3-Carbamimidoylphenyl)-1-[4-[2-(diaminomethylideneamino)ethyl]piperidin-1-yl]-1-oxopropan-2-yl]sulfamoyl]phenyl]-3-(diaminomethylideneamino)propanamide | Ki | 8.7 [1] |
 | 3-[3-[4-[2-(Diaminomethylideneamino)acetyl]piperazin-1-yl]-3-oxo-2-[[2,4,6-tri(propan-2-yl)phenyl]sulfonylamino]propyl]benzenecarboximidamide | Ki | 330.0 [1] |
 | 3-[(2S)-3-[4-[3-(Diaminomethylideneamino)propanoyl]piperazin-1-yl]-2-[(9,10-dioxoanthracen-2-yl)sulfonylamino]-3-oxopropyl]benzenecarboximidamide | Ki | 53.0 [1] |
 | 4-[1-[(2S)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]piperidin-4-yl]piperidine-1-carboximidamide | Ki | 45.0 [1] |
 | 3-Amino-N-[4-[[(2S)-1-[4-(2-aminoethyl)piperidin-1-yl]-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl]sulfamoyl]phenyl]propanamide | Ki | 28.0 [1] |
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