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Maternal embryonic leucine zipper kinase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-Methyl-4-[4-(4-{3-[(Piperidin-4-Yl)methoxy]pyridin-4-Yl}-1h-Pyrazol-1-Yl)phenyl]piperazineIC502.0 [1], 5.0 [2], 140.0 [3]
Otssp167IC500.41 [1], 0.6 [2], 1.1 [3]
CID 73442760IC5037.0 [1], 23000.0 [2]
[6-(3-Chloro-4-hydroxy-5-methoxyphenyl)-4-[[4-(diethylamino)cyclohexyl]amino]quinolin-3-yl]-cyclopropylmethanoneIC502.6 [1], 3.1 [2], 3.2 [3]
7-[3-[4-(Piperazin-1-ylmethyl)-3-(trifluoromethyl)phenoxy]prop-1-ynyl]isoquinolineIC507.6 [1], 300.0 [2]
1-Methyl-4-(4-{4-[3-(2-Methylpropoxy)pyridin-4-Yl]-1h-Pyrazol-1-Yl}phenyl)piperazineIC509.0 [1], 410.0 [2]
1-[4-[4-(3-Fluoropyridin-4-yl)pyrazol-1-yl]phenyl]-4-methylpiperazineIC5070.0 [1], 5000.0 [2]
1-Methyl-4-[4-(4-pyridin-4-ylpyrazol-1-yl)phenyl]piperazineIC5080.0 [1], 5000.0 [2]
4-[[4-[1-[4-(4-Methylpiperazin-1-yl)phenyl]pyrazol-4-yl]pyridin-3-yl]oxymethyl]cyclohexan-1-amineIC501.0 [1], 57.0 [2]
1-Methyl-4-[4-[4-[3-(pyridin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]piperazineIC5025.0 [1], 1440.0 [2]
1-Methyl-4-[4-[4-(3-piperidin-4-yloxypyridin-4-yl)pyrazol-1-yl]phenyl]piperazineIC506.0 [1], 260.0 [2]
1-[4-[4-(3-Cyclohexyloxypyridin-4-yl)pyrazol-1-yl]phenyl]-4-methylpiperazineIC504.0 [1], 150.0 [2]
4-[4-[4-[3-(Piperidin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]morpholineIC506.0 [1], 210.0 [2]
N-[(Pyridin-2-Yl)methyl]-4-[4-(Pyridin-4-Yl)-1h-Pyrazol-1-Yl]benzamideIC50180.0 [1], 18800.0 [2]
N-Methyl-7-[3-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenoxy]prop-1-ynyl]isoquinolin-3-amineIC5019.0 [1], 20.0 [2]
7-[3-[3-Methoxy-4-(piperazin-1-ylmethyl)phenoxy]prop-1-ynyl]isoquinolineIC50520.0 [1], 720.0 [2]
1-[6-(3-Chloro-5-fluoro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]ethanoneIC501.1 [1], 1.3 [2]
{4-(cis-4-Aminocyclohexylamino)-6-(4-hydroxy-3-methoxyphenyl)quinolin-3-yl}(cyclopropyl)methanoneIC501.9 [1], 7.0 [2]
[4-(cis-4-Aminocyclohexylamino)-6-(3,5-difluoro-4-hydroxyphenyl)quinolin-3-yl](cyclopropyl)methanoneIC502.6 [1], 23.0 [2]
Cyclopropyl-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]quinolin-3-yl]methanoneIC500.85 [1], 2.1 [2]
[4-[[4-(Aminomethyl)cyclohexyl]amino]-6-(3-chloro-5-fluoro-4-hydroxyphenyl)quinolin-3-yl]-cyclopropylmethanoneIC503.4 [1], 46.0 [2]
[6-(3-Chloro-4-hydroxy-5-methoxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]quinolin-3-yl]-cyclopropylmethanoneIC502.0 [1], 11.0 [2]
NintedanibKi5.6 [1]
TozasertibIC50420.0 [1]
Pyridone 6IC50330.0 [1]
EntrectinibIC5010000.0 [1]
1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaIC50685.0 [1]
HesperadinIC50225.0 [1]
5-[(Z)-(5-Chloro-2-oxo-1H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamideIC50760.0 [1]
CC-401IC50340.0 [1]
Nms-P937 (nms1286937)IC50744.0 [1]
5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-CarboxamideIC5010.0 [1]
2-Hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylic acidKi149.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC5010000.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanoneIC50100000.0 [1]
N-[2-Hydroxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-5-yl]-2,2-dimethylpropanamideIC502800.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-olIC5010000.0 [1]
4-(1H-Pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamideIC50410.0 [1]
[4-(3-Isoquinolin-7-ylprop-2-ynoxy)phenyl]methanamineIC5024000.0 [1]
[4-(3-Isoquinolin-7-ylprop-2-ynoxy)-2-methoxyphenyl]methanamineIC505100.0 [1]
N-[(R)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC50160.0 [1]
4-[1-(2-Fluorophenyl)-1h-Pyrazol-4-Yl]-3-[(Piperidin-4-Yl)methoxy]pyridineIC5013.0 [1]
3-(Carbamoylamino)-5-(3-fluorophenyl)-N-[(3R)-piperidin-3-yl]thiophene-2-carboxamide;hydrochlorideIC50900.0 [1]
1-N,1-N-Diethyl-4-N-[6-methoxy-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazolin-4-yl]pentane-1,4-diamineIC506100.0 [1]
1-Methyl-4-[4-(3-phenyl-1H-pyrazol-5-yl)phenyl]piperazineIC50670.0 [1]
4-[1-(4-Methylsulfonylphenyl)pyrazol-4-yl]phenolIC50520.0 [1]
1-[4-[4-(3-Methoxypyridin-4-yl)pyrazol-1-yl]phenyl]-4-methylpiperazineIC5064.0 [1]
4-(1-Phenylpyrazol-4-yl)-3-(piperidin-4-ylmethoxy)pyridineIC5036.0 [1]
4-[3-Fluoro-4-[4-[3-(piperidin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]morpholineIC500.3 [1]
5-[2-[4-(Dimethylamino)phenoxy]-4,6-dihydroxyphenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamideIC5010.0 [1]
Drak2-IN-1IC5010000.0 [1]
5-[2,4-Dihydroxy-6-[4-(propan-2-ylamino)phenoxy]phenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamideIC5010.0 [1]
Nintedanib impurity EKi0.47 [1]
5-[2-[4-(Dimethylamino)phenoxy]-4,6-dihydroxyphenyl]-N-[1-(1,4-dioxaspiro[4.5]decan-8-yl)piperidin-4-yl]-1,2-oxazole-3-carboxamideIC5010.0 [1]
N-[2-Hydroxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-5-yl]butanamideIC501000.0 [1]
Melk-IN-1Ki0.39 [1]
2-Hydroxy-N-methyl-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-5-carboxamideKi2.3 [1]
N-[3-(Dimethylamino)propyl]-2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxamideKi358.0 [1]
N-(3-Aminopropyl)-2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxamideKi650.0 [1]
N-[4-[[(5-Fluoro-2-hydroxy-1H-indol-3-yl)-phenylmethylidene]amino]phenyl]-N-methyl-2-(4-methylpiperazin-1-yl)acetamideKi3.1 [1]
2-Hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-5-carboxylic acidKi0.68 [1]
N-[4-[[(5-Acetyl-2-hydroxy-1H-indol-3-yl)-phenylmethylidene]amino]phenyl]-N-methyl-2-(4-methylpiperazin-1-yl)acetamideKi46.0 [1]
N-(2-Anilino-2-oxoethyl)-4-[2-(methylamino)-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]benzamideIC50120.0 [1]
4-N-(3-Morpholin-4-ylpropyl)-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]quinazoline-4,6-diamineIC503500.0 [1]
N-(1H-Benzimidazol-2-ylmethyl)-4-[2-(methylamino)-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]benzamideIC509.2 [1]
4-N-[1-(Diethylamino)propan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamineIC503700.0 [1]
N-[(E)-(6-Bromo-7aH-inden-1-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide;hydrochlorideIC50400.0 [1]
4-N-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-[3-(trifluoromethyl)phenyl]ethenyl]quinazoline-4,6-diamineIC506800.0 [1]
2-Hydroxy-N,N-dimethyl-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-5-carboxamideKi8.8 [1]
N-[(6-Methoxy-1H-benzimidazol-2-yl)methyl]-4-[4-(piperidin-4-ylmethoxy)pyridin-3-yl]benzamideIC501.5 [1]
N-(2-Anilino-2-oxoethyl)-4-[2-anilino-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]benzamideIC508.8 [1]
4-N-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-[2-(trifluoromethyl)phenyl]ethenyl]quinazoline-4,6-diamineIC508900.0 [1]
4-[2-Anilino-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]-N-(1H-benzimidazol-2-ylmethyl)benzamideIC501.1 [1]
(8Z)-8-(1H-Imidazol-5-ylmethylidene)-6H-pyrrolo[3,2-e][1,3]benzothiazol-7-oneIC50720.0 [1]
4-N-[4-(Diethylamino)butan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamineIC502600.0 [1]
4-N-[5-(Diethylamino)pentan-2-yl]-2-[2-[4-(trifluoromethyl)phenyl]ethyl]quinazoline-4,6-diamineIC501300.0 [1]
4-[2-Anilino-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]-N-[(6-methoxy-1H-benzimidazol-2-yl)methyl]benzamideIC500.15 [1]
4-N-[4-(Diethylamino)butyl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamineIC502100.0 [1]
N-(2-Anilino-2-oxoethyl)-4-[4-(piperidin-4-ylmethoxy)pyridin-3-yl]benzamideIC50740.0 [1]
N-[(6-Methoxy-1H-benzimidazol-2-yl)methyl]-4-[2-(methylamino)-4-(piperidin-4-ylmethoxy)pyrimidin-5-yl]benzamideIC501.5 [1]
N-(1H-Benzimidazol-2-ylmethyl)-4-[4-(piperidin-4-ylmethoxy)pyridin-3-yl]benzamideIC5012.0 [1]
4-N-[5-(Diethylamino)pentan-2-yl]-2-[2-(2,4,6-trichlorophenyl)ethyl]quinazoline-4,6-diamineIC507700.0 [1]
HA 1004, DihydrochlorideIC50440.0 [1]
1-(4-Methylsulfonylphenyl)-4-phenylpyrazoleIC5020000.0 [1]
4-[1-(4-Methylsulfonylphenyl)pyrazol-4-yl]pyridineIC50400.0 [1]
2-{[2-Amino-5-(1,3-Benzodioxol-5-Ylmethyl)[1,2,4]triazolo[1,5-C]quinazolin-8-Yl]amino}ethanolIC5010000.0 [1]
5-(1,3-Benzodioxol-5-ylmethyl)-[1,2,4]triazolo[1,5-c]quinazoline-2,8-diamineIC5010000.0 [1]
5-(1,3-Benzodioxol-5-Ylmethyl)-10-Fluoro[1,2,4]triazolo[1,5-C]quinazolin-2-AmineIC5010000.0 [1]
5-(1,3-Benzodioxol-5-ylmethyl)-10-fluoro-8-(4-methylpiperazin-1-yl)-[1,2,4]triazolo[1,5-c]quinazolin-2-amineIC5010000.0 [1]
N-[6-Fluoro-2-methyl-3-[5-[(5-methyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1H-pyridazin-3-yl]phenyl]-1-benzothiophene-2-carboxamideIC5010000.0 [1]
N~4~-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamineIC501400.0 [1]
4-Fluoro-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamideIC50160000.0 [1]
2-[(4S)-7-(3-Chlorophenyl)-1-oxo-3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-4-yl]-N-[(1S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethyl]acetamideIC5010000.0 [1]
4-(3-Hydroxy-5-methoxyanilino)-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamideIC502100.0 [1]
4-Bromo-N-(2,3,4,5-Tetrahydro-1h-3-Benzazepin-7-Yl)benzamideIC5031000.0 [1]
3-(Isoquinolin-7-Yl)prop-2-Yn-1-OlIC503100.0 [1]
2-(3-Aminopropoxy)-4-(3-hydroxy-5-methoxyanilino)-N-phenylbenzamideIC504200.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Maternal embryonic leucine zipper kinase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/maternal-embryonic-leucine-zipper-kinase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Maternal embryonic leucine zipper kinase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/maternal-embryonic-leucine-zipper-kinase-inhibitors-ic50-ki.
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