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MAP kinase signal-integrating kinase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
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▼
N3-(4-Fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamineIC501530.0 [1], 1600.0 [2]
N3-(4-Fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamineKi340.0 [1], 880.0 [2]
Methyl 4-(4-fluoro-2-isopropoxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateIC504.0 [1], 60.0 [2]
Methyl 4-(4-fluoro-2-isopropoxyphenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateKi4050.0 [1]
(9Ar)-8-acetyl-1,3,7-trihydroxy-9a-methyl-9-oxodibenzofuran-4-carboxamideIC5011.0 [1]
(9Ar)-8-acetyl-1,3,7-trihydroxy-9a-methyl-9-oxodibenzofuran-4-carboxamideKi79.0 [1]
N-[3-(Dimethylamino)propyl]-4-(4-fluoro-2-propan-2-yloxyanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideIC506.0 [1]
StaurosporineIC5027.12 [1]
SorafenibIC50262.0 [1]
CeritinibIC502240.0 [1]
4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acidIC5013.0 [1]
Bms-777607IC50500.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC50171.0 [1]
Ast-487IC5020.0 [1]
Aigialomycin DIC50450.0 [1]
CID 58539301IC50600.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
TomivosertibIC501.0 [1]
CID 59604787IC5010000.0 [1]
CID 44814409IC5010000.0 [1]
CID 73442760IC50760000.0 [1]
4-[5-(4-Piperidinyl)-1H-pyrazol-3-yl]PyridineIC50575.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC5010000.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi9350.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC501100.0 [1]
3-(1H-Benzimidazol-2-yl)-5-phenylpyridin-2-amineIC50720.0 [1]
(4S,6Z)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dioneIC5010000.0 [1]
9-Cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamineIC503200.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
(4-Methylpiperazin-1-yl)-[4-[3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-6-yl]phenyl]methanoneIC50389.0 [1]
[4-[3-(4-Chlorophenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanoneIC50217.0 [1]
4-(4-Fluoro-2-methylanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acidKi500.0 [1]
CID 118598634IC501.2 [1]
N-[6-[(8-Chloro-1,5-dioxospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamideIC501.8 [1]
N-[6-[(3,3-Dimethyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamideIC502.3 [1]
3,3-Dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dioneIC5057.0 [1]
6-[(6-Aminopyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dioneIC500.68 [1]
6-[(6-Aminopyrimidin-4-yl)amino]-4',4'-difluoro-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dioneIC501.0 [1]
3,3,8-Trimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dioneIC5019.0 [1]
6-[(6-Aminopyrimidin-4-yl)amino]-8-chloro-3,3-dimethyl-2H-imidazo[1,5-a]pyridine-1,5-dioneIC500.14 [1]
6-[(6-Aminopyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclopentane]-1,5-dioneIC500.13 [1]
N-[6-[[8-Chloro-3-(3-chlorophenyl)-3-methyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl]amino]pyrimidin-4-yl]cyclopropanecarboxamideIC501.2 [1]
6-[(6-Amino-5-chloropyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dioneIC500.36 [1]
8-Fluoro-3,3-dimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dioneIC502.6 [1]
3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-olIC5010000.0 [1]
Methyl 4-[(1,5-dimethyl-2-oxopyridin-3-yl)amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylateKi10000.0 [1]
Methyl 4-[[1-(2-methoxyethyl)-5-methyl-2-oxopyridin-3-yl]amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylateKi10000.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acidKi350.0 [1]
4-[[1-(2-Methoxyethyl)-5-methyl-2-oxopyridin-3-yl]amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acidKi240.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi10000.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N,5-dimethylthieno[2,3-d]pyrimidine-6-carboxamideKi9050.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N-ethyl-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi5990.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi3170.0 [1]
4-[(1,5-Dimethyl-2-oxopyridin-3-yl)amino]-N-(3-methoxypropyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi2630.0 [1]
4-[[1-(2-Methoxyethyl)-5-methyl-2-oxopyridin-3-yl]amino]-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi340.0 [1]
Methyl 5-methyl-4-[(1-methyl-6-oxopyridin-3-yl)amino]thieno[2,3-d]pyrimidine-6-carboxylateKi10000.0 [1]
5-Methyl-4-[(1-methyl-6-oxopyridin-3-yl)amino]thieno[2,3-d]pyrimidine-6-carboxylic acidKi900.0 [1]
5-Methyl-4-[(1-methyl-6-oxopyridin-3-yl)amino]thieno[2,3-d]pyrimidine-6-carboxamideKi1600.0 [1]
4-(4-Fluoro-2-propan-2-yloxyanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi110.0 [1]
4-(4-Fluoro-2-propan-2-yloxyanilino)-N,5-dimethylthieno[2,3-d]pyrimidine-6-carboxamideKi18.0 [1]
N-Ethyl-4-(4-fluoro-2-propan-2-yloxyanilino)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi18.0 [1]
4-(4-Fluoro-2-propan-2-yloxyanilino)-N-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi31.0 [1]
4-(4-Fluoro-2-propan-2-yloxyanilino)-N-(3-methoxypropyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamideKi164.0 [1]
(4-Methylpiperazin-1-yl)-[4-(3-phenylimidazo[1,2-a]pyrazin-6-yl)phenyl]methanoneIC501430.0 [1]
3-[6-Amino-5-(1H-benzimidazol-2-yl)pyridin-3-yl]-N,N-dimethylbenzamideIC5034.0 [1]
3-[6-Amino-5-(4-piperazin-1-yl-1H-benzimidazol-2-yl)pyridin-3-yl]-N,N-dimethylbenzamideIC502.0 [1]
3-[5-Amino-6-(4-piperazin-1-yl-1H-benzimidazol-2-yl)pyrazin-2-yl]-N,N-dimethylbenzamideIC5020.0 [1]
3-[5-Amino-6-(1-methyl-7-piperazin-1-ylbenzimidazol-2-yl)pyrazin-2-yl]-N,N-dimethylbenzamideIC501.0 [1]
3-[5-Amino-6-[1-methyl-7-[(3S)-3-methylpiperazin-1-yl]benzimidazol-2-yl]pyrazin-2-yl]-N,N-dimethylbenzamideIC500.7 [1]
2-[5-Amino-6-[1-methyl-7-[(3S)-3-methylpiperazin-1-yl]benzimidazol-2-yl]pyrazin-2-yl]-N,N-dimethylpyridine-4-carboxamideIC503.0 [1]
N-[4-[(1-Ethylpiperidin-4-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)acetamideIC5010000.0 [1]
N-[3-Cyclopropyl-4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-2-(4-pyridin-3-ylphenoxy)acetamideIC50130.0 [1]
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)propanamideIC5010000.0 [1]
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-[4-[2-(methylamino)pyridin-4-yl]oxyphenyl]acetamideIC508.0 [1]
2-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-N-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]acetamideIC50760.0 [1]
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-4-yloxyphenyl)acetamideIC5010.0 [1]
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-2-ylphenoxy)acetamideIC5010000.0 [1]
5-[4-[2-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethoxy]phenyl]-N-methylpyridine-2-carboxamideIC506860.0 [1]
2-Methyl-N-[5-[4-[[2-oxo-2-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)anilino]ethyl]amino]phenyl]pyridin-2-yl]propanamideIC50130.0 [1]
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-4-ylphenoxy)acetamideIC501910.0 [1]
N-[4-[(4-Ethylpiperidin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)acetamideIC5082.0 [1]
3-Methyl-5-(pyrimidin-4-ylamino)-2,3-dihydroisoindol-1-oneIC5045.0 [1]
3,3-Dimethyl-5-(pyrimidin-4-ylamino)-2H-isoindol-1-oneIC5061.0 [1]
N-[6-[(1-Oxo-2,3-dihydroisoindol-5-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamideIC505.7 [1]
1-[4-[4-Amino-3-[4-(2-morpholin-4-ylethoxy)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)ureaIC5061.0 [1]
1-Quinolin-6-yl-8-thiophen-3-ylimidazo[4,5-c][1,7]naphthyridineIC501400.0 [1]
2-Pyridinamine, 3-(1H-benzimidazol-2-yl)-IC50900.0 [1]
[4-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-morpholin-4-ylmethanoneIC50113.0 [1]
N-Hydroxy-4-[6-[4-(4-methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzamideIC5031.0 [1]
(4-(3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanoneIC50140.0 [1]
1-[4-(3-Bromoanilino)quinazolin-6-yl]-3-(3-chlorophenyl)thioureaIC502700.0 [1]
3-(3-Isoquinolin-6-ylimidazo[1,2-b]pyridazin-6-yl)oxycyclobutan-1-amineIC507.8 [1]
[4-[3-(4-Methylphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanoneIC50410.0 [1]
4-(6-Phenylimidazo[1,2-a]pyrazin-3-yl)phenolIC50415.0 [1]
N-(2,4-Dimethoxyphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amineKi110.0 [1]
N-(2,4-Dimethoxyphenyl)-4-[4-methyl-2-(2-morpholin-4-ylethylsulfanyl)-1,3-thiazol-5-yl]pyrimidin-2-amineKi2500.0 [1]
N-(2,4-Dimethoxyphenyl)-4-(1-ethylindol-3-yl)pyrimidin-2-amineKi430.0 [1]
N-(2,4-Dimethoxyphenyl)-4-[2-(2-methoxyethoxy)-4-methyl-1,3-thiazol-5-yl]pyrimidin-2-amineKi860.0 [1]
4-(2-Butoxy-4-methyl-1,3-thiazol-5-yl)-N-(2,4-dimethoxyphenyl)pyrimidin-2-amineKi560.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ MAP kinase signal-integrating kinase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/map-kinase-signal-integrating-kinase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ MAP kinase signal-integrating kinase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/map-kinase-signal-integrating-kinase-2-inhibitors-ic50-ki.
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