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MAP kinase p38 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazoleIC5083.0 [1]
4-[5-(4-Fluorophenyl)-2-(4-methanesulfinyl-benzylsulfanyl)-3H-imidazol-4-yl]pyridineIC502780.0 [1]
6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazoleIC50400.0 [1], 520.0 [2], 5500.0 [3], 12000.0 [4], 27000.0 [5]
NeflamapimodIC500.8 [1], 10.0 [2], 70.0 [3], 150.0 [4], 700.0 [5]
p38 MAP Kinase Inhibitor IIIIC5039.0 [1], 160.0 [2], 380.0 [3], 990.0 [4], 2700.0 [5]
4-(5-(4-Fluorophenyl)-3-(4-piperidyl)imidazol-4-yl)pyridineIC5050.0 [1], 71.0 [2], 90.0 [3], 125.0 [4], 272.0 [5]
CID 10450926IC5075.0 [1], 500.0 [2], 1100.0 [3], 10800.0 [4], 12500.0 [5]
(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)(2-methylphenyl)methanoneIC504.0 [1], 5.0 [2], 17.0 [3], 30.0 [4], 74.0 [5]
2-(Methylthio)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazoleIC5044.0 [1], 630.0 [2], 900.0 [3], 1200.0 [4], 4200.0 [5]
4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanylimidazol-4-yl]-N-(1-phenylethyl)pyridin-2-amineIC5015.0 [1], 110.0 [2], 220.0 [3], 3000.0 [4], 4100.0 [5]
4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanylimidazol-4-yl]pyridineIC50450.0 [1], 1080.0 [2], 2200.0 [3], 5100.0 [4]
4-(2-Aminophenylamino)-2-chloro-2'-methylbenzophenoneIC506.0 [1], 12.0 [2], 14.0 [3], 18.0 [4]
N-[4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3-(2,2,6,6-tetramethylpiperidin-4-yl)imidazol-4-yl]pyridin-2-yl]acetamideIC50340.0 [1], 460.0 [2], 2150.0 [3], 4500.0 [4], 5400.0 [5]
5-(4-Fluorophenyl)-2-[(4-methylsulfinylphenyl)methylsulfanyl]-4-pyridin-4-ylpyrimidineIC505600.0 [1], 14100.0 [2], 36000.0 [3], 45500.0 [4], 95500.0 [5]
N-Ethyl-4-[5-(4-fluorophenyl)-2-methylsulfanyl-3-(2,2,6,6-tetramethylpiperidin-4-yl)imidazol-4-yl]pyridin-2-amineIC50220.0 [1], 620.0 [2], 2700.0 [3], 2900.0 [4], 11000.0 [5]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3-(2,2,6,6-tetramethylpiperidin-4-yl)imidazol-4-yl]pyridineIC50850.0 [1], 16000.0 [2], 17000.0 [3], 18500.0 [4], 19100.0 [5]
N-Ethyl-4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanylimidazol-4-yl]pyridin-2-amineIC5071.0 [1], 600.0 [2], 700.0 [3], 2000.0 [4], 5000.0 [5]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]-2-propan-2-yloxypyridineIC5047.0 [1], 400.0 [2], 560.0 [3], 2200.0 [4], 7200.0 [5]
[2-Chloro-4-(4-fluoro-2-methyl-phenylamino)-phenyl]-o-tolyl-methanoneIC504.0 [1], 17.0 [2], 35.0 [3], 51.0 [4], 79.0 [5]
6-(4-Fluorophenyl)-7-[2-[[(2S)-3-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-4-yl]-2,3-dihydro-1H-pyrazolo[1,2-a]pyrazol-5-oneIC508.0 [1], 22.0 [2], 42.0 [3], 54.0 [4]
4-[4-(4-Fluorophenyl)-2-[(3-methylsulfinylphenyl)methylsulfanyl]-1H-imidazol-5-yl]pyridineIC501000.0 [1], 4100.0 [2], 23500.0 [3], 33500.0 [4]
4-[4-(4-Fluorophenyl)-2-[(2-methylsulfinylphenyl)methylsulfanyl]-1H-imidazol-5-yl]pyridineIC50900.0 [1], 4000.0 [2], 15000.0 [3], 47500.0 [4]
6-(4-Fluorophenyl)-7-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]-2,3-dihydro-1H-pyrazolo[1,2-a]pyrazol-5-oneIC500.4 [1], 0.8 [2], 3.0 [3], 8.0 [4]
5-(4-Fluorophenyl)-2-[(4-methylsulfanylphenyl)methylsulfanyl]-4-pyridin-4-ylpyrimidineIC507400.0 [1], 60000.0 [2], 100000.0 [3]
5-(4-Fluorophenyl)-2-[(4-methylsulfonylphenyl)methylsulfanyl]-4-pyridin-4-ylpyrimidineIC507700.0 [1], 17800.0 [2], 100000.0 [3]
4-(4-Fluorophenyl)-2-[(4-methylsulfinylphenyl)methylsulfanyl]-5-pyridin-4-ylpyrimidineIC5017800.0 [1], 29900.0 [2], 100000.0 [3]
5-(4-Fluorophenyl)-2-[(4-methylsulfinylphenyl)methylsulfanyl]-4-pyridin-3-ylpyrimidineIC5054000.0 [1], 75500.0 [2], 100000.0 [3]
6-(4-Fluorophenyl)-7-[2-[[(2S)-1-methoxypropan-2-yl]amino]pyrimidin-4-yl]-2,3-dihydro-1H-pyrazolo[1,2-a]pyrazol-5-oneIC5016.0 [1], 27.0 [2], 39.0 [3], 50.0 [4]
5-(4-Fluorophenyl)-2-[(4-methylsulfinylphenyl)methylsulfanyl]-4-pyridin-4-yl-1H-pyrimidin-6-oneIC5025500.0 [1], 27000.0 [2], 100000.0 [3]
DasatinibIC50100.0 [1]
Tpl2 Kinase InhibitorIC50700.0 [1], 8500.0 [2], 180000.0 [3]
4-(4-Fluorophenyl)-5-(4-pyridyl)-1H-imidazoleIC50170.0 [1], 210.0 [2], 10000.0 [3]
4-(3-Chloro-4-fluoro-phenylamino)-6-(2-morpholin-4-yl-ethylamino)-1,7-naphthyridine-3-carbonitrileIC504500.0 [1], 6800.0 [2], 58000.0 [3]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyrimidin-2-amineIC500.11 [1], 4.3 [2]
2-(2-(Methylsulfinyl)benzylthio)-5-(4-fluorophenyl)-4-(pyridin-4-yl)pyrimidineIC502300.0 [1], 3200.0 [2], 5100.0 [3]
{4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridin-2-yl}-phenylamineIC5030.0 [1], 130.0 [2], 340.0 [3]
4-[1-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyrimidin-2-amineIC501220.0 [1], 12000.0 [2], 24000.0 [3]
{4-[5-(4-Fluoro-phenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenyl-ethyl)-amineIC5041.0 [1], 170.0 [2], 340.0 [3]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amineIC5044.0 [1], 370.0 [2], 900.0 [3]
2-(Benzylthio)-4-(4-fluorophenyl)-5-(2-fluoro-4-pyridinyl)-1H-imidazoleIC502900.0 [1], 4200.0 [2], 40500.0 [3]
Benzyl-{4-[5-(4-fluoro-phenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-amineIC50108.0 [1], 630.0 [2], 650.0 [3]
2-Fluoro-4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridineIC50300.0 [1], 2800.0 [2], 3800.0 [3]
6-(2-Morpholinoethylamino)-4-(4-phenoxyphenylamino)-1,7-naphthyridine-3-carbonitrileIC501400.0 [1], 14900.0 [2], 400000.0 [3]
4-[6-Morpholin-4-yl-3-[3-(trifluoromethyl)phenyl]pyridazin-4-yl]-N-[(1S)-1-phenylethyl]pyrimidin-2-amineIC502.6 [1], 292.0 [2], 1200.0 [3]
4-[2-Benzylsulfanyl-5-(4-fluorophenyl)-1H-imidazol-4-yl]-N-(1-phenylethyl)pyridin-2-amineIC5045.0 [1], 380.0 [2], 2700.0 [3]
4-[5-(4-Fluorophenyl)-2-[(4-methylsulfinylphenyl)methylsulfanyl]-1H-imidazol-4-yl]-N-(1-phenylethyl)pyridin-2-amineIC5040.0 [1], 270.0 [2], 910.0 [3]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amineIC5056.0 [1], 640.0 [2], 790.0 [3]
5-(4-Fluorophenyl)-2-[(3-methylsulfinylphenyl)methylsulfanyl]-4-pyridin-4-ylpyrimidineIC505400.0 [1], 6500.0 [2], 19000.0 [3]
N-Benzyl-4-[5-(4-fluorophenyl)-2-[(4-methylsulfinylphenyl)methylsulfanyl]-1H-imidazol-4-yl]pyridin-2-amineIC50470.0 [1], 1450.0 [2], 2000.0 [3]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]-N-(2-phenylethyl)pyridin-2-amineIC5031.0 [1], 240.0 [2], 350.0 [3]
N-[(4-Chlorophenyl)methyl]-4-[5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]pyridin-2-amineIC50150.0 [1], 500.0 [2], 950.0 [3]
4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanylimidazol-4-yl]pyridin-2-amineIC50270.0 [1], 2300.0 [2], 3200.0 [3]
N-Benzyl-4-[2-benzylsulfanyl-5-(4-fluorophenyl)-1H-imidazol-4-yl]pyridin-2-amineIC50200.0 [1], 1420.0 [2], 3200.0 [3]
N-Benzyl-4-[5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]-N-methylpyridin-2-amineIC502700.0 [1], 4600.0 [2], 8700.0 [3]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]-N-[(4-methylphenyl)methyl]pyridin-2-amineIC5085.0 [1], 670.0 [2], 830.0 [3]
2-Fluoro-4-[5-(4-fluorophenyl)-2-[(4-methylsulfinylphenyl)methylsulfanyl]-1H-imidazol-4-yl]pyridineIC502450.0 [1], 6900.0 [2], 9300.0 [3]
N-[(3,4-Dichlorophenyl)methyl]-4-[5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]pyridin-2-amineIC50230.0 [1], 700.0 [2], 720.0 [3]
4-(4-Benzylphenylamino)-6-(2-morpholinoethylamino)-1,7-naphthyridine-3-carbonitrileIC50800.0 [1], 13600.0 [2], 400000.0 [3]
N-Benzyl-4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanylimidazol-4-yl]pyridin-2-amineIC5082.0 [1], 580.0 [2], 930.0 [3]
6-(2-Morpholinoethylamino)-4-(4-(phenylthio)phenylamino)-1,7-naphthyridine-3-carbonitrileIC502700.0 [1], 20100.0 [2], 31000.0 [3]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3-propylimidazol-4-yl]pyridineIC50360.0 [1], 1300.0 [2], 2200.0 [3]
DoramapimodIC508.0 [1], 9.0 [2]
4-[3-[4-(4-Fluorophenyl)-5-pyridin-4-ylimidazol-1-yl]propyl]morpholineIC50120.0 [1], 1300.0 [2]
4-(4-Fluorophenyl)-1-cycloropropylmethyl-5-(4-pyridyl)-imidazoleIC5024.0 [1], 90.0 [2]
2-(4-Fluorophenyl)-4-methoxy-3-(pyridin-4-YL)-1H-pyrrolo[2,3-B]pyridin-6-amineIC506.3 [1], 7.0 [2]
4-[(3-Chloro-4-fluorophenyl)amino]-6-[(1H-imidazol-4-ylmethyl)amino]quinoline-3-carbonitrileIC502110.0 [1], 30000.0 [2]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amineIC500.19 [1], 2.8 [2]
N-[1-[(3-Fluorophenyl)methyl]indazol-5-yl]-5-[[(2S)-morpholin-2-yl]methoxymethyl]pyrrolo[2,1-f][1,2,4]triazin-4-amineIC5050000.0 [1]
5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-oneIC500.5 [1], 36.0 [2]
5-(2-Chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(1-propan-2-ylpiperidin-4-yl)-3,4-dihydroquinazolin-2-oneIC500.6 [1], 5.6 [2]
3-{5-[(2-Fluorophenyl)amino]-1h-Indazol-1-Yl}-N-(3,4,5-Trimethoxyphenyl)benzamideIC5030.0 [1]
2-Phenyl-4-[3-(trifluoromethyl)phenyl]-5-(4-pyridyl)-1H-imidazoleIC5086.0 [1], 100000.0 [2]
1-(3-Morpholinopropyl)-4-(4-fluorophenyl)-5-(2-methyl-4-pyridyl)-1H-imidazoleIC502100.0 [1], 3050.0 [2]
4-(2,4-Diphenyl-1H-imidazol-5-yl)-N-methylpyrimidin-2-amineIC50120.0 [1], 100000.0 [2]
4-[3-[5-(2,6-Dimethylpyridin-4-yl)-4-(4-fluorophenyl)imidazol-1-yl]propyl]morpholineIC5017000.0 [1], 25000.0 [2]
6-[2-(2,4-Difluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-(2-methylphenyl)-4,5-dihydropyridazin-3-oneIC5014.0 [1], 440.0 [2]
2-Chloro-4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridineIC50350.0 [1], 2200.0 [2]
2-(Benzylthio)-4-(4-fluorophenyl)-5-(2-chloro-4-pyridinyl)-1H-imidazoleIC501800.0 [1], 60000.0 [2]
{4-[(2-Aminophenyl)amino]phenyl}(Phenyl)methanoneIC50159.0 [1], 226.0 [2]
2-(2,6-Dichlorophenyl)-6-[2-(2,4-difluorophenyl)imidazo[1,2-a]pyridin-3-yl]-4,5-dihydropyridazin-3-oneIC5010.0 [1], 205.0 [2]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1R)-1-phenylethyl]pyrimidin-2-amineIC501.5 [1], 50.0 [2]
(2-Chloro-4-(phenylamino)phenyl)(o-tolyl)methanoneIC5024.0 [1], 119.0 [2]
[4-(2-Amino-phenylamino)-2-chloro-phenyl]-phenyl-methanoneIC50214.0 [1], 437.0 [2]
6-[2-(2-Chloro-4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-(2-methylphenyl)-4,5-dihydropyridazin-3-oneIC5022.0 [1], 220.0 [2]
6-[2-(2-Chloro-4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-(2-methylphenyl)pyridazin-3-oneIC5020.0 [1], 100.0 [2]
N-[(1S)-1-Phenylethyl]-4-[2-piperidin-4-yl-4-[3-(trifluoromethyl)phenyl]-1H-imidazol-5-yl]pyrimidin-2-amineIC500.75 [1], 6.0 [2]
6-[2-(2,3-Dichlorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-(2-methylphenyl)pyridazin-3-oneIC506.0 [1], 500.0 [2]
[4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyrimidin-2-yl]-(4-methoxy-benzyl)-amineIC5038.0 [1], 100000.0 [2]
N-[(4-Methoxyphenyl)methyl]-4-[2-piperidin-4-yl-4-[3-(trifluoromethyl)phenyl]-1H-imidazol-5-yl]pyrimidin-2-amineIC507.6 [1], 290.0 [2]
4-[2-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyridineIC5034.0 [1], 70.0 [2]
4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyrimidin-2-ylamineIC5057.0 [1], 100000.0 [2]
4-[5-(4-Fluoro-phenyl)-2-piperidin-3-yl-3H-imidazol-4-yl]-pyridineIC5019.0 [1], 585.0 [2]
N-[(1R)-1-Phenylethyl]-4-[2-piperidin-4-yl-4-[3-(trifluoromethyl)phenyl]-1H-imidazol-5-yl]pyrimidin-2-amineIC500.4 [1], 0.97 [2]
4-[2-(4-Piperidinyl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole-5-yl]pyrimidine-2-amineIC507.0 [1], 190.0 [2]
4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyrimidineIC50700.0 [1], 100000.0 [2]
4-[5-(4-Fluorophenyl)-4-pyridin-4-yl-1H-imidazol-2-yl]piperidineIC509.0 [1], 175.0 [2]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-2-methoxypyridineIC50150.0 [1], 1900.0 [2]
6-[2-(2,4-Difluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-(2-methylphenyl)pyridazin-3-oneIC5068.0 [1], 870.0 [2]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]-1H-pyridin-2-oneIC50500.0 [1], 3100.0 [2]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3-propylimidazol-4-yl]pyridin-2-amineIC50500.0 [1], 5400.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ MAP kinase p38 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/map-kinase-p38-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ MAP kinase p38 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/map-kinase-p38-inhibitors-ic50-ki.
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