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MAP kinase p38 alpha Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazoleIC5048.0 [1]
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazoleKi18.0 [1], 57.0 [2]
DoramapimodIC5017.0 [1]
DoramapimodKi0.1 [1], 6.4 [2], 22.0 [3], 46.0 [4]
NeflamapimodIC5051.0 [1]
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazoleIC5028.0 [1]
[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-YL](3-{[(2R)-2,3-dihydroxypropyl]oxy}phenyl)methanoneIC50400.0 [1]
N~3~-Cyclopropyl-N~4~'-(Cyclopropylmethyl)-6-Methylbiphenyl-3,4'-DicarboxamideIC5018.0 [1], 199.53 [2], 1584.89 [3]
N~3~-Cyclopropyl-N~4~'-(Cyclopropylmethyl)-6-Methylbiphenyl-3,4'-DicarboxamideKi9.0 [1], 10.0 [2], 12.0 [3], 12.59 [4]
SorafenibIC5084.2 [1]
3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamideIC501.05 [1], 5.8 [2], 17.4 [3], 247.0 [4]
3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamideKi2.9 [1], 5.8 [2]
Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)-IC50480.0 [1]
4-(2-Cyanophenoxy)-N-(pyridin-4-ylmethyl)benzamideIC50600.0 [1], 5400.0 [2], 10000.0 [3], 21000.0 [4], 25000.0 [5]
4-(2-Cyanophenoxy)-N-(pyridin-4-ylmethyl)benzamideKi290.0 [1]
N-[5-(Dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamideIC5061.0 [1], 970.0 [2], 1500.0 [3], 9700.0 [4], 10000.0 [5]
N-[5-(Dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamideKi14.0 [1]
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridineIC50590.0 [1], 594.0 [2], 668.0 [3]
LosmapimodIC5025.12 [1], 100.0 [2]
LosmapimodKi7.94 [1], 63.1 [2]
TalmapimodIC509.0 [1], 10.0 [2], 36.0 [3], 96.0 [4]
N-[4-Methyl-3-[[4-(1,3-thiazol-4-ylmethoxy)benzoyl]amino]phenyl]-3-morpholin-4-ylbenzamideIC5010.0 [1], 15.85 [2], 17.0 [3], 25.12 [4], 1258.93 [5]
7-(1-Tert-butylpiperidin-4-yl)-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)quinolin-2-oneIC500.08 [1], 0.14 [2], 1.7 [3], 2.4 [4], 28.0 [5]
N-Cyclopropyl-3-(4'-hydroxy-2-oxospiro[1H-indole-3,1'-cyclohexane]-6-yl)-4-methylbenzamideIC501.4 [1], 5.0 [2], 11.0 [3]
CK1 InhibitorIC504154.0 [1], 5800.0 [2], 12000.0 [3]
4-(4-Fluorophenyl)-1-(4-piperidinyl)-5-(2-amino-4-pyrimidinyl)-imidazoleIC5019.0 [1], 20.0 [2]
Skepinone-LIC505.0 [1], 40.0 [2]
4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidineIC5019.0 [1], 40.0 [2], 130.0 [3]
4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidineKi36.0 [1]
N-[3-[4-(Cyclopropylmethylcarbamoyl)phenyl]-4-methylphenyl]furan-3-carboxamideIC5016.0 [1]
N-[3-[4-(Cyclopropylmethylcarbamoyl)phenyl]-4-methylphenyl]furan-3-carboxamideKi6.0 [1], 15.0 [2]
3-(2,4-Difluoroanilino)-6H-benzo[c][1]benzoxepin-11-oneIC50239.0 [1], 240.0 [2], 22000.0 [3]
Methyl 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2,3,4-tetrahydroquinazoline-7-carboxylateIC501.0 [1], 2.0 [2]
1-(2,6-Dichlorophenyl)-5-(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinoneIC501.0 [1], 6.0 [2]
1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-7-(4-piperidinyl)-1,2,3,4-tetrahydroquinazoline-2-oneIC500.2 [1]
N-Cyclopropyl-4-Methyl-3-(2'-Oxo-1',2'-Dihydrospiro[cyclopentane-1,3'-Indol]-6'-Yl)benzamideIC501.3 [1], 18.0 [2]
4-[5-(4-Fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]-N-(oxan-4-yl)pyridin-2-amineIC505.0 [1], 180.0 [2]
13-(2,4-Difluoroanilino)-5-(3-hydroxypropoxy)tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-oneIC508.0 [1], 13.0 [2], 190.0 [3], 191.0 [4]
13-(2,4-Difluoroanilino)-5-hydroxytricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-oneIC5020.0 [1], 49.0 [2], 700.0 [3], 1247.0 [4]
13-(2,4-Difluoroanilino)-5-[(2S)-2,3-dihydroxypropoxy]tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-oneIC508.0 [1], 17.0 [2], 52.0 [3], 60.0 [4]
13-(2,4-Difluoroanilino)-5-methoxytricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-oneIC5020.0 [1], 44.0 [2], 1200.0 [3], 1647.0 [4]
13-(2,4-Difluoroanilino)-5-(2-hydroxyethoxy)tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-oneIC5010.0 [1], 19.0 [2], 480.0 [3], 583.0 [4]
2-(4-Fluorophenyl)-N-[4-[5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]pyridin-2-yl]acetamideIC509.0 [1], 2980.0 [2]
13-(3-Benzamido-4-fluoroanilino)-N-(2-morpholin-4-ylethyl)-2-oxotricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene-5-carboxamideIC500.2 [1], 31.0 [2], 38.0 [3]
N-Benzyl-4-(2-cyanophenoxy)benzamideIC50450.0 [1], 1400.0 [2], 10000.0 [3], 100000.0 [4]
4-(2-Cyanophenoxy)-N-(pyridin-3-ylmethyl)benzamideIC50560.0 [1], 4700.0 [2], 10000.0 [3], 15000.0 [4]
4-(2-Cyanophenoxy)-N-(pyrimidin-4-ylmethyl)benzamideIC502800.0 [1], 7100.0 [2], 10000.0 [3], 100000.0 [4]
N-(5-Cyano-2-methylphenyl)-1-phenyl-5-propylpyrazole-4-carboxamideIC5015.0 [1], 210.0 [2], 890.0 [3], 10000.0 [4]
4-Methyl-3-[(1-phenyl-5-propylpyrazole-4-carbonyl)amino]benzoic acidIC5086.0 [1], 4200.0 [2], 10000.0 [3], 21000.0 [4]
N-[5-[[14-[(2S)-2,3-Dihydroxypropoxy]-2-oxo-6-tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaenyl]amino]-2-fluorophenyl]benzamideIC501.0 [1], 3.0 [2], 280.0 [3]
6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazoleIC50110.0 [1], 400.0 [2], 820.0 [3]
1-(5-Tert-butyl-2-methyl-2H-pyrazol-3-YL)-3-(4-chloro-phenyl)-ureaIC50794.33 [1], 16800.0 [2], 21000.0 [3]
4-(5-(4-Fluorophenyl)-3-(4-piperidyl)imidazol-4-yl)pyridineIC5038.0 [1], 60.0 [2]
4-(5-(4-Fluorophenyl)-3-(4-piperidyl)imidazol-4-yl)pyridineKi60.0 [1]
2-Amino-Phenylamino-DibenzosuberoneIC5050.0 [1], 100.0 [2], 104.0 [3]
N-(3-Cyanophenyl)-2'-Methyl-5'-(5-Methyl-1,3,4-Oxadiazol-2-Yl)-4-BiphenylcarboxamideKi240.0 [1]
N-Cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamideIC5015.85 [1], 17.38 [2], 27.54 [3]
2-Phenoxy-4-[1-(piperidine-4-yl)-4-(4-fluorophenyl)-5-imidazolyl]pyrimidineIC5019.0 [1], 19.2 [2], 20.0 [3]
4-Phenoxy-N-(pyridin-4-ylmethyl)benzamideIC502300.0 [1], 4000.0 [2], 10000.0 [3]
4-(4-Methylphenoxy)-N-(4-pyridinylmethyl)benzenecarboxamideIC504700.0 [1], 10000.0 [2], 22000.0 [3]
N-{4'-[(Cyclopropylmethyl)carbamoyl]-6-Methylbiphenyl-3-Yl}-2-Morpholin-4-Ylpyridine-4-CarboxamideIC506.0 [1]
N-{4'-[(Cyclopropylmethyl)carbamoyl]-6-Methylbiphenyl-3-Yl}-2-Morpholin-4-Ylpyridine-4-CarboxamideKi4.4 [1], 6.0 [2]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amineIC500.1 [1], 2.0 [2], 34.0 [3]
N-[2-Methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamideIC503.5 [1], 4.0 [2]
3-(2-Aminoquinazolin-6-Yl)-4-Methyl-N-[3-(Trifluoromethyl)phenyl]benzamideIC506.0 [1]
N-(4-(2-(Phenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamideIC50180.0 [1], 199.53 [2]
N-[4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-yl]acetamideIC50500.0 [1], 710.0 [2], 1072.0 [3]
4-[3-(4-Fluorophenyl)-5-isopropylisoxazol-4-yl]pyridineIC50450.0 [1]
4-[5-(4-Fluorophenyl)-3-isopropylisoxazol-4-yl]pyridineIC502200.0 [1]
N-(Cyclopropylmethyl)-2'-Methyl-5'-(5-Methyl-1,3,4-Oxadiazol-2-Yl)biphenyl-4-CarboxamideKi480.0 [1]
5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2(1H)-oneIC500.5 [1]
1-Methyl-3-tert-butyl-5-[3-(2,3-dichlorophenyl)ureido]-1H-pyrazoleIC5053.0 [1]
6-(2,4-Difluoroanilino)tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaen-2-oneIC5095.0 [1], 130.0 [2], 1907.0 [3]
1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-7-piperazin-1-YL-3,4-dihydroquinazolin-2(1H)-oneIC502.6 [1]
5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-piperazin-1-yl-3,4-dihydroquinazolin-2-oneIC501.4 [1]
5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-piperidin-4-yloxy-3,4-dihydroquinazolin-2-oneIC500.2 [1]
5-(2-Chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(piperazine-1-carbonyl)-3,4-dihydroquinazolin-2-oneIC501.1 [1]
2-(2-Chloro-4-fluorophenyl)sulfanyl-5-(2,6-dichlorophenyl)pyrimido[1,6-b]pyridazin-6-oneIC5036.0 [1], 53.0 [2], 275.0 [3]
5-(2,6-Dichlorophenyl)-2-(4-methylphenyl)sulfanylpyrimido[1,6-b]pyridazin-6-oneIC50370.0 [1], 870.0 [2], 1400.0 [3]
5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-oneIC50250.0 [1], 400.0 [2], 460.0 [3]
2-(3-Chlorophenyl)sulfanyl-5-(2,6-dichlorophenyl)pyrimido[1,6-b]pyridazin-6-oneIC50280.0 [1], 350.0 [2], 900.0 [3]
2-(4-Chloro-2-methylphenyl)sulfanyl-5-(2,6-dichlorophenyl)pyrimido[1,6-b]pyridazin-6-oneIC50160.0 [1], 180.0 [2]
5-(2,6-Dichlorophenyl)-2-(3,4-dichlorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-oneIC50800.0 [1], 970.0 [2], 1200.0 [3]
5-(2,6-Dichlorophenyl)-2-(4-fluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-oneIC5099.0 [1], 123.0 [2], 293.0 [3]
5-(2,6-Dichlorophenyl)-2-(2,4-dimethylphenyl)sulfanylpyrimido[1,6-b]pyridazin-6-oneIC50260.0 [1], 320.0 [2], 690.0 [3]
5-(2,6-Dichlorophenyl)-2-(2-hydroxyphenyl)sulfanylpyrimido[1,6-b]pyridazin-6-oneIC50140.0 [1], 360.0 [2], 490.0 [3]
5-(2,6-Dichlorophenyl)-2-(3,4-dimethylphenyl)sulfanylpyrimido[1,6-b]pyridazin-6-oneIC501900.0 [1], 2400.0 [2], 3500.0 [3]
5-(2,6-Dichlorophenyl)-2-(3-fluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-oneIC50440.0 [1], 450.0 [2], 720.0 [3]
5-(2,6-Dichlorophenyl)-2-(3-methylphenyl)sulfanylpyrimido[1,6-b]pyridazin-6-oneIC50210.0 [1], 280.0 [2], 1400.0 [3]
5-(2,6-Dichlorophenyl)-2-(2-methylphenyl)sulfanylpyrimido[1,6-b]pyridazin-6-oneIC50200.0 [1], 330.0 [2], 3700.0 [3]
2-(2-Amino-4-fluorophenyl)sulfanyl-5-(2,6-dichlorophenyl)pyrimido[1,6-b]pyridazin-6-oneIC50220.0 [1], 280.0 [2], 1200.0 [3]
2-(3-Chloro-4-fluorophenyl)sulfanyl-5-(2,6-dichlorophenyl)pyrimido[1,6-b]pyridazin-6-oneIC50180.0 [1], 480.0 [2], 500.0 [3]
N-[4-Methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3-yl]phenyl]-2-morpholin-4-ylpyridine-4-carboxamideIC5026.3 [1], 123.03 [2], 416.87 [3]
1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinoneIC5010.99 [1], 11.0 [2]
5-(2-Chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-piperidin-4-yl-3,4-dihydroquinazolin-2-oneIC500.1 [1]
1-(2,6-Dichlorophenyl)-5-(2-chloro-4-fluorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinoneIC503.0 [1]
1-(2,6-Dichlorophenyl)-5-(2,4-difluorophenyl)-7-(piperidin-4-ylamino)-3,4-dihydroquinazolin-2-oneIC500.6 [1]
1-(2,6-Dichlorophenyl)-5-(2-chlorophenyl)-7-(4-piperidinyl)-1,2,3,4-tetrahydroquinazoline-2-oneIC500.9 [1]
Cyclohexyl-{4-[5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]pyridin-2-yl}amineIC5020.0 [1], 27.0 [2], 170.0 [3]
2-(4-Fluorophenyl)-3-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]imidazo[1,2-a]pyrimidin-7-amineIC501.0 [1], 6.0 [2], 8.5 [3]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ MAP kinase p38 alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/map-kinase-p38-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ MAP kinase p38 alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/map-kinase-p38-alpha-inhibitors-ic50-ki.
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