![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_1475ac4f13187836f3e8e4e00ac9ba17.svg) | Tomivosertib | IC50 | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_788ffa50ad2324d6d75a7a55d852420b.svg) | (4-Methylpiperazin-1-yl)-[4-[3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-6-yl]phenyl]methanone | IC50 | 1990.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_4930f533fecc332ce5869be47355d3f6.svg) | [4-[3-(4-Chlorophenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanone | IC50 | 759.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_7dd6dcf3976c37def8fd58a8a6c0be6e.svg) | CID 118598634 | IC50 | 73.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_d7e248d170c164ac29f3680e52c2e2c7.svg) | N-[6-[(8-Chloro-1,5-dioxospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide | IC50 | 0.31 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_45829346b5531454687bfe3f0d281b6e.svg) | N-[6-[(3,3-Dimethyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide | IC50 | 12.3 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_60a199319b65e74bed08f31beaee020d.svg) | 3,3-Dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione | IC50 | 3800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_59f344bd9d8a72f86f8f53d7b89c990c.svg) | 6-[(6-Aminopyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione | IC50 | 0.79 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_91e83a6c6efd832a6cc18fd69385fef9.svg) | 6-[(6-Aminopyrimidin-4-yl)amino]-4',4'-difluoro-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione | IC50 | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_47bc1f5bc8fa5a485297cea104348cbd.svg) | 3,3,8-Trimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione | IC50 | 160.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_dd5ff19881e7f87c2ce4322ae624a438.svg) | 6-[(6-Aminopyrimidin-4-yl)amino]-8-chloro-3,3-dimethyl-2H-imidazo[1,5-a]pyridine-1,5-dione | IC50 | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_c9bc984f4088e12cfb0f8d6041e4084a.svg) | 6-[(6-Aminopyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclopentane]-1,5-dione | IC50 | 0.62 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_8f494f100af9a2fe79b232b08c4f3e95.svg) | N-[6-[[8-Chloro-3-(3-chlorophenyl)-3-methyl-1,5-dioxo-2H-imidazo[1,5-a]pyridin-6-yl]amino]pyrimidin-4-yl]cyclopropanecarboxamide | IC50 | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_ef0d261acfc7516652665c0e69429558.svg) | 6-[(6-Amino-5-chloropyrimidin-4-yl)amino]-8-chlorospiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione | IC50 | 0.08 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_130356d1808108824537acdf81f266d9.svg) | 8-Fluoro-3,3-dimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione | IC50 | 580.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_64e5548509b74a00717b8546418b7db3.svg) | (4-Methylpiperazin-1-yl)-[4-(3-phenylimidazo[1,2-a]pyrazin-6-yl)phenyl]methanone | IC50 | 1920.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_4c93c0e5891a1bba2acc76ee26629254.svg) | 2-Methyl-N-[5-[4-[[2-oxo-2-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)anilino]ethyl]amino]phenyl]pyridin-2-yl]propanamide | IC50 | 860.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_4c32e94241463824e89f53a7046ec309.svg) | 3-Methyl-5-(pyrimidin-4-ylamino)-2,3-dihydroisoindol-1-one | IC50 | 28000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_be9cf9c6a16c5c1a5b67c6a7577281ee.svg) | 3,3-Dimethyl-5-(pyrimidin-4-ylamino)-2H-isoindol-1-one | IC50 | 4400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_c256799714d8002f12793f43947669d0.svg) | N-[6-[(1-Oxo-2,3-dihydroisoindol-5-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide | IC50 | 430.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_5585735df5f94c3ca1082734ebe90f41.svg) | [4-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-morpholin-4-ylmethanone | IC50 | 130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_11cd1ab0ffd384d5c5e043bd7e3eddf9.svg) | N-Hydroxy-4-[6-[4-(4-methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzamide | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_6ec081eb3c44586e6880293a7087fc13.svg) | (4-(3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone | IC50 | 189.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_8d441e4ad0abdc121ebd470ab93e2ee8.svg) | 3-(3-Isoquinolin-6-ylimidazo[1,2-b]pyridazin-6-yl)oxycyclobutan-1-amine | IC50 | 120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_8b29455057fbc5ca321b29eda3cdbc08.svg) | [4-[3-(4-Methylphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanone | IC50 | 1210.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_adec0e281b29860945a9ddeb5b379082.svg) | 4-(6-Phenylimidazo[1,2-a]pyrazin-3-yl)phenol | IC50 | 819.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_7840b5bc6d1142d83ddbbabc49934fde.svg) | 1-[4-[4-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]benzoyl]piperazin-1-yl]ethanone | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_4394a51763929b44e32bb2ac076d6d03.svg) | N-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]acetamide | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_4084156f32924ff46468a92216e1b6a2.svg) | 4-[3-(4-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]benzamide | IC50 | 1080.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_f24e57627ea9e8641735c5a4d6bfd40e.svg) | 4-[6-[4-(4-Methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzoic acid | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_c22f24c2ca01d94fb76b75a19d09b405.svg) | [4-[3-(3-Hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanone | IC50 | 1330.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_809ffdd81b515c9790b7da538339c333.svg) | 4-[6-[4-(4-Methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzamide | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_73f2c76c1d26e48a1f65c9309028d032.svg) | 4-(6-(4-(Morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile | IC50 | 421.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_b84c8f15ef82768038d8616617da9d24.svg) | 4-(6-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile | IC50 | 431.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_17fd13d649adeeabb154448e8f82fc85.svg) | 4-(6-(4-(Morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)benzonitrile | IC50 | 748.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_262706c2f444aea8cb0b599aaba183e8.svg) | 4-[6-[4-(Morpholine-4-carbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl]benzonitrile | IC50 | 321.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_fa9dcb045fd114c597562234b4fef1af.svg) | N-[5-[3-Fluoro-4-[[2-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]amino]phenyl]pyridin-2-yl]cyclopropanecarboxamide | IC50 | 280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_0c7f5ba98572686dc16c3224d5435c30.svg) | 2-[4-(6-Acetamidopyridin-3-yl)phenoxy]-N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]acetamide | IC50 | 680.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_63572266cbe10a24bb9fa3ec82914ee4.svg) | 2-[4-(6-Acetamidopyridin-3-yl)anilino]-N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]acetamide | IC50 | 320.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_0f1dc93ba97f7fd3d01de6e7d8e5b268.svg) | N-[5-[4-[[2-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]amino]phenyl]pyridin-2-yl]cyclopropanecarboxamide | IC50 | 180.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_e9c6b4983c7dfa24c5ce631537956793.svg) | N-[5-[4-[[2-Oxo-2-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)anilino]ethyl]amino]phenyl]pyridin-2-yl]cyclopropanecarboxamide | IC50 | 320.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_e402297cd69ea8608a6de642b822fafe.svg) | 2-[4-(6-Acetamidopyridin-3-yl)anilino]-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]acetamide | IC50 | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_bc68d57d8ee72372d44d45321e952976.svg) | N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2-(4-pyridin-3-ylphenoxy)acetamide | IC50 | 98.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_acc22e1a69e21b3816f69b7b19367f43.svg) | 4-(6-(4-(4-Methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile | IC50 | 229.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_c484b596bf06c46e6211f4938616a973.svg) | [4-[3-[4-(Difluoromethyl)phenyl]imidazo[1,2-a]pyrazin-6-yl]phenyl]-(4-methylpiperazin-1-yl)methanone | IC50 | 1630.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_72303ac048d400551e3e58e12529b226.svg) | 4-[6-[4-[4-(Dimethylamino)piperidine-1-carbonyl]phenyl]imidazo[1,2-a]pyrazin-3-yl]benzonitrile | IC50 | 640.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_83da9a0f74e8088a9cb47a0d77b84835.svg) | 4-[6-[4-(4-Methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile | IC50 | 326.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_ae5398313e8f03c39679110dae6dd478.svg) | 4-[6-[4-(4-Methylpiperazine-1-carbonyl)phenyl]imidazo[1,2-a]pyrazin-3-yl]benzonitrile | IC50 | 440.0 [1] |
![](https://images.aatbio.com/dataset/ic50/map-kinase-interacting-serine-threonine-protein-kinase-1-2_fc365b5b6f8a45800e29fa256f7c6a50.svg) | 4-(6-(4-(Piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile | IC50 | 220.0 [1] |