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MAP kinase-activated protein kinase 5 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadieneIC5050000.0 [1]
RottlerinIC501900.0 [1]
2-(2-Quinolin-3-Ylpyridin-4-Yl)-1,5,6,7-Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-OneIC5081.0 [1], 100.0 [2]
(4-Morpholin-4-ylphenyl)-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]amineIC50816.0 [1], 2608.0 [2]
4-[8-(4-Morpholin-4-ylanilino)imidazo[1,2-a]pyrazin-5-yl]benzamideIC50914.0 [1], 1370.0 [2]
4-[8-(4-Morpholin-4-ylanilino)imidazo[1,2-a]pyrazin-5-yl]benzenesulfonamideIC5010000.0 [1]
N-(4-Morpholin-4-ylphenyl)-5-(2H-triazol-4-yl)imidazo[1,2-a]pyrazin-8-amineIC501490.0 [1], 10000.0 [2]
4-[8-(4-Morpholin-4-yl-phenylamino)imidazo[1,2-a]pyrazin-5-yl]-1H-pyridin-2-oneIC50390.0 [1], 871.0 [2]
N-(4-Morpholin-4-ylphenyl)-5-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amineIC50829.0 [1], 2823.0 [2]
5-(8-(4-Morpholinophenylamino)-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)isoindolin-1-oneIC50195.0 [1], 445.0 [2]
2-Fluoro-4-[8-(4-morpholin-4-ylanilino)imidazo[1,2-a]pyrazin-5-yl]benzamideIC502390.0 [1], 10000.0 [2]
5-[8-(4-Morpholin-4-yl-phenylamino)-imidazo[1,2-a]pyrazin-5-yl]-thiazole-2-carboxylic acid amideIC503200.0 [1], 10000.0 [2]
5-[8-(4-Morpholin-4-yl-phenylamino)-imidazo[1,2-a]pyrazin-5-yl]-2,3-dihydro-isoindol-1-oneIC50239.0 [1], 676.0 [2]
4-{8-[4-(4-Methylpiperazin-1-yl)phenylamino]imidazo[1,2-a]pyrazin-5-yl}-1H-pyridin-2-oneIC50290.0 [1], 871.0 [2]
4-[8-(4-Morpholin-4-ylanilino)imidazo[1,2-a]pyrazin-5-yl]furan-2-carboxamideIC5088.0 [1], 702.0 [2]
4-[8-(4-Morpholin-4-ylanilino)imidazo[1,2-a]pyrazin-5-yl]thiophene-2-carboxamideIC50327.0 [1], 437.0 [2]
5-[8-(4-Morpholin-4-ylanilino)imidazo[1,2-a]pyrazin-5-yl]thiophene-2-carboxamideIC50392.0 [1], 1420.0 [2]
2-[8-(4-Morpholin-4-yl-phenylamino)-imidazo[1,2-a]pyrazin-5-yl]-thiazole-5-carboxylic acid amideIC502820.0 [1], 10000.0 [2]
5-[8-(4-Morpholin-4-ylanilino)imidazo[1,2-a]pyrazin-5-yl]furan-3-carboxamideIC50148.0 [1], 227.0 [2]
(-)-Epigallocatechin gallateIC501000.0 [1]
TofacitinibIC5010000.0 [1]
DoramapimodIC5030000.0 [1]
Nvp-aew541IC5010000.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC50500.0 [1]
JNK Inhibitor VIC5010000.0 [1]
(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dioneIC50640.0 [1]
CID 59604787IC5010000.0 [1]
2-[2-(2-Fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneIC50210.0 [1]
CID 44814409IC5010000.0 [1]
6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acidIC5019000.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi1525.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
6-Acetyl-8-cyclopentyl-5-methyl-2-(4-piperazin-1-yl-phenylamino)-8H-pyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC503700.0 [1]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5010000.0 [1]
6-[2-[(E)-2-[4-(Morpholin-4-ylmethyl)phenyl]ethenyl]pyridin-4-yl]-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-oneIC5024.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
5-[[6-Chloro-5-(4-phenylphenyl)-1H-benzimidazol-2-yl]oxy]-2-methylbenzoic acidIC5010000.0 [1]
(4S,6Z)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dioneIC5010000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrileIC501700.0 [1]
9-Cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamineIC5010000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
TilfrinibIC5010000.0 [1]
5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4-difluorophenyl)-1,3-oxazoleIC5010000.0 [1]
5-(3-Propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazoleIC5010000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
6-[2-[(E)-2-[4-[2-(Dimethylamino)ethoxy]phenyl]ethenyl]pyridin-4-yl]-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-oneIC5028.0 [1]
2-(2-Phenylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-oneIC50140.0 [1]
4-(2-Chloro-4-fluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazoleIC5010000.0 [1]
N-Ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-[1,2,4]triazolo[4,3-a]pyridin-3-amineIC5010000.0 [1]
6-[5-(2,5-Difluorophenyl)-1H-pyrazol-4-yl]-3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridineIC5010000.0 [1]
7-Methoxy-3,4,5,10-tetrahydro-1H-2,5-methanoazepino[3,4-b]indole-1-carboxylic AcidIC5024000.0 [1]
N-[5-(4-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamideIC5010000.0 [1]
5-(1H-Indol-5-yl)-N-(4-morpholin-4-ylphenyl)imidazo[1,2-a]pyrazin-8-amineIC5010000.0 [1]
4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-iumIC5010000.0 [1]
5-Methoxy-9,12-diazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3(8),4,6-tetraene-11-carboxylic acidIC5025000.0 [1]
Cdk4-IN-1IC5010000.0 [1]
N-[5-[4-(Dimethylamino)piperidin-1-yl]pyridin-2-yl]-4-[5-propan-2-yl-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyrimidin-2-amineIC5010000.0 [1]
N-[5-[6-(Methylamino)pyrazin-2-yl]-2-oxo-1H-pyridin-3-yl]-4-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]benzamideKi1000.0 [1]
Infigratinib phosphateIC5010000.0 [1]
N-Methyl-N-(4-morpholin-4-ylphenyl)-5-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amineIC5010000.0 [1]
4-[8-[4-(4-Methylpiperazin-1-yl)anilino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl]-1H-pyridin-2-oneIC503730.0 [1]
5-(2-Ethoxypyridin-4-yl)-N-(4-morpholin-4-ylphenyl)imidazo[1,2-a]pyrazin-8-amineIC5010000.0 [1]
[5-(2-Dimethylamino-pyridin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-yl-phenyl)-amineIC5010000.0 [1]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5010000.0 [1]
1-[4-[3-[4-Amino-5-[2-fluoro-5-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanoneIC5010000.0 [1]
6-(1,9-Diazaspiro[5.5]undecan-9-Yl)-9h-PurineIC50226000.0 [1]
6-(2,9-Diazaspiro[5.5]undecan-9-Yl)-9h-PurineIC5041000.0 [1]
2-(2,6-Dichloroanilino)-7-[(E)-3-(diethylamino)prop-1-enyl]-1,6-dimethyl-8H-imidazo[4,5-h]isoquinolin-9-oneIC501000.0 [1]
5-N-(4-Aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamineIC5011000.0 [1]
3-Isopropyl-6-(4-phenyl-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridineIC5010000.0 [1]
5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazoleIC5010000.0 [1]
3-Chloro-4-[(3,5-difluoropyridin-2-yl)methoxy]-1-[2-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-5-methylpyridin-4-yl]-6-methylpyridin-2-oneIC508100.0 [1]
Items per page: 1 - 10 of 76
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References

This online tool may be cited as follows

MLA

"Quest Database™ MAP kinase-activated protein kinase 5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/map-kinase-activated-protein-kinase-5-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ MAP kinase-activated protein kinase 5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/map-kinase-activated-protein-kinase-5-inhibitors-ic50-ki.
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