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MAP kinase-activated protein kinase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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StaurosporineIC5036.25 [1], 110.0 [2], 150.0 [3], 400.0 [4], 660.0 [5]
6-(4-Chlorophenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]quinolin-4-amineIC50600.0 [1]
6-(4-Chlorophenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]quinolin-4-amineKi96.0 [1], 310.0 [2], 320.0 [3], 480.0 [4]
2-[2-(2-Fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneIC50126.0 [1], 560.0 [2], 4000.0 [3], 8900.0 [4]
5-(4-Chlorophenyl)-N-(4-piperazin-1-ylphenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamideIC50110.0 [1]
(3R)-9-Methoxy-3-methyl-1,2,3,4-tetrahydrobenzothiopheno[3,2-e][1,4]diazepin-5-oneIC5040.0 [1], 700.0 [2]
5-(4-Chlorophenyl)-N-(4-piperazin-1-ylphenyl)furan-2-carboxamideIC505000.0 [1], 5500.0 [2]
4-[5-(2-Methoxyethoxy)pyridin-3-yl]-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,8,11(16)-hexaen-12-oneIC5010.0 [1], 12.0 [2], 700.0 [3], 1500.0 [4]
Adenosine-5'-triphosphateIC502800.0 [1], 6300.0 [2], 12000.0 [3]
(15R)-15-Methyl-5-(6-methylpyridin-3-yl)-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC505.0 [1], 201.0 [2]
(15R)-15-Methyl-5-(6-methylpyridin-3-yl)-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneKi5.0 [1]
N-[1-(2,2-Dimethylpropyl)piperidin-4-yl]-2-[(1-oxospiro[2,3-dihydropyrazino[1,2-a]indole-4,1'-cyclobutane]-7-carbonyl)amino]-1,3-thiazole-4-carboxamideIC502.0 [1], 710.0 [2], 30000.0 [3]
N~7~-(4-Ethoxyphenyl)-6-Methyl-N~5~-[(3s)-Piperidin-3-Yl]pyrazolo[1,5-A]pyrimidine-5,7-DiamineIC50130.0 [1], 7200.0 [2], 11000.0 [3]
TofacitinibIC5010000.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC50171.0 [1], 470.0 [2]
2-(2-Quinolin-3-Ylpyridin-4-Yl)-1,5,6,7-Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-OneIC508.5 [1]
(1)Benzothieno(2,3-f)-1,4-thiazepin-5(2H)-one, 3,4-dihydro-9-methoxy-IC501090.0 [1], 5500.0 [2]
9-Methoxy-1,2,3,4-tetrahydrobenzothiopheno[3,2-e][1,4]diazepin-5-oneIC50180.0 [1], 1400.0 [2]
(3S)-9-Methoxy-3-methyl-1,2,3,4-tetrahydrobenzothiopheno[3,2-e][1,4]diazepin-5-oneIC50300.0 [1], 3800.0 [2]
6-[2-(4-Methoxyphenyl)pyridin-4-yl]-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-oneIC50540.0 [1], 550.0 [2]
8-Bromo-4-(3-chloro-4-fluoroanilino)-6-(2H-triazol-4-ylmethylamino)quinoline-3-carbonitrileIC5035800.0 [1], 49000.0 [2]
8-Chloro-4-(3-chloro-4-fluoroanilino)-6-(1H-imidazol-5-ylmethylamino)-3-quinolinecarbonitrileIC5040200.0 [1], 48000.0 [2]
2-[(4-Methyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indole-6-carbonyl)amino]-N-(1-methylpiperidin-4-yl)-1,3-thiazole-4-carboxamideIC5010.0 [1]
N-Cyclohexyl-2-[(4-methyl-1-oxo-2,3,4,9-tetrahydropyrido[3,4-b]indole-6-carbonyl)amino]-1,3-thiazole-4-carboxamideIC5044.0 [1]
4-(4-Oxo-8-piperazin-1-yl-5,10-dihydrofuro[2,3-c][1]benzazepin-2-yl)benzonitrileIC50110.0 [1]
2-(4-Chlorophenyl)-8-piperazin-1-yl-5-[(2-pyrimidin-5-ylphenyl)methyl]-10H-furo[2,3-c][1]benzazepin-4-oneIC505.7 [1]
2-(4-Chlorophenyl)-8-piperazin-1-yl-5,10-dihydrofuro[2,3-c][1]benzazepin-4-oneIC5096.0 [1]
4-(3-Fluorophenyl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-oneIC503.0 [1], 200.0 [2]
4-(3-Fluorophenyl)-1'-methylspiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-oneIC506.0 [1], 4500.0 [2]
5-(4-Chlorophenyl)-N-methyl-N-(4-piperazin-1-ylphenyl)furan-2-carboxamideIC50600.0 [1]
5-(4-Chlorophenyl)-N-ethyl-N-(4-piperazin-1-ylphenyl)furan-2-carboxamideIC50130.0 [1]
1,3-Diamino-6-hydroxy-9H-xanthene-2-carbonitrileIC50180.0 [1], 1080.0 [2]
1,3-Diamino-7-hydroxy-9H-xanthene-2-carbonitrileIC50470.0 [1], 25400.0 [2]
1,3-Diamino-6,7-dimethoxy-9H-xanthene-2-carbonitrileIC50330.0 [1], 64800.0 [2]
1,3-Diamino-5-hydroxy-9H-xanthene-2-carbonitrileIC50460.0 [1], 7120.0 [2]
8,10-Diamino-3,11-dihydro-2H-[1,4]dioxino[2,3-b]xanthene-9-carbonitrileIC50490.0 [1], 55700.0 [2]
1,3,7-Triamino-9H-xanthene-2-carbonitrileIC50530.0 [1], 100000.0 [2]
1,3-Diamino-9H-xanthene-2-carbonitrileIC50560.0 [1], 100000.0 [2]
1,3-Diamino-6-(1,4-dioxan-2-yl)-7-hydroxy-9H-xanthene-2-carbonitrileIC50620.0 [1], 11900.0 [2]
1,3-Diamino-6,8-dihydroxy-9H-xanthene-2-carbonitrileIC50690.0 [1], 100000.0 [2]
1,3-Diamino-6-ethoxy-7-hydroxy-9H-xanthene-2-carbonitrileIC50770.0 [1], 9400.0 [2]
1,3-Diamino-5,6-dihydroxy-9H-xanthene-2-carbonitrileIC50850.0 [1], 6920.0 [2]
1,3-Diamino-6,7-dihydroxy-9H-xanthene-2-carbonitrileIC50130.0 [1], 920.0 [2]
1,3-Diamino-6-(pyrrolidin-1-ylmethoxy)-9H-xanthene-2-carbonitrileIC501680.0 [1], 2910.0 [2]
3-Fluoro-4-(3-fluorophenyl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-oneIC503.0 [1], 370.0 [2]
3-Fluoro-4-(3-fluoro-4-methoxyphenyl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-oneIC503.0 [1], 370.0 [2]
3-Fluoro-4-(6-methoxypyridin-3-yl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-oneIC503.0 [1], 480.0 [2]
4-(2-Chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-iumIC5010000.0 [1]
4-[3-(2-Morpholin-4-ylethoxy)phenyl]-5,13,16-triazatetracyclo[8.6.0.02,7.011,15]hexadeca-1(10),2,4,6,8,11(15)-hexaen-12-oneIC5032.0 [1], 1280.0 [2]
4-[5-(2-Morpholin-4-ylethoxy)pyridin-3-yl]-5,13,16-triazatetracyclo[8.6.0.02,7.011,15]hexadeca-1(10),2,4,6,8,11(15)-hexaen-12-oneIC505.0 [1], 9330.0 [2]
4-[3-(2-Morpholin-4-ylethoxy)phenyl]-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,8,11(16)-hexaen-12-oneIC5016.0 [1], 1300.0 [2]
4-[5-(2-Morpholin-4-ylethoxy)pyridin-3-yl]-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,8,11(16)-hexaen-12-oneIC5010.0 [1], 2500.0 [2]
4-[5-(2-Morpholin-4-ylethoxy)pyridin-3-yl]-5,13,18-triazatetracyclo[8.8.0.02,7.011,17]octadeca-1(10),2,4,6,8,11(17)-hexaen-12-oneIC5080.0 [1], 30000.0 [2]
4-[5-(2-Methoxyethoxy)pyridin-3-yl]-5,13,18-triazatetracyclo[8.8.0.02,7.011,17]octadeca-1(10),2,4,6,8,11(17)-hexaen-12-oneIC5096.0 [1], 8300.0 [2]
4-[5-(2-Methoxyethoxy)pyridin-3-yl]-5,13,16-triazatetracyclo[8.6.0.02,7.011,15]hexadeca-1(10),2,4,6,8,11(15)-hexaen-12-oneIC505.0 [1], 1680.0 [2]
2-(3-Fluoro-4-methoxy-phenyl)-8,9,10,11-tetrahydro-3,8,11-triaza-benzo[a]fluoren-7-oneIC5015.0 [1], 500.0 [2]
4-(3-Fluoro-4-methoxyphenyl)-5,16-diazatetracyclo[8.6.0.02,7.011,15]hexadeca-1(10),2,4,6,8,11(15)-hexaen-12-oneIC50160.0 [1], 5800.0 [2]
4-(4-Methoxyphenyl)spiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,1'-cyclopropane]-12-oneIC50150.0 [1], 5600.0 [2]
4-(4-Methoxyphenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,3'-azetidine]-12-oneIC5012.0 [1], 3100.0 [2]
4-(6-Fluoropyridin-3-yl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-oneIC5050.0 [1], 1100.0 [2]
4-(2-Fluorophenyl)-1'-methylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-oneIC503.0 [1], 300.0 [2]
4-(4-Methoxyphenyl)-1'-methylspiro[3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-oneIC503.0 [1], 3000.0 [2]
(R)-10-Methyl-9,10,11,12-tetrahydro-7-thia-4,9,12-triaza-naphtho[1,2-a]azulen-8-oneIC501.0 [1], 50.0 [2]
(5R)-5-Methyl-14-oxa-9-thia-3,6-diazatetracyclo[8.7.0.02,8.013,17]heptadeca-1(10),2(8),11,13(17),15-pentaen-7-oneIC5016.0 [1], 90.0 [2]
4-(4-(2-(Cyclopentylamino)pyrimidin-4-yl)-1H-pyrazol-3-yl)cyclohexanolIC5013000.0 [1], 30000.0 [2]
(3R)-3-Methyl-9-(2-methylpropoxy)-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC5030.0 [1], 1800.0 [2]
(15R)-5-Chloro-15-methyl-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC502.0 [1], 130.0 [2]
(15R)-15-Methyl-5-pyridin-3-yl-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC505.0 [1], 220.0 [2]
(3R)-9-Hydroxy-3-methyl-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC50190.0 [1], 3500.0 [2]
Methyl 2-[[(3R)-3-methyl-5-oxo-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-9-yl]oxy]acetateIC503440.0 [1], 78000.0 [2]
(15R)-5-(2-Methoxyphenyl)-15-methyl-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC5020.0 [1], 1040.0 [2]
(3S)-3-(Hydroxymethyl)-9-methoxy-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC5014.0 [1], 400.0 [2]
(3R)-9-Methoxy-3-(propylaminomethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC50450.0 [1], 14900.0 [2]
(3R)-9-(Cyclopropylmethoxy)-3-methyl-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC501320.0 [1], 27000.0 [2]
(5R)-5-Methyl-15-phenyl-14-oxa-9-thia-3,6-diazatetracyclo[8.7.0.02,8.013,17]heptadeca-1(10),2(8),11,13(17),15-pentaen-7-oneIC50150.0 [1], 6800.0 [2]
(15R)-5-(3-Methoxyphenyl)-15-methyl-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC5041.0 [1], 690.0 [2]
(3S)-3-[[Benzyl(methyl)amino]methyl]-9-methoxy-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC501910.0 [1], 24000.0 [2]
(3R)-9-[(3-Methoxyphenyl)methoxy]-3-methyl-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC50110.0 [1], 4600.0 [2]
(3R)-9-(2-Methoxyethoxy)-3-methyl-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC50270.0 [1], 3100.0 [2]
(15R)-15-Methyl-5-pyrimidin-5-yl-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC5023.0 [1], 640.0 [2]
(3R)-3-(Ethylaminomethyl)-9-methoxy-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC50570.0 [1], 21600.0 [2]
(15R)-15-Methyl-5-phenyl-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC509.0 [1], 180.0 [2]
(15R)-15-Methyl-5-pyridin-4-yl-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC5014.0 [1], 740.0 [2]
(15R)-5-(2-Fluorophenyl)-15-methyl-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC5014.0 [1], 930.0 [2]
(15R)-15-Methyl-5-(4-methylpyridin-3-yl)-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC505.0 [1], 150.0 [2]
(3R)-9-Methoxy-3-propyl-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC501520.0 [1], 5450.0 [2]
7-Methoxy-2,3,4,5-tetrahydro-[1]benzothiolo[2,3-c]azepin-1-oneIC50500.0 [1], 4700.0 [2]
(3R)-3-[(Benzylamino)methyl]-9-methoxy-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-e][1,4]diazepin-5-oneIC50570.0 [1], 21000.0 [2]
(5R)-5-Methyl-14-oxa-9-thia-3,6-diazatetracyclo[8.7.0.02,8.013,17]heptadeca-1(10),2(8),11,13(17)-tetraen-7-oneIC5028.0 [1], 260.0 [2]
(15R)-15-Methyl-5-(2-methylphenyl)-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-oneIC5030.0 [1], 3360.0 [2]
(3R)-3-(Aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-oneIC505.0 [1], 2600.0 [2]
8-[(4-Aminocyclohexyl)amino]-2-(4-chlorophenyl)imidazo[1,2-a]pyrazine-5-carboxamideIC5060.0 [1], 1900.0 [2]
12-(2-Fluorophenyl)-1'-methylspiro[4,8,13-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-1(9),2(7),10,12,14-pentaene-6,3'-azetidine]-3-oneIC50230.0 [1], 10000.0 [2]
4-(3-Fluorophenyl)-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaen-12-oneIC508.0 [1], 1300.0 [2]
4-(3-Fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,1'-cyclopropane]-12-oneIC50100.0 [1], 900.0 [2]
4-(4-Methoxyphenyl)-3,5,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaen-12-oneIC50270.0 [1], 4300.0 [2]
4-(2-Fluorophenyl)-1',17-dimethylspiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-oneIC5013.0 [1], 1700.0 [2]
4-(4-Methoxyphenyl)-5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaen-12-oneIC5080.0 [1], 700.0 [2]
4-(3-Fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-14,1'-cyclopropane]-12-oneIC50230.0 [1], 500.0 [2]
1'-Acetyl-4-(2-fluorophenyl)spiro[5,13,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16)-pentaene-15,3'-azetidine]-12-oneIC50120.0 [1], 25000.0 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ MAP kinase-activated protein kinase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/map-kinase-activated-protein-kinase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ MAP kinase-activated protein kinase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/map-kinase-activated-protein-kinase-2-inhibitors-ic50-ki.
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