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Macrophage colony stimulating factor receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
Ethyl (2S)-5-oxopyrrolidine-2-carboxylateIC5038.0 [1]
Cfms Receptor Tyrosine Kinase InhibitorIC5030.0 [1], 60.0 [2], 140.0 [3], 148.0 [4]
5-Cyano-Furan-2-Carboxylic Acid [5-Hydroxymethyl-2-(4-Methyl-Piperidin-1-Yl)-Phenyl]-AmideIC5024.0 [1], 250.0 [2]
Csf1R-IN-1IC500.5 [1], 9.0 [2], 16.0 [3], 24.0 [4]
N-[4-Methyl-3-[[3-(1-methylpyrazol-4-yl)benzoyl]amino]phenyl]-4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzamideIC501.0 [1], 69.0 [2], 337.0 [3], 443.0 [4]
StaurosporineIC501.14 [1], 3.13 [2], 970.0 [3]
IlorasertibIC502.22 [1], 16.0 [2]
IlorasertibKi3.16 [1]
c-FMS inhibitorIC500.78 [1], 0.8 [2]
5-Cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl)furan-2-carboxamideIC501.0 [1]
5-Nitro-N-[2-(piperidin-1-yl)phenyl]furan-2-carboxamideIC5047.0 [1], 53.0 [2], 360.0 [3]
8-(2,3-Dihydro-1H-inden-5-yl)-2-[4-(4-methylpiperazin-1-yl)anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamideIC5013.0 [1]
N-[4-(3-Amino-3-oxopropyl)-2-(cyclohexen-1-yl)phenyl]-5-cyano-1H-imidazole-2-carboxamideIC502.7 [1]
3-[4-[(5-Cyano-1H-imidazole-2-carbonyl)amino]-3-(cyclohexen-1-yl)phenyl]propanoic acidIC505.9 [1]
N-[4-(3-Amino-3-oxopropyl)-2-(4,4-dimethylcyclohexen-1-yl)phenyl]-5-cyano-1H-imidazole-2-carboxamideIC501.7 [1]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-(1,1-dioxo-1,4-thiazinan-4-yl)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC503.3 [1], 3.5 [2]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-(2-methylsulfonylethylamino)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC501.5 [1], 1.8 [2]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-[methyl(2-methylsulfonylethyl)amino]propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC507.2 [1]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-(2-methoxyethylamino)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC500.44 [1], 0.51 [2], 0.6 [3]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-[2-methoxyethyl(methyl)amino]propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC501.7 [1], 2.1 [2]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-(2-morpholin-4-ylpropan-2-yl)phenyl]-1H-imidazole-2-carboxamideIC500.9 [1], 0.94 [2]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-(4-methylpiperazin-1-yl)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC502.3 [1], 2.9 [2], 5.1 [3]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-(2-morpholin-4-ylethylamino)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC501.2 [1]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-(morpholin-4-ylsulfonylmethyl)phenyl]-1H-imidazole-2-carboxamideIC5012.8 [1], 13.0 [2]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-(2-morpholin-4-ylethyl)phenyl]-1H-imidazole-2-carboxamideIC501.4 [1], 1.43 [2]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-(morpholin-4-ylmethyl)phenyl]-1H-imidazole-2-carboxamideIC503.2 [1], 4.6 [2]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-(2-morpholin-4-ylethyl)phenyl]-1H-imidazole-2-carboxamideIC500.8 [1]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-(4-ethylpiperazin-1-yl)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC501.5 [1]
N-[4-[2-(4-Acetylpiperazin-1-yl)propan-2-yl]-2-(4,4-dimethylcyclohexen-1-yl)phenyl]-5-cyano-1H-imidazole-2-carboxamideIC501.7 [1]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-(2-morpholin-4-ylethoxy)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC501.9 [1]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-(2-pyrrolidin-1-ylethoxy)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC501.2 [1]
4-(2-((1S,2S)-2-Hydroxycyclohexylamino)benzo[d]thiazol-6-yloxy)-N-methylpicolinamideIC502.0 [1], 30.0 [2], 58.0 [3]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-(2-methyl-1-morpholin-4-ylpropan-2-yl)phenyl]-1H-imidazole-2-carboxamideIC508.0 [1]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-(pyridin-2-ylamino)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC5019.0 [1]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-[4-(2-hydroxyethyl)piperazin-1-yl]propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC500.69 [1], 0.7 [2], 0.88 [3]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[1-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpropan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC502.0 [1]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-methyl-1-(2-methylsulfonylethylamino)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC501.5 [1], 1.6 [2]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-[4-(2-methoxyethyl)piperazin-1-yl]propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC501.3 [1]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-(2-morpholin-4-ylsulfonylethyl)phenyl]-1H-imidazole-2-carboxamideIC503.2 [1], 3.5 [2], 3.6 [3]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[1-(2-methoxyethylamino)-2-methylpropan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC500.6 [1], 0.64 [2]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[1-(1,1-dioxo-1,4-thiazinan-4-yl)-2-methylpropan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC503.5 [1]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-(2-morpholin-4-ylsulfonylethyl)phenyl]-1H-imidazole-2-carboxamideIC504.5 [1]
N-[4-[1-(4-Acetylpiperazin-1-yl)-2-methylpropan-2-yl]-2-(4,4-dimethylcyclohexen-1-yl)phenyl]-5-cyano-1H-imidazole-2-carboxamideIC505.7 [1]
ImatinibIC50291.0 [1], 960.0 [2]
SorafenibIC5019.0 [1], 58.0 [2]
PazopanibIC50146.0 [1], 274.0 [2]
DovitinibIC501.0 [1], 3.0 [2]
LinifanibIC503.0 [1]
PexidartinibIC5010.8 [1], 13.0 [2]
JNJ-28312141 free baseIC500.69 [1]
2-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamideIC50100.0 [1]
CID 118295624IC508.1 [1], 1500.0 [2]
N-[2-(4-Methylpiperazin-1-yl)phenyl]-5-nitrofuran-2-carboxamideIC50390.0 [1], 1400.0 [2]
N-[2-(4-Methylpiperidin-1-yl)phenyl]-5-nitrofuran-2-carboxamideIC5078.0 [1], 300.0 [2]
5-Cyano-N-[4-(4-Methylpiperazin-1-Yl)-2-Piperidin-1-Ylphenyl]furan-2-CarboxamideIC500.8 [1]
N-[4-(1-Acetylpiperidin-4-yl)-2-(cyclohexen-1-yl)phenyl]-5-cyano-1H-imidazole-2-carboxamideIC502.0 [1], 2.4 [2]
2-[4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenyl]-N-(1-propan-2-ylpyrazol-4-yl)acetamideIC501000.0 [1]
N-(2-(Piperidin-1-yl)phenyl)isoxazole-5-carboxamideIC50400.0 [1]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-(4-methylpiperazin-1-yl)phenyl]furan-2-carboxamideIC5018.0 [1]
5-Cyano-N-[2-(4-methylpiperidin-1-yl)-4-piperidin-4-ylphenyl]furan-2-carboxamideIC500.3 [1]
4-Cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)-1H-pyrrole-2-carboxamideIC501.7 [1], 2.0 [2]
8-(2,3-Dihydro-1H-inden-5-yl)-2-[4-[2-(4-methylpiperazin-1-yl)ethyl]anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamideIC500.8 [1], 8.0 [2]
4-(2,4-Difluorophenylamino)-6,7-dimethoxyquinoline-3-carboxamideIC5025.0 [1]
5-Cyano-N-(5-(hydroxymethyl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamideIC5025.0 [1], 190.0 [2]
5-Cyano-N-(5-cyano-2-(piperidin-1-yl)phenyl)furan-2-carboxamideIC50120.0 [1], 750.0 [2]
4-Cyano-N-(2-(piperidin-1-yl)phenyl)-1H-pyrrole-2-carboxamideIC5047.0 [1], 150.0 [2]
5-Cyano-N-(2-(piperidin-1-yl)phenyl)furan-2-carboxamideIC5036.0 [1], 370.0 [2]
N-(2-(3-Methylpiperidin-1-yl)phenyl)-5-nitrofuran-2-carboxamideIC50380.0 [1], 2200.0 [2]
5-Cyano-N-[5-[(diaminomethylideneamino)methyl]-2-piperidin-1-ylphenyl]furan-2-carboxamideIC5034.0 [1], 2600.0 [2]
5-Cyano-N-[5-(methanesulfonamidomethyl)-2-piperidin-1-ylphenyl]furan-2-carboxamideIC5037.0 [1], 310.0 [2]
N-(2-(4-Hydroxypiperidin-1-yl)phenyl)-5-nitrofuran-2-carboxamideIC50140.0 [1], 370.0 [2]
5-Cyano-N-(5-((4-methylpiperazin-1-yl)methyl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamideIC5080.0 [1], 1010.0 [2]
N-(2-(4-(Hydroxymethyl)piperidin-1-yl)phenyl)-5-nitrofuran-2-carboxamideIC50130.0 [1], 1400.0 [2]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-[1-(2-methylsulfonylethyl)piperidin-4-yl]phenyl]-1H-imidazole-2-carboxamideIC501.5 [1]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-[1-(2-morpholin-4-ylethyl)piperidin-4-yl]phenyl]-1H-imidazole-2-carboxamideIC501.1 [1]
(8E)-14-(2-Pyrrolidin-1-ylethoxy)-6,11,25-trioxa-18,20,23-triazatetracyclo[17.3.1.12,5.113,17]pentacosa-1(23),2,4,8,13,15,17(24),19,21-nonaeneIC5069.0 [1], 277.0 [2]
8-(2,3-Dihydro-1H-inden-5-yl)-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamideIC5014.0 [1]
5-Cyano-N-[4-[2-[2-(dimethylamino)ethoxy]propan-2-yl]-2-(4,4-dimethylcyclohexen-1-yl)phenyl]-1H-imidazole-2-carboxamideIC500.8 [1], 2.1 [2]
N-[4-[2-(2-Acetamidoethylamino)propan-2-yl]-2-(4,4-dimethylcyclohexen-1-yl)phenyl]-5-cyano-1H-imidazole-2-carboxamideIC500.68 [1], 0.7 [2]
5-Cyano-N-(2,5-di(piperidin-1-yl)phenyl)furan-2-carboxamideIC5017.0 [1], 76.0 [2]
N-[2-(Azepin-1-yl)phenyl]-5-nitrofuran-2-carboxamideIC50260.0 [1], 2000.0 [2]
N-(2-(4-(2-Hydroxyethyl)piperidin-1-yl)phenyl)-5-nitrofuran-2-carboxamideIC5043.0 [1], 230.0 [2]
4-Nitro-N-(2-(piperidin-1-yl)phenyl)-1H-pyrrole-2-carboxamideIC5047.0 [1], 180.0 [2]
5-Cyano-N-(5-hydroxy-2-(piperidin-1-yl)phenyl)furan-2-carboxamideIC5017.0 [1], 2700.0 [2]
5-Cyano-N-(5-methoxy-2-(piperidin-1-yl)phenyl)furan-2-carboxamideIC5090.0 [1], 960.0 [2]
N-(5-(Aminomethyl)-2-(piperidin-1-yl)phenyl)-5-cyanofuran-2-carboxamideIC50200.0 [1], 3100.0 [2]
5-Cyano-N-(5-formyl-2-(piperidin-1-yl)phenyl)furan-2-carboxamideIC5037.0 [1], 330.0 [2]
3-(2-Cyanofuran-5-carboxamido)-4-(piperidin-1-yl)benzoic acidIC502000.0 [1]
5-Cyano-N-[5-(2,3-dihydroxypropoxymethyl)-2-piperidin-1-ylphenyl]furan-2-carboxamideIC5019.0 [1], 170.0 [2]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[2-(3-hydroxypropylamino)-2-oxoethyl]phenyl]-1H-imidazole-2-carboxamideIC502.4 [1]
5-Cyano-N-[2-(4,4-dimethylcyclohexen-1-yl)-4-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]phenyl]-1H-imidazole-2-carboxamideIC500.75 [1], 0.8 [2]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-[2-(methanesulfonamido)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC504.7 [1]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-prop-1-en-2-ylphenyl]-1H-imidazole-2-carboxamideIC5032.9 [1]
N-[4-(2-Acetamidopropan-2-yl)-2-(cyclohexen-1-yl)phenyl]-5-cyano-1H-imidazole-2-carboxamideIC506.1 [1]
N-[4-[2-(Carbamoylamino)propan-2-yl]-2-(cyclohexen-1-yl)phenyl]-5-cyano-1H-imidazole-2-carboxamideIC5012.4 [1]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-[2-(2-hydroxyethylcarbamoylamino)propan-2-yl]phenyl]-1H-imidazole-2-carboxamideIC5031.7 [1]
N'-[2-[4-[(5-Cyano-1H-imidazole-2-carbonyl)amino]-3-(cyclohexen-1-yl)phenyl]propan-2-yl]oxamideIC508.6 [1]
3-[4-[(5-Carbamoyl-1H-imidazole-2-carbonyl)amino]-3-(cyclohexen-1-yl)phenyl]propanoic acidIC5079.0 [1]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-(1,3-dihydroxypropan-2-yl)phenyl]-1H-imidazole-2-carboxamideIC5060.0 [1]
[3-Acetyloxy-2-[4-[(5-cyano-1H-imidazole-2-carbonyl)amino]-3-(cyclohexen-1-yl)phenyl]propyl] acetateIC504.4 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Macrophage colony stimulating factor receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/macrophage-colony-stimulating-factor-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Macrophage colony stimulating factor receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/macrophage-colony-stimulating-factor-receptor-inhibitors-ic50-ki.
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