Lysosomal Pro-X carboxypeptidase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-Amino-N-[(2S,3S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)butan-2-yl]-2-methylpropanamide	IC50	1.0 [1]
	[(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chloro-3-methylphenyl)-5-methyl-1,2,4-triazol-3-yl]piperidin-1-yl]methanone	IC50	0.9 [1]
	Dizocilpine	IC50	5.3 [1]
	Phencyclidine	IC50	91.0 [1]
	1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(1-methyl-5-pyridin-4-ylpyrazol-3-yl)piperidin-1-yl]propan-1-one	IC50	1.1 [1], 1.4 [2]
	1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]propan-1-one	IC50	12.0 [1]
	1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-(4-phenylpiperidin-1-yl)propan-1-one	IC50	10.0 [1]
	CID 54670056	IC50	0.08 [1], 0.16 [2]
	[(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(2,5-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone	IC50	0.3 [1]
	1-[(2S)-2-[5-(3-Fluorophenyl)-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-(4-phenylphenyl)propan-1-one	IC50	158.0 [1], 3314.0 [2]
	1-[(2S)-2-[5-(3-Fluorophenyl)-1H-imidazol-2-yl]pyrrolidin-1-yl]-2,2-dimethyl-3-(4-phenylphenyl)propan-1-one	IC50	79.0 [1], 1460.0 [2]
	1-[(1R,2S,5S)-2-(4-Methyl-1H-benzimidazol-2-yl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-(4-phenylphenoxy)ethanone	IC50	308.0 [1], 1970.0 [2]
	2-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2-methylpropanamide	IC50	4.0 [1], 356.0 [2]
	2-Amino-N-[(2S)-3-(4-chlorophenyl)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl]-2-methylpropanamide	IC50	54.0 [1], 114.0 [2]
	2-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)azetidin-1-yl]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-2-methylpropanamide	IC50	9.0 [1], 829.0 [2]
	3-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2,2-dimethylpropanamide	IC50	3.0 [1], 42.0 [2]
	3-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-3-methylbutanamide	IC50	5.0 [1], 71.0 [2]
	2-Amino-N-[(2S)-1-[(2S)-2-(5-tert-butyl-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2-methylpropanamide	IC50	2.0 [1], 7.0 [2]
	N-[(2S)-1-[(2S)-2-(5-Tert-butyl-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2-hydroxy-2-methylpropanamide	IC50	4.0 [1]
	2-Amino-N-[(2S,3S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)azetidin-1-yl]-1-oxo-3-phenylbutan-2-yl]-2-methylpropanamide	IC50	37.0 [1], 67.0 [2]
	2-Amino-N-[(2S,3S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-phenylbutan-2-yl]-2-methylpropanamide	IC50	5.0 [1], 10.0 [2]
	N-[(2S,3S)-1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(4-fluorophenyl)phenyl]-1-oxobutan-2-yl]-2-hydroxy-2-methylpropanamide	IC50	2.0 [1]
	N-[(2S,3S)-1-[(2S)-2-(5,6-Dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-1-oxo-3-phenylbutan-2-yl]-2-hydroxy-2-methylpropanamide	IC50	21.0 [1], 59.0 [2]
	2-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]-1-oxopropan-2-yl]-2-methylpropanamide	IC50	5.0 [1], 7.0 [2]
	2-Amino-N-[(2S)-1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-methyl-1-oxo-3-phenylbutan-2-yl]-2-methylpropanamide	IC50	12.0 [1], 39.0 [2]
	1-[(2S)-2-[5-(3-Bromophenyl)-1H-imidazol-2-yl]-4,4-difluoropyrrolidin-1-yl]-3-[4-(2,3-dichlorophenyl)phenyl]-2,2-dimethylpropan-1-one	IC50	22.0 [1], 20000.0 [2]
	1-(4-Chloropyridin-2-yl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1H-2-benzofuran-3,4'-piperidine]	IC50	0.44 [1], 0.66 [2]
	1-(4-Chloro-1-oxidopyridin-1-ium-2-yl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[1H-2-benzofuran-3,4'-piperidine]	IC50	1.2 [1], 1.3 [2]
	(1R,2R,4R)-N-[Bis(4-fluorophenyl)methyl]-2-(4-bromophenyl)-4-morpholin-4-ylcyclohexane-1-carboxamide	IC50	0.66 [1], 1.4 [2]
	(1R,2R,4R)-N-[Bis(4-chlorophenyl)methyl]-2-(4-bromophenyl)-4-morpholin-4-ylcyclohexane-1-carboxamide	IC50	2.6 [1]
	(1R,2R,4R)-N-[Bis(4-fluorophenyl)methyl]-2-(4-bromophenyl)-4-[[2-(diethylamino)acetyl]amino]cyclohexane-1-carboxamide	IC50	16.7 [1], 17.0 [2]
	[(3S,4R)-1-Tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone	IC50	0.5 [1]
	[4-[2-(3-Chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone	IC50	10.7 [1], 11.0 [2]
	[(1R,2R,4S)-4-Amino-2-(2,4-difluorophenyl)-4-methylcyclopentyl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone	IC50	6.4 [1], 8.1 [2]
	[(1S,2S,4S)-4-Amino-2-(2,4-difluorophenyl)-4-methylcyclopentyl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone	IC50	18.0 [1]
	(2S)-N-Dodecyl-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide	Ki	34100.0 [1], 43100.0 [2]
	5-(4-Chloropyridin-2-yl)-1'-[2-[4-(trifluoromethoxy)phenyl]propan-2-yl]spiro[5H-furo[3,4-b]pyridine-7,4'-piperidine]	IC50	0.49 [1]
	5-(3,5-Dichlorophenyl)-1'-[4-(trifluoromethoxy)phenyl]sulfonylspiro[5H-furo[3,4-b]pyridine-7,4'-piperidine]	IC50	1.6 [1]
	5-(3,5-Dichlorophenyl)-1'-[[4-(trifluoromethoxy)phenyl]methyl]spiro[5H-furo[3,4-b]pyridine-7,4'-piperidine]	IC50	3.2 [1], 5.2 [2]
	(1R,2R,4R)-2-(4-Bromophenyl)-N-[(4-chlorophenyl)-(3-chloropyridin-4-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide	IC50	2.7 [1]
	(1R,2R,4R)-2-(4-Bromophenyl)-N-[(4-chlorophenyl)-pyridin-4-ylmethyl]-4-morpholin-4-ylcyclohexane-1-carboxamide	IC50	0.18 [1]
	(1R,2R,4R)-2-(4-Bromophenyl)-N-[(4-chlorophenyl)-(5-fluoropyridin-2-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide	IC50	0.95 [1]
	(1R,2R,4R)-2-(4-Bromophenyl)-N-[(4-chlorophenyl)-(2-methylpyridin-4-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide	IC50	2.2 [1], 3.1 [2]
	Benzyl (2S)-2-[(2S)-2-(hexadecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	61000.0 [1], 141400.0 [2]
	Benzyl (2S)-2-[(2S)-2-[[2-(trifluoromethyl)phenyl]methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	135400.0 [1], 488600.0 [2]
	Benzyl (2S)-2-[(2S)-2-[(4-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	257100.0 [1], 264600.0 [2]
	Benzyl (2S)-2-[(2S)-2-[(2,6-difluorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	541500.0 [1], 835700.0 [2]
	Benzyl (2S)-2-[(2S)-2-[(3-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	467700.0 [1], 900000.0 [2]
	Benzyl (2S)-2-[(2S)-2-[(2-methoxyphenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	289200.0 [1], 771400.0 [2]
	Benzyl (2S)-2-[(2S)-2-[(3-methoxyphenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	393800.0 [1], 450000.0 [2]
	Benzyl (2S)-2-[(2S)-2-[2-(4-bromophenyl)ethylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	110800.0 [1], 282900.0 [2]
	Benzyl (2S)-2-[(2S)-2-(pentylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	289200.0 [1], 565700.0 [2]
	Benzyl (2S)-2-[(2S)-2-(heptylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	80000.0 [1], 437100.0 [2]
	Benzyl (2S)-2-[(2S)-2-(dodecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	61500.0 [1], 64300.0 [2]
	Benzyl (2S)-2-[[4-[(2-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Ki	332300.0 [1], 694300.0 [2]
	Benzyl (2S)-2-[[4-[(3-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Ki	227700.0 [1], 565700.0 [2]
	Benzyl (2S)-2-[[4-[(4-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Ki	258500.0 [1], 668600.0 [2]
	Benzyl (2S)-2-[[4-[(2,4-dichlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Ki	147700.0 [1], 604300.0 [2]
	Benzyl (2S)-2-[[4-[(3,4-dichlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Ki	110800.0 [1], 456400.0 [2]
	Benzyl (2S)-2-[[4-[3-[2-(2-ethoxyethoxy)ethoxy]propylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Ki	192900.0 [1], 350800.0 [2]
	N-Dodecylazetidine-2-carboxamide	Ki	50140.0 [1], 195100.0 [2]
	N-Dodecyl-1-(pyrrolidine-2-carbonyl)azetidine-2-carboxamide	Ki	50400.0 [1], 84900.0 [2]
	Benzyl (2S)-2-[(2S)-2-(pentadecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Ki	61500.0 [1], 64200.0 [2]
	1-(Azetidine-2-carbonyl)-N-dodecylazetidine-2-carboxamide	Ki	29600.0 [1], 108900.0 [2]
	(2S)-1-[(2S)-Azetidine-2-carbonyl]-N-dodecylpyrrolidine-2-carboxamide	Ki	17400.0 [1], 43700.0 [2]
	(2S)-N-[4-(Dodecylamino)-4-oxobutyl]pyrrolidine-2-carboxamide	Ki	6400.0 [1], 36900.0 [2]
	(2S)-N-Dodecylpyrrolidine-2-carboxamide	Ki	61500.0 [1], 477000.0 [2]
	Tenocyclidine	IC50	20.0 [1]
	Caramiphen	Ki	26.0 [1]
	2-(4-Morpholino)ethyl-1-phenylcyclohexane-1-carboxylate	IC50	100000.0 [1]
	Carbetapentane	IC50	32.0 [1]
	Metaphit	Ki	16.0 [1]
	1-Benzyl-1,2,3,4-tetrahydroisoquinoline	IC50	1000.0 [1]
	(2S)-N-Benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide	IC50	100000.0 [1]
	(R)-Preclamol	IC50	100000.0 [1]
	4-Phenyl-1,2,3,4-tetrahydroisoquinoline	IC50	30000.0 [1]
	1-Phenyl-1,2,3,4-tetrahydroisoquinoline	IC50	1900.0 [1]
	2-Methyl-1,2,3,4-tetrahydroisoquinoline	IC50	30000.0 [1]
	1,3-Dimethyl-1,2,3,4-tetrahydroisoquinoline	IC50	30000.0 [1]
	3-Phenyl-1,2,3,4-tetrahydroisoquinoline	IC50	3900.0 [1]
	1-Isopropyl-1,2,3,4-tetrahydroisoquinoline	IC50	11000.0 [1]
	1-Cyclohexyl-1,2,3,4-tetrahydro-isoquinoline	IC50	12000.0 [1]
	1-(1-Tricyclo[6.2.2.02,7]dodeca-2,4,6-trienyl)piperidine	IC50	117500.0 [1]
	1-(4-Chlorophenyl)-1,2,3,4-tetrahydroisoquinoline	IC50	5300.0 [1]
	1-Isobutyl-1,2,3,4-tetrahydro-isoquinoline	IC50	20000.0 [1]
	1-Phenyl-2,3-dihydro-1H-isoindole	IC50	30000.0 [1]
	1-Phenyl-2-prop-2-enyl-3,4-dihydro-1H-isoquinoline	IC50	2300.0 [1]
	1-(4-Fluorophenyl)-1,2,3,4-tetrahydroisoquinoline	IC50	4900.0 [1]
	1-(4-Methylphenyl)-1,2,3,4-tetrahydroisoquinoline	IC50	9500.0 [1]
	1-Naphthalen-2-yl-1,2,3,4-tetrahydro-isoquinoline	IC50	30000.0 [1]
	2-Allyl-1-cyclohexyl-1,2,3,4-tetrahydro-isoquinoline	IC50	6200.0 [1]
	2-Benzyl-3-methyl-1,2,3,4-tetrahydroisoquinoline	IC50	30000.0 [1]
	2-Allyl-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinoline	IC50	5400.0 [1]
	1-Phenyl-2-ethyl-1,2,3,4-tetrahydroisoquinoline	IC50	3800.0 [1]
	2-Methyl-1-phenyl-3,4-dihydro-1H-isoquinoline	IC50	24000.0 [1]
	Isoquinoline, 1,2,3,4-tetrahydro-2,3-dimethyl-	IC50	30000.0 [1]
	(1S,13R)-1,13-Dimethyl-10-prop-2-enyl-10-azatricyclo[7.3.1.02,7]trideca-2,4,6-triene	IC50	760.0 [1]
	1-(3,4-Dihydro-2H-1,4-methano-naphthalen-1-yl)-piperidine	IC50	107000.0 [1]
	3-[4-(3-Aminophenyl)phenyl]-1-[(2S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidin-1-yl]propan-1-one	IC50	4090.0 [1]
	3-[4-(2-Methylphenyl)phenyl]-1-[(2S)-2-(5-phenyl-1H-imidazol-2-yl)pyrrolidin-1-yl]propan-1-one	IC50	352.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Lysosomal Pro-X carboxypeptidase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/lysosomal-pro-x-carboxypeptidase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Lysosomal Pro-X carboxypeptidase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lysosomal-pro-x-carboxypeptidase-inhibitors-ic50-ki.
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