Lysine-specific histone demethylase 1B Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Iadademstat	IC50	12900.0 [1], 43400.0 [2], 43450.0 [3], 100000.0 [4]
	4-N-[(1R,1As,6aS)-1,1a,6,6a-tetrahydrocyclopropa[a]inden-1-yl]cyclohexane-1,4-diamine;hydrochloride	IC50	100000.0 [1]
	4-N-[(1S,1As,6aS)-1,1a,6,6a-tetrahydrocyclopropa[a]inden-1-yl]cyclohexane-1,4-diamine;hydrochloride	IC50	4510.0 [1], 6770.0 [2]
	Tranylcypromine	IC50	100000.0 [1]
	(1S,2R)-2-Phenylcyclopropan-1-amine;(1R,2S)-2-phenylcyclopropan-1-amine	IC50	100000.0 [1]
	Tranylcypromine hydrochloride	IC50	34900.0 [1]
	N-[(2S)-4-[3-(2-Aminocyclopropyl)phenoxy]-1-(benzylamino)-1-oxobutan-2-yl]benzamide	IC50	26000.0 [1]
	Tert-butyl 4-[[1-[(4-methylphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	IC50	36600.0 [1]
	4-Methyl-N-[3-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide	IC50	100000.0 [1]
	4-Methyl-N-[3-[(4-piperidin-4-yloxyphenoxy)methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide	IC50	100000.0 [1]
	Benzyl N-[1-[4-(2-aminocyclopropyl)anilino]-1-oxo-3-phenylpropan-2-yl]carbamate	Ki	38000.0 [1]
	N-(3-(Methoxymethyl)phenyl)-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxamide	IC50	100000.0 [1]
	Tert-butyl 4-[[1-[(2-fluorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate	IC50	49100.0 [1]
	N-[(2S)-1-(Benzylamino)-1-oxo-6-[(2-phenylcyclopropyl)amino]hexan-2-yl]benzamide	IC50	60000.0 [1]
	DDP-38003 dihydrochloride	IC50	49300.0 [1]
	N-[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]-4-(1-methylpiperidin-4-yl)benzamide;hydrochloride	IC50	34700.0 [1]
	N-[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]-3-(2-oxo-1,3-oxazolidin-3-yl)benzamide;hydrochloride	IC50	12600.0 [1]
	N-[3-(Methoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamide	IC50	16600.0 [1]
	4-Ethyl-N-[3-(methoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide	IC50	16700.0 [1]
	N-[3-(Ethoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamide	IC50	12900.0 [1]
	N-[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]-4-(furan-3-yl)benzamide;hydrochloride	IC50	51000.0 [1]
	Benzyl N-[3-[[4-[(1S,2R)-2-aminocyclopropyl]phenyl]carbamoyl]phenyl]carbamate;hydrochloride	IC50	11600.0 [1]
	Benzyl N-[4-[[4-[(1S,2R)-2-aminocyclopropyl]phenyl]carbamoyl]-2-morpholin-4-ylphenyl]carbamate;hydrochloride	IC50	14900.0 [1]
	Benzyl N-[5-[[4-[(1S,2R)-2-aminocyclopropyl]phenyl]carbamoyl]-2-(4-methylpiperazin-1-yl)phenyl]carbamate;dihydrochloride	IC50	4300.0 [1]
	CID 145948622	IC50	7510.0 [1]
	CID 145948655	IC50	13200.0 [1]
	(3R)-4-[(2R)-2-[[(2R)-4-Amino-1-[[(2R)-1-[[(2R)-6-amino-1-[(2R)-2-[[(2S)-4-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-1,5-diamino-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-[[(2R)-2-[[(2R)-1-[(2R)-6-amino-2-[[(2R)-5-carbamimidamido-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-5-carbamimidamido-2-[[(2S)-pyrrolidine-2-carbonyl]amino]pentanoyl]amino]-3-hydroxypropanoyl]amino]-5-(2-methylhydrazinyl)pentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]pentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid	IC50	50000.0 [1]
	CID 145949023	IC50	23200.0 [1]
	(3R)-4-[(2R)-2-[[(2R)-4-Amino-1-[[(2R)-1-[[(2R)-6-amino-1-[(2R)-2-[[(2S)-4-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-1,5-diamino-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-[[(2R)-2-[[(2R)-1-[(2R)-6-amino-2-[[(2R)-5-carbamimidamido-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-5-carbamimidamido-2-[[(2S)-pyrrolidine-2-carbonyl]amino]pentanoyl]amino]-3-hydroxypropanoyl]amino]-5-hydrazinylpentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]pentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid	IC50	50000.0 [1]
	(1S,1As,6aS)-N-(piperidin-4-ylmethyl)-1,1a,6,6a-tetrahydrocyclopropa[a]inden-1-amine;hydrochloride	IC50	1430.0 [1]
	(1R,1As,6aS)-N-[(2-methoxypyridin-3-yl)methyl]-1,1a,6,6a-tetrahydrocyclopropa[a]inden-1-amine;hydrochloride	IC50	100000.0 [1]
	(1R,1As,6aS)-4-phenyl-1,1a,6,6a-tetrahydrocyclopropa[a]inden-1-amine;hydrochloride	IC50	100000.0 [1]
	(1S,1As,6aS)-4-phenyl-1,1a,6,6a-tetrahydrocyclopropa[a]inden-1-amine;hydrochloride	IC50	44800.0 [1]
	(1R,1As,6aS)-N-(piperidin-4-ylmethyl)-1,1a,6,6a-tetrahydrocyclopropa[a]inden-1-amine;hydrochloride	IC50	100000.0 [1]
	N-[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]benzamide	IC50	58300.0 [1]
	N-[(2S)-1-(Benzylamino)-1-oxo-6-[(2-phenylcyclopropyl)amino]hexan-2-yl]-4-phenylbenzamide	IC50	230000.0 [1]
	N-[(2S)-1-Oxo-6-[(2-phenylcyclopropyl)amino]-1-[[3-(trifluoromethyl)phenyl]methylamino]hexan-2-yl]-4-phenylbenzamide	IC50	540000.0 [1]
	N-[(2S)-1-[(4-Chlorophenyl)methylamino]-1-oxo-6-[(2-phenylcyclopropyl)amino]hexan-2-yl]-4-phenylbenzamide	IC50	250000.0 [1]
	N-[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]-4-morpholin-4-ylbenzamide	IC50	74700.0 [1]
	Benzyl N-[5-[[4-[(1S,2R)-2-aminocyclopropyl]phenyl]carbamoyl]-2-morpholin-4-ylphenyl]carbamate	IC50	5700.0 [1]
	Benzyl N-[5-[[4-[(1S,2R)-2-aminocyclopropyl]phenyl]carbamoyl]-2-piperidin-1-ylphenyl]carbamate	IC50	4300.0 [1]
	N-[4-[(1R,2S)-2-Aminocyclopropyl]phenyl]-4-(4-methylpiperazin-1-yl)benzamide	IC50	44000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 42 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Lysine-specific histone demethylase 1B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/lysine-specific-histone-demethylase-1b-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 21). Quest Database™ Lysine-specific histone demethylase 1B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lysine-specific-histone-demethylase-1b-inhibitors-ic50-ki.
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