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Lysine-specific demethylase 5B Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
2-{5-[(4-Chloro-2-Methylphenyl)methoxy]-1h-Pyrazol-1-Yl}pyridine-4-Carboxylic AcidIC502.0 [1], 100.0 [2]
2-[5-[(4-Chlorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC504.0 [1], 100.0 [2]
2-[5-(4-Methoxyphenyl)-1-methylimidazol-4-yl]pyridine-4-carboxylic acidIC50100.0 [1], 1000.0 [2]
2-[5-[(4-Fluorophenyl)methoxy]-4-(2-hydroxyethyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC5068.0 [1], 100.0 [2]
2-(1-Methylimidazol-4-yl)pyridine-4-carboxylic acidIC50100.0 [1], 10000.0 [2]
2-(1-Methylimidazol-4-yl)-4-(2H-tetrazol-5-yl)pyridineIC50100.0 [1], 10000.0 [2]
2-[5-[4-(Cyclopropylmethoxy)phenyl]-1-methylimidazol-4-yl]pyridine-4-carboxylic acidIC50100.0 [1], 1000.0 [2]
Ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinateIC50100.0 [1], 1000.0 [2]
2-(((2-((2-(Dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acidIC50100.0 [1], 1000.0 [2]
2-[5-(4-Hydroxyphenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 320.0 [2]
3-[(1-Cyclopentyl-5-fluoroindazol-3-yl)amino]pyridine-4-carboxylic acidIC50100.0 [1]
2-(5-p-Tolyl-1H-pyrazol-1-yl)isonicotinic acidIC50100.0 [1], 200.0 [2]
2-[5-(3-Hydroxy-4-methylphenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC5076.0 [1], 100.0 [2]
2-[5-(2,4-Difluorophenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 170.0 [2]
2-[5-(3-Fluorophenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 500.0 [2]
2-[5-(4-Methylsulfonylphenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 350.0 [2]
2-[5-(3-Methoxy-4-methylphenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 540.0 [2]
2-[5-(3-Hydroxyphenyl)-1H-pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 120.0 [2]
2-(5-Phenyl-1H-pyrazol-1-yl)isonicotinic acidIC501000.0 [1], 4400.0 [2]
2-(5-(Benzyloxy)-1H-pyrazol-1-yl)isonicotinic acidIC501.0 [1], 100.0 [2]
2-[5-[(4-Cyanophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC500.6 [1], 100.0 [2]
Methyl 2-[[[2-[2-(dimethylamino)ethyl-ethylamino]-2-oxoethyl]amino]methyl]pyridine-4-carboxylateIC50100.0 [1], 1000.0 [2]
2-[5-[(4-Chloro-2-methoxyphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC501.0 [1], 100.0 [2]
2-[5-[(4-Methoxyphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC504.0 [1], 100.0 [2]
2-[5-[(4-Fluorophenyl)methoxy]-4-methylpyrazol-1-yl]pyridine-4-carboxylic acidIC5054.0 [1], 100.0 [2]
2-[5-[(4-Bromophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC502.0 [1], 100.0 [2]
2-[5-[(4-Cyclopropylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC508.0 [1], 100.0 [2]
2-[5-[[4-Chloro-2-(cyclopropylmethoxy)phenyl]methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC506.0 [1], 100.0 [2]
2-[5-[(2-Fluorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5042.0 [1], 100.0 [2]
2-[5-(3,4-Difluorophenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 370.0 [2]
2-[5-[(4-Chloro-2-fluorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC504.0 [1], 100.0 [2]
2-[5-[(4-Methylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC504.0 [1], 100.0 [2]
2-[5-[(4-Ethylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC503.0 [1], 100.0 [2]
2-[5-[(4-Chloro-2-ethoxyphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC504.0 [1], 100.0 [2]
2-[4-[2-(Dimethylamino)ethyl]-5-[(4-fluorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC501.0 [1], 100.0 [2]
2-[5-(4-Chloro-3-methoxyphenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 230.0 [2]
2-[5-[(3-Fluorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5022.0 [1], 100.0 [2]
2-[5-[(4-Fluorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC504.0 [1], 100.0 [2]
2-[5-[(4-Chloro-2-phenylmethoxyphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC504.0 [1], 100.0 [2]
2-[5-(4-Fluorophenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 240.0 [2]
2-[4-Ethyl-5-[(4-fluorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5024.0 [1], 100.0 [2]
2-[5-[1-(4-Fluorophenyl)ethoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5041.0 [1], 100.0 [2]
3-[(1-Methylpyrazolo[3,4-b]pyridin-3-yl)amino]pyridine-4-carboxylic acidIC50100.0 [1]
Pyridine-2,4-dicarboxylic acidIC502700.0 [1]
N-(4-Pyridin-2-yl-thiazol-2-yl)-benzamideIC5051200.0 [1]
Kdm5A-IN-1IC5056.0 [1]
8-(1-Methyl-1h-Imidazol-4-Yl)-2-(4,4,4-Trifluorobutoxy)pyrido[3,4-D]pyrimidin-4-OlIC50100.0 [1]
9-Oxo-4,5,6,7,8,9-hexahydro-pyrazolo[5,1-b]quinazoline-3-carbonitrileIC501000.0 [1]
3-[[(1R)-6-(N-Methylanilino)-1,2,3,4-tetrahydronaphthalen-1-yl]methylamino]pyridine-4-carboxylic acidIC50750.0 [1]
Pyrido[3,4-d]pyrimidin-4(3H)-oneIC501300.0 [1]
3-Ethylsulfonyl-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)benzamideIC5052600.0 [1]
2-(2-Azanyl-1,3-Thiazol-4-Yl)pyridine-4-CarboxamideIC502200.0 [1]
6-[[(2-Oxo-2-piperidin-1-ylethyl)amino]methyl]pyridazine-4-carboxylic acidIC50250.0 [1]
2-[[(1-Ethyl-2-oxopyrrolidin-3-yl)methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[[[(3R)-1-Ethyl-2-oxopiperidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[[[1-[(E)-3-Phenylprop-2-enyl]imidazol-2-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[(2-Methyl-5,6,8,9-tetrahydroimidazo[1,2-d][1,4]diazepin-7-yl)methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[[[(3S)-2-Oxo-1-[(1R)-1-phenylethyl]piperidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[[4-Chloro-3-(cyclopropylmethoxy)phenyl]methoxy]-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acidIC50100.0 [1]
2-(2-Benzamido-1,3-thiazol-4-yl)pyridine-4-carboxylic acidIC50590.0 [1]
Lithium;2-[(furan-2-ylmethylamino)methyl]pyridine-4-carboxylateIC5040.0 [1]
Lithium;2-[(benzylamino)methyl]pyridine-4-carboxylateIC50130.0 [1]
2-[(4-Chloro-3-methoxyphenyl)methoxy]-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acidIC501000.0 [1]
2-[[4-Chloro-3-(trifluoromethoxy)phenyl]methoxy]-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acidIC50100.0 [1]
2-[[[(3S)-2-Oxo-1-[(1R)-1-phenylethyl]pyrrolidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[[[(3S)-1-[(1R)-1-(4-Methoxyphenyl)ethyl]-2-oxopiperidin-3-yl]methylamino]methyl]pyridine-4-carboxylic acidIC50250.0 [1]
2-[5-(2-Methoxyethanoylamino)-2-Oxidanyl-Phenyl]pyridine-4-Carboxylic AcidIC5012000.0 [1]
2-[5-[(5-Methyl-1,2-oxazol-3-yl)carbonylamino]-2-oxidanyl-phenyl]pyridine-4-carboxylic acidIC502700.0 [1]
2-(5-Acetamido-2-Oxidanyl-Phenyl)pyridine-4-Carboxylic AcidIC5072000.0 [1]
2-[5-[(4-Hydroxyphenyl)carbonylamino]-2-Oxidanyl-Phenyl]pyridine-4-Carboxylic AcidIC5019000.0 [1]
2-[5-[2-(3-Methoxyphenyl)ethanoylamino]-2-Oxidanyl-Phenyl]pyridine-4-Carboxylic AcidIC5022000.0 [1]
8-(2-Azanyl-1,3-Thiazol-4-Yl)-3~{h}-Pyrido[3,4-D]pyrimidin-4-OneIC50124.0 [1]
8-(1,3-Thiazol-4-Yl)-3~{h}-Pyrido[3,4-D]pyrimidin-4-OneIC50310.0 [1]
8-[4-[2-[(4-Fluorophenyl)methyl-Methyl-Amino]ethyl]pyrazol-1-Yl]-3~{h}-Pyrido[3,4-D]pyrimidin-4-OneIC5042.0 [1]
8-[4-[2-(Dimethylamino)ethyl]pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC50350.0 [1]
8-[4-[2-[4-(4-Chlorophenyl)piperidin-1-Yl]ethyl]pyrazol-1-Yl]-3~{h}-Pyrido[3,4-D]pyrimidin-4-OneIC5030.0 [1]
8-[4-[2-[4-[(4-Chlorophenyl)methyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC5014.0 [1]
8-Pyrazol-1-yl-3H-pyrido[3,4-d]pyrimidin-4-oneIC507000.0 [1]
8-[4-[2-[4-(3,5-Dichlorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC5014.0 [1]
8-[[(Phenylmethyl)amino]methyl]-1~{h}-Pyrido[3,4-D]pyrimidin-4-OneIC50690.0 [1]
8-[4-(2-Hydroxyethyl)pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC504600.0 [1]
2-[1-(2-Morpholin-4-ylethyl)pyrazol-4-yl]oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50100.0 [1]
2-[1-[(3S)-1-Ethylsulfonylpyrrolidin-3-yl]pyrazol-4-yl]oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50100.0 [1]
2-[1-[(3R)-1-Benzylpiperidin-3-yl]pyrazol-4-yl]oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50100.0 [1]
8-(1H-Pyrazol-5-yl)-3H-pyrido[3,4-d]pyrimidin-4-oneIC504100.0 [1]
8-[4-(2-Pyrrolidin-1-ylethyl)pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC5071.0 [1]
8-[4-(2-Piperidin-1-ylethyl)pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC50199.0 [1]
8-[4-[2-[(3,4-Dichlorophenyl)methyl-methylamino]ethyl]pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC5048.0 [1]
8-[4-[2-[Methyl-[(4-methylsulfonylphenyl)methyl]amino]ethyl]pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC5072.0 [1]
4-[[Methyl-[2-[1-(4-oxo-3H-pyrido[3,4-d]pyrimidin-8-yl)pyrazol-4-yl]ethyl]amino]methyl]benzonitrileIC5048.0 [1]
4-[[Methyl-[3-[1-(4-oxo-3H-pyrido[3,4-d]pyrimidin-8-yl)pyrazol-4-yl]propyl]amino]methyl]benzonitrileIC5048.0 [1]
8-(1-Methylpyrazol-3-yl)-3H-pyrido[3,4-d]pyrimidin-4-oneIC5021400.0 [1]
8-[(Furan-2-ylmethylamino)methyl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC50630.0 [1]
8-[(4-Methylpiperazin-1-yl)methyl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC501400.0 [1]
8-[(4-Phenylpiperazin-1-yl)methyl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC503900.0 [1]
8-[(4-Pyridin-2-ylpiperazin-1-yl)methyl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC502000.0 [1]
8-[4-[2-[4-(3-Chlorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-oneIC5023.0 [1]
8-[4-[2-[4-(3,5-Difluorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC5043.0 [1]
8-[4-[2-[4-(2,4-Difluorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC5011.0 [1]
8-[4-[2-[4-[3-(Trifluoromethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-oneIC5018.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Lysine-specific demethylase 5B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/lysine-specific-demethylase-5b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Lysine-specific demethylase 5B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lysine-specific-demethylase-5b-inhibitors-ic50-ki.
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