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Lysine-specific demethylase 4C Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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▼
Standard Values (in nM)
▲
▼
Pyridine-2,4-dicarboxylic acidIC501500.0 [1]
Pyridine-2,4-dicarboxylic acidKi2.2 [1], 13000.0 [2]
2-[5-(2-Methoxyethanoylamino)-2-Oxidanyl-Phenyl]pyridine-4-Carboxylic AcidIC507400.0 [1]
2-[5-(2-Methoxyethanoylamino)-2-Oxidanyl-Phenyl]pyridine-4-Carboxylic AcidKi682.9 [1]
2-[5-[(4-Hydroxyphenyl)carbonylamino]-2-Oxidanyl-Phenyl]pyridine-4-Carboxylic AcidIC504800.0 [1]
2-[5-[(4-Hydroxyphenyl)carbonylamino]-2-Oxidanyl-Phenyl]pyridine-4-Carboxylic AcidKi43.2 [1]
N-OxalylglycineIC50250000.0 [1], 430000.0 [2], 500000.0 [3]
2-[5-[(5-Methyl-1,2-oxazol-3-yl)carbonylamino]-2-oxidanyl-phenyl]pyridine-4-carboxylic acidIC5065.0 [1], 5000.0 [2], 5500.0 [3], 16000.0 [4]
2-(5-Acetamido-2-Oxidanyl-Phenyl)pyridine-4-Carboxylic AcidIC501200.0 [1], 15000.0 [2], 40000.0 [3], 63000.0 [4]
2-[5-[2-(3-Methoxyphenyl)ethanoylamino]-2-Oxidanyl-Phenyl]pyridine-4-Carboxylic AcidIC50140.0 [1], 1500.0 [2], 7300.0 [3], 9900.0 [4]
2-{5-[(4-Chloro-2-Methylphenyl)methoxy]-1h-Pyrazol-1-Yl}pyridine-4-Carboxylic AcidIC5035.0 [1], 100.0 [2]
3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acidIC501000.0 [1], 2200.0 [2]
4-Oxo-4-[4-[4-(1-naphthylcarbamoyloxymethyl)benzylamino]butylhydroxyamino]-2-butenoic acidIC503400.0 [1], 4300.0 [2]
2-[5-[(4-Chlorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5054.0 [1], 100.0 [2]
2-[5-[(4-Fluorophenyl)methoxy]-4-(2-hydroxyethyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC501000.0 [1], 2000.0 [2]
8-Hydroxy-5-quinolinecarboxylic acidIC50600.0 [1], 630.96 [2]
3-Aminoisonicotinic acidIC50630.96 [1]
2-[5-(4-Methoxyphenyl)-1-methylimidazol-4-yl]pyridine-4-carboxylic acidIC501000.0 [1]
3-[[(1R)-6-(N-Methylanilino)-1,2,3,4-tetrahydronaphthalen-1-yl]methylamino]pyridine-4-carboxylic acidIC509.0 [1], 35.0 [2]
Pyrido[3,4-d]pyrimidin-4(3H)-oneIC501995.26 [1], 100000.0 [2]
2-[(1-Benzyl-1h-Pyrazol-4-Yl)oxy]pyrido[3,4-D]pyrimidin-4(3h)-OneIC50501.19 [1], 2000.0 [2]
2-[(3-Methylthiophen-2-yl)methylamino]pyridine-3-carboxylic acidIC50100000.0 [1]
3-[(4-Methylthiophen-2-Yl)methylamino]pyridine-4-Carboxylic AcidIC50100.0 [1], 7943.28 [2]
3-(1,3-Thiazol-4-ylmethylamino)pyridine-4-carboxylic acidIC50100.0 [1], 31622.78 [2]
3-(1H-Pyrazol-5-ylmethylamino)pyridine-4-carboxylic acidIC50125.89 [1], 100000.0 [2]
3-(1-Benzothiophen-2-ylmethylamino)pyridine-4-carboxylic acidIC501258.93 [1], 39810.72 [2]
3-[(2,3-Dimethylphenyl)methylamino]pyridine-4-carboxylic acidIC50316.23 [1], 15848.93 [2]
3-[(2,5-Dimethylphenyl)methylamino]pyridine-4-carboxylic acidIC50630.96 [1], 50118.72 [2]
2-(1h-Pyrazol-4-Yloxy)-3h-Pyrido[3,4-D]pyrimidin-4-OneIC50398.11 [1], 7943.28 [2]
2-(1,3-Dimethylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC502511.89 [1], 100000.0 [2]
2-[1-(Pyridin-3-ylmethyl)pyrazol-4-yl]oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50630.96 [1], 12589.25 [2]
2-[1-[(3-Methoxyphenyl)methyl]pyrazol-4-yl]oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50630.96 [1], 6309.57 [2]
2-(1-Phenylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50398.11 [1], 3981.07 [2]
2-[1-(Cyclohexylmethyl)pyrazol-4-yl]oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50630.96 [1], 2000.0 [2]
2-(1-Cycloheptylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50501.19 [1], 2511.89 [2]
2-(1-Cyclohexylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50398.11 [1], 3981.07 [2]
2-(1-Cyclopentylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50630.96 [1], 2000.0 [2]
2-(1-Propan-2-ylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50501.19 [1], 5011.87 [2]
2-(1-Methylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50398.11 [1], 7943.28 [2]
2-(6-Propan-2-ylpyridin-3-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC501000.0 [1], 2000.0 [2]
2-(4-Chloro-3-hydroxyphenoxy)-3H-pyrido[3,4-d]pyrimidin-4-oneIC50398.11 [1], 2000.0 [2]
2-(3-Hydroxyphenoxy)-3H-pyrido[3,4-d]pyrimidin-4-oneIC50199.53 [1], 10000.0 [2]
2-(4-Chlorophenoxy)-3H-pyrido[3,4-d]pyrimidin-4-oneIC50501.19 [1], 10000.0 [2]
2-Pyridin-3-yloxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50501.19 [1], 12589.25 [2]
2-(Cyclohexylmethoxy)-3H-pyrido[3,4-d]pyrimidin-4-oneIC503162.28 [1], 100000.0 [2]
2-Cyclohexyloxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC503162.28 [1], 25118.86 [2]
2-Phenylmethoxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC501995.26 [1], 100000.0 [2]
2-Phenoxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50630.96 [1], 12589.25 [2]
2-Ethoxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC501000.0 [1], 63095.73 [2]
2-Ethylsulfanyl-3H-pyrido[3,4-d]pyrimidin-4-oneIC50794.33 [1], 100000.0 [2]
2-[2-Hydroxy-5-[(2-phenylacetyl)amino]phenyl]pyridine-4-carboxylic acidIC50430.0 [1], 17000.0 [2]
2-[5-[[2-(3-Bromophenyl)acetyl]amino]-2-hydroxyphenyl]pyridine-4-carboxylic acidIC50170.0 [1], 3400.0 [2]
2-[2-Hydroxy-5-[[2-(4-methoxyphenyl)acetyl]amino]phenyl]pyridine-4-carboxylic acidIC5069.0 [1], 3700.0 [2]
2-[5-(4-Hydroxyphenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 450.0 [2]
2-(1-Benzylpyrazol-4-yl)oxy-3H-pyrido[2,3-d]pyrimidin-4-oneIC50100000.0 [1]
2-[(2-Furylmethyl)amino]nicotinic acidIC50100000.0 [1]
3-(4-Phenylbutylamino)pyridine-4-carboxylic acidIC50158.49 [1], 6309.57 [2]
3-(Cyclohexylmethylamino)isonicotinic acidIC50125.89 [1], 5011.87 [2]
3-[(3-Phenylphenyl)methylamino]pyridine-4-carboxylic acidIC501995.26 [1], 100000.0 [2]
3-(2-Phenylethylamino)pyridine-4-carboxylic acidIC5031622.78 [1]
3-(Benzylamino)pyridine-4-carboxylic acidIC50100.0 [1], 40000.0 [2]
2-(5-p-Tolyl-1H-pyrazol-1-yl)isonicotinic acidIC50100.0 [1], 1100.0 [2]
2-[5-(3-Hydroxy-4-methylphenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 1100.0 [2]
2-[5-(2,4-Difluorophenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 380.0 [2]
2-[5-(3-Fluorophenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 660.0 [2]
2-[5-(4-Methylsulfonylphenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC501000.0 [1], 2700.0 [2]
2-[5-(3-Methoxy-4-methylphenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC501000.0 [1], 1800.0 [2]
2-[5-(3-Hydroxyphenyl)-1H-pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 410.0 [2]
3-{[(5-Methylthiophen-2-yl)methyl]amino}pyridine-4-carboxylic acidIC50199.53 [1], 19952.62 [2]
3-{[(Furan-2-yl)methyl]amino}pyridine-4-carboxylic acidIC50100.0 [1], 7943.28 [2]
4-Pyridinecarboxylic acid, 3-[(cyclopropylmethyl)amino]-IC50125.89 [1], 31622.78 [2]
3-(1-Phenylethylamino)pyridine-4-carboxylic acidIC50630.96 [1], 63095.73 [2]
4-Pyridinecarboxylic acid, 3-[(2-thienylmethyl)amino]-IC50100.0 [1], 6309.57 [2]
4-Pyridinecarboxylic acid, 3-[(cyclopentylmethyl)amino]-IC50199.53 [1], 6309.57 [2]
2-(1-Methylimidazol-4-yl)pyridine-4-carboxylic acidIC50100.0 [1]
2-(5-Phenyl-1H-pyrazol-1-yl)isonicotinic acidIC501000.0 [1], 6200.0 [2]
2-(5-(Benzyloxy)-1H-pyrazol-1-yl)isonicotinic acidIC505.0 [1], 100.0 [2]
2-[5-[(4-Cyanophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5014.0 [1], 100.0 [2]
4-Pyridinecarboxylic acid, 3-[(3-thienylmethyl)amino]-IC50100.0 [1], 6309.57 [2]
3-[(3-Methylthiophen-2-yl)methylamino]pyridine-4-carboxylic acidIC50100.0 [1], 6309.57 [2]
2-[5-[(4-Chloro-2-methoxyphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5038.0 [1], 100.0 [2]
2-[5-[(4-Methoxyphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5068.0 [1], 100.0 [2]
2-[5-[(4-Fluorophenyl)methoxy]-4-methylpyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 2900.0 [2]
2-[5-[[4-Chloro-2-(cyclopropylmethoxy)phenyl]methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 280.0 [2]
2-[5-(3,4-Difluorophenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 560.0 [2]
2-[5-[(4-Methylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 1100.0 [2]
2-[5-[(4-Ethylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 3600.0 [2]
2-[5-[(4-Chloro-2-ethoxyphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5078.0 [1], 100.0 [2]
2-[4-[2-(Dimethylamino)ethyl]-5-[(4-fluorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5019.0 [1], 100.0 [2]
2-[5-(4-Chloro-3-methoxyphenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC501000.0 [1], 2900.0 [2]
2-[5-[(4-Fluorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5024.0 [1], 100.0 [2]
2-[5-[(4-Chloro-2-phenylmethoxyphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC5074.0 [1], 100.0 [2]
2-[5-(4-Fluorophenyl)pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 490.0 [2]
2-[4-Ethyl-5-[(4-fluorophenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 260.0 [2]
2-[5-[1-(4-Fluorophenyl)ethoxy]pyrazol-1-yl]pyridine-4-carboxylic acidIC50100.0 [1], 310.0 [2]
2-(1-Methylimidazol-4-yl)-4-(2H-tetrazol-5-yl)pyridineIC5010000.0 [1]
2-[5-[4-(Cyclopropylmethoxy)phenyl]-1-methylimidazol-4-yl]pyridine-4-carboxylic acidIC50100.0 [1]
PyrazoleKi200000.0 [1]
2,4-DihydroxythiazoleKi200000.0 [1]
NitrazepamKi200000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Lysine-specific demethylase 4C Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/lysine-specific-demethylase-4c-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Lysine-specific demethylase 4C Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lysine-specific-demethylase-4c-inhibitors-ic50-ki.
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