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LXR-alpha Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamideKi24.0 [1]
3-(3-(N-(2-Chloro-3-trifluoromethylbenzyl)(2,2-diphenylethyl)amino)propoxy)phenylacetic acidIC50100.0 [1], 235.0 [2]
2-[2-(2-Phenylethyl)phenyl]-2,3-dihydro-1H-isoindole-1,3-dioneIC509800.0 [1], 13000.0 [2]
3-Methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8-(trifluoromethyl)quinolineIC501.0 [1], 2.0 [2]
2-{4-[({3-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acidIC507.6 [1], 8.0 [2]
2-Hydroxy-5-methyl-11-methylidenebenzo[c][1]benzazepin-6-oneIC503500.0 [1], 4100.0 [2]
F3MethylAAIC5032.0 [1], 35.4 [2]
N-(4-(2-Phenylethyl)phenyl)phthalimideIC5030000.0 [1]
N-{2-[2-(3,4-Dimethoxyphenyl)ethyl]phenyl}phthalimideIC507400.0 [1], 23000.0 [2]
N-[3-(2-Phenylethyl)phenyl]phthalimideIC5011000.0 [1], 30000.0 [2]
2-(2-Hexylphenyl)-2,3-dihydro-1H-isoindole-1,3-dioneIC5013000.0 [1]
2-{4-[({3-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}methyl)amino]phenyl}acetic acidIC5047.0 [1]
[3-[3-[3-Methyl-8-(trifluoromethyl)quinolin-4-yl]phenoxy]phenyl]methanolIC503.0 [1], 10.2 [2]
2-(4-(3-(3-Benzyl-8-(trifluoromethyl)quinolin-4-yl)benzylamino)-2,3-dimethylphenyl)acetic acidIC5058.0 [1], 58000.0 [2]
2-Methyl-1-{3-[3-(methylsulfonyl)phenoxy]phenyl}-4-(trifluoromethyl)-1H-benzimidazoleIC507.0 [1]
[(1S,4As,10aR)-6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbonyl] (4aS,10aR)-6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylateIC502.0 [1]
(4As,10aR)-N-[(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbonyl]-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxamideIC501.0 [1]
Methyl 3-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenoxy}benzoateIC50231.0 [1]
Methyl 3-[3-(8-chloro-3-methylquinolin-4-yl)phenoxy]benzoateIC501002.0 [1]
3-[3-(8-Chloro-3-methylquinolin-4-yl)phenoxy]-N-methylbenzamideIC509.0 [1], 125.0 [2]
4-(3-(3-Chloro-5-(methylsulfonyl)phenoxy)phenyl)-8-(trifluoromethyl)quinoline-3-carboxamideIC501770.0 [1], 1772.0 [2]
[4-[(3R)-4-[5-(Hydroxymethyl)-4-(trifluoromethyl)pyrimidin-2-yl]-3-propan-2-ylpiperazin-1-yl]-2-methylsulfonylphenyl]methanolKi81.0 [1]
N-Benzyl-N-[[5-[4-(hydroxymethyl)-3-methylsulfonylphenyl]thiophen-2-yl]methyl]-2-(trifluoromethyl)benzenesulfonamideIC5034.0 [1]
N-Benzyl-N-[[5-[4-(hydroxymethyl)-3-methylsulfonylphenyl]thiophen-2-yl]methyl]-2-(trifluoromethyl)benzenesulfonamideKi20.0 [1]
GenisteinIC5031000.0 [1]
1-DeoxynojirimycinIC50100000.0 [1]
(22S)-22-HydroxycholesterolKi180.0 [1]
Podocarpic acidIC5050000.0 [1]
SR-9009IC506300.0 [1]
CID 50905018IC505000.0 [1]
2-(2-Chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazoleIC50179.0 [1]
Riccardin CIC504900.0 [1]
SR-9011IC5013000.0 [1]
CID 71478195IC50214.0 [1]
N-[4-(1,1,1,3,3,3-Hexafluoro-2-Hydroxypropan-2-Yl)phenyl]-N-MethylbenzenesulfonamideIC5040.0 [1]
(1R,3E,5S,6R,7S)-3-[(3,4-Dihydroxyphenyl)-hydroxymethylidene]-7-[(2E)-3,7-dimethylocta-2,6-dienyl]-6-methyl-1,5-bis(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)bicyclo[3.3.1]nonane-2,4,9-trioneIC503400.0 [1]
3-Methyl-2-[4-(3-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)quinoxalineIC501000.0 [1]
2-[2,6-Di(propan-2-yl)phenyl]-3-sulfanylideneisoindol-1-oneIC503100.0 [1]
4-Dehydroxyriccardin CIC508400.0 [1]
4,5,6,7-Tetrachloro-2-[2-(2-phenylethyl)phenyl]isoindole-1,3-dioneIC503000.0 [1]
N-{2-[2-(3,4-Dihydroxyphenyl)ethyl]phenyl}phthalimideIC509800.0 [1]
N-{3-[2-(3,4-Dihydroxyphenyl)ethyl]phenyl}phthalimideIC506100.0 [1]
CID 122192273IC503300.0 [1]
4-[[N-Butyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)anilino]methyl]-2,6-dichlorophenolIC50180.0 [1]
17-Dehydroxyriccardin CIC506600.0 [1]
2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-5-methylphenanthridin-6-oneIC504100.0 [1]
4,5,6,7-Tetrachloro-2-[4-[2-(3,4-dihydroxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC505100.0 [1]
N-{4-[2-(3,4-Dimethoxyphenyl)ethyl]phenyl}phthalimideIC504800.0 [1]
4,5,6,7-Tetrachloro-2-[2-[2-(3,4-dimethoxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC506100.0 [1]
4,5,6,7-Tetrachloro-2-[2-[2-(3,4-dihydroxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC5015000.0 [1]
4,5,6,7-Tetrachloro-2-[3-(2-phenylethyl)phenyl]isoindole-1,3-dioneIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[3-[2-(3,4-dimethoxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[3-[2-(3,4-dihydroxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC506300.0 [1]
N-{3-[2-(3,4-Dimethoxyphenyl)ethyl]phenyl}phthalimideIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[4-(2-phenylethyl)phenyl]isoindole-1,3-dioneIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[4-[2-(3,4-dimethoxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC5030000.0 [1]
(1S,4As,10aR)-N-(1-adamantylmethyl)-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxamideIC50100.0 [1]
5,16,24-Trimethoxy-14-oxapentacyclo[20.2.2.210,13.115,19.02,7]nonacosa-1(24),2(7),3,5,10(29),11,13(28),15,17,19(27),22,25-dodecaeneIC502000.0 [1]
3-(1-(3-(7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indol-5-yl)propanoic acidIC5018.0 [1]
2-(1-(3-(7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indol-5-yl)acetic acidIC5016.0 [1]
1,1,1,3,3,3-Hexafluoro-2-{4-[methyl(phenylmethyl)amino]phenyl}-2-propanolIC50310.0 [1]
2-(4-(Dibenzylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-olIC50315.0 [1]
5-Methyl-11-methylidenebenzo[c][1]benzazepin-6-oneIC5010000.0 [1]
16-Methoxy-14-oxapentacyclo[20.2.2.210,13.115,19.02,7]nonacosa-1(24),2,4,6,10(29),11,13(28),15,17,19(27),22,25-dodecaeneIC507600.0 [1]
24-Methoxy-14-oxapentacyclo[20.2.2.210,13.115,19.02,7]nonacosa-1(24),2,4,6,10(29),11,13(28),15,17,19(27),22,25-dodecaeneIC502500.0 [1]
12-Dehydroxyriccardin CIC504400.0 [1]
12,17-Dehydroxyriccardin CIC505700.0 [1]
4,17-Dehydroxyriccardin CIC503200.0 [1]
4,12,17-Dehydroxyriccardin CIC507100.0 [1]
Benzyl (1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylateIC502800.0 [1]
2-[3-Chloro-4-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propoxy]phenyl]acetic acidIC5039.0 [1]
2-[4-[3-[[7-Propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propoxy]phenyl]acetic acidIC50730.0 [1]
2-[4-[Methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]phenyl]acetic acidIC5018.0 [1]
2-[4-[3-[[7-Propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propylamino]phenyl]acetic acidIC5068.0 [1]
2-[3-[Methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]phenyl]acetic acidIC50102.0 [1]
2-[3-Methyl-4-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]phenyl]acetic acidIC50580.0 [1]
2-[2-Methyl-4-[methyl-[3-[[7-propyl-3-(trifluoromethyl)-1,2-benzoxazol-6-yl]oxy]propyl]amino]phenyl]acetic acidIC50117.0 [1]
4,5,6,7-Tetrachloro-2-[3-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]phenyl]isoindole-1,3-dioneIC506600.0 [1]
N-{4-[2-(4-Methoxyphenyl)ethyl]phenyl}phthalimideIC50200.0 [1]
4,5,6,7-Tetrachloro-2-[4-[2-(3-hydroxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC503900.0 [1]
4,5,6,7-Tetrachloro-2-[3-[(E)-2-phenylethenyl]phenyl]isoindole-1,3-dioneIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[3-[2-(3-methoxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC504200.0 [1]
N-{4-[2-(4-Hydroxyphenyl)ethyl]phenyl}phthalimideIC502900.0 [1]
4,5,6,7-Tetrachloro-2-[4-[2-(4-methoxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC508800.0 [1]
4,5,6,7-Tetrachloro-2-[4-[2-(4-hydroxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC5030000.0 [1]
N-{4-[2-(3,4-Dihydroxyphenyl)ethyl]phenyl}phthalimideIC501700.0 [1]
4,5,6,7-Tetrachloro-2-[3-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl]isoindole-1,3-dioneIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[3-[2-(3-hydroxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC502600.0 [1]
4,5,6,7-Tetrachloro-2-[3-[2-(4-methoxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC505500.0 [1]
4,5,6,7-Tetrachloro-2-[4-[(E)-2-phenylethenyl]phenyl]isoindole-1,3-dioneIC5030000.0 [1]
4,5,6,7-Tetrachloro-2-[3-[2-(4-hydroxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC502600.0 [1]
N-{4-[(1E)-2-(3,4-Dihydroxyphenyl)ethenyl]phenyl}phthalimideIC501600.0 [1]
N-{4-[2-(3-Methoxyphenyl)ethyl]phenyl}phthalimideIC502400.0 [1]
4,5,6,7-Tetrachloro-2-[4-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]phenyl]isoindole-1,3-dioneIC5020000.0 [1]
4,5,6,7-Tetrachloro-2-[4-[2-(3-methoxyphenyl)ethyl]phenyl]isoindole-1,3-dioneIC503700.0 [1]
N-{4-[2-(3-Hydroxyphenyl)ethyl]phenyl}phthalimideIC507500.0 [1]
3-Methyl-2-[4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)quinoxalineIC501000.0 [1]
2-[2-[2-(2,6-Dichlorophenyl)propan-2-yl]-1-[2-fluoro-4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-olIC5069.0 [1]
N-{4-[(1E)-2-Phenylethenyl]phenyl}phthalimideIC5030000.0 [1]
Items per page: 1 - 10 of 99
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References

This online tool may be cited as follows

MLA

"Quest Database™ LXR-alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/lxr-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ LXR-alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lxr-alpha-inhibitors-ic50-ki.
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