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LSD1/CoREST complex Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
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▼
Standard Values (in nM)
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▼
N-(3-(Methoxymethyl)phenyl)-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxamideIC502900.0 [1], 13400.0 [2], 27100.0 [3]
N-(3-(Methoxymethyl)phenyl)-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxamideKi43000.0 [1]
1-[4-(2,8-Diazaspiro[4.5]decan-2-ylmethyl)phenyl]ethanoneIC505000.0 [1], 8100.0 [2], 82400.0 [3]
1-[4-(2,8-Diazaspiro[4.5]decan-2-ylmethyl)phenyl]ethanoneKi48400.0 [1]
(1S,2R)-2-Phenylcyclopropan-1-amine;(1R,2S)-2-phenylcyclopropan-1-amineIC508800.0 [1], 20700.0 [2], 30600.0 [3]
IadademstatIC500.38 [1], 0.6 [2], 6.5 [3]
Benzyl N-[1-[4-[(1S,2R)-2-aminocyclopropyl]anilino]-1-oxo-3-phenylpropan-2-yl]carbamateIC50149.0 [1], 150.0 [2]
Benzyl N-[1-[4-[(1S,2R)-2-aminocyclopropyl]anilino]-1-oxo-3-phenylpropan-2-yl]carbamateKi1300.0 [1]
4-Methyl-N-phenyl-4H-thieno[3,2-b]pyrrole-5-carboxamideIC5025700.0 [1]
4-Methyl-N-[3-(pyridin-4-ylmethoxy)phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC505800.0 [1], 7200.0 [2]
4-Methyl-N-[3-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50440.0 [1]
4-Methyl-N-[3-[(4-piperidin-4-yloxyphenoxy)methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50160.0 [1]
4-Methyl-N-[3-(pyridin-4-yloxymethyl)phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC509400.0 [1]
N-(3-Methoxyphenyl)-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxamideIC5026500.0 [1]
4-Methyl-N-[2-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50310.0 [1]
4-Methyl-N-[2-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideKi2300.0 [1]
N,N'-Bis(2-methoxybenzyl)-1H-1,2,4-triazole-3,5-diamineIC502220.0 [1]
3-N-[(2-Chloro-6-phenoxyphenyl)methyl]-1H-1,2,4-triazole-3,5-diamineIC501190.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acidKi50.0 [1]
(2S)-1-[(2S)-6-Amino-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-pyrrolidine-2-carbonyl]amino]pentanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]pentanoyl]amino]hexanoyl]pyrrolidine-2-carboxamideKi140.0 [1]
N-(2-Methoxyphenyl)-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S,5S,8S,11S,14S,23S)-11-(4-aminobutyl)-23-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-8-(3-carbamimidamidopropyl)-2-[(1R)-1-hydroxyethyl]-5-methyl-3,6,9,12,17,24-hexaoxo-1,4,7,10,13,18-hexazacyclotetracosane-14-carbonyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pentanediamideIC502100.0 [1]
DDP-38003 dihydrochlorideIC50188.5 [1]
N-Phenyl-4H-thieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
N-[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]-4-(1-methylpiperidin-4-yl)benzamide;hydrochlorideIC5051.2 [1]
N-[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]-4-(2-oxo-1,3-oxazolidin-3-yl)benzamide;hydrochlorideIC5033.5 [1]
N-[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]-3-(2-oxo-1,3-oxazolidin-3-yl)benzamide;hydrochlorideIC5028.0 [1]
(1S,2R)-2-(3-Bromophenyl)-1-(2-phenylethyl)cyclopropan-1-amine;hydrochlorideIC5094.0 [1]
4-Methyl-N-[2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC5018.0 [1]
4-Methyl-N-[2-[[3-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC501000.0 [1]
4-Methyl-N-[2-[[4-(1-methylpiperidin-4-yl)oxyphenyl]methoxy]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50336.0 [1]
4-Methyl-N-[2-[(4-piperidin-3-yloxyphenoxy)methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50674.0 [1]
4-Methyl-N-[2-[(4-piperidin-4-yloxyphenoxy)methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC5090.0 [1]
4-Methyl-N-[2-[[4-(pyrrolidin-3-ylmethoxy)phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC5022.0 [1]
4-Methyl-N-[2-[[4-[(4-methylpiperazin-1-yl)methyl]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC502900.0 [1]
N-[2-[[4-(4-Aminocyclohexyl)oxyphenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC50121.0 [1]
N-[2-[[4-(Azepan-4-yloxy)phenoxy]methyl]-3-(methoxymethyl)phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC5029.2 [1]
4-Methyl-N-[2-[[4-(piperidin-4-ylmethoxy)phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50149.0 [1]
4-Methyl-N-[4-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC502500.0 [1]
N-[2-[[4-[[(1S,5R)-8-Azabicyclo[3.2.1]octan-3-yl]oxy]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC50124.0 [1]
4-Methyl-N-[2-[[4-(piperidin-4-ylamino)phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC502500.0 [1]
4-Methyl-N-[2-[(4-piperidin-4-yloxyphenyl)carbamoyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC502200.0 [1]
N-[2-[[4-(Azepan-4-yloxy)phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC5064.0 [1]
4-Methyl-N-[2-[[4-[3-(methylamino)propoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC501300.0 [1]
N-[3-(Methoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC508.4 [1]
N-[2-[[4-(Azetidin-3-ylmethoxy)phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC50618.0 [1]
4-Methyl-N-[2-[(4-pyrrolidin-3-yloxyphenoxy)methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50804.0 [1]
N-[3-(Methoxymethyl)-2-[(4-piperidin-4-yloxyphenoxy)methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC5074.6 [1]
4-Methyl-N-[2-[(4-piperazin-1-ylphenoxy)methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC501500.0 [1]
N-[3-[(4-Hydroxyphenoxy)methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC5025200.0 [1]
N-[2-[[4-(1-Ethylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC50451.0 [1]
4-Ethyl-N-[3-(methoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC506.7 [1]
N-[2-[[4-[(Diaminomethylideneamino)methyl]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC503200.0 [1]
4-Methyl-N-[3-(morpholin-4-ylmethyl)-2-[(4-piperidin-4-yloxyphenoxy)methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC5065.0 [1]
N-[3-(Methoxymethyl)-2-[[4-[[(3S)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC5085.7 [1]
4-Methyl-N-[2-[(4-piperidin-4-yloxyphenoxy)methyl]-3-(propan-2-yloxymethyl)phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC5066.0 [1]
4-Methyl-N-[2-[2-(4-piperidin-4-yloxyphenyl)ethyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50177.0 [1]
N-[3-(Ethoxymethyl)-2-[(4-piperidin-4-yloxyphenoxy)methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC5056.0 [1]
N-[3-(Ethoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC507.8 [1]
N-[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]-4-(furan-3-yl)benzamide;hydrochlorideIC5022.5 [1]
Benzyl N-[3-[[4-[(1S,2R)-2-aminocyclopropyl]phenyl]carbamoyl]phenyl]carbamate;hydrochlorideIC5042.6 [1]
Benzyl N-[4-[[4-[(1S,2R)-2-aminocyclopropyl]phenyl]carbamoyl]-2-morpholin-4-ylphenyl]carbamate;hydrochlorideIC5075.0 [1]
Benzyl N-[5-[[4-[(1S,2R)-2-aminocyclopropyl]phenyl]carbamoyl]-2-(4-methylpiperazin-1-yl)phenyl]carbamate;dihydrochlorideIC5089.0 [1]
N-[2-(4,5-Dimethyl-6-oxo-1H-pyrimidin-2-yl)-5-thiophen-2-ylpyrazol-3-yl]-2-(2-fluorophenoxy)acetamideIC50760.0 [1]
3,4-Dimethyl-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
2,3,4-Trimethyl-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
N-(3-Bromophenyl)-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
4-(2-Aminoethyl)-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC5048100.0 [1]
4-Methyl-N-[4-(pyridin-4-yloxymethyl)phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC5046400.0 [1]
4-Methyl-N-phenylpyrrolo[3,2-d][1,3]thiazole-5-carboxamideIC50100000.0 [1]
2-[(Dimethylamino)methyl]-4-methyl-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
N,4-Diphenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
4-Methyl-N-(3-pyridin-4-yloxyphenyl)thieno[3,2-b]pyrrole-5-carboxamideIC5089900.0 [1]
N-[3-(Dimethylamino)phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC5029600.0 [1]
1,4-Dimethyl-N-phenylpyrrolo[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
2,6-Diiodo-4-methyl-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
4-Methyl-N-[2-(pyridin-4-yloxymethyl)phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
N-Phenyl-4-propylthieno[3,2-b]pyrrole-5-carboxamideIC5053200.0 [1]
4-Methyl-N-pyrimidin-2-ylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
4-Methyl-N-[2-[[1-(piperidin-4-ylmethyl)piperidin-4-yl]methoxy]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC501700.0 [1]
4-Methyl-N-[4-(pyridin-4-ylmethoxy)phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
N-[4-(Methoxymethyl)phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
2,4-Dimethyl-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
2-Fluoro-4-methyl-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
2-Iodo-4-methyl-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
6-Methyl-N-phenylthieno[2,3-b]pyrrole-5-carboxamideIC5038800.0 [1]
1-Methyl-N-phenylthieno[2,3-d]imidazole-2-carboxamideIC50100000.0 [1]
N-[3-[(Dimethylamino)methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC5016700.0 [1]
6-(Methoxymethyl)-4-methyl-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
2-Bromo-4-methyl-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
4-Methyl-N-[2-[[2-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC5068200.0 [1]
1-Methyl-N-phenyl-4H-pyrrolo[2,3-d]imidazole-5-carboxamideIC50100000.0 [1]
4-Methyl-N-[3-(4-methylpiperazin-1-yl)phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC5021500.0 [1]
4-Methyl-N-phenylpyrrolo[2,3-d][1,3]thiazole-5-carboxamideIC50100000.0 [1]
N-[3-(Hydroxymethyl)phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC5052300.0 [1]
N-[2-[[4-(4-Aminocyclohexyl)phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC50340.0 [1]
4-Methyl-N-[2-[[4-[[(3S)-pyrrolidin-3-yl]methyl]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50209.0 [1]
4-Methyl-N-[2-(pyridin-4-ylmethoxy)phenyl]thieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
N-[2-(Methoxymethyl)phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
6-Chloro-4-methyl-N-phenylthieno[3,2-b]pyrrole-5-carboxamideIC50100000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ LSD1/CoREST complex Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/lsd1-corest-complex-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ LSD1/CoREST complex Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lsd1-corest-complex-inhibitors-ic50-ki.
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