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Low molecular weight phosphotyrosine protein phosphatase Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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Standard Values (in nM)
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▼
Oleanolic acidIC5021200.0 [1], 22900.0 [2]
3-[[4-(3,4-Dihydroxyphenyl)phenyl]methyl]-7-hydroxy-2-(4-hydroxyphenyl)chromen-4-oneIC507400.0 [1], 12400.0 [2]
3-[[4-(3,4-Dihydroxyphenyl)phenyl]methyl]-7-hydroxy-2-(4-hydroxyphenyl)chromen-4-oneKi2230.0 [1], 2680.0 [2]
6,7-Dihydroxy-2-(4-hydroxyphenyl)-3-[(4-phenylphenyl)methyl]chromen-4-oneIC501100.0 [1], 3000.0 [2]
6,7-Dihydroxy-2-(4-hydroxyphenyl)-3-[(4-phenylphenyl)methyl]chromen-4-oneKi270.0 [1], 340.0 [2]
7-Hydroxy-2-(4-hydroxyphenyl)-3-[(4-phenylphenyl)methyl]chromen-4-oneIC505700.0 [1], 13900.0 [2]
7-Hydroxy-2-(4-hydroxyphenyl)-3-[(4-phenylphenyl)methyl]chromen-4-oneKi2500.0 [1], 7800.0 [2]
Ursolic acidIC507200.0 [1], 11100.0 [2]
Moronic acidIC5020600.0 [1], 27400.0 [2]
Morolic acidIC5013400.0 [1], 30600.0 [2]
3-Biphenyl-4-ylmethyl-7-hydroxy-2-(4-hydroxy-benzyl)-chromen-4-oneIC505300.0 [1], 17500.0 [2]
4-[5-(4-Benzyloxybenzylidene)-2,4-dioxothiazolidin-3-yl]methylbenzoic acidIC502500.0 [1], 5600.0 [2]
4-[[(5Z)-5-[[3-[(4-Carboxyphenyl)methoxy]phenyl]methylidene]-4-oxo-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC50220.0 [1], 500.0 [2]
2-Naphthalen-1-ylethylphosphonic acidIC5010000000.0 [1], 14000000.0 [2]
2-(4-Aminopyridin-3-yl)ethylphosphonic acidIC50300000.0 [1], 2210000.0 [2]
(4As,6aR,6aS,6bR,8aR,10S,12aR,14bS)-2,2,6a,6b,9,9,12a-heptamethyl-10-[(E)-3-phenylprop-2-enoyl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acidIC506900.0 [1], 12300.0 [2]
(4As,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-ethoxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acidIC5016400.0 [1], 47400.0 [2]
[(4'As,6'aR,6'aR,6'bR,8'aR,12'aR,14'aS)-2',2',6'a,6'b,9',9',12'a-heptamethylspiro[1,3-dioxolane-2,10'-4,5,6,6a,7,8,8a,11,12,13,14,14a-dodecahydro-3H-picene]-4'a-yl]methanolIC5016100.0 [1], 29300.0 [2]
2-(1H-Pyrrolo[3,2-c]pyridin-7-yl)ethylphosphonic acidIC501790000.0 [1], 2760000.0 [2]
4-[5-(4-Hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]methylbenzoic acidIC5030000.0 [1], 85000.0 [2]
4-[5-(4-Carboxymethoxybenzylidene)-2,4-dioxothiazolidin-3-yl]methylbenzoic acidIC50219000.0 [1], 1642000.0 [2]
4-[[(5Z)-5-[(3-Methoxy-4-phenylmethoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5010300.0 [1], 50000.0 [2]
4-[5-(4-Hydroxy-3-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]methylbenzoic acidIC509100.0 [1], 26600.0 [2]
Methyl (4aS,6aR,6aR,6bR,8aR,12aR,14aS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-4,5,6,6a,7,8,8a,11,12,13,14,14a-dodecahydro-3H-picene-4a-carboxylateIC5033700.0 [1], 62500.0 [2]
2-Hydroxy-4-[4-[[7-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]methyl]phenyl]benzoic acidIC501300.0 [1], 2200.0 [2]
4-[2,4-Dioxo-5-(3-phenoxybenzylidene)thiazolidin-3-yl]methylbenzoic acidIC5037000.0 [1], 130000.0 [2]
4-[2,4-Dioxo-5-(4-phenoxybenzylidene)thiazolidin-3-yl]methylbenzoic acidIC50900.0 [1], 13000.0 [2]
4-[5-(3-Benzyloxybenzylidene)-2,4-dioxothiazolidin-3-yl]methylbenzoic acidIC507100.0 [1], 18400.0 [2]
4-[[(5Z)-5-(Naphthalen-1-ylmethylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acidIC50122000.0 [1], 138000.0 [2]
4-[[(5Z)-5-(Naphthalen-2-ylmethylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5012000.0 [1], 92000.0 [2]
4-[5-(3-Hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]methylbenzoic acidIC5085700.0 [1], 112400.0 [2]
7-Hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-3-[(4-phenylphenyl)methyl]chromen-4-oneIC506500.0 [1], 17300.0 [2]
6-Hydroxy-2-[(4-hydroxyphenyl)methyl]-3-[(4-phenylphenyl)methyl]chromen-4-oneIC508600.0 [1], 17200.0 [2]
7-Hydroxy-2-(4-hydroxyphenyl)-3-[[4-(4-hydroxyphenyl)phenyl]methyl]chromen-4-oneIC508200.0 [1], 18400.0 [2]
3-[4-[[7-Hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]methyl]phenyl]benzoic acidIC5011400.0 [1], 26800.0 [2]
3-[[4-(3,4-Dihydroxyphenyl)phenyl]methyl]-2-(4-hydroxyphenyl)chromen-4-oneIC5012600.0 [1], 14300.0 [2]
2-Hydroxy-4-[4-[[2-(4-hydroxyphenyl)-4-oxochromen-3-yl]methyl]phenyl]benzoic acidIC50700.0 [1], 5700.0 [2]
4-{[4-Oxo-5-(3-phenoxybenzylidene)-2-phenyliminothiazolidin-3-yl]methyl}benzoic acidIC505400.0 [1], 26100.0 [2]
4-{[4-Oxo-5-(4-phenoxybenzylidene)-2-phenyliminothiazolidin-3-yl]methyl}benzoic acidIC503100.0 [1], 8200.0 [2]
4-[[(5Z)-4-Oxo-2-phenylimino-5-[(3-phenylmethoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl]benzoic acidIC503100.0 [1], 12100.0 [2]
4-[[(5Z)-4-Oxo-2-phenylimino-5-[(4-phenylmethoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl]benzoic acidIC502700.0 [1], 21500.0 [2]
4-[[(5Z)-5-(Naphthalen-1-ylmethylidene)-4-oxo-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5016100.0 [1], 1004000.0 [2]
4-[[(5Z)-5-(Naphthalen-2-ylmethylidene)-4-oxo-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC503700.0 [1], 13800.0 [2]
4-{[5-(3-Hydroxybenzylidene)-4-oxo-2-phenyliminothiazolidin-3-yl]methyl}benzoic acidIC5062500.0 [1], 250000.0 [2]
4-[5-(4-Hydroxybenzylidene)-4-oxo-2-phenyliminothiazolidin-3-ylmethyl]benzoic acidIC5047700.0 [1], 269700.0 [2]
4-[5-(3-Hydroxy-4-methoxybenzylidene)-4-oxo-2-phenyliminothiazolidin-3-ylmethyl]benzoic acidIC5087100.0 [1], 250000.0 [2]
4-[[(5Z)-5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-4-oxo-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5071200.0 [1], 250000.0 [2]
5-[(Z)-[3-[(4-Carboxyphenyl)methyl]-4-oxo-2-phenylimino-1,3-thiazolidin-5-ylidene]methyl]-2-hydroxybenzoic acidIC5043100.0 [1], 389000.0 [2]
4-[[(5Z)-4-Oxo-5-[(3-phenoxyphenyl)methylidene]-2-[4-(trifluoromethyl)phenyl]imino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5013700.0 [1], 150000.0 [2]
4-[[(5Z)-4-Oxo-5-[(4-phenoxyphenyl)methylidene]-2-[4-(trifluoromethyl)phenyl]imino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC507300.0 [1], 33200.0 [2]
4-[[(5Z)-4-Oxo-5-[(3-phenylmethoxyphenyl)methylidene]-2-[4-(trifluoromethyl)phenyl]imino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5012000.0 [1], 150000.0 [2]
4-[[(5Z)-4-Oxo-5-[(4-phenylmethoxyphenyl)methylidene]-2-[4-(trifluoromethyl)phenyl]imino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC504000.0 [1], 25400.0 [2]
4-[[(5Z)-5-(Naphthalen-2-ylmethylidene)-4-oxo-2-[4-(trifluoromethyl)phenyl]imino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC505800.0 [1], 15200.0 [2]
4-[[(5Z)-2-(4-Methoxyphenyl)imino-4-oxo-5-[(3-phenoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5012000.0 [1], 21800.0 [2]
4-[[(5Z)-2-(4-Methoxyphenyl)imino-4-oxo-5-[(4-phenoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5011200.0 [1], 18000.0 [2]
4-[[(5Z)-2-(4-Methoxyphenyl)imino-4-oxo-5-[(3-phenylmethoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl]benzoic acidIC509600.0 [1], 17500.0 [2]
4-[[(5Z)-2-(4-Methoxyphenyl)imino-4-oxo-5-[(4-phenylmethoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]methyl]benzoic acidIC506400.0 [1], 9100.0 [2]
4-[[(5Z)-2-(4-Methoxyphenyl)imino-5-(naphthalen-2-ylmethylidene)-4-oxo-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5011600.0 [1], 11700.0 [2]
2-Aminostyrylphosphonic AcidIC505300000.0 [1], 13000000.0 [2]
4-[[(5Z)-2,4-Dioxo-5-[[3-(2-phenylethoxy)phenyl]methylidene]-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5020100.0 [1], 50000.0 [2]
4-[[(5Z)-5-[[4-Methoxy-3-(2-phenylethoxy)phenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5050000.0 [1]
4-[[(5Z)-4-Oxo-5-[[4-(2-phenylethoxy)phenyl]methylidene]-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC504000.0 [1], 8900.0 [2]
4-[[(5Z)-5-[[3-Methoxy-4-(2-phenylethoxy)phenyl]methylidene]-4-oxo-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5010700.0 [1], 19700.0 [2]
4-[[(5Z)-5-[(4-Methoxy-3-phenylmethoxyphenyl)methylidene]-4-oxo-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC509100.0 [1], 50000.0 [2]
4-[[(5Z)-5-[(4-Methoxy-3-phenylmethoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5022300.0 [1], 50000.0 [2]
4-[[(5Z)-5-[(3-Fluoro-4-phenylmethoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5034300.0 [1], 50000.0 [2]
4-[[(5Z)-4-Oxo-5-[[3-(2-phenylethoxy)phenyl]methylidene]-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5010900.0 [1], 26800.0 [2]
4-[[(5Z)-5-[(3-Fluoro-4-phenylmethoxyphenyl)methylidene]-4-oxo-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC503300.0 [1], 15500.0 [2]
4-[[(5Z)-5-[[4-Methoxy-3-(2-phenylethoxy)phenyl]methylidene]-4-oxo-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5017200.0 [1], 50000.0 [2]
4-[[(5Z)-5-[(3-Methoxy-4-phenylmethoxyphenyl)methylidene]-4-oxo-2-phenylimino-1,3-thiazolidin-3-yl]methyl]benzoic acidIC504500.0 [1], 10000.0 [2]
4-[[(5Z)-5-[[3-Methoxy-4-(2-phenylethoxy)phenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5010800.0 [1], 50000.0 [2]
4-[[(5Z)-2,4-Dioxo-5-[[4-(2-phenylethoxy)phenyl]methylidene]-1,3-thiazolidin-3-yl]methyl]benzoic acidIC5020100.0 [1], 50000.0 [2]
2-Aminophenethylphosphonic AcidIC50250000.0 [1], 1400000.0 [2]
RK-682, Streptomyces sp.IC508600.0 [1]
Cefsulodin sodium saltIC50200000.0 [1]
6-Hydroxy-1-methyl-3-[1-[3-oxo-3-(4-phenylanilino)propyl]triazol-4-yl]-2-phenylindole-5-carboxylic acidIC5031100.0 [1]
CID 71734765IC50340.0 [1]
[3-[3-[(3S)-3-(Methylcarbamoyl)-7-(sulfoamino)-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropyl]phenyl]sulfamic acidIC503100.0 [1]
3-Hexadecanoyl-4-hydroxy-5-methylenefuran-2(5H)-oneIC502500.0 [1]
6-Hydroxy-2-phenyl-3-[2-[3-(trifluoromethyl)phenyl]ethynyl]benzofuran-5-carboxylic acidIC504300.0 [1]
3-[2-(3,5-Difluorophenyl)ethynyl]-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acidIC502900.0 [1]
6-Hydroxy-2-phenyl-3-[2-[4-(trifluoromethoxy)phenyl]ethynyl]benzofuran-5-carboxylic acidIC503000.0 [1]
3-Chloro-N-(5-methyl-1,3-benzothiazol-2-yl)-1-benzothiophene-2-carboxamideIC5090000.0 [1]
2-Hydroxy-4-[1-(cyclohexylcarbamoyl)pentyloxy]-5-[2-(trifluoromethoxy)phenylethynyl]benzoic acidIC5050000.0 [1]
(4-Hexadecanoyl-3-hydroxy-5-oxo-2H-furan-2-yl)methyl 2-benzoylbenzoateIC5010100.0 [1]
[6-Oxo-2-(phenylmethoxymethyl)-2,3-dihydropyran-4-yl] hexadecanoateIC50100000.0 [1]
(3Z)-3-(1-Hydroxyhexadecylidene)-6-(phenylmethoxymethyl)oxane-2,4-dioneIC50100000.0 [1]
(3Z)-3-(1-Hydroxyhexadecylidene)-6-(hydroxymethyl)oxane-2,4-dioneIC50100000.0 [1]
5-(1-Hydroxyoctadecylidene)-2,2-dimethyl-1,3-dioxane-4,6-dioneIC505300.0 [1]
2-Ethyl-5-(1-hydroxyhexadecylidene)-2-methyl-1,3-dioxane-4,6-dioneIC5029300.0 [1]
2,2-Diethyl-5-(1-hydroxyhexadecylidene)-1,3-dioxane-4,6-dioneIC50100000.0 [1]
8-(1-Hydroxyhexadecylidene)-6,10-dioxaspiro[4.5]decane-7,9-dioneIC509600.0 [1]
2-[4-[[2-(4-Iodoanilino)-2-oxoacetyl]amino]anilino]-2-oxo-1-phenylethanesulfonic acidIC5050000.0 [1]
2-Oxo-2-[4-[[2-oxo-2-(4-phenylanilino)acetyl]amino]anilino]-1-phenylethanesulfonic acidIC5050000.0 [1]
2-Oxo-2-[4-[[2-oxo-2-(4-propan-2-ylanilino)acetyl]amino]anilino]-1-phenylethanesulfonic acidIC5050000.0 [1]
1-[4-(6-Bromonaphthalen-2-yl)-1,3-thiazol-2-yl]-4-methylpiperidin-4-amineIC50100000.0 [1]
[Fluoro-[4-[2-fluoro-3-[(2,4,5-trichlorophenyl)methyl]phenyl]phenyl]-morpholin-4-ylsulfonylmethyl]phosphonic acidKi6200.0 [1]
CID 1435211IC5090000.0 [1]
2-(3-Cyano-5,8-dimethylquinolin-2-yl)sulfanyl-N-(2-ethyl-6-methylphenyl)acetamideIC5071900.0 [1]
2-(3-Cyano-7-methoxyquinolin-2-yl)sulfanyl-N-(2,3-dimethylphenyl)acetamideIC5060900.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Low molecular weight phosphotyrosine protein phosphatase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/low-molecular-weight-phosphotyrosine-protein-phosphatase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Low molecular weight phosphotyrosine protein phosphatase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/low-molecular-weight-phosphotyrosine-protein-phosphatase-inhibitors-ic50-ki.
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