Low affinity sodium-glucose cotransporter Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Phlorizin	IC50	16.0 [1]
	Dapagliflozin	IC50	1.35 [1]
	Ertugliflozin	IC50	0.88 [1]
	Sergliflozin A	IC50	4.8 [1]
	Sergliflozin etabonate	IC50	260.0 [1]
	(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[(4-methoxyphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol	IC50	42.0 [1]
	(6S,7R,8R,9S)-6-[3-[(4-Methoxyphenyl)methyl]-4-methylphenyl]-2,5-dioxaspiro[3.5]nonane-7,8,9-triol	IC50	6.98 [1]
	(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[(4-methylsulfanylphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol	IC50	19.0 [1]
	(1R,2S,3R,4R,6R)-4-[2-[(4-Cyclopropylphenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol	IC50	11.0 [1]
	(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[[4-(trifluoromethyl)phenyl]methyl]phenoxy]cyclohexane-1,2,3-triol	IC50	120.0 [1]
	(1R,2S,3R,4R,6R)-4-(2-Benzylphenoxy)-6-(hydroxymethyl)cyclohexane-1,2,3-triol	IC50	690.0 [1]
	(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[(4-propylphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol	IC50	120.0 [1]
	(1R,2S,3R,4R,6R)-4-[2-[(4-Ethenylphenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol	IC50	29.0 [1]
	(1R,2S,3R,4R,6R)-4-[2-[(4-Ethoxyphenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol	IC50	110.0 [1]
	(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[(4-hydroxyphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol	IC50	290.0 [1]
	(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[(4-methylphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol	IC50	59.0 [1]
	(1R,2S,3R,4R,6R)-4-[2-[(4-Chlorophenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol	IC50	150.0 [1]
	(1R,2S,3R,4R,6R)-4-[2-[(4-Ethylphenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol	IC50	28.0 [1]
	(1R,2S,3R,4R,6R)-4-[2-[(4-Fluorophenyl)methyl]phenoxy]-6-(hydroxymethyl)cyclohexane-1,2,3-triol	IC50	630.0 [1]
	(1R,2S,3R,4R,6R)-4-(Hydroxymethyl)-6-[2-[(4-propan-2-ylphenyl)methyl]phenoxy]cyclohexane-1,2,3-triol	IC50	150.0 [1]
	(1S,2S,3S,4S,5S)-5-[4-Chloro-3-[(4-methoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol	IC50	43.1 [1]
	(1S,2S,3S,4R,5S)-5-[4-Chloro-3-[(4-methoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol	IC50	0.88 [1]
	(1S,2S,3S,4S,5S)-5-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol	IC50	89.9 [1]
	(1S,2S,3S,4R,5S)-1-(Hydroxymethyl)-5-[3-[(4-methoxyphenyl)methyl]-4-methylphenyl]-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol	IC50	1.07 [1]
	(2R,3S,4R,5R,6S)-2-(Hydroxymethyl)-6-[(13E)-16-oxatricyclo[15.2.2.03,8]henicosa-1(19),3(8),4,6,13,17,20-heptaen-5-yl]oxane-3,4,5-triol	IC50	103.0 [1]
	(2R,3S,4R,5R,6S)-2-(Hydroxymethyl)-6-(15-oxatricyclo[14.2.2.03,8]icosa-1(18),3(8),4,6,16,19-hexaen-5-yl)oxane-3,4,5-triol	IC50	81.9 [1]
	(2R,3S,4R,5R,6S)-2-(Hydroxymethyl)-6-[(12E)-15-oxatricyclo[14.2.2.03,8]icosa-1(18),3(8),4,6,12,16,19-heptaen-5-yl]oxane-3,4,5-triol	IC50	89.6 [1]
	(2R,3S,4R,5R,6S)-2-(Hydroxymethyl)-6-(16-oxatricyclo[15.2.2.03,8]henicosa-1(19),3(8),4,6,17,20-hexaen-5-yl)oxane-3,4,5-triol	IC50	99.7 [1]
	(2R,3S,4R,5R,6S)-2-(Hydroxymethyl)-6-[3-[[4-[(E)-pent-2-enoxy]phenyl]methyl]phenyl]oxane-3,4,5-triol	IC50	59.5 [1]
	(1S,2S,3S,4R,5S)-5-[3-[(4-Ethoxyphenyl)methyl]-4-methylphenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol	IC50	1.11 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 30 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Low affinity sodium-glucose cotransporter Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/low-affinity-sodium-glucose-cotransporter-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Low affinity sodium-glucose cotransporter Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/low-affinity-sodium-glucose-cotransporter-inhibitors-ic50-ki.
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