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LIM domain kinase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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[3-[[4-(Aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC501.6 [1], 4.3 [2], 7.5 [3]
1-Ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]ureaIC5038.0 [1], 696.0 [2]
(2S)-2-Methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-[3-(propan-2-ylcarbamoyl)phenyl]piperazine-1-carboxamideIC505.5 [1]
[3-[[(2S)-2-Methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC501.2 [1]
N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramideIC5085.0 [1]
CID 58688563IC508.0 [1]
CID 58688690IC50173.0 [1]
N-Benzyl-N-methyl-4-[methyl(phenyl)sulfamoyl]benzamideIC5095.0 [1]
CID 27666048IC5039.0 [1]
(2S)-N'-(3-Bromophenyl)-N-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamideIC500.9 [1]
CID 44543082IC500.8 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
5-[6-(2-Chlorophenyl)-2-pyridin-2-ylpyrimidin-4-yl]-N-propan-2-yl-1,3-thiazol-2-amineIC50362.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
N-Benzyl-N-methyl-4-[(3-methylphenyl)sulfamoyl]benzamideIC5022.0 [1]
N-Benzyl-4-[(3-fluorophenyl)sulfamoyl]-N-methylbenzamideIC5022.0 [1]
1-(5-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(3-phenoxyphenyl)piperidine-4-carboxamideIC5064.0 [1]
N-[5-[3-[4-Methoxy-2-(trifluoromethyl)phenyl]pyridin-4-yl]-1,3-thiazol-2-yl]-2-methylpropanamideIC5048.0 [1]
N-[5-[3-(2-Chloro-4-methylphenyl)pyridin-4-yl]-1,3-thiazol-2-yl]-2-methylpropanamideIC503.0 [1]
N-Benzyl-4-[(3-chlorophenyl)sulfamoyl]-N-methylbenzamideIC5051.0 [1]
N-Benzyl-4-[(3-methoxyphenyl)sulfamoyl]-N-methylbenzamideIC50540.0 [1]
N-Benzyl-4-[(3-tert-butylphenyl)sulfamoyl]-N-methylbenzamideIC5027000.0 [1]
N-Benzyl-4-[[3-(dimethylamino)phenyl]sulfamoyl]-N-methylbenzamideIC5027000.0 [1]
N-[[4-(2-Methoxyethoxy)phenyl]methyl]-N-methyl-4-(phenylsulfamoyl)benzamideIC5034.0 [1]
3-[4-[[Methyl-[4-(phenylsulfamoyl)benzoyl]amino]methyl]phenyl]propanoic acidIC5019.0 [1]
N-[[4-(1,2-Dihydroxyethyl)phenyl]methyl]-N-methyl-4-(phenylsulfamoyl)benzamideIC5092.0 [1]
N-Methyl-4-(phenylsulfamoyl)-N-[(4-piperidin-4-ylphenyl)methyl]benzamideIC501640.0 [1]
N-[(1-Acetylpiperidin-4-yl)methyl]-N-methyl-4-(phenylsulfamoyl)benzamideIC50900.0 [1]
Tert-butyl 4-[[methyl-[4-(phenylsulfamoyl)benzoyl]amino]methyl]piperidine-1-carboxylateIC5036.0 [1]
N-Methyl-4-(phenylsulfamoyl)-N-(piperidin-4-ylmethyl)benzamideIC5027000.0 [1]
N-Methyl-N-[(1-methylpiperidin-4-yl)methyl]-4-(phenylsulfamoyl)benzamideIC5027000.0 [1]
N-Methyl-4-(phenylsulfamoyl)-N-[(1-propan-2-ylpiperidin-4-yl)methyl]benzamideIC5027000.0 [1]
N-Benzyl-N-(2-hydroxyethyl)-4-(phenylsulfamoyl)benzamideIC5019.0 [1]
N-Benzyl-N-(2-cyanoethyl)-4-(phenylsulfamoyl)benzamideIC5052.0 [1]
N-Benzyl-N-[2-(dimethylamino)ethyl]-4-(phenylsulfamoyl)benzamideIC50160.0 [1]
N-(2-Aminoethyl)-N-benzyl-4-(phenylsulfamoyl)benzamideIC501200.0 [1]
N-(3-Aminopropyl)-N-benzyl-4-(phenylsulfamoyl)benzamideIC501500.0 [1]
4-(4-Benzyl-1,3-oxazol-5-yl)-N-phenylbenzenesulfonamideIC501530.0 [1]
4-(1-Benzyl-6-oxopyrimidin-2-yl)-N-phenylbenzenesulfonamideIC5027000.0 [1]
4-(1-Benzylimidazol-2-yl)-N-phenylbenzenesulfonamideIC5022.0 [1]
4-(3-Benzylpyridin-2-yl)-N-phenylbenzenesulfonamideIC50100.0 [1]
4-(3-Benzylpyrazin-2-yl)-N-phenylbenzenesulfonamideIC5090.0 [1]
(2S)-2-Methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-phenylpiperazine-1-carboxamideIC501.2 [1]
1-[(2S)-2-Methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]-2-phenylethanoneIC50660.0 [1]
(2S)-2-Methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-[(1S)-1-phenylethyl]piperazine-1-carboxamideIC509.9 [1]
(2S)-2-Methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-[(1R)-1-phenylethyl]piperazine-1-carboxamideIC50180.0 [1]
[3-[[4-(5-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-1-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC50220.0 [1]
[3-[[2-Tert-butyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC5026.0 [1]
7-(5-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-phenyl-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-3-oneIC501000.0 [1]
1-(5-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(3-propan-2-yloxyphenyl)piperidine-4-carboxamideIC50330.0 [1]
[3-[[(3R,4S)-3-Methyl-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC50210.0 [1]
[3-[[(3S,4S)-3-Methyl-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC50110.0 [1]
[3-[[1-(5-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-prop-2-enylpiperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC502.2 [1]
Methyl 3-[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC501.0 [1]
Methyl 3-[[4-[(dimethylamino)methyl]-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC501.5 [1]
Methyl 3-[[4-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC507.4 [1]
Methyl 3-[[4-(dimethylamino)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC5012.0 [1]
Methyl 2-[3-[[4-[(dimethylamino)methyl]-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenoxy]acetateIC501.0 [1]
Methyl 2-[3-[[4-[(dimethylamino)methyl]-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl]acetateIC501.0 [1]
Methyl 4-[[4-[(dimethylamino)methyl]-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC507.7 [1]
Propyl 3-[[4-[(dimethylamino)methyl]-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC502.1 [1]
Propan-2-yl 3-[[4-[(dimethylamino)methyl]-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC502.2 [1]
Butan-2-yl 3-[[4-[(dimethylamino)methyl]-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC504.6 [1]
Prop-2-ynyl 3-[[4-[(dimethylamino)methyl]-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC501.0 [1]
Methyl 3-[[4-[(dimethylamino)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC5013.0 [1]
Methyl 3-[[4-[(dimethylamino)methyl]-1-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC50193.0 [1]
Methyl 3-[[4-[(dimethylamino)methyl]-1-(1H-pyrazolo[3,4-b]pyridin-4-yl)piperidine-4-carbonyl]amino]benzoateIC50274.0 [1]
Methyl 3-[[4-[(dimethylamino)methyl]-1-(6-oxo-5,7-dihydropyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC501860.0 [1]
Methyl 3-[[4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC509.6 [1]
Methyl 3-[(4-amino-1-pyrimidin-4-ylpiperidine-4-carbonyl)amino]benzoateIC5010000.0 [1]
Methyl 3-[[4-amino-1-(6-aminopyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC504560.0 [1]
Methyl 3-[[4-amino-1-(2-aminopyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC5010000.0 [1]
Methyl 3-[[1-(6-acetamidopyrimidin-4-yl)-4-aminopiperidine-4-carbonyl]amino]benzoateIC50494.0 [1]
Methyl 3-[[1-(2-acetamidopyrimidin-4-yl)-4-aminopiperidine-4-carbonyl]amino]benzoateIC5010000.0 [1]
Methyl 3-[[1-(5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-[(dimethylamino)methyl]piperidine-4-carbonyl]amino]benzoateIC504.0 [1]
Methyl 3-[[4-[(dimethylamino)methyl]-1-(5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC502.8 [1]
Methyl 3-[[4-[(dimethylamino)methyl]-1-(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC508.0 [1]
Methyl 3-[[4-[(dimethylamino)methyl]-1-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]benzoateIC501.6 [1]
[3-[[4-[(Dimethylamino)methyl]-1-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC501.4 [1]
4-[[5-[3-(2-Chlorophenyl)pyridin-4-yl]-1,3-thiazol-2-yl]amino]phenolIC501.0 [1]
3-Chloro-4-[6-[2-(propylamino)-1,3-thiazol-5-yl]-2-pyrazin-2-ylpyrimidin-4-yl]phenolIC5012500.0 [1]
N-Benzyl-N-methyl-4-(thiophen-2-ylsulfonylamino)benzamideIC502320.0 [1]
N-Benzyl-4-[(4-methoxyphenyl)sulfamoyl]-N-methylbenzamideIC5024100.0 [1]
(2S)-N'-(3-Tert-butylphenyl)-N-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamideIC501.1 [1]
(2S)-N-Cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]piperazine-1-carboximidamideIC501.9 [1]
(2S)-N-Cyano-N'-[3-(2-hydroxyethylsulfamoyl)phenyl]-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamideIC502.9 [1]
(2S)-N-Cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N'-[3-(propan-2-ylsulfamoyl)phenyl]piperazine-1-carboximidamideIC501.7 [1]
(2S)-N-Cyano-N'-(3-cyanophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamideIC501.2 [1]
(2R)-N-(3-Bromophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamideIC5037.0 [1]
(2S)-N-(3-Bromophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamideIC503.9 [1]
(2S)-N-(3-Chlorophenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamideIC502.3 [1]
(2S)-N-[3-(2-Hydroxyethylcarbamoyl)phenyl]-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamideIC503.0 [1]
(2S)-N-(3-Methoxyphenyl)-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamideIC502.7 [1]
N-Methyl-N-[(1R)-1-phenylethyl]-4-(phenylsulfamoyl)benzamideIC50120.0 [1]
N-Methyl-N-[(1S)-1-phenylethyl]-4-(phenylsulfamoyl)benzamideIC50110.0 [1]
N-Benzyl-N-methyl-4-[(4-methylphenyl)sulfamoyl]benzamideIC503200.0 [1]
N-[(4-Ethylphenyl)methyl]-N-methyl-4-(phenylsulfamoyl)benzamideIC5053.0 [1]
N-Benzyl-4-[(2-fluorophenyl)sulfamoyl]-N-methylbenzamideIC5052.0 [1]
N-Benzyl-4-[(4-fluorophenyl)sulfamoyl]-N-methylbenzamideIC5081.0 [1]
N-Benzyl-N-methyl-4-[(2-methylphenyl)sulfamoyl]benzamideIC50120.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ LIM domain kinase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/lim-domain-kinase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ LIM domain kinase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lim-domain-kinase-2-inhibitors-ic50-ki.
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