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LIM domain kinase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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[3-[[4-(Aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC5024.0 [1], 32.0 [2], 54.0 [3]
5-Methyl-7-phenylpyrimido[5,4-b]indol-4-amineIC50260.0 [1]
1-Ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]ureaIC501.0 [1], 54.0 [2], 58.0 [3]
Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amineIC509000.0 [1]
[1]Benzothiolo[3,2-d]pyrimidin-4-amineIC507000.0 [1]
3-Aminothieno[2,3-b]pyridine-2-carboxamideIC5037000.0 [1]
3-Amino-1-benzothiophene-2-carboxamideIC5033000.0 [1]
5-Methylpyrimido[5,4-b]indol-4-amineIC504000.0 [1]
7-Phenyl-[1]benzothiolo[3,2-d]pyrimidin-4-amineIC50300.0 [1]
3-(4-Amino-[1]benzothiolo[3,2-d]pyrimidin-7-yl)benzamideIC50120.0 [1], 30000.0 [2]
N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramideIC5010.0 [1], 220.0 [2]
5,6-Dimethylthieno[2,3-d]pyrimidin-4-amineIC504400.0 [1]
2-Phenyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamineIC50100000.0 [1]
5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amineIC504000.0 [1]
2-(Methylsulfanyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamineIC50100000.0 [1]
6,6-Dimethyl-5,8-dihydro-6H-7-oxa-9-thia-1,3-diaza-fluoren-4-ylamineIC5012700.0 [1]
2-(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamino)ethanolIC50100000.0 [1]
N,N-Dimethyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-3-amineIC50100000.0 [1]
10-Methylsulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-amineIC50100000.0 [1]
N-(4-Methoxyphenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amineIC50100000.0 [1]
6,7,8,9-Tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-amineIC502500.0 [1]
2-(Methylsulfanyl)-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-amineIC50100000.0 [1]
7-Methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amineIC5018000.0 [1]
5-[6-(2-Chlorophenyl)-2-pyridin-2-ylpyrimidin-4-yl]-N-propan-2-yl-1,3-thiazol-2-amineIC50252.0 [1]
N-(2-Phenylethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amineIC50100000.0 [1]
N-Propyl-5-(3-(2-chlorophenyl)-4-pyridyl)thiazole-2-amineIC5015.0 [1], 3800.0 [2]
5-(3-(2-Chlorophenyl)-4-pyridyl)thiazole-2-amineIC50270.0 [1], 30000.0 [2]
5-[3-(2-Chlorophenyl)pyridin-4-yl]-N-[(1S)-1-phenylethyl]-1,3-thiazol-2-amineIC5040.0 [1], 9200.0 [2]
N-[5-[3-(2-Chlorophenyl)pyridin-4-yl]-1,3-thiazol-2-yl]acetamideIC5020.0 [1], 1400.0 [2]
N-Propyl-5-(3-(2-trifluoromethylphenyl)-4-pyridyl)thiazole-2-amineIC5037.0 [1], 2200.0 [2]
5-[3-(2-Chlorophenyl)pyridin-4-yl]-N-(2-methylpropyl)-1,3-thiazol-2-amineIC505.0 [1], 1500.0 [2]
N-Propyl-5-(3-(2-trifluoromethyl-4-methoxyphenyl)-4-pyridyl)thiazole-2-amineIC5013.0 [1], 2500.0 [2]
N-[5-[3-(2-Chlorophenyl)pyridin-4-yl]-1,3-thiazol-2-yl]-2-methylpropanamideIC503.0 [1], 800.0 [2]
N-Propyl-5-(3-(o-tolyl)-4-pyridyl)thiazole-2-amineIC5082.0 [1], 11500.0 [2]
N-Ethyl-5-(3-(2-chlorophenyl)-4-pyridyl)thiazole-2-amineIC50120.0 [1], 14000.0 [2]
N-[5-[3-[4-Methoxy-2-(trifluoromethyl)phenyl]pyridin-4-yl]-1,3-thiazol-2-yl]-2-methylpropanamideIC508.0 [1], 2000.0 [2]
5-[3-(2-Chlorophenyl)pyridin-4-yl]-N-phenyl-1,3-thiazol-2-amineIC503.0 [1], 600.0 [2]
4-[[5-[3-(2-Chlorophenyl)pyridin-4-yl]-1,3-thiazol-2-yl]amino]phenolIC500.3 [1], 6600.0 [2]
7-Benzyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amineIC50660.0 [1]
5-Methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amineIC502700.0 [1]
N-(1-Phenylethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amineIC50100000.0 [1]
N'-(5,6,7,8-Tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)ethane-1,2-diamineIC50100000.0 [1]
17-Thia-13,15-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11,13,15-heptaen-12-amineIC504300.0 [1]
2-Methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amineIC50100000.0 [1]
4-Amino-6,7,8,9-tetrahydro-5H-10-thia-1,3-diaza-benzo[a]azulene-2-thiolIC50100000.0 [1]
6,7-Dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amineIC505300.0 [1]
4-(1-Piperidinyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidineIC50100000.0 [1]
7,7-Dimethyl-6,8-dihydro-5H-[1]benzothiolo[2,3-d]pyrimidin-4-amineIC502800.0 [1]
3-Thia-5,7-diazatetracyclo[10.1.1.02,10.04,9]tetradeca-2(10),4,6,8-tetraen-8-amineIC501800.0 [1]
11-Oxa-8-thia-4,6-diazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6-tetraen-3-amineIC503500.0 [1]
4-Amino-N-benzyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine-7-carboxamideIC509500.0 [1]
Ethyl 4-amino-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine-7-carboxylateIC502300.0 [1]
7-Phenyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amineIC5020000.0 [1]
4-Amino-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine-7-carboxamideIC509100.0 [1]
4-Amino-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine-7-carboxylic acidIC5020000.0 [1]
3,3-Dimethyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-amineIC502100.0 [1]
5-Methyl-6-phenylthieno[2,3-d]pyrimidin-4-amineIC5017000.0 [1]
6-(3,4-Dimethoxyphenyl)-5-methylthieno[2,3-d]pyrimidin-4-amineIC503200.0 [1]
8-Thia-4,6-diazatetracyclo[7.7.0.02,7.010,15]hexadeca-1(9),2,4,6,10,12,14-heptaen-3-amineIC5011000.0 [1]
(4-Amino-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-7-yl)-morpholin-4-ylmethanoneIC508600.0 [1]
N-Methyl-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-3-amineIC50100000.0 [1]
4-Amino-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine-2-thiolIC50100000.0 [1]
[(4-Amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)sulfanyl]acetic acidIC50100000.0 [1]
2-Thiophen-2-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amineIC50100000.0 [1]
5-[3-(2-Chlorophenyl)pyridin-4-yl]-N-[(1R)-1-phenylethyl]-1,3-thiazol-2-amineIC504.0 [1], 2100.0 [2]
N-[3-(4-Amino-[1]benzothiolo[3,2-d]pyrimidin-7-yl)phenyl]formamideIC5055.0 [1]
1-[3-(4-Amino-[1]benzothiolo[3,2-d]pyrimidin-7-yl)phenyl]-3-ethylureaIC5087.0 [1], 30000.0 [2]
N-[3-(4-Amino-[1]benzothiolo[3,2-d]pyrimidin-7-yl)phenyl]-4-methylpiperazine-1-carboxamideIC5095.0 [1], 1600.0 [2]
N-[3-(4-Amino-[1]benzothiolo[3,2-d]pyrimidin-7-yl)phenyl]pyrrolidine-1-carboxamideIC5095.0 [1], 2400.0 [2]
3-(4-Amino-[1]benzothiolo[3,2-d]pyrimidin-7-yl)-N-(2-morpholin-4-yl-2-oxoethyl)benzamideIC5081.0 [1], 1400.0 [2]
7-[3-(2H-Tetrazol-5-yl)phenyl]-[1]benzothiolo[3,2-d]pyrimidin-4-amineIC5050.0 [1], 30000.0 [2]
3-(4-Amino-[1]benzothiolo[3,2-d]pyrimidin-7-yl)-N-(2-pyridin-3-ylethyl)benzamideIC5097.0 [1], 4100.0 [2]
DasatinibIC50114.0 [1]
DamnacanthalIC50800.0 [1]
JNK Inhibitor VIIIKi9600.0 [1]
CID 59604787IC5010000.0 [1]
3-Amino-6-phenylthieno[2,3-b]pyridine-2-carboxamideIC503000.0 [1]
CID 58688563IC5030.0 [1]
CID 58688690IC5066.0 [1]
3-Amino-6-(3-pyridyl)thiopheno[2,3-b]pyridine-2-carboxamideIC507100.0 [1]
CID 45381385IC5043.0 [1]
[4-Amino-2-(prop-2-en-1-ylamino)-1,3-thiazol-5-yl](1,3-benzodioxol-5-yl)methanoneIC504000.0 [1]
3-Amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamideIC509000.0 [1]
3-Amino-6-methylthieno[2,3-b]pyridine-2-carboxamideIC5056000.0 [1]
1-Amino-5-phenyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamideIC502800.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi9600.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi9500.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi9546.0 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi9600.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi9600.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi9600.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi9600.0 [1]
3-Amino-4-(furan-2-yl)-6-phenylthieno[2,3-b]pyridine-2-carboxamideIC502000.0 [1]
CID 27666048IC503200.0 [1]
3-Aminothieno[2,3-b]pyridine-2-carboxylic acidIC50100000.0 [1]
(2S)-N'-(3-Bromophenyl)-N-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamideIC500.5 [1]
[3-[[(2S)-2-Methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC503.2 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ LIM domain kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/lim-domain-kinase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ LIM domain kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/lim-domain-kinase-1-inhibitors-ic50-ki.
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