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Leukotriene C4 synthase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
FiboflaponIC5036000.0 [1]
CID 53385780IC5029.0 [1]
CID 122670075IC509.0 [1]
CID 122670110IC500.29 [1]
CID 56589615IC503000.0 [1]
5-[1-[(2-Chlorophenyl)methyl]-2-[1-[4-(2-methylpropyl)phenyl]ethyl]benzimidazol-5-yl]-3H-1,3,4-oxadiazole-2-thioneIC506190.0 [1]
3-[1-[(2-Chlorophenyl)methyl]-2-[1-[4-(2-methylpropyl)phenyl]ethyl]benzimidazol-5-yl]propanoic acidIC5030.0 [1]
4-[1-[(2-Chlorophenyl)methyl]-2-[1-[4-(2-methylpropyl)phenyl]ethyl]benzimidazol-5-yl]benzoic acidIC5015860.0 [1]
4-[(4-Phenylbenzoyl)-[(3-phenylmethoxyphenyl)methyl]amino]benzoic acidIC501800.0 [1]
2-[4-[Cyclopropylmethyl-(8-methylquinolin-5-yl)amino]-2-methoxybenzoyl]cyclopropane-1-carboxylic acidIC50359.0 [1]
2-[4-[Cyclopropylmethyl-(4-methylnaphthalen-1-yl)amino]-2-methoxybenzoyl]cyclopropane-1-carboxylic acidIC5062.0 [1]
[5-[Cyclopropylmethyl-(4-fluoronaphthalen-1-yl)amino]-3-methoxypyridin-2-yl]-[2-(2H-tetrazol-5-yl)cyclopropyl]methanoneIC5039.0 [1]
2-[5-[(3-Chlorophenyl)methyl-(cyclopropylmethyl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5039.0 [1]
2-[5-[Cyclopropylmethyl-(4-fluoronaphthalen-1-yl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5018.0 [1]
2-[5-[Cyclopropylmethyl-[(4-phenylphenyl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC502178.0 [1]
2-[5-[Cyclopropylmethyl(naphthalen-1-ylmethyl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5066.0 [1]
2-[4-[Cyclopropylmethyl-[5-(trifluoromethyl)quinolin-8-yl]amino]-2-methoxybenzoyl]cyclopropane-1-carboxylic acidIC50152.0 [1]
2-[5-[Cyclopropylmethyl-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5088.0 [1]
[5-[Cyclopropylmethyl(naphthalen-1-yl)amino]-3-methoxypyridin-2-yl]-[2-(2H-tetrazol-5-yl)cyclopropyl]methanoneIC5096.0 [1]
2-[5-[Cyclopropylmethyl-(4-fluoronaphthalen-1-yl)amino]-4-methoxypyrimidine-2-carbonyl]cyclopropane-1-carboxylic acidIC5019.0 [1]
2-[5-[Cyclopropylmethyl-[(4-fluorophenyl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50105.0 [1]
2-[5-[Cyclopropylmethyl-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5053.0 [1]
2-[4-[(4-Chloronaphthalen-1-yl)-(cyclopropylmethyl)amino]-2-methoxybenzoyl]cyclopropane-1-carboxylic acidIC5061.0 [1]
(1S,2S)-2-[5-[2-Fluoro-N-(2-fluoro-2-methylpropyl)-5-(trifluoromethyl)anilino]-3-methoxypyrazine-2-carbonyl]cyclopropane-1-carboxylic acidIC500.25 [1]
2-[5-[(3-Chloro-2,4-difluorophenyl)methyl-(cyclopropylmethyl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50152.0 [1]
2-[5-[Cyclopropylmethyl-[(2,6-dichlorophenyl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50800.0 [1]
2-[5-[Cyclopropylmethyl-(4-methylnaphthalen-1-yl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5035.0 [1]
2-[4-[(4-Chlorophenyl)methyl-(cyclopropylmethyl)amino]-2-methoxybenzoyl]cyclopropane-1-carboxylic acidIC5068.0 [1]
2-[5-[Cyclopropylmethyl-[5-(trifluoromethyl)quinolin-8-yl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50229.0 [1]
(1S,2S)-2-[5-[2-Fluoro-N-(2-methylpropyl)-5-(trifluoromethyl)anilino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC500.66 [1]
2-[5-[4-Chloro-N-(cyclopropylmethyl)anilino]-3-methoxypyridine-2-carbonyl]-N-(2-fluorophenyl)sulfonylcyclopropane-1-carboxamideIC5074.0 [1]
2-[5-[4-Chloro-N-(cyclopropylmethyl)anilino]-3-methoxypyridine-2-carbonyl]-N-(4-methoxyphenyl)sulfonylcyclopropane-1-carboxamideIC5081.0 [1]
2-[4-[Cyclopropylmethyl-(4-fluoronaphthalen-1-yl)amino]-2-methoxybenzoyl]cyclopropane-1-carboxylic acidIC5026.0 [1]
2-[5-[[2-Chloro-3-(trifluoromethyl)phenyl]methyl-(cyclopropylmethyl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50112.0 [1]
2-[5-[4-Chloro-N-[(1-methylcyclopropyl)methyl]anilino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5038.0 [1]
2-[5-[Cyclopropylmethyl-[(2-methylnaphthalen-1-yl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC501839.0 [1]
2-[5-[Cyclopropylmethyl(naphthalen-2-ylmethyl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5034.0 [1]
2-[5-[Cyclopropylmethyl-[(4-methylphenyl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5022.0 [1]
2-[5-[Cyclopropylmethyl-(4-methylquinolin-8-yl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50445.0 [1]
2-[4-[N-(Cyclopropylmethyl)-3,4-dimethylanilino]-2-methoxybenzoyl]cyclopropane-1-carboxylic acidIC5075.0 [1]
N-(Benzenesulfonyl)-2-[5-[4-chloro-N-(cyclopropylmethyl)anilino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxamideIC5068.0 [1]
2-[4-[Cyclopropylmethyl(naphthalen-1-yl)amino]-2-methoxybenzoyl]cyclopropane-1-carboxylic acidIC5046.0 [1]
2-[5-[Cyclopropylmethyl-[[2-fluoro-3-(trifluoromethyl)phenyl]methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50331.0 [1]
2-[5-[4-Chloro-N-(cyclopropylmethyl)anilino]-3-methoxypyridine-2-carbonyl]-N-[4-(trifluoromethoxy)phenyl]sulfonylcyclopropane-1-carboxamideIC50277.0 [1]
(1S,2S)-2-[5-(5-Chloro-2,4-difluoro-N-propylanilino)-3-methoxypyrazine-2-carbonyl]cyclopropane-1-carboxylic acidIC500.48 [1]
2-[5-[(4-Chloronaphthalen-1-yl)-(cyclopropylmethyl)amino]-4-methoxypyrimidine-2-carbonyl]cyclopropane-1-carboxylic acidIC5017.0 [1]
2-[5-[4-Chloro-N-(cyclopropylmethyl)anilino]pyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50424.0 [1]
2-[5-[Cyclopropylmethyl(naphthalen-1-yl)amino]-4-methoxypyrimidine-2-carbonyl]cyclopropane-1-carboxylic acidIC5050.0 [1]
2-[4-[4-Chloro-N-(cyclopropylmethyl)anilino]-2-methoxybenzoyl]cyclopropane-1-carboxylic acidIC5065.0 [1]
2-[5-[Cyclopropylmethyl(1,2-dihydroacenaphthylen-3-yl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5031.0 [1]
2-[5-[Cyclopropylmethyl-[5-(trifluoromethyl)naphthalen-1-yl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5025.0 [1]
2-[5-[Cyclopropylmethyl-[(2,3-difluoro-4-methylphenyl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50185.0 [1]
2-[5-[Cyclopropylmethyl-[(3-methylphenyl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50171.0 [1]
2-[5-[Cyclopropylmethyl-[(2,6-difluoro-3-methylphenyl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC501671.0 [1]
2-[5-[Cyclopropylmethyl-(4-methylnaphthalen-1-yl)amino]-4-methoxypyrimidine-2-carbonyl]cyclopropane-1-carboxylic acidIC5018.0 [1]
2-[5-[2,3-Dihydro-1H-inden-5-yl-[(1-methylcyclopropyl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5047.0 [1]
2-[5-[Cyclopropylmethyl-[(2,3-dimethylphenyl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5067.0 [1]
2-[5-[4-Chloro-N-(cyclopropylmethyl)anilino]-3-methoxypyridine-2-carbonyl]-N-cyclopropylsulfonylcyclopropane-1-carboxamideIC50356.0 [1]
2-[5-[Cyclopropylmethyl-[4-(trifluoromethyl)naphthalen-1-yl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5019.0 [1]
2-[5-[Cyclopropylmethyl(naphthalen-2-yl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5028.0 [1]
2-[5-[Cyclopropylmethyl-[(2,3,4-trifluorophenyl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50370.0 [1]
2-[5-[4-Chloro-N-(cyclopropylmethyl)anilino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5034.0 [1]
2-[5-[Cyclopropylmethyl-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50478.0 [1]
2-[5-[(4-Chloronaphthalen-1-yl)-(cyclopropylmethyl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5018.0 [1]
2-[5-[Cyclopropylmethyl-(8-methylquinolin-5-yl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50279.0 [1]
2-[5-[Cyclopropylmethyl(naphthalen-1-yl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC5024.0 [1]
2-[5-[(6-Chloro-1,3-benzodioxol-4-yl)methyl-(cyclopropylmethyl)amino]-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50588.0 [1]
2-[5-[(4-Chlorophenyl)methyl-(cyclopropylmethyl)amino]pyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50636.0 [1]
2-[6-[Cyclopropylmethyl-(4-methylnaphthalen-1-yl)amino]-4-methoxypyridine-3-carbonyl]cyclopropane-1-carboxylic acidIC5056.0 [1]
2-[5-(4-Chloro-N-(1-cyclopropyl-2,2,2-trifluoroethyl)anilino)-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50149.0 [1]
2-[5-(4-Chloro-N-(1-cyclopropyl-2-methoxyethyl)anilino)-3-methoxypyridine-2-carbonyl]cyclopropane-1-carboxylic acidIC50263.0 [1]
2-Benzoyl-5-[5-[N-methyl-4-(trifluoromethyl)anilino]pyridine-2-carbonyl]benzoic acidIC5078.0 [1]
5-[5-[4-Chloro-N-(cyclopropylmethyl)anilino]pyridine-2-carbonyl]-2-(1-phenylcyclopropanecarbonyl)benzoic acidIC5041.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(1-phenylcyclohexanecarbonyl)benzoic acidIC5032.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-[1-(4-methoxyphenyl)cyclopropanecarbonyl]benzoic acidIC5022.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(1-phenylcyclopentanecarbonyl)benzoic acidIC5076.0 [1]
2-(Adamantane-1-carbonyl)-5-[5-(4-chloro-N-methylanilino)pyridine-2-carbonyl]benzoic acidIC5065.0 [1]
5-[5-[4-Chloro-N-(cyclopropylmethyl)anilino]pyridine-2-carbonyl]-2-(3-methoxybenzoyl)benzoic acidIC5018.0 [1]
5-[5-[4-Chloro-N-(cyclopropylmethyl)anilino]pyridine-2-carbonyl]-2-(3-hydroxybenzoyl)benzoic acidIC5030.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(2-methyl-2-phenylpropanoyl)benzoic acidIC5055.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(3-cyclohexylpropanoyl)benzoic acidIC5059.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(2-phenylcyclopropanecarbonyl)benzoic acidIC50141.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(2-cyclopentylacetyl)benzoic acidIC5081.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-[2-(3-methoxyphenyl)acetyl]benzoic acidIC50192.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-heptanoylbenzoic acidIC5090.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(1-phenylcyclopropanecarbonyl)benzoic acidIC5032.0 [1]
2-(1,3-Benzodioxole-5-carbonyl)-5-[5-(4-chloro-N-methylanilino)pyridine-2-carbonyl]benzoic acidIC5077.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(4-fluorobenzoyl)benzoic acidIC50126.0 [1]
2-Benzoyl-5-[5-(N,4-dimethylanilino)pyridine-2-carbonyl]benzoic acidIC50250.0 [1]
2-Benzoyl-5-[5-(4-ethyl-N-methylanilino)pyridine-2-carbonyl]benzoic acidIC50184.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(2-methoxybenzoyl)benzoic acidIC50154.0 [1]
5-[5-[4-Chloro-N-(cyclopropylmethyl)-2-fluoroanilino]pyridine-2-carbonyl]-2-(4-methoxybenzoyl)benzoic acidIC5046.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-[3-(trifluoromethyl)benzoyl]benzoic acidIC5054.0 [1]
5-[5-[4-Chloro-2-fluoro-N-(2,2,2-trifluoroethyl)anilino]pyridine-2-carbonyl]-2-(4-methoxybenzoyl)benzoic acidIC50401.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(2,4-dimethoxybenzoyl)benzoic acidIC5068.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-[3-(trifluoromethoxy)benzoyl]benzoic acidIC5060.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(2,2-dimethylpropanoyl)benzoic acidIC50491.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(4-ethoxybenzoyl)benzoic acidIC50101.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(3,4-diethoxybenzoyl)benzoic acidIC5077.0 [1]
5-[5-(4-Chloro-N-methylanilino)pyridine-2-carbonyl]-2-(2,3-dihydro-1,4-benzodioxine-6-carbonyl)benzoic acidIC5027.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Leukotriene C4 synthase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/leukotriene-c4-synthase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Leukotriene C4 synthase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/leukotriene-c4-synthase-inhibitors-ic50-ki.
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