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Leukocyte proteinase 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(3S)-3-[[(2R,5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-Aminobenzoyl)amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]-2-methyl-4-oxooctanoyl]amino]-4-[[(2S)-1-[[(2S)-5-amino-1-[2-(2,4-dinitroanilino)ethylamino]-1,5-dioxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acidIC50530.0 [1], 1910.0 [2]
(3S)-3-[[(2R,5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-Aminobenzoyl)amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]-2-methyl-4-oxooctanoyl]amino]-4-[[(2S)-1-[[(2S)-5-amino-1-[2-(2,4-dinitroanilino)ethylamino]-1,5-dioxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acidKi1500.0 [1]
SivelestatIC50340.0 [1], 100000.0 [2]
Phenylmethylsulfonyl fluorideIC5019230.0 [1]
CID 66561876IC501400.0 [1]
(3S)-1-Diazo-3-[(aminoacetyl)amino]-4-(4-iodophenyl)-2-butanoneIC5050000.0 [1]
[4-[[2-[(E)-N-Methoxy-C-methylcarbonimidoyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoateIC50610.0 [1]
[4-[[2-[(Z)-N-Methoxy-C-methylcarbonimidoyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoateIC502370.0 [1]
[4-[[2-[(Z)-C-Ethyl-N-hydroxycarbonimidoyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoateIC502500.0 [1]
[4-[(2-Acetylphenyl)sulfamoyl]phenyl] 2,2-dimethylpropanoateIC50470.0 [1]
2,2-Dimethylpropanoic acid 4-[[2-[(E)-1-(hydroxyimino)ethyl]phenyl]sulfamoyl]phenyl esterIC50220.0 [1]
[4-[(2-Formylphenyl)sulfamoyl]phenyl] 2,2-dimethylpropanoateIC502050.0 [1]
[4-[(2-Propanoylphenyl)sulfamoyl]phenyl] 2,2-dimethylpropanoateIC501090.0 [1]
[4-[[2-[(Z)-N-Hydroxy-C-propylcarbonimidoyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoateIC501730.0 [1]
[4-[(2-Butanoylphenyl)sulfamoyl]phenyl] 2,2-dimethylpropanoateIC50360.0 [1]
(4S)-4-[[(2R,5S)-5-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[(2-aminobenzoyl)amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-2-methyl-4-oxooctanoyl]amino]-5-[[(2S)-1-[[(2S)-5-amino-1-[2-(2,4-dinitroanilino)ethylamino]-1,5-dioxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-oxopentanoic acidIC5010380.0 [1]
[4-[(2-Pentanoylphenyl)sulfamoyl]phenyl] 2,2-dimethylpropanoateIC502310.0 [1]
[4-[[2-[(Z)-Hydroxyiminomethyl]phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoateIC50530.0 [1]
Methyl 2-[[4-(2,2-dimethylpropanoyloxy)benzoyl]amino]benzoateIC502050.0 [1]
Ethyl 2-[[4-(2,2-dimethylpropanoyloxy)benzoyl]amino]benzoateIC503020.0 [1]
Propyl 2-[[4-(2,2-dimethylpropanoyloxy)benzoyl]amino]benzoateIC503910.0 [1]
Methyl 2-[[4-(3,3,3-trifluoro-2,2-dimethylpropanoyl)oxybenzoyl]amino]benzoateIC5010000.0 [1]
Ethyl 2-[[4-(3,3,3-trifluoro-2,2-dimethylpropanoyl)oxybenzoyl]amino]benzoateIC5010000.0 [1]
Propyl 2-[[4-(3,3,3-trifluoro-2,2-dimethylpropanoyl)oxybenzoyl]amino]benzoateIC5010000.0 [1]
Methyl 2-[[4-(3,3,3-trifluoro-2,2-dimethylpropanoyl)oxyphenyl]sulfonylamino]benzoateIC504940.0 [1]
N-(2-Acetylphenyl)-4-(tert-butylsulfinylamino)benzenesulfonamideIC5010000.0 [1]
4-(Tert-butylsulfinylamino)-N-(2-formylphenyl)benzenesulfonamideIC5010000.0 [1]
[4-[[2-(2-Hydroxyethylcarbamoyl)phenyl]sulfamoyl]phenyl] 2,2-dimethylpropanoateIC50310.0 [1]
2-Hydroxyethyl 2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoateIC50610.0 [1]
2-[(1R,4S,7S,13S,19S,22S,25S,31R,34S,40S,43S,49S)-25,49-Dibenzyl-4,19-bis[(2S)-butan-2-yl]-28-butyl-34-[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-40-yl]acetamideKi10000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acidKi5.4 [1]
2-[(1R,4S,7S,13S,19S,22S,25S,31R,34S,40S,43S,49S)-40-(2-Amino-2-oxoethyl)-25,49-dibenzyl-4-[(2S)-butan-2-yl]-28-butyl-34-[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-19-yl]acetic acidKi10000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-1-[5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylethylamino]-4-oxobutanoic acidKi21.0 [1]
2-[(1R,4S,7S,13S,19S,22S,25S,31R,34S,40S,43S,49S)-40-(2-Amino-2-oxoethyl)-49-benzyl-4-[(2S)-butan-2-yl]-28-butyl-25-[[4-(diaminomethylideneamino)phenyl]methyl]-34-[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-19-yl]acetic acidKi10000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylethylamino]-4-oxobutanoic acidKi3600.0 [1]
[6-[[5-(Cyclopropanecarbonylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-4-oxopyran-3-yl] 3-fluorobenzoateIC50134000.0 [1]
5,5-Dimethyl-3-(phenylmethyl)-2,4-oxazolidinedioneIC5012800.0 [1]
cis-(S)-2-Amino-N-((1R,2R)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamideIC5050000.0 [1]
Methyl 2-[[4-(2,2-dimethylpropanoylamino)phenyl]sulfonylamino]benzoateIC5010000.0 [1]
(2S)-2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acidIC5050000.0 [1]
5,5-Dimethyl-3-(4-methylphenyl)sulfonyl-1,3-oxazolidine-2,4-dioneIC5014500.0 [1]
3-(4-Methoxybenzoyl)-5-phenyl-1,3-oxazolidine-2,4-dioneIC505000.0 [1]
2-(Benzothiazole-2-ylthiomethyl)-5-(pivaloyloxy)-4H-pyran-4-oneIC505900.0 [1]
2-(5-Carboxybenzoxazole-2-ylthiomethyl)-5-(pivaloyloxy)-4H-pyran-4-oneIC5047500.0 [1]
2-[[5-(2,2-Dimethylpropanoyloxy)-4-oxo-1-phenylpyridin-2-yl]methylsulfanyl]-1,3-benzoxazole-5-carboxylic acidIC50100000.0 [1]
2-[(5-Amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-(3,5-dichlorophenyl)-2-phenylacetamideIC50139000.0 [1]
Items per page: 1 - 10 of 46
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References

This online tool may be cited as follows

MLA

"Quest Database™ Leukocyte proteinase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/leukocyte-proteinase-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Leukocyte proteinase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/leukocyte-proteinase-3-inhibitors-ic50-ki.
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