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Leukocyte adhesion glycoprotein LFA-1 alpha Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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5-[[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]methyl]thiophene-3-carboxylic acidIC5018.0 [1], 276.0 [2], 280.0 [3]
Bms-688521IC502.5 [1], 60.0 [2], 276.0 [3]
2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyrimidine-5-carboxylic acidIC5011.0 [1], 260.0 [2]
5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyrazine-2-carboxylic acidIC5019.0 [1], 1260.0 [2]
6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridazine-3-carboxylic acidIC5013.0 [1], 270.0 [2]
2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridine-4-carboxylic acidIC503.6 [1], 50.0 [2]
4-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridine-2-carboxylic acidIC5056.0 [1], 140.0 [2]
2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyrimidine-4-carboxylic acidIC5026.0 [1], 310.0 [2]
6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyrimidine-4-carboxylic acidIC508.0 [1], 100.0 [2]
6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-2-methylpyridine-3-carboxylic acidIC5012.0 [1], 280.0 [2]
6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-4-methylpyridine-3-carboxylic acidIC5011.0 [1], 240.0 [2]
2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-thiazole-5-carboxylic acidIC505.0 [1], 170.0 [2]
2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-benzoxazole-7-carboxylic acidIC504.8 [1], 70.0 [2]
2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-benzoxazole-6-carboxylic acidIC506.0 [1], 410.0 [2]
2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-benzoxazole-5-carboxylic acidIC504.0 [1], 400.0 [2]
2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-benzothiazole-7-carboxylic acidIC501.8 [1], 80.0 [2]
2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-benzothiazole-6-carboxylic acidIC504.4 [1], 280.0 [2]
4-[(5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-7-pyridin-2-yl-1,3,7-triazaspiro[4.4]nonan-9-yl]benzonitrileIC5011.0 [1], 200.0 [2]
6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridine-3-carbonitrileIC5011.0 [1], 80.0 [2]
5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]pyridine-2-carbonitrileIC5012.0 [1], 140.0 [2]
4-[(5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-7-[5-(2H-tetrazol-5-yl)pyridin-2-yl]-1,3,7-triazaspiro[4.4]nonan-9-yl]benzonitrileIC501.8 [1], 80.0 [2]
Cucurbitacin IIC50950.0 [1]
Cucurbitacin EIC50180.0 [1]
Cucurbitacin DIC501360.0 [1]
[(E,6R)-6-[(2S,8S,9R,10S,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetateIC50300.0 [1]
2-Propen-1-one, 1-(4-acetyl-1-piperazinyl)-3-(4-((2-(1-methylethyl)phenyl)thio)-3-nitrophenyl)-IC5044.0 [1]
23,24-Dihydrocucurbitacin DIC5050000.0 [1]
Unii-nug7541qvzIC5040.0 [1]
3-[3-Chloro-4-(2,4-dichlorophenylthio)phenyl]-1-(4-acetylpiperazino)-2-propene-1-oneIC50140.0 [1]
1-[(E)-3-[4-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfanyl)-3-(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC5050.0 [1]
(2S)-2-[[2-(1-Benzofuran-6-carbonyl)-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acidIC50260.0 [1]
(2S)-2-[[5,7-Dichloro-2-(4-chlorobenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acidIC50430.0 [1]
3-[3-Nitro-4-(2,3-dichlorophenylthio)phenyl]-1-(4-acetylpiperazino)-2-propene-1-oneIC50105.0 [1]
(2S)-2-[[2,6-Dichloro-4-[3-hydroxy-3-(3-hydroxyphenyl)propyl]benzoyl]amino]-3-(thiophene-2-carbonylamino)propanoic acidIC501.4 [1]
1-[(E)-3-[4-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfanyl)-2,3-bis(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC503.0 [1]
3-[2,3-Bis(trifluoromethyl)-4-(2-methoxyphenylthio)phenyl]-1-(4-carboxypiperidino)-2-propene-1-oneIC505.0 [1]
3-[4-(2,3-Dihydro-1,4-benzodioxin-6-ylthio)-1-naphthyl]-1-(4-carboxypiperidino)-2-propene-1-oneIC50295.0 [1]
(Benzodioxan-6-yl)[2,3-dichloro-4-(E-((4-carboxypiperidin-1-yl)carbonyl)ethenyl)phenyl]sulfideIC507.0 [1]
1-[(E)-3-[3-Chloro-4-(2-methoxyphenyl)sulfanyl-2-(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC506.0 [1]
1-[(E)-3-[3-Chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)-5-(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC5020000.0 [1]
1-[(E)-3-[3-Chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC50145.0 [1]
1-{3-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-phenyl]-acryloyl}-piperidine-4-carboxylic acidIC5010.0 [1]
5-[(E)-3-(4-Acetylpiperazin-1-yl)-3-oxoprop-1-enyl]-2-(2,3-dichlorophenyl)sulfanyl-N,N-dimethylbenzenesulfonamideIC503750.0 [1]
1-{3-[4-(2-Methoxy-phenylsulfanyl)-2-methyl-phenyl]-acryloyl}-piperidine-4-carboxylic acidIC5020000.0 [1]
1-{3-[2,3-Dichloro-4-(2-methoxy-phenylsulfanyl)-phenyl]-acryloyl}-piperidine-4-carboxylic acidIC508.0 [1]
(E)-1-(4-Acetylpiperazin-1-yl)-3-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)-3-(trifluoromethyl)phenyl]prop-2-en-1-oneIC5055.0 [1]
1-[(E)-3-[4-(1-Methylindol-5-yl)sulfanyl-2,3-bis(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC505.0 [1]
3-[2,3-Dichloro-4-(2-methoxyphenylthio)phenyl]-1-morpholino-2-propene-1-oneIC5010.0 [1]
1-{3-[2-Chloro-4-(2-methoxy-phenylsulfanyl)-phenyl]-acryloyl}-piperidine-4-carboxylic acidIC501400.0 [1]
(E)-3-[4-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfanyl)-3-(trifluoromethyl)phenyl]-1-morpholin-4-ylprop-2-en-1-oneIC5030.0 [1]
(E)-1-(4-Acetylpiperazin-1-yl)-3-[2,3-dichloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]prop-2-en-1-oneIC507.0 [1]
3-[2,3-Dimethyl-4-(2-methoxyphenylthio)phenyl]-1-morpholino-2-propene-1-oneIC5090.0 [1]
1-[(E)-3-[4-(2-Methoxyphenyl)sulfanyl-2-methyl-5-nitrophenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC5020000.0 [1]
1-[(E)-3-[2,5-Dichloro-4-(2-methoxyphenyl)sulfanylphenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC5020000.0 [1]
3-[2-(Trifluoromethyl)-3-chloro-4-(2-methoxyphenylthio)phenyl]-1-morpholino-2-propene-1-oneIC508.0 [1]
1-[(E)-3-[5-Chloro-4-(2-methoxyphenyl)sulfanyl-2-methylphenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC5020000.0 [1]
3-[2-Fluoro-4-(2-methoxyphenylthio)phenyl]-1-(4-acetylpiperazino)-2-propene-1-oneIC503900.0 [1]
1-[(E)-3-[3-Chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)-2-(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC505.0 [1]
3-[3-Methoxy-4-(2-methoxyphenylthio)phenyl]-1-(4-acetylpiperazino)-2-propene-1-oneIC5010700.0 [1]
1-[(E)-3-[4-(2-Methoxyphenyl)sulfanyl-2-(trifluoromethyl)phenyl]prop-2-enoyl]piperidine-4-carboxylic acidIC50265.0 [1]
3-[3-Chloro-4-(2-methoxyphenylthio)phenyl]-1-morpholino-2-propene-1-oneIC50150.0 [1]
3-[4-(2,4-Dichlorophenylthio)phenyl]-1-(4-acetylpiperazino)-2-propene-1-oneIC504300.0 [1]
(E)-1-(4-Acetylpiperazin-1-yl)-3-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)-3-nitrophenyl]prop-2-en-1-oneIC50139.0 [1]
(1-Methylindol-5-yl)[2,3-dichloro-4-(E-((4-carboxypiperidin-1-yl)carbonyl)ethenyl)phenyl]sulfideIC506.0 [1]
3-[4-(2,3-Dichlorophenylthio)phenyl]-1-morpholino-2-propene-1-oneIC509100.0 [1]
(2S)-2-[[5,7-Dichloro-2-(2,3-dihydro-1-benzofuran-6-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acidIC50650.0 [1]
1-[(E)-3-[5,6-Difluoro-4-(2-propan-2-ylphenyl)sulfanylcyclohexa-1,3-dien-1-yl]prop-2-enoyl]piperidine-4-carboxylic acidIC50115.0 [1]
(2S)-2-[[2-(1-Benzofuran-2-carbonyl)-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acidIC5069.0 [1]
(2S)-3-Benzamido-2-[[5,7-dichloro-2-(4-chlorobenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]propanoic acidIC50550.0 [1]
(8S,9R,13R,14S,16R)-17-[(2S)-2,6-Dihydroxy-6-methyl-3-oxoheptan-2-yl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthrene-3,11-dioneIC5050000.0 [1]
2-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]-1,3-oxazole-4-carboxylic acidIC5058.0 [1]
4-[(5S,9R)-7-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl]benzonitrileIC5060.0 [1]
(2S)-2-[(2-Benzoyl-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl)amino]-3-(thiophene-2-carbonylamino)propanoic acidIC501200.0 [1]
(2S)-2-[[5,7-Dichloro-2-(4-methylbenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acidIC501600.0 [1]
(2S)-2-[[5,7-Dichloro-2-(3-chlorobenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(thiophene-2-carbonylamino)propanoic acidIC50240.0 [1]
(2S)-2-[[5,7-Dichloro-2-(4-chlorobenzoyl)-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(furan-2-carbonylamino)propanoic acidIC503800.0 [1]
N-Ethyl-2-[[4-[[(1R)-1-phenylethyl]amino]-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxamideIC5010000.0 [1]
2-[[4-(Benzylamino)-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-N-ethyl-1,3-dihydroindene-2-carboxamideIC507900.0 [1]
N-Ethyl-2-[[4-(2-phenylethylamino)-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxamideIC50488.0 [1]
N-Ethyl-2-[[4-(ethylamino)-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxamideIC5010000.0 [1]
2-[[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxylic acidIC5037.0 [1]
[5-[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-(2,3-dihydro-1H-inden-2-ylamino)-1,3,5-triazin-2-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-[3-(trifluoromethyl)phenyl]methanoneIC50358.0 [1]
[5-[4-(Cyclopentylamino)-6-[2-(3,4-dichlorophenyl)ethylamino]-1,3,5-triazin-2-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-[3-(trifluoromethyl)phenyl]methanoneIC5010000.0 [1]
2-[[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-[5-[3-(trifluoromethyl)phenyl]sulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxylic acidIC5065.0 [1]
(2E)-2-[(E)-3-[1-[6-[4-[[2-[[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carbonyl]amino]butylamino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindol-1-ium-2-yl]prop-2-enylidene]-1-ethyl-3,3-dimethylindole-5-sulfonic acidIC50100.0 [1]
(2E)-2-[(E)-3-[1-[6-[4-[[2-[[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-[5-[3-(trifluoromethyl)phenyl]sulfonyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carbonyl]amino]butylamino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindol-1-ium-2-yl]prop-2-enylidene]-1-ethyl-3,3-dimethylindole-5-sulfonic acidIC5028.0 [1]
2-[[4-[2-(3,4-Dichlorophenyl)ethylamino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino]-N-ethyl-1,3-dihydroindene-2-carboxamideIC5012900.0 [1]
N-Ethyl-2-[[4-[[(1S)-1-phenylethyl]amino]-6-[5-[3-(trifluoromethyl)benzoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,3,5-triazin-2-yl]amino]-1,3-dihydroindene-2-carboxamideIC50180.0 [1]
Items per page: 1 - 10 of 88
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References

This online tool may be cited as follows

MLA

"Quest Database™ Leukocyte adhesion glycoprotein LFA-1 alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 13 Nov. 2024, https://www.aatbio.com/data-sets/leukocyte-adhesion-glycoprotein-lfa-1-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 13). Quest Database™ Leukocyte adhesion glycoprotein LFA-1 alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/leukocyte-adhesion-glycoprotein-lfa-1-alpha-inhibitors-ic50-ki.
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