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Leucyl-tRNA synthetase Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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Standard Values (in nM)
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▼
[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-phenyl-1,3-thiazol-2-yl)oxolan-2-yl]methyl N-[(2S,3S)-2-amino-3-methylpentanoyl]sulfamateIC501000.0 [1], 20000.0 [2], 200000.0 [3]
[(2R,3S,4R,5R)-3,4-Dihydroxy-5-[4-(4-phenoxyphenyl)-1,3-thiazol-2-yl]oxolan-2-yl]methyl N-[(2S)-2-amino-4-methylpentanoyl]sulfamateIC501.6 [1], 600.0 [2]
[(2R,3S,4R,5R)-3,4-Dihydroxy-5-[4-[2-(4-phenoxyphenyl)ethyl]-1,3-thiazol-2-yl]oxolan-2-yl]methyl N-[(2S)-2-amino-4-methylpentanoyl]sulfamateIC506.0 [1], 1150.0 [2]
[(2R,3S,4R,5R)-3,4-Dihydroxy-5-[4-(2-phenylethyl)-1,3-thiazol-2-yl]oxolan-2-yl]methyl N-[(2S)-2-amino-4-methylpentanoyl]sulfamateIC502.0 [1], 730.0 [2]
(4Ar,6S,7R,7aS)-7-[[2-[[(2S,3S)-2-amino-3-methylpentanoyl]sulfamoyl]acetyl]amino]-4-carbamoyl-6-hydroxy-2-methyl-4a,5,6,7a-tetrahydro-1H-cyclopenta[c]pyridine-7-carboxylic acidIC501550.0 [1]
1-[5-[4-(4-Chlorophenyl)phenoxy]pentyl]-3-(4-pyridyl)imidazolidin-2-oneIC501310.0 [1]
2-[[(3S)-3-(Aminomethyl)-4-chloro-1-hydroxy-3H-2,1-benzoxaborol-7-yl]oxy]ethanol;hydrochlorideIC50132000.0 [1]
Ethyl 2-[(2E)-2-[(4-hydroxy-3-methoxy-phenyl)methylene]hydrazino]-4-methyl-thiazole-5-carboxylateIC50116300.0 [1]
(4Ar,6S,7R,7aS)-7-[[2-[[(2S)-2-amino-4-methylpentanoyl]sulfamoyl]acetyl]amino]-4-carbamoyl-6-hydroxy-2-methyl-4a,5,6,7a-tetrahydro-1H-cyclopenta[c]pyridine-7-carboxylic acidIC5016.0 [1]
(4Ar,6S,7R,7aS)-7-[[2-[[(2S)-2-amino-3-methylbutanoyl]sulfamoyl]acetyl]amino]-4-carbamoyl-6-hydroxy-2-methyl-4a,5,6,7a-tetrahydro-1H-cyclopenta[c]pyridine-7-carboxylic acidIC502300.0 [1]
Methyl (4aR,6S,7R,7aS)-7-[[2-[[(2S,3S)-2-amino-3-methylpentanoyl]sulfamoyl]acetyl]amino]-4-carbamoyl-6-hydroxy-2-methyl-4a,5,6,7a-tetrahydro-1H-cyclopenta[c]pyridine-7-carboxylateIC50186000.0 [1]
1-[(3S)-5-[4-(4-Chlorophenyl)phenoxy]-3-methyl-pentyl]-3-(4-pyridyl)imidazolidin-2-oneIC5025000.0 [1]
1-[(3R)-5-[4-(4-Chlorophenyl)phenoxy]-3-methyl-pentyl]-3-(4-pyridyl)imidazolidin-2-oneIC5025000.0 [1]
(2S)-2-Amino-N-(benzenesulfonyl)-4-methylpentanamideIC501100.0 [1]
(2S)-2-Amino-4-methyl-N-[3-(6-methylpyrimidin-4-yl)phenyl]sulfonylpentanamideIC502000.0 [1]
(2S)-2-Amino-4-methyl-N-(3-phenylphenyl)sulfonylpentanamideIC503400.0 [1]
(2S)-2-Amino-N-[3-(2-aminopyridin-4-yl)phenyl]sulfonyl-4-methylpentanamideIC50490.0 [1]
(2S)-2-Amino-4-methyl-N-naphthalen-2-ylsulfonylpentanamideIC50220.0 [1]
N-[(3,4-Dimethoxyphenyl)methyl]-4-[(4S)-4-(2-methylpropyl)-2,5-dioxoimidazolidin-1-yl]benzenesulfonamideIC50800000.0 [1]
(2S)-2-Amino-N-[3-(2-amino-6-methylpyrimidin-4-yl)phenyl]sulfonyl-4-methylpentanamideIC50160.0 [1]
(2S)-2-Amino-N-[3-(2-aminopyrimidin-4-yl)phenyl]sulfonyl-4-methylpentanamideIC503900.0 [1]
(2S)-2-Amino-N-[3-(2-amino-6-phenylpyrimidin-4-yl)phenyl]sulfonyl-4-methylpentanamideIC5033.0 [1]
(2S)-2-Amino-4-methyl-N-(3-pyridin-4-ylphenyl)sulfonylpentanamideIC501200.0 [1]
(2S)-2-Amino-N-[3-(6-aminopyridin-2-yl)phenyl]sulfonyl-4-methylpentanamideIC50850.0 [1]
2-Methoxy-6-nitro-4-[(Z)-{2-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]phenolIC5045800.0 [1]
4-[(Z)-{2-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]-2-methoxy-6-nitrophenolIC50115700.0 [1]
2-Bromo-4-[(E)-{2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]-6-methoxyphenolIC5027600.0 [1]
2,6-Dibromo-4-[(E)-[[4-(4-nitrophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]phenolIC5018700.0 [1]
[(3S)-4-Chloro-1-hydroxy-7-methoxy-3H-2,1-benzoxaborol-3-yl]methanamine;hydrochlorideIC50260000.0 [1]
[(3S)-4-Bromo-1-hydroxy-7,8-dihydro-3H-oxaborolo[4,3-h][1,4]benzodioxin-3-yl]methanamine;hydrochlorideIC50118000.0 [1]
(2S)-2-Amino-N-[4-[(3,4-dimethoxyphenyl)methylsulfamoyl]phenyl]-4-methylpentanamideIC50800000.0 [1]
[(3S)-4-Bromo-1-hydroxy-7-methoxy-3H-2,1-benzoxaborol-3-yl]methanamine;hydrochlorideIC50300000.0 [1]
2-[[(3S)-3-(Aminomethyl)-4-bromo-1-hydroxy-3H-2,1-benzoxaborol-7-yl]oxy]ethanol;hydrochlorideIC50118000.0 [1]
[(3S)-4-Chloro-1-hydroxy-7,8-dihydro-3H-oxaborolo[4,3-h][1,4]benzodioxin-3-yl]methanamine;hydrochlorideIC5096600.0 [1]
[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-phenyl-1,3-thiazol-2-yl)oxolan-2-yl]methyl N-[(2S)-2-amino-3-phenylpropanoyl]sulfamateIC50100000.0 [1]
[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-phenyl-1,3-thiazol-2-yl)oxolan-2-yl]methyl N-[(2S)-2-aminopropanoyl]sulfamateIC50100000.0 [1]
[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-phenyl-1,3-thiazol-2-yl)oxolan-2-yl]methyl N-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]sulfamateIC50100000.0 [1]
[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-phenyl-1,3-thiazol-2-yl)oxolan-2-yl]methyl N-[(2S)-2-amino-3-methylbutanoyl]sulfamateIC5014000.0 [1]
CID 56944759IC5066900.0 [1]
(2S)-2-Amino-N-[3-[[2-(4-bromo-2-chlorophenoxy)acetyl]carbamothioylamino]phenyl]sulfonyl-4-methylpentanamideIC504500.0 [1]
CID 56944652IC5038800.0 [1]
Items per page: 1 - 10 of 41
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References

This online tool may be cited as follows

MLA

"Quest Database™ Leucyl-tRNA synthetase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/leucyl-trna-synthetase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Leucyl-tRNA synthetase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/leucyl-trna-synthetase-inhibitors-ic50-ki.
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