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Leucine-rich repeat serine/threonine-protein kinase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Lrrk2-IN-1IC5013.0 [1]
Lrrk2-IN-1Ki6.0 [1]
6-Azanyl-4-(3-Methylphenyl)-1~{h}-Pyrrolo[2,3-B]pyridine-3-CarbonitrileIC5061.66 [1]
6-Azanyl-4-(3-Methylphenyl)-1~{h}-Pyrrolo[2,3-B]pyridine-3-CarbonitrileKi0.5 [1], 2.0 [2]
CID 58539301IC5020.3 [1]
CID 58539301Ki3.0 [1]
Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-IC5010.9 [1]
3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrileIC503.0 [1], 11.0 [2], 15.0 [3], 25.0 [4]
5-(1-Methyl-1H-pyrazol-4-yl)-4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidineIC5012.0 [1], 36.0 [2], 50.0 [3], 278.0 [4]
3-[4-(Dimethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrileIC505.0 [1], 15.0 [2], 42.0 [3], 89.0 [4]
5-[4-(Morpholin-4-Ylmethyl)phenyl]-3-(1-Propan-2-Yl-1,2,3-Triazol-4-Yl)pyridin-2-AmineIC50160.0 [1], 300.0 [2], 920.0 [3], 2100.0 [4]
4-(3-Methylphenyl)-6-[(1-Methylpyrazol-3-Yl)amino]-1~{h}-Pyrrolo[2,3-B]pyridine-3-CarbonitrileIC501.0 [1], 2.0 [2], 17.0 [3], 18.0 [4]
4-(3-Methylphenyl)-6-[(1-Methylpyrazol-3-Yl)amino]-1~{h}-Pyrrolo[2,3-B]pyridine-3-CarbonitrileKi0.06 [1], 0.1 [2]
6-[(1,4-Dimethylpyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC50108.0 [1], 210.0 [2], 215.0 [3], 580.0 [4]
6-[(1-Methylpyrazol-3-yl)amino]-4-(5-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC5027.0 [1], 37.0 [2], 70.0 [3], 90.0 [4]
6-[(1,4-Dimethylpyrazol-3-yl)amino]-4-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC5036.0 [1], 50.0 [2], 130.0 [3], 170.0 [4]
6-[(1-Methylpyrazol-3-yl)amino]-4-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC5085.0 [1], 99.0 [2], 100.0 [3], 112.0 [4]
CID 58539171IC509.0 [1], 46.0 [2], 97.0 [3]
CID 58539171Ki1.0 [1], 2.0 [2]
CID 44252884IC501.3 [1], 1.9 [2], 4.0 [3], 7.0 [4]
CID 44252884Ki7.0 [1]
4-[5-(1-Methylpyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholineIC5053.0 [1], 90.0 [2], 2570.0 [3]
2-Fluoro-3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrileIC502.0 [1], 3.0 [2], 7.0 [3], 9.0 [4], 20.0 [5]
3-(4-Pyrrolidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrileIC508.0 [1], 64.0 [2], 432.0 [3]
3-[4-(Diethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrileIC5013.0 [1], 20.0 [2], 119.0 [3], 151.0 [4], 443.0 [5]
4-[5-(3-Methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholineIC5028.0 [1], 46.0 [2], 882.0 [3]
4-(5-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholineIC509.0 [1], 14.0 [2], 198.0 [3]
4-[5-(3-Chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholineIC508.0 [1], 13.0 [2], 144.0 [3]
6-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]pyridine-2-carbonitrileIC509.0 [1], 26.0 [2], 298.0 [3]
3-(4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrileIC506.0 [1], 28.0 [2], 182.0 [3]
3-[4-[(3S)-3-Methylpiperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrileIC5016.0 [1], 45.0 [2], 49.0 [3], 210.0 [4]
4-[6-(5-Propan-2-yloxy-1H-indazol-3-yl)pyrimidin-4-yl]morpholineIC505.95 [1], 7.12 [2], 7.2 [3], 41.0 [4], 96.0 [5]
4-[5-(5-Methylpyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholineIC5018.0 [1], 30.0 [2], 211.0 [3]
Nvp-tae 684IC506.1 [1], 7.8 [2], 21.9 [3], 93.3 [4]
6-(2,5-Dimethoxyphenyl)sulfanyl-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazineIC5040.0 [1], 82.0 [2], 173.0 [3], 1380.0 [4]
2-[2-Methoxy-4-(morpholine-4-carbonyl)-phenylamino]-4-methylamino-pyrimidine-5-carbonitrileIC50105.0 [1]
2-[2-Methoxy-4-(morpholine-4-carbonyl)-phenylamino]-4-methylamino-pyrimidine-5-carbonitrileKi2.4 [1], 11.0 [2], 13.0 [3]
[3-Methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneIC509.0 [1]
[3-Methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneKi1.0 [1], 2.0 [2], 2.7 [3]
6-[(1-Methylpyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC5055.0 [1], 102.0 [2], 130.0 [3], 700.0 [4]
6-[(1-Methylpyrazol-3-yl)amino]-4-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC5028.0 [1], 41.0 [2], 76.0 [3], 160.0 [4]
6-[(4-Chloro-1-methylpyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC50158.0 [1], 180.0 [2], 210.0 [3], 1300.0 [4]
6-[(4-Chloro-1-methylpyrazol-3-yl)amino]-4-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC5044.0 [1], 57.0 [2], 94.0 [3], 110.0 [4]
6-[(4-Chloro-1-methylpyrazol-3-yl)amino]-4-(5-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC5067.0 [1], 68.0 [2], 93.0 [3], 190.0 [4]
6-[(1,4-Dimethylpyrazol-3-yl)amino]-4-(5-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC5043.0 [1], 48.0 [2], 160.0 [3], 170.0 [4]
3-{4-[(2S)-2-Methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrileIC507.0 [1], 18.0 [2], 69.0 [3], 122.0 [4]
3-[4-[3-(Methoxymethyl)piperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrileIC5095.0 [1], 219.0 [2]
3-[4-(3-Methoxypiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrileIC5079.0 [1], 154.0 [2]
3-(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)-5-(1-methyl-2,3-dihydroindol-5-yl)pyridin-2-amineIC50710.0 [1], 970.0 [2]
3-(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)-5-[4-(morpholin-4-ylmethyl)phenyl]pyridin-2-amineIC50390.0 [1], 490.0 [2]
5-(1-Methylindol-5-yl)-3-(1-propan-2-yltriazol-4-yl)pyridin-2-amineIC50540.0 [1], 550.0 [2]
5-(4-Morpholin-4-ylphenyl)-3-(1-propan-2-yltriazol-4-yl)pyridin-2-amineIC50280.0 [1], 340.0 [2]
5-[4-(2-Morpholin-4-ylethyl)phenyl]-3-(1-propan-2-yltriazol-4-yl)pyridin-2-amineIC50340.0 [1], 600.0 [2]
3-(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)-5-(1H-indol-5-yl)pyridin-2-amineIC50570.0 [1], 1000.0 [2], 1300.0 [3], 1600.0 [4]
6-Amino-4-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC50216.0 [1], 240.0 [2]
6-Amino-4-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileKi3.0 [1], 12.0 [2]
4-Thiophen-3-yl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC50851.0 [1], 1279.0 [2]
4-Thiophen-3-yl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileKi31.0 [1], 60.0 [2]
CID 86287875IC50170.0 [1], 195.0 [2]
CID 86287875Ki4.0 [1], 13.0 [2]
4-(3-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileIC50201.0 [1], 247.0 [2]
4-(3-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrileKi6.0 [1], 24.0 [2]
3-[4-[2-(3-Methyl-1,2,4-oxadiazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrileIC5020.0 [1], 176.0 [2], 390.0 [3]
3-[4-[(2R)-2-Methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrileIC5018.0 [1], 69.0 [2], 377.0 [3]
3-[4-[2-(1,2-Oxazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrileIC5037.0 [1], 234.0 [2], 1467.0 [3]
1-[5-Chloro-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]pyrazol-1-yl]-2-methylpropan-2-olIC5028.0 [1]
1-[5-Chloro-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]pyrazol-1-yl]-2-methylpropan-2-olKi9.0 [1]
4-(4-Isopropoxy-1H-pyrazolo[4,3-c]pyridin-3-yl)-1-isopropyl-N-(oxetan-3-yl)-1H-pyrrole-2-carboxaMideKi2.4 [1]
[2-Fluoro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneIC5016.0 [1]
[2-Fluoro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneKi2.9 [1], 6.0 [2]
(4-(5-Bromo-4-(methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl)(morpholino)methanoneIC5013.0 [1]
(4-(5-Bromo-4-(methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl)(morpholino)methanoneKi1.0 [1], 2.0 [2]
(4-(5-Fluoro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl)(morpholino)methanoneIC50418.0 [1]
(4-(5-Fluoro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl)(morpholino)methanoneKi58.0 [1], 71.0 [2]
4-[[(1R)-1-Cyclopropylethyl]amino]-7-pyridin-4-ylcinnoline-3-carboxamideIC502.0 [1], 6.0 [2]
7-(4-Methylsulfonylphenyl)-4-(propan-2-ylamino)quinoline-3-carboxamideIC5035.0 [1], 39.0 [2], 41.0 [3]
(2S)-2-Methyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholineIC503.8 [1], 5.8 [2], 76.0 [3]
(7R)-3-(Cyclopropylmethylsulfanyl)-7-methyl-1-(1H-pyrazol-5-yl)-6,7-dihydro-5H-thieno[3,4-c]pyridin-4-oneIC5031.0 [1]
(7R)-3-(Cyclopropylmethylsulfanyl)-7-methyl-1-(1H-pyrazol-5-yl)-6,7-dihydro-5H-thieno[3,4-c]pyridin-4-oneKi34.0 [1], 83.0 [2]
3-[4-(Azetidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrileIC50115.0 [1], 325.0 [2], 7687.0 [3]
2-Fluoro-5-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrileIC50117.0 [1], 920.0 [2], 2460.0 [3]
3-Fluoro-5-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrileIC5080.0 [1], 688.0 [2], 2082.0 [3]
3-[2-[(3R,4R)-3,4-Difluoropyrrolidin-1-yl]pyridin-4-yl]-5-propan-2-yloxy-1H-indazoleIC506.6 [1], 128.0 [2], 341.0 [3]
[5-Fluoro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneIC5063.0 [1]
[5-Fluoro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneKi4.8 [1], 7.0 [2]
[4-[(5-Chloro-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanoneIC5069.0 [1]
[4-[(5-Chloro-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanoneKi9.0 [1], 10.4 [2]
[5-Chloro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneIC5024.0 [1]
[5-Chloro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneKi2.0 [1], 4.0 [2]
[2-Chloro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneIC507.0 [1]
[2-Chloro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneKi2.0 [1]
[2-Fluoro-3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneIC5035.0 [1]
[2-Fluoro-3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanoneKi12.0 [1], 14.5 [2]
[5-Chloro-4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-methoxyphenyl]-morpholin-4-ylmethanoneIC5027.0 [1]
[5-Chloro-4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-methoxyphenyl]-morpholin-4-ylmethanoneKi3.0 [1], 3.4 [2]
2-N-(5-Fluoro-2-methoxy-4-methylsulfonylphenyl)-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamineIC5027.0 [1]
2-N-(5-Fluoro-2-methoxy-4-methylsulfonylphenyl)-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamineKi2.0 [1], 3.0 [2]
5-[[4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-(2-hydroxy-2-methylpropyl)-6-methoxy-3H-isoindol-1-oneIC5022.0 [1]
5-[[4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-(2-hydroxy-2-methylpropyl)-6-methoxy-3H-isoindol-1-oneKi3.0 [1], 4.0 [2]
2-N-[2-Chloro-4-(1-methyltetrazol-5-yl)phenyl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamineIC50100.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Leucine-rich repeat serine/threonine-protein kinase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/leucine-rich-repeat-serine-threonine-protein-kinase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Leucine-rich repeat serine/threonine-protein kinase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/leucine-rich-repeat-serine-threonine-protein-kinase-2-inhibitors-ic50-ki.
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